RGD Reference Report - Vitamin K-dependent carboxylase: mRNA distribution and effects of vitamin K-deficiency and warfarin treatment. - Rat Genome Database

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Vitamin K-dependent carboxylase: mRNA distribution and effects of vitamin K-deficiency and warfarin treatment.

Authors: Liu, Y  Nelson, AN  Lipsky, JJ 
Citation: Liu Y, etal., Biochem Biophys Res Commun. 1996 Jul 16;224(2):549-54.
RGD ID: 2316484
Pubmed: PMID:8702425   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1996.1063   (Journal Full-text)

A cDNA encoding vitamin K-dependent gamma-glutamyl carboxylase was cloned from a human Hep G2 cDNA library. The RNA transcript of the enzyme was found to be widely distributed in various human and rat tissues with liver showing the highest level. The carboxylase transcription in liver was not affected in rats treated with a single dose of warfarin (10 mg/kg) when measured up to 48 hours after the dose, though, at 12 hours, carboxylase activity measured in liver microsomes was elevated 5.4 fold over controls (p < 0.001). In rats fasted for 72 hours there was no affect on transcription in the liver while hepatic carboxylase activity increased 4.1 fold (p < 0.001). These data suggest that the increase in activity of the liver carboxylase in warfarin treated or fasted rats was not regulated by transcription but more likely was due to a posttranscriptional mechanism.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to vitamin K  IEP 2316484 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ggcx  (gamma-glutamyl carboxylase)


Additional Information