Kcnc2 (potassium voltage-gated channel subfamily C member 2) - Rat Genome Database

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Pathways
Gene: Kcnc2 (potassium voltage-gated channel subfamily C member 2) Rattus norvegicus
Analyze
Symbol: Kcnc2
Name: potassium voltage-gated channel subfamily C member 2
RGD ID: 628829
Description: Enables delayed rectifier potassium channel activity; transmembrane transporter binding activity; and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including cellular response to nitric oxide; nervous system development; and protein complex oligomerization. Located in several cellular components, including axon; basolateral plasma membrane; and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is active in GABA-ergic synapse and presynaptic membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 103. Orthologous to human KCNC2 (potassium voltage-gated channel subfamily C member 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-Tetrachlorodibenzofuran; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KShIIIA; Kv3.2; potassium channel voltage-gated Shaw-related subfamily C member 2; potassium channel, voltage gated Shaw-related subfamily C, member 2; potassium voltage gated channel, Shaw-related subfamily, member 2; shaw-like potassium channel; voltage-gated potassium channel KCNC2; voltage-gated potassium channel subunit Kv3.2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8749,586,274 - 49,770,212 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl749,586,136 - 49,770,212 (+)EnsemblGRCr8
mRatBN7.2747,700,035 - 47,883,979 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl747,700,288 - 47,883,968 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx749,609,550 - 49,792,283 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0751,812,632 - 51,995,385 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0751,590,463 - 51,773,199 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0754,978,453 - 55,159,362 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl754,980,120 - 55,159,351 (+)Ensemblrn6Rnor6.0
Rnor_5.0754,998,077 - 55,177,456 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4751,326,602 - 51,487,958 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera744,495,328 - 44,675,986 (+)NCBICelera
RGSC_v3.1751,347,043 - 51,508,400 (+)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Potassium channel subunit Kv3.2 and the water channel aquaporin-4 are selectively localized to cerebellar pinceau. Bobik M, etal., Brain Res. 2004 Nov 12;1026(2):168-78.
2. Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays. Cheung HC, etal., BMC Genomics. 2008 May 12;9:216. doi: 10.1186/1471-2164-9-216.
3. K(+) channel expression distinguishes subpopulations of parvalbumin- and somatostatin-containing neocortical interneurons. Chow A, etal., J Neurosci. 1999 Nov 1;19(21):9332-45.
4. Kv3.1b is a novel component of CNS nodes. Devaux J, etal., J Neurosci. 2003 Jun 1;23(11):4509-18.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Neuronal activity and TrkB ligands influence Kv3.1b and Kv3.2 expression in developing cortical interneurons. Grabert J and Wahle P, Neuroscience. 2008 Oct 15;156(3):618-29. doi: 10.1016/j.neuroscience.2008.08.008. Epub 2008 Aug 12.
7. Visual experience regulates Kv3.1b and Kv3.2 expression in developing rat visual cortex. Grabert J and Wahle P, Neuroscience. 2009 Jan 23;158(2):654-64. doi: 10.1016/j.neuroscience.2008.07.035. Epub 2008 Jul 25.
8. Kv3.1-Kv3.2 channels underlie a high-voltage-activating component of the delayed rectifier K+ current in projecting neurons from the globus pallidus. Hernandez-Pineda R, etal., J Neurophysiol. 1999 Sep;82(3):1512-28.
9. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
10. KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel a-subunit composition. Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1364-75. doi: 10.1016/j.bpj.2011.08.014. Epub 2011 Sep 20.
11. Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins. Lau D, etal., J Neurosci. 2000 Dec 15;20(24):9071-85.
12. Shaw-like rat brain potassium channel cDNA's with divergent 3' ends. Luneau C, etal., FEBS Lett 1991 Aug 19;288(1-2):163-7.
13. Molecular cloning of a member of a third class of Shaker-family K+ channel genes in mammals. McCormack T, etal., Proc Natl Acad Sci U S A 1990 Jul;87(13):5227-31.
14. Molecular cloning of a member of a third class of Shaker-family K+ channel genes in mammals. McCormack T, etal., Proc Natl Acad Sci U S A 1991 May 1;88(9):4060.
15. Differential expression of Kv3.1b and Kv3.2 potassium channel subunits in interneurons of the basolateral amygdala. McDonald AJ and Mascagni F, Neuroscience. 2006;138(2):537-47. Epub 2006 Jan 18.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Thalamocortical projections have a K+ channel that is phosphorylated and modulated by cAMP-dependent protein kinase. Moreno H, etal., J Neurosci. 1995 Aug;15(8):5486-501.
18. Modulation of Kv3 potassium channels expressed in CHO cells by a nitric oxide-activated phosphatase. Moreno H, etal., J Physiol. 2001 Feb 1;530(Pt 3):345-58.
19. K+ channel subunit isoforms with divergent carboxy-terminal sequences carry distinct membrane targeting signals. Ponce A, etal., J Membr Biol. 1997 Sep 15;159(2):149-59.
20. Characterization of a Shaw-related potassium channel family in rat brain. Rettig J, etal., EMBO J 1992 Jul;11(7):2473-86.
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Region-specific expression of a K+ channel gene in brain. Rudy B, etal., Proc Natl Acad Sci U S A 1992 May 15;89(10):4603-7.
24. Selective underexpression of Kv3.2 and Kv3.4 channels in the cortex of rats exposed to ethanol during early postnatal life. Tavian D, etal., Neurol Sci. 2011 Aug;32(4):571-7. doi: 10.1007/s10072-010-0446-7. Epub 2011 Jan 14.
25. Gating currents from a Kv3 subfamily potassium channel: charge movement and modification by BDS-II toxin. Wang Z, etal., J Physiol. 2007 Nov 1;584(Pt 3):755-67. Epub 2007 Sep 13.
26. Differential expression of Shaw-related K+ channels in the rat central nervous system. Weiser M, etal., J Neurosci. 1994 Mar;14(3 Pt 1):949-72. doi: 10.1523/JNEUROSCI.14-03-00949.1994.
27. Modulation of Kv3 subfamily potassium currents by the sea anemone toxin BDS: significance for CNS and biophysical studies. Yeung SY, etal., J Neurosci. 2005 Sep 21;25(38):8735-45.
Additional References at PubMed
PMID:12000114   PMID:15240761   PMID:17761775   PMID:19332619   PMID:22871113  


Genomics

Comparative Map Data
Kcnc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8749,586,274 - 49,770,212 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl749,586,136 - 49,770,212 (+)EnsemblGRCr8
mRatBN7.2747,700,035 - 47,883,979 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl747,700,288 - 47,883,968 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx749,609,550 - 49,792,283 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0751,812,632 - 51,995,385 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0751,590,463 - 51,773,199 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0754,978,453 - 55,159,362 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl754,980,120 - 55,159,351 (+)Ensemblrn6Rnor6.0
Rnor_5.0754,998,077 - 55,177,456 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4751,326,602 - 51,487,958 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera744,495,328 - 44,675,986 (+)NCBICelera
RGSC_v3.1751,347,043 - 51,508,400 (+)NCBI
Cytogenetic Map7q22NCBI
KCNC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381275,040,078 - 75,209,839 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1275,040,077 - 75,209,839 (-)Ensemblhg38GRCh38
GRCh371275,433,858 - 75,603,619 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361273,720,163 - 73,889,778 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341273,720,162 - 73,889,778NCBI
Celera1275,101,336 - 75,270,876 (-)NCBICelera
Cytogenetic Map12q21.1NCBI
HuRef1272,483,472 - 72,653,079 (-)NCBIHuRef
CHM1_11275,399,235 - 75,568,820 (-)NCBICHM1_1
T2T-CHM13v2.01275,014,738 - 75,184,480 (-)NCBIT2T-CHM13v2.0
Kcnc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910112,105,803 - 112,302,209 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10112,107,026 - 112,302,929 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3810112,269,898 - 112,466,304 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10112,271,121 - 112,467,024 (+)Ensemblmm10GRCm38
MGSCv3710111,708,179 - 111,903,360 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610111,675,233 - 111,870,414 (+)NCBIMGSCv36mm8
Celera10114,210,354 - 114,400,944 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1060.3NCBI
Kcnc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540514,422,396 - 14,600,341 (-)Ensembl
ChiLan1.0NW_00495540514,420,447 - 14,599,780 (-)NCBIChiLan1.0ChiLan1.0
KCNC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21083,082,905 - 83,251,756 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11283,079,301 - 83,248,152 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01272,566,924 - 72,736,270 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11275,419,465 - 75,588,535 (-)NCBIPanPan1.1PanPan1.1panPan2
KCNC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11015,599,428 - 15,822,579 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1015,643,962 - 15,818,097 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1015,541,357 - 15,767,201 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01015,785,996 - 16,011,988 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1015,789,212 - 16,007,557 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11015,595,746 - 15,821,564 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01015,848,484 - 16,075,795 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01015,974,622 - 16,200,463 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494542,033,763 - 42,220,108 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365683,511,244 - 3,694,781 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365683,508,212 - 3,694,459 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl538,326,414 - 38,533,110 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1538,326,408 - 38,535,826 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2541,759,389 - 41,781,754 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11170,603,034 - 70,770,625 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1170,603,003 - 70,768,859 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037174,772,549 - 174,940,514 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475022,807,370 - 22,996,753 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475022,807,234 - 22,996,614 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcnc2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11190,413,118 - 190,579,293 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcnc2
771 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:649
Count of miRNA genes:275
Interacting mature miRNAs:337
Transcripts:ENSRNOT00000005690, ENSRNOT00000005700, ENSRNOT00000005773, ENSRNOT00000049943
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)72154197751639954Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)72154197751639954Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74299622658678836Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
D7Rat26  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8749,682,832 - 49,682,996 (+)Marker Load Pipeline
Rnor_6.0755,072,862 - 55,073,022NCBIRnor6.0
Celera744,590,656 - 44,590,819UniSTS
RH 3.4 Map7412.9UniSTS
RH 3.4 Map7412.9RGD
RH 2.0 Map7380.4RGD
SHRSP x BN Map731.05RGD
Cytogenetic Map7q12-q22UniSTS
D7Rat169  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8749,605,702 - 49,605,909 (+)Marker Load Pipeline
mRatBN7.2747,719,466 - 47,719,673 (+)MAPPERmRatBN7.2
Rnor_6.0754,998,209 - 54,998,415NCBIRnor6.0
Rnor_5.0755,017,742 - 55,017,948UniSTSRnor5.0
RGSC_v3.4751,344,692 - 51,344,898UniSTSRGSC3.4
RGSC_v3.4751,344,691 - 51,344,898RGDRGSC3.4
Celera744,513,417 - 44,513,623UniSTS
RGSC_v3.1751,365,111 - 51,365,507RGD
FHH x ACI Map726.78RGD
FHH x ACI Map726.78UniSTS
Cytogenetic Map7q12-q22UniSTS
D7Got205  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0755,072,801 - 55,073,014NCBIRnor6.0
Celera744,590,664 - 44,590,881UniSTS
Cytogenetic Map7q12-q22UniSTS
BF404636  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2747,881,223 - 47,881,330 (+)MAPPERmRatBN7.2
Rnor_6.0755,156,607 - 55,156,713NCBIRnor6.0
Rnor_5.0755,174,701 - 55,174,807UniSTSRnor5.0
RGSC_v3.4751,485,214 - 51,485,320UniSTSRGSC3.4
Celera744,673,242 - 44,673,348UniSTS
RH 3.4 Map7417.8UniSTS
Cytogenetic Map7q12-q22UniSTS
AU046555  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2747,721,167 - 47,721,291 (+)MAPPERmRatBN7.2
mRatBN7.2747,721,167 - 47,721,315 (+)MAPPERmRatBN7.2
Rnor_6.0754,999,910 - 55,000,057NCBIRnor6.0
Rnor_6.0754,999,910 - 55,000,033NCBIRnor6.0
Rnor_5.0755,019,621 - 55,019,768UniSTSRnor5.0
Rnor_5.0755,019,621 - 55,019,744UniSTSRnor5.0
RGSC_v3.4751,346,393 - 51,346,516UniSTSRGSC3.4
RGSC_v3.4751,346,393 - 51,346,540UniSTSRGSC3.4
Celera744,515,109 - 44,515,256UniSTS
Celera744,515,109 - 44,515,232UniSTS
Cytogenetic Map7q12-q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 8 36 141 46 39 16 31 16 6 158 91 7 118 35 86 23 16 16

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001439883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_139216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_139217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX839889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M59211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M59313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M84202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M84203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000005690   ⟹   ENSRNOP00000005690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl749,586,350 - 49,770,200 (+)Ensembl
mRatBN7.2 Ensembl747,701,378 - 47,883,968 (+)Ensembl
Rnor_6.0 Ensembl754,980,120 - 55,159,351 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000005773   ⟹   ENSRNOP00000005773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl749,586,352 - 49,762,647 (+)Ensembl
mRatBN7.2 Ensembl747,701,421 - 47,881,436 (+)Ensembl
Rnor_6.0 Ensembl754,980,163 - 55,156,819 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099049   ⟹   ENSRNOP00000084708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl749,586,136 - 49,770,212 (+)Ensembl
mRatBN7.2 Ensembl747,700,288 - 47,880,696 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105247   ⟹   ENSRNOP00000088724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl747,700,288 - 47,883,968 (+)Ensembl
RefSeq Acc Id: NM_139216   ⟹   NP_631962
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,587,614 - 49,770,202 (+)NCBI
mRatBN7.2747,701,378 - 47,883,968 (+)NCBI
Rnor_6.0754,980,120 - 55,159,351 (+)NCBI
Rnor_5.0754,998,077 - 55,177,456 (+)NCBI
RGSC_v3.4751,326,602 - 51,487,958 (+)RGD
Celera744,495,328 - 44,675,986 (+)RGD
Sequence:
RefSeq Acc Id: NM_139217   ⟹   NP_631963
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,587,657 - 49,767,670 (+)NCBI
mRatBN7.2747,701,421 - 47,881,436 (+)NCBI
Rnor_6.0754,980,163 - 55,156,819 (+)NCBI
Rnor_5.0754,998,077 - 55,177,456 (+)NCBI
RGSC_v3.4751,326,602 - 51,487,958 (+)RGD
Celera744,495,371 - 44,673,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006241327   ⟹   XP_006241389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,770,212 (+)NCBI
mRatBN7.2747,700,035 - 47,883,979 (+)NCBI
Rnor_6.0754,978,783 - 55,159,362 (+)NCBI
Rnor_5.0754,998,077 - 55,177,456 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594660   ⟹   XP_017450149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,771 - 49,770,212 (+)NCBI
mRatBN7.2747,700,511 - 47,883,979 (+)NCBI
Rnor_6.0754,979,277 - 55,159,362 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594661   ⟹   XP_017450150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,770,212 (+)NCBI
mRatBN7.2747,700,035 - 47,880,956 (+)NCBI
Rnor_6.0754,978,783 - 55,156,287 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594662   ⟹   XP_017450151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,770,212 (+)NCBI
mRatBN7.2747,700,035 - 47,883,979 (+)NCBI
Rnor_6.0754,978,453 - 55,159,362 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078411   ⟹   XP_038934339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,770,212 (+)NCBI
mRatBN7.2747,700,035 - 47,883,979 (+)NCBI
RefSeq Acc Id: XM_039078412   ⟹   XP_038934340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,767,181 (+)NCBI
mRatBN7.2747,700,035 - 47,883,979 (+)NCBI
RefSeq Acc Id: XM_039078413   ⟹   XP_038934341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,770,212 (+)NCBI
mRatBN7.2747,700,035 - 47,883,979 (+)NCBI
RefSeq Acc Id: XM_039078416   ⟹   XP_038934344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,770,212 (+)NCBI
mRatBN7.2747,700,035 - 47,883,979 (+)NCBI
RefSeq Acc Id: XR_005486545
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8749,586,274 - 49,769,130 (+)NCBI
mRatBN7.2747,700,035 - 47,882,895 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001426812 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426813 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426814 (Get FASTA)   NCBI Sequence Viewer  
  NP_631962 (Get FASTA)   NCBI Sequence Viewer  
  NP_631963 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241389 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450149 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450150 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450151 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934339 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934340 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934341 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934344 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41819 (Get FASTA)   NCBI Sequence Viewer  
  AAA41820 (Get FASTA)   NCBI Sequence Viewer  
  AAA42142 (Get FASTA)   NCBI Sequence Viewer  
  AAA42143 (Get FASTA)   NCBI Sequence Viewer  
  CAE85434 (Get FASTA)   NCBI Sequence Viewer  
  EDM16703 (Get FASTA)   NCBI Sequence Viewer  
  EDM16704 (Get FASTA)   NCBI Sequence Viewer  
  EDM16705 (Get FASTA)   NCBI Sequence Viewer  
  EDM16706 (Get FASTA)   NCBI Sequence Viewer  
  EDM16707 (Get FASTA)   NCBI Sequence Viewer  
  EDM16708 (Get FASTA)   NCBI Sequence Viewer  
  EDM16709 (Get FASTA)   NCBI Sequence Viewer  
  EDM16710 (Get FASTA)   NCBI Sequence Viewer  
  EDM16711 (Get FASTA)   NCBI Sequence Viewer  
  EDM16712 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005690
  ENSRNOP00000005690.2
  ENSRNOP00000005773
  ENSRNOP00000005773.4
  ENSRNOP00000084708
  ENSRNOP00000084708.1
  ENSRNOP00000088724.1
GenBank Protein P22462 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_631962   ⟸   NM_139216
- Peptide Label: isoform a
- UniProtKB: A6IGJ0 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_631963   ⟸   NM_139217
- Peptide Label: isoform b
- UniProtKB: P22463 (UniProtKB/Swiss-Prot),   P22461 (UniProtKB/Swiss-Prot),   Q63735 (UniProtKB/Swiss-Prot),   P22462 (UniProtKB/Swiss-Prot),   A6IGJ3 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241389   ⟸   XM_006241327
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017450151   ⟸   XM_017594662
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017450150   ⟸   XM_017594661
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017450149   ⟸   XM_017594660
- Peptide Label: isoform X1
- UniProtKB: P22463 (UniProtKB/Swiss-Prot),   P22461 (UniProtKB/Swiss-Prot),   Q63735 (UniProtKB/Swiss-Prot),   P22462 (UniProtKB/Swiss-Prot),   A6IGJ3 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005690   ⟸   ENSRNOT00000005690
Ensembl Acc Id: ENSRNOP00000005773   ⟸   ENSRNOT00000005773
RefSeq Acc Id: XP_038934340   ⟸   XM_039078412
- Peptide Label: isoform X5
- UniProtKB: A6IGJ4 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934341   ⟸   XM_039078413
- Peptide Label: isoform X5
- UniProtKB: A6IGJ4 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934344   ⟸   XM_039078416
- Peptide Label: isoform X5
- UniProtKB: A6IGJ4 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934339   ⟸   XM_039078411
- Peptide Label: isoform X4
- UniProtKB: A6IGJ0 (UniProtKB/TrEMBL),   A6IGI6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088724   ⟸   ENSRNOT00000105247
Ensembl Acc Id: ENSRNOP00000084708   ⟸   ENSRNOT00000099049
Protein Domains
BTB   Ion transport

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22462-F1-model_v2 AlphaFold P22462 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628829 AgrOrtholog
BioCyc Gene G2FUF-34097 BioCyc
Ensembl Genes ENSRNOG00000004077 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005690 ENTREZGENE
  ENSRNOT00000005690.5 UniProtKB/Swiss-Prot
  ENSRNOT00000005773 ENTREZGENE
  ENSRNOT00000005773.8 UniProtKB/Swiss-Prot
  ENSRNOT00000099049 ENTREZGENE
  ENSRNOT00000099049.1 UniProtKB/Swiss-Prot
  ENSRNOT00000105247.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.350 UniProtKB/Swiss-Prot
  Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv3 UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
  T1-type_BTB UniProtKB/Swiss-Prot
  VG_K_chnl UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:246153 UniProtKB/Swiss-Prot
NCBI Gene 246153 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY C MEMBER 2 UniProtKB/Swiss-Prot
  PTHR11537 UniProtKB/Swiss-Prot
Pfam BTB_2 UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
PhenoGen Kcnc2 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot
  KVCHANNEL UniProtKB/Swiss-Prot
  SHAWCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004077 RatGTEx
SMART BTB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A6IGI6 ENTREZGENE, UniProtKB/TrEMBL
  A6IGI7 ENTREZGENE, UniProtKB/TrEMBL
  A6IGJ0 ENTREZGENE, UniProtKB/TrEMBL
  A6IGJ3 ENTREZGENE, UniProtKB/TrEMBL
  A6IGJ4 ENTREZGENE, UniProtKB/TrEMBL
  A6IGJ5_RAT UniProtKB/TrEMBL
  KCNC2_RAT UniProtKB/Swiss-Prot
  P22461 ENTREZGENE
  P22462 ENTREZGENE
  P22463 ENTREZGENE
  Q63735 ENTREZGENE
UniProt Secondary P22461 UniProtKB/Swiss-Prot
  P22463 UniProtKB/Swiss-Prot
  Q63735 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnc2  potassium voltage-gated channel subfamily C member 2  Kcnc2  potassium channel, voltage gated Shaw-related subfamily C, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnc2  potassium channel, voltage gated Shaw-related subfamily C, member 2  Kcnc2  potassium voltage gated channel, Shaw-related subfamily, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Kcnc2  potassium voltage gated channel, Shaw-related subfamily, member 2      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Kcnc2  potassium voltage gated channel, Shaw-related subfamily, member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression prominantly expressed in dorsal thalamus 729132