RGD Reference Report - Shaw-like rat brain potassium channel cDNA's with divergent 3' ends. - Rat Genome Database

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Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.

Authors: Luneau, C  Wiedmann, R  Smith, JS  Williams, JB 
Citation: Luneau C, etal., FEBS Lett 1991 Aug 19;288(1-2):163-7.
RGD ID: 729260
Pubmed: PMID:1879548   (View Abstract at PubMed)

The complete amino acid sequence of a potassium channel protein of rat brain, Kv3.2b, plus a partial sequence of a related channel, Kv3.2c, are deduced from molecular cloning of the respective cDNA's. Kv3.2b and Kv3.2c share extensive amino acid sequence identity with a previously identified channel, RKShIIIA[1], before diverging to unique carboxy termini. Probes specific for Kv3.2b and RKShIIIA detect similarly sized mRNA's on Northern blots. These two proteins are encoded by a single gene based on genomic Southern blotting, and therefore arise by alternative splicing. In vitro transcribed mRNA for Kv3.2b induces the expression of outward K+ currents in Xenopus oocytes under voltage-clamp conditions.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of potassium ion transmembrane transport  IDA 729260 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kcnc2  (potassium voltage-gated channel subfamily C member 2)


Additional Information