Ggcx (gamma-glutamyl carboxylase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ggcx (gamma-glutamyl carboxylase) Heterocephalus glaber
Analyze
Symbol: Ggcx
Name: gamma-glutamyl carboxylase
RGD ID: 18910672
Description: ENCODES a protein that exhibits gamma-glutamyl carboxylase activity (ortholog); vitamin binding (ortholog); INVOLVED IN lung growth (ortholog); peptidyl-glutamic acid carboxylation (ortholog); response to dexamethasone (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH blood coagulation disease (ortholog); Coagulation Protein Disorders (ortholog); combined deficiency of vitamin K-dependent clotting factors 1 (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Vitamin K-dependent gamma-carboxylase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474917,579,661 - 17,593,150 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474917,579,690 - 17,595,111 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ggcx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474917,579,661 - 17,593,150 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474917,579,690 - 17,595,111 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
GGCX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,544,720 - 85,561,493 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,544,720 - 85,561,532 (-)EnsemblGRCh38hg38GRCh38
GRCh37285,771,843 - 85,788,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,629,714 - 85,642,090 (-)NCBINCBI36Build 36hg18NCBI36
Build 34285,687,861 - 85,700,237NCBI
Celera285,604,381 - 85,616,845 (-)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,669,320 - 85,686,004 (-)NCBIHuRef
CHM1_1285,701,785 - 85,718,463 (-)NCBICHM1_1
T2T-CHM13v2.0285,546,779 - 85,563,552 (-)NCBIT2T-CHM13v2.0
Ggcx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,391,262 - 72,407,696 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl672,391,291 - 72,407,695 (+)EnsemblGRCm39 Ensembl
GRCm38672,414,279 - 72,433,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,414,308 - 72,430,712 (+)EnsemblGRCm38mm10GRCm38
MGSCv37672,364,327 - 72,380,701 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36672,343,842 - 72,360,216 (+)NCBIMGSCv36mm8
Celera674,509,409 - 74,525,757 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.27NCBI
Ggcx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,027,918 - 106,043,653 (+)NCBIGRCr8
mRatBN7.24104,469,737 - 104,485,631 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4104,469,765 - 104,487,063 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4109,849,413 - 109,865,120 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04105,624,526 - 105,640,233 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04104,237,548 - 104,253,262 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04100,277,345 - 100,293,097 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4100,277,391 - 100,293,250 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04165,047,672 - 165,063,604 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44105,719,323 - 105,735,037 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14105,963,803 - 105,979,517 (+)NCBI
Celera493,622,596 - 93,638,331 (+)NCBICelera
Cytogenetic Map4q32NCBI
Ggcx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554241,936,772 - 1,952,635 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554241,926,924 - 1,952,635 (+)NCBIChiLan1.0ChiLan1.0
GGCX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21240,819,956 - 40,833,578 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A40,822,718 - 40,836,051 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A85,599,227 - 85,612,274 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A87,152,108 - 87,164,567 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A87,152,111 - 87,164,567 (-)Ensemblpanpan1.1panPan2
GGCX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,512,293 - 39,525,251 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1739,512,387 - 39,529,121 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1739,183,664 - 39,196,637 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01740,258,976 - 40,271,953 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1740,259,006 - 40,275,813 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11739,388,607 - 39,401,574 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01739,460,505 - 39,473,477 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01739,860,352 - 39,873,319 (+)NCBIUU_Cfam_GSD_1.0
Ggcx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629279,147,378 - 79,158,577 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367121,699,750 - 1,709,087 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367121,696,264 - 1,709,087 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GGCX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl359,202,429 - 59,218,145 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1359,202,363 - 59,219,807 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,263,519 - 62,276,716 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GGCX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,593,202 - 21,605,800 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1421,593,088 - 21,604,885 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604590,859,363 - 90,872,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000019647   ⟹   ENSHGLP00000019455
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474917,579,661 - 17,593,150 (+)Ensembl
RefSeq Acc Id: XM_004844606   ⟹   XP_004844663
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474917,579,690 - 17,595,111 (+)NCBI
RefSeq Acc Id: XM_021258212   ⟹   XP_021113871
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474917,579,893 - 17,595,111 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004844663 (Get FASTA)   NCBI Sequence Viewer  
  XP_021113871 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB12841 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000019455
  ENSHGLP00100035760
GenBank Protein JAN99932 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004844663   ⟸   XM_004844606
- Peptide Label: isoform X2
- UniProtKB: A0A0P6J6T9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021113871   ⟸   XM_021258212
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J6T9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000019455   ⟸   ENSHGLT00000019647


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000013929 Ensembl, ENTREZGENE
  ENSHGLG00100018352 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000019647 ENTREZGENE
  ENSHGLT00100061590 UniProtKB/TrEMBL
InterPro HTTM UniProtKB/TrEMBL
  RmlC_Cupin_sf UniProtKB/TrEMBL
  VKG_COase UniProtKB/TrEMBL
NCBI Gene Ggcx ENTREZGENE
PANTHER PTHR12639 UniProtKB/TrEMBL
  VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE UniProtKB/TrEMBL
Pfam VKG_Carbox UniProtKB/TrEMBL
SMART HTTM UniProtKB/TrEMBL
Superfamily-SCOP SSF51182 UniProtKB/TrEMBL
UniProt A0A0P6J6T9 ENTREZGENE, UniProtKB/TrEMBL