Ggcx (gamma-glutamyl carboxylase) - Rat Genome Database

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Gene: Ggcx (gamma-glutamyl carboxylase) Rattus norvegicus
Analyze
Symbol: Ggcx
Name: gamma-glutamyl carboxylase
RGD ID: 68383
Description: Enables gamma-glutamyl carboxylase activity and vitamin binding activity. Involved in several processes, including lung growth; response to dexamethasone; and response to vitamin D. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum lumen and endoplasmic reticulum membrane. Biomarker of urolithiasis. Human ortholog(s) of this gene implicated in combined deficiency of vitamin K-dependent clotting factors 1. Orthologous to human GGCX (gamma-glutamyl carboxylase); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: peptidyl-glutamate 4-carboxylase; vitamin K gamma glutamyl carboxylase; vitamin K-dependent gamma-carboxylase; vitamin K-dependent gamma-glutamyl carboxylase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,027,918 - 106,043,653 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4106,027,912 - 106,043,923 (+)EnsemblGRCr8
mRatBN7.24104,469,737 - 104,485,631 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,469,765 - 104,487,063 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4109,849,413 - 109,865,120 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,624,526 - 105,640,233 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,237,548 - 104,253,262 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,277,345 - 100,293,097 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,277,391 - 100,293,250 (+)Ensemblrn6Rnor6.0
Rnor_5.04165,047,672 - 165,063,604 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44105,719,323 - 105,735,037 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera493,622,596 - 93,638,331 (+)NCBICelera
RGSC_v3.14105,963,803 - 105,979,517 (+)NCBI
Cytogenetic Map4q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acenocoumarol  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
choline  (ISO)
chromium atom  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
glafenine  (EXP)
hydrogen cyanide  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
N-nitrosodimethylamine  (ISO)
nickel dichloride  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
phenprocoumon  (EXP)
phenylmercury acetate  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (ISO)
topotecan  (EXP)
trovafloxacin  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
warfarin  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Enhanced renal vitamin-K-dependent gamma-glutamyl carboxylase activity in experimental rat urolithiasis. Angayarkanni N and Selvam R, Eur Urol. 1998;33(1):116-20.
2. Liver-specific gamma-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span. Azuma K, etal., PLoS One. 2014 Feb 10;9(2):e88643. doi: 10.1371/journal.pone.0088643. eCollection 2014.
3. A missense mutation in gamma-glutamyl carboxylase gene causes combined deficiency of all vitamin K-dependent blood coagulation factors. Brenner B, etal., Blood. 1998 Dec 15;92(12):4554-9.
4. Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K-dependent coagulation factor deficiency. Darghouth D, etal., Blood. 2006 Sep 15;108(6):1925-31. Epub 2006 May 23.
5. Vitamin K-dependent carboxylase activity in fetal rat lung: developmental effects of dexamethasone and triiodothyronine. Gallaher KJ, etal., Pediatr Res. 1989 May;25(5):530-4.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Glucocorticoid effects on vitamin K-dependent carboxylase activity and matrix Gla protein expression in rat lung. Gilbert KA and Rannels SR, Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L569-77. Epub 2003 May 16.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Effects of parathyroid hormone and vitamin D on the renal vitamin K-dependent carboxylating system. Karl PI and Friedman PA, J Biol Chem. 1983 Nov 10;258(21):12783-6.
10. Effects of 1,25-dihydroxycholecalciferol administration on the rat renal vitamin K-dependent carboxylating system. Karl PI, etal., FEBS Lett. 1985 Nov 18;192(2):243-6.
11. Vitamin K-dependent carboxylase: effect of Mn2+ and other divalent cations. Larson AE and Suttie JW, FEBS Lett. 1980 Aug 25;118(1):95-8.
12. Vitamin K-dependent carboxylase: mRNA distribution and effects of vitamin K-deficiency and warfarin treatment. Liu Y, etal., Biochem Biophys Res Commun. 1996 Jul 16;224(2):549-54.
13. Oxygen dependence of vitamin K-dependent carboxylase and vitamin K epoxidase. McTigue JJ and Suttie JW, FEBS Lett. 1986 May 5;200(1):71-5.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Congenital deficiency of vitamin K dependent coagulation factors in two families presents as a genetic defect of the vitamin K-epoxide-reductase-complex. Oldenburg J, etal., Thromb Haemost. 2000 Dec;84(6):937-41.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Cloning, structural organization, and transcriptional activity of the rat vitamin K-dependent gamma-glutamyl carboxylase gene. Romero EE, etal., Biochem Biophys Res Commun 1998 Jul 30;248(3):783-8.
24. Cloning of rat vitamin K-dependent gamma-glutamyl carboxylase and developmentally regulated gene expression in postimplantation embryos. Romero EE, etal., Exp Cell Res 1998 Sep 15;243(2):334-46.
25. Compound heterozygous mutations in the gamma-glutamyl carboxylase gene cause combined deficiency of all vitamin K-dependent blood coagulation factors. Rost S, etal., Br J Haematol. 2004 Aug;126(4):546-9.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Structural and functional insights into enzymes of the vitamin K cycle. Tie JK and Stafford DW, J Thromb Haemost. 2016 Feb;14(2):236-47. doi: 10.1111/jth.13217. Epub 2016 Jan 29.
28. Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity. Vanakker OM, etal., J Invest Dermatol. 2007 Mar;127(3):581-7. Epub 2006 Nov 16.
29. Vitamin K 2,3-epoxide reductase and the vitamin K-dependent gamma-carboxylation system. Wallin R, etal., Thromb Res. 2002 Nov 25;108(4):221-6.
Additional References at PubMed
PMID:12477932   PMID:15075329   PMID:23118128   PMID:27488359   PMID:27846632  


Genomics

Comparative Map Data
Ggcx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,027,918 - 106,043,653 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4106,027,912 - 106,043,923 (+)EnsemblGRCr8
mRatBN7.24104,469,737 - 104,485,631 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,469,765 - 104,487,063 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4109,849,413 - 109,865,120 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,624,526 - 105,640,233 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,237,548 - 104,253,262 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,277,345 - 100,293,097 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,277,391 - 100,293,250 (+)Ensemblrn6Rnor6.0
Rnor_5.04165,047,672 - 165,063,604 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44105,719,323 - 105,735,037 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera493,622,596 - 93,638,331 (+)NCBICelera
RGSC_v3.14105,963,803 - 105,979,517 (+)NCBI
Cytogenetic Map4q32NCBI
GGCX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,544,720 - 85,561,493 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,544,720 - 85,561,819 (-)Ensemblhg38GRCh38
GRCh37285,771,843 - 85,788,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,629,714 - 85,642,090 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34285,687,861 - 85,700,237NCBI
Celera285,604,381 - 85,616,845 (-)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,669,320 - 85,686,004 (-)NCBIHuRef
CHM1_1285,701,785 - 85,718,463 (-)NCBICHM1_1
T2T-CHM13v2.0285,546,779 - 85,563,552 (-)NCBIT2T-CHM13v2.0
Ggcx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,391,262 - 72,407,696 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl672,391,291 - 72,407,695 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38672,414,279 - 72,433,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,414,308 - 72,430,712 (+)Ensemblmm10GRCm38
MGSCv37672,364,327 - 72,380,701 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36672,343,842 - 72,360,216 (+)NCBIMGSCv36mm8
Celera674,509,409 - 74,525,757 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.27NCBI
Ggcx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554241,936,772 - 1,952,635 (+)Ensembl
ChiLan1.0NW_0049554241,926,924 - 1,952,635 (+)NCBIChiLan1.0ChiLan1.0
GGCX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21240,819,956 - 40,833,578 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A40,822,718 - 40,836,051 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A85,599,227 - 85,612,274 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A87,152,108 - 87,164,567 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A87,152,111 - 87,164,567 (-)EnsemblpanPan2panpan1.1
GGCX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,512,293 - 39,525,251 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,512,387 - 39,529,121 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1739,183,664 - 39,196,637 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01740,258,976 - 40,271,953 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1740,259,006 - 40,275,813 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11739,388,607 - 39,401,574 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01739,460,505 - 39,473,477 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01739,860,352 - 39,873,319 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ggcx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629279,147,378 - 79,158,577 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367121,699,750 - 1,709,087 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367121,696,264 - 1,709,087 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GGCX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl359,202,429 - 59,218,145 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1359,202,363 - 59,219,807 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,263,519 - 62,276,716 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GGCX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,593,202 - 21,605,800 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1421,593,088 - 21,604,885 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604590,859,363 - 90,872,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ggcx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474917,579,661 - 17,593,150 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474917,579,690 - 17,595,111 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ggcx
59 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:102
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000017927
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat

Markers in Region
RH133207  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24104,474,837 - 104,475,029 (+)MAPPERmRatBN7.2
Rnor_6.04100,282,463 - 100,282,654NCBIRnor6.0
Rnor_5.04165,052,752 - 165,052,943UniSTSRnor5.0
RGSC_v3.44105,724,403 - 105,724,594UniSTSRGSC3.4
Celera493,627,672 - 93,627,863UniSTS
RH 3.4 Map4631.74UniSTS
Cytogenetic Map4q33UniSTS
RH140466  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24104,485,354 - 104,485,470 (+)MAPPERmRatBN7.2
Rnor_6.04100,292,979 - 100,293,094NCBIRnor6.0
Rnor_5.04165,063,486 - 165,063,601UniSTSRnor5.0
RGSC_v3.44105,734,919 - 105,735,034UniSTSRGSC3.4
Celera493,638,213 - 93,638,328UniSTS
RH 3.4 Map4651.23UniSTS
Cytogenetic Map4q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017927   ⟹   ENSRNOP00000017928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4106,027,912 - 106,043,806 (+)Ensembl
mRatBN7.2 Ensembl4104,469,765 - 104,485,627 (+)Ensembl
Rnor_6.0 Ensembl4100,277,412 - 100,293,250 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084281   ⟹   ENSRNOP00000072920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4106,027,962 - 106,033,600 (+)Ensembl
mRatBN7.2 Ensembl4104,469,781 - 104,475,419 (+)Ensembl
Rnor_6.0 Ensembl4100,277,406 - 100,283,044 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086820   ⟹   ENSRNOP00000071364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4104,484,088 - 104,487,063 (+)Ensembl
Rnor_6.0 Ensembl4100,277,391 - 100,293,250 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107225   ⟹   ENSRNOP00000088854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4106,027,946 - 106,043,923 (+)Ensembl
mRatBN7.2 Ensembl4104,469,794 - 104,487,063 (+)Ensembl
RefSeq Acc Id: NM_031756   ⟹   NP_113944
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84106,027,939 - 106,043,653 (+)NCBI
mRatBN7.24104,469,758 - 104,485,473 (+)NCBI
Rnor_6.04100,277,383 - 100,293,097 (+)NCBI
Rnor_5.04165,047,672 - 165,063,604 (+)NCBI
RGSC_v3.44105,719,323 - 105,735,037 (+)RGD
Celera493,622,596 - 93,638,331 (+)RGD
Sequence:
RefSeq Acc Id: XM_017592909   ⟹   XP_017448398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84106,027,918 - 106,041,607 (+)NCBI
mRatBN7.24104,469,737 - 104,483,457 (+)NCBI
Rnor_6.04100,277,345 - 100,291,081 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063286749   ⟹   XP_063142819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84106,027,918 - 106,033,644 (+)NCBI
RefSeq Acc Id: NP_113944   ⟸   NM_031756
- UniProtKB: O88496 (UniProtKB/Swiss-Prot),   A0A8I6AAB6 (UniProtKB/TrEMBL),   B5DEF3 (UniProtKB/TrEMBL),   F7FCW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448398   ⟸   XM_017592909
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000072920   ⟸   ENSRNOT00000084281
Ensembl Acc Id: ENSRNOP00000071364   ⟸   ENSRNOT00000086820
Ensembl Acc Id: ENSRNOP00000017928   ⟸   ENSRNOT00000017927
Ensembl Acc Id: ENSRNOP00000088854   ⟸   ENSRNOT00000107225
RefSeq Acc Id: XP_063142819   ⟸   XM_063286749
- Peptide Label: isoform X2
- UniProtKB: A6IAC0 (UniProtKB/TrEMBL),   Q497C4 (UniProtKB/TrEMBL)
Protein Domains
HTTM   HTTM-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88496-F1-model_v2 AlphaFold O88496 1-758 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693130
Promoter ID:EPDNEW_R3652
Type:initiation region
Name:Ggcx_1
Description:gamma-glutamyl carboxylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04100,277,390 - 100,277,450EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68383 AgrOrtholog
BioCyc Gene G2FUF-44147 BioCyc
Ensembl Genes ENSRNOG00000012975 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000084281 ENTREZGENE
  ENSRNOT00000107225 ENTREZGENE
InterPro HTTM UniProtKB/Swiss-Prot
  HTTM_dom UniProtKB/Swiss-Prot
  RmlC_Cupin_sf UniProtKB/Swiss-Prot
  VKG_COase UniProtKB/Swiss-Prot
  VKGC_lumenal_dom UniProtKB/Swiss-Prot
KEGG Report rno:81716 UniProtKB/Swiss-Prot
NCBI Gene 81716 ENTREZGENE
PANTHER PTHR12639 UniProtKB/Swiss-Prot
  VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE UniProtKB/Swiss-Prot
Pfam VKG_Carbox UniProtKB/Swiss-Prot
  VKGC_lumenal_dom UniProtKB/Swiss-Prot
PharmGKB GGCX RGD
PhenoGen Ggcx PhenoGen
RatGTEx ENSRNOG00000012975 RatGTEx
SMART HTTM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51182 UniProtKB/Swiss-Prot
TIGR TC207826
UniProt A0A8I6AAB6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8XYF4_RAT UniProtKB/TrEMBL
  A6IAB9_RAT UniProtKB/TrEMBL
  A6IAC0 ENTREZGENE, UniProtKB/TrEMBL
  B5DEF3 ENTREZGENE, UniProtKB/TrEMBL
  F7FCW3 ENTREZGENE
  O88496 ENTREZGENE
  Q497C4 ENTREZGENE, UniProtKB/TrEMBL
  Q6P9X3_RAT UniProtKB/TrEMBL
  VKGC_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ggcx  gamma-glutamyl carboxylase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation highly regulated in a developmental and tissue-specific manner 728649