RGD Reference Report - Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo. - Rat Genome Database

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Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo.

Authors: Heemers, H  Vanderhoydonc, F  Roskams, T  Shechter, I  Heyns, W  Verhoeven, G  Swinnen, JV 
Citation: Heemers H, etal., Mol Cell Endocrinol. 2003 Jul 31;205(1-2):21-31.
RGD ID: 2316300
Pubmed: PMID:12890564   (View Abstract at PubMed)

In prostate cancer cell lines in culture androgens cause a marked and coordinated upregulation of the expression of several lipogenic genes. Here, using castrated male Wistar rats as an experimental paradigm, we investigated whether coordinated androgen stimulation of lipogenic gene expression represents a more general physiological regulation in non-cancerous androgen-responsive cells as well. In typical target tissues for androgen action such as the ventral prostate and the lacrimal gland, androgen deprivation resulted in a marked reduction in the mRNA and protein levels of genes involved in fatty acid (fatty acid synthase and acetyl-CoA-carboxylase) and cholesterol synthesis (HMG-CoA-reductase and farnesyl diphosphate synthase). Readministration of testosterone immediately following orchidectomy restored the expression of all four genes. Substitution of testosterone by the non-aromatizable androgen dihydrotestosterone gave rise to comparable changes in the mRNA and protein levels of the lipogenic genes under investigation, confirming the involvement of the androgen receptor in the observed effects. In support of the coordinate nature of this regulation, androgen-induced upregulation of lipogenic gene expression is accompanied by an increase in the nuclear content of SREBP, a key lipogenic transcription factor. Taken together, these findings provide evidence for a coordinate regulation of lipogenic gene expression not only in prostate cancer cell lines in culture but also in non-cancerous androgen-responsive tissues in vivo.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FdpsRatresponse to testosterone  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fdps  (farnesyl diphosphate synthase)


Additional Information