Ddit3 (DNA-damage inducible transcript 3) - Rat Genome Database

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Gene: Ddit3 (DNA-damage inducible transcript 3) Rattus norvegicus
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Symbol: Ddit3
Name: DNA-damage inducible transcript 3
RGD ID: 62391
Description: Enables DNA-binding transcription factor activity and protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including cellular response to manganese ion; positive regulation of autophagy in response to ER overload; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of CHOP-C/EBP complex. Biomarker of several diseases, including borna disease; brain ischemia; chronic obstructive pulmonary disease; pulmonary venoocclusive disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C/EBP homologous protein; C/EBP zeta; c/EBP-homologous protein; c/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; CHOP; CHOP-10; Chop10; DDIT-3; DNA damage-inducible transcript 3; Gadd153; growth arrest and DNA-damage-inducible protein GADD153; MGC124604; RM4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,001,695 - 65,006,517 (+)NCBIGRCr8
mRatBN7.2763,115,645 - 63,121,203 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,116,380 - 63,121,201 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,005,654 - 65,010,476 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,208,074 - 67,212,896 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,009,429 - 67,014,244 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,578,564 - 70,585,074 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,580,198 - 70,585,084 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,753,800 - 70,759,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,247,749 - 67,252,571 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,268,487 - 67,273,294 (+)NCBI
Celera760,256,651 - 60,261,474 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(-)-quinic acid  (ISO)
(E)-thiamethoxam  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(R,S)-Scoulerine  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-D  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dichlorophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-arachidonoylglycerol  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydrocoumarin  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-phenylbutylamine  (ISO)
4-phenylbutyric acid  (EXP,ISO)
4-phenylcoumarin  (ISO)
5-(N,N-hexamethylene)amiloride  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
[6]-Shogaol  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
aconitic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
agomelatine  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
alloxan  (ISO)
Aloe emodin  (ISO)
alpha-(methylamino)isobutyric acid  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-naphthoflavone  (ISO)
AM-251  (ISO)
amiloride  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amosite asbestos  (ISO)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
anandamide  (ISO)
andrographolide  (ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony trichloride  (ISO)
antimycin A  (EXP,ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
auraptene  (ISO)
Auriculasin  (ISO)
Aurin  (ISO)
avermectin  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
BAPTA  (ISO)
Bardoxolone methyl  (ISO)
benomyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
bepridil  (ISO)
beta-cyclodextrin  (ISO)
beta-D-glucosamine  (ISO)
betulinic acid  (ISO)
bexarotene  (EXP)
bilirubin IXalpha  (EXP,ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
bongkrekic acid  (ISO)
boric acid  (ISO)
borrelidin  (ISO)
bortezomib  (EXP,ISO)
brefeldin A  (ISO)
Brevetoxin B  (ISO)
bromoacetate  (ISO)
bromobenzene  (EXP)
bufalin  (ISO)
busulfan  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
butyric acid  (EXP,ISO)
C.I. Natural Red 20  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium carbonate  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (EXP,ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon atom  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
carboxy-PTIO  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chlormequat chloride  (EXP)
chloroacetaldehyde  (ISO)
chloroacetic acid  (ISO)
Chloroacetonitrile  (ISO)
chloroform  (EXP)
chlorogenic acid  (EXP)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium(6+)  (EXP)
chrysazin  (ISO)
chrysophanol  (ISO)
cibenzoline  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cimetidine  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cobicistat  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corilagin  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyanocob(III)alamin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP)
cylindrospermopsin  (ISO)
D-cycloserine  (ISO)
D-glucose  (EXP,ISO)
D-mannopyranose  (ISO)
D-penicillamine  (ISO)
dantrolene  (EXP,ISO)
dapagliflozin  (EXP)
DDE  (ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desipramine  (EXP)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP,ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
dihydrocapsaicin  (ISO)
dihydroxyacetone  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (EXP,ISO)
Dinitramine  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (EXP,ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
duvoglustat  (EXP)
echinacoside  (ISO)
efavirenz  (ISO)
elemental carbon  (ISO)
emodin  (EXP)
empagliflozin  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
erastin  (ISO)
erlotinib hydrochloride  (EXP,ISO)
erythromycin estolate  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
EUK-134  (ISO)
Evodiamine  (ISO)
excitatory amino acid agonist  (ISO)
fangchinoline  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
ferric oxide  (ISO)
ferrostatin-1  (EXP,ISO)
fisetin  (ISO)
flavokawain B  (ISO)
flavonoids  (EXP)
flufenoxuron  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
fomepizole  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (EXP,ISO)
furazolidone  (ISO)
furosemide  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP)
galactose  (EXP,ISO)
gedunin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycine  (ISO)
glycochenodeoxycholic acid  (EXP,ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
GSK2656157  (ISO)
Guanabenz  (EXP,ISO)
GW 4064  (ISO)
halothane  (ISO)
helenalin  (ISO)
hemin  (EXP,ISO)
hesperetin  (ISO)
hexachlorophene  (ISO)
hexadecanoic acid  (EXP,ISO)
homocysteine  (ISO)
Honokiol  (EXP,ISO)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxytyrosol  (EXP)
hypochlorous acid  (ISO)
Ibutilide  (EXP)
ifosfamide  (ISO)
Ilimaquinone  (ISO)
imidazopyrazole  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
ionomycin  (ISO)
iprodione  (ISO)
irinotecan  (EXP)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(III) citrate  (ISO)
isoliquiritigenin  (EXP)
isoniazide  (EXP,ISO)
isoprenaline  (EXP,ISO)
itraconazole  (ISO)
ivermectin  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
KN-93  (EXP,ISO)
kojic acid  (EXP)
L-1,4-dithiothreitol  (EXP,ISO)
L-ascorbic acid  (EXP)
L-glutamic acid  (EXP)
L-glutamine  (EXP)
L-methionine  (EXP,ISO)
lactacystin  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP)
leflunomide  (ISO)
letrozole  (EXP)
Licochalcone B  (ISO)
licoricidin  (ISO)
linagliptin  (ISO)
linoleic acid  (ISO)
linsidomine  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
lomustine  (ISO)
lucanthone  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
metacetamol  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
metyrapone  (ISO)
mevastatin  (ISO)
microcystin-LR  (ISO)
minocycline  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
morphine  (ISO)
morusin  (ISO)
motexafin gadolinium  (ISO)
myriocin  (ISO)
N(4)-hydroxycytidine  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N-dimethylformamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-hexadecanoylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naltrexone  (ISO)
nefazodone  (ISO)
nelfinavir  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP)
Niflumic acid  (ISO)
nilotinib  (ISO)
nimesulide  (EXP,ISO)
nitrofen  (EXP)
nitroprusside  (ISO)
nobiletin  (EXP,ISO)
Nodularin  (ISO)
Nonidet P-40  (ISO)
nonivamide  (ISO)
Nonylphenol  (EXP)
Norbinaltorphimine  (ISO)
NORCANTHARIDIN  (ISO)
NS-398  (ISO)
NSC 23766  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
Octicizer  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleuropein  (EXP)
omeprazole  (ISO)
orlistat  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
Pachymic acid  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
patulin  (ISO)
pemetrexed  (ISO)
Pendulone  (ISO)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
perhexiline  (ISO)
permethrin  (ISO)
phalloidin  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (ISO)
plumbagin  (ISO)
poly(guanylic acid)  (EXP)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (ISO)
procymidone  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
prostaglandin E2  (ISO)
prothioconazole  (ISO)
psoralen  (ISO)
Ptaquiloside  (ISO)
pterostilbene  (ISO)
pyrazinecarboxamide  (EXP,ISO)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raspberry ketone  (ISO)
reactive oxygen species  (ISO)
Repaglinide  (EXP)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
roflumilast  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
ryanodine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salidroside  (ISO)
Salinomycin  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
SB-239063  (ISO)
SCH 23390  (EXP)
scopoletin  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenomethionine  (EXP)
serpentine asbestos  (ISO)
sertraline  (ISO)
Shikonin  (EXP)
sibutramine  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sinapic acid  (ISO)
sirolimus  (EXP,ISO)
SKF-96365 hydrochloride  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium disulfite  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
Sodium iodate  (ISO)
Soman  (EXP)
sorafenib  (ISO)
SR 144528  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
SU6656  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
T-2 toxin  (EXP,ISO)
tacrine  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
tebufenpyrad  (ISO)
telmisartan  (EXP)
TEMPO  (EXP)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thiamethoxam  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP,ISO)
thiostrepton  (ISO)
thymoquinone  (EXP,ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torin 1  (ISO)
triacetin  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimethylamine N-oxide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
tunicamycin  (EXP,ISO)
umbelliferone  (EXP)
undecane  (EXP)
uranium atom  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vanillic acid  (ISO)
vemurafenib  (ISO)
verapamil  (ISO)
vildagliptin  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
vitexin  (ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)
XAV939  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zileuton  (EXP)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior axis specification  (ISO)
apoptotic process  (IEA,ISO,ISS)
artery development  (ISO)
blood vessel maturation  (ISO,ISS)
cell redox homeostasis  (IEA,ISO)
cellular response to manganese ion  (IEP)
embryonic organ development  (IEP)
endoplasmic reticulum unfolded protein response  (ISO,ISS)
ER overload response  (IBA,IEA,IMP,ISO)
establishment of protein localization to mitochondrion  (ISO)
gene expression  (ISO)
integrated stress response signaling  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IBA,IEA,ISO,ISS)
intrinsic apoptotic signaling pathway in response to nitrosative stress  (ISO)
luteolysis  (IEP)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of CREB transcription factor activity  (IDA)
negative regulation of determination of dorsal identity  (IEA,ISO)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of fat cell differentiation  (ISO)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of interleukin-4 production  (IEA,ISO)
negative regulation of myoblast differentiation  (ISO,ISS)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,ISO,ISS)
negative regulation of type II interferon production  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of autophagy in response to ER overload  (IMP)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO,ISS)
positive regulation of intrinsic apoptotic signaling pathway  (IBA,IEA,ISO,ISS)
positive regulation of neuron apoptotic process  (IMP,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO,ISS)
regulation of autophagy  (IMP)
regulation of cell cycle  (IEA)
regulation of DNA-templated transcription  (IDA,IEA,ISO)
regulation of transcription by RNA polymerase II  (ISO)
release of sequestered calcium ion into cytosol  (ISO,ISS)
response to amphetamine  (IEP)
response to endoplasmic reticulum stress  (IDA,ISO,ISS)
response to hydrogen peroxide  (IEP)
response to kainic acid  (IEP)
response to nutrient  (IEP)
response to oxidative stress  (IEP)
response to platelet-derived growth factor  (ISO)
response to starvation  (ISO,ISS)
response to toxic substance  (IEP)
response to unfolded protein  (IEA,ISO,ISS)
response to wounding  (ISO)
response to xenobiotic stimulus  (IEP)
sensory perception of sound  (ISO)
vascular associated smooth muscle cell migration  (ISO)
vascular associated smooth muscle cell proliferation  (ISO)
Wnt signaling pathway  (IEA)

Cellular Component
CHOP-ATF3 complex  (IBA,IEA,ISO)
CHOP-ATF4 complex  (IBA,IEA,ISO)
CHOP-C/EBP complex  (IBA,IEA,IPI,ISO)
cytoplasm  (IBA,IEA,ISO)
late endosome  (ISO)
nucleoplasm  (TAS)
nucleus  (IDA,IEA,ISO,NAS)
protein-DNA complex  (IEA,ISO)
RNA polymerase II transcription regulator complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11). Aman P, etal., Genes Chromosomes Cancer. 1992 Nov;5(4):278-85.
2. Expression and function of C/EBP homology protein (GADD153) in podocytes. Bek MF, etal., Am J Pathol. 2006 Jan;168(1):20-32.
3. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cai D, etal., Cell Death Dis. 2016 Mar 31;7:e2161. doi: 10.1038/cddis.2016.67.
4. Serial analysis of gene expression in the rat striatum following methamphetamine administration. Cai NS, etal., Ann N Y Acad Sci. 2006 Aug;1074:13-30.
5. Enhanced expression of C/EBP homologous protein (CHOP) precedes degeneration of fibrocytes in the lateral wall after acute cochlear mitochondrial dysfunction induced by 3-nitropropionic acid. Fujinami Y, etal., Neurochem Int. 2010 Feb;56(3):487-94. doi: 10.1016/j.neuint.2009.12.008. Epub 2009 Dec 21.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Involvement of GADD153 and cardiac ankyrin repeat protein in hypoxia-induced apoptosis of H9c2 cells. Han XJ, etal., J Biol Chem. 2005 Jun 17;280(24):23122-9. Epub 2005 Apr 12.
9. Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury. Ikeyama S, etal., J Biol Chem 2003 May 9;278(19):16726-31. Epub 2003 Feb 27.
10. A projectionist speaks. Kesterton DB, Med Biol Illus. 1977 Feb;27(1):15-9.
11. Bidirectional regulation of monocyte chemoattractant protein-1 gene at distinct sites of its promoter by nitric oxide in vascular smooth muscle cells. Kodama K, etal., Am J Physiol Cell Physiol. 2005 Sep;289(3):C582-90. Epub 2005 Apr 13.
12. The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers. Li F, etal., Brain Res. 2005 Jun 28;1048(1-2):59-68.
13. Ginsenoside-Rg1 inhibits endoplasmic reticulum stress-induced apoptosis after unilateral ureteral obstruction in rats. Li SS, etal., Ren Fail. 2015 Jun;37(5):890-5. doi: 10.3109/0886022X.2015.1015427. Epub 2015 Feb 24.
14. [Resveratrol attenuates endoplasmic reticulum stress and alveolar epithelial apoptosis in a rat model of chronic obstructive pulmonary disease]. Li Y, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2014 Jan;37(1):30-5.
15. Cellular communication network factor 1 (CCN1) knockdown exerts a protective effect for hepatic ischemia/reperfusion injury by deactivating the MEK/ERK pathway. Liu H, etal., Clin Res Hepatol Gastroenterol. 2021 Sep;45(5):101737. doi: 10.1016/j.clinre.2021.101737. Epub 2021 Jun 16.
16. Bax inhibitor-1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats. Liu J, etal., Int J Mol Med. 2018 Nov;42(5):2891-2902. doi: 10.3892/ijmm.2018.3858. Epub 2018 Sep 5.
17. Role of HMGB1 in Post-traumatic Endoplasmic Reticulum Stress in Rat Lung Tissues. Lu JF, etal., Fa Yi Xue Za Zhi. 2018 Aug;34(4):347-351. doi: 10.12116/j.issn.1004-5619.2018.04.001. Epub 2018 Aug 25.
18. Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
19. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. McCullough KD, etal., Mol Cell Biol 2001 Feb;21(4):1249-59.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. The unfolded protein response in lens epithelial cells from galactosemic rat lenses. Mulhern ML, etal., Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3951-9.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress. Okla M, etal., J Biol Chem. 2015 Oct 30;290(44):26476-90. doi: 10.1074/jbc.M115.677724. Epub 2015 Sep 14.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. Expression of the growth arrest genes (GAS and GADD) changes during organogenesis in the rat fetus. Rees WD, etal., J Nutr 1999 Aug;129(8):1532-6.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Induction of ER stress in macrophages of tuberculosis granulomas. Seimon TA, etal., PLoS One. 2010 Sep 15;5(9):e12772. doi: 10.1371/journal.pone.0012772.
31. CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. Silva RM, etal., J Neurochem. 2005 Nov;95(4):974-86. Epub 2005 Aug 31.
32. Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain. Sokka AL, etal., J Neurosci. 2007 Jan 24;27(4):901-8.
33. Valsartan Protects Against Contrast-Induced Acute Kidney Injury in Rats by Inhibiting Endoplasmic Reticulum Stress-Induced Apoptosis. Sun Y, etal., Curr Vasc Pharmacol. 2017;15(2):174-183. doi: 10.2174/1570161114666161025100656.
34. Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression. Sylvester SL, etal., J Biol Chem. 1994 Aug 5;269(31):20119-25.
35. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
36. ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
37. Mechanism of oxidative stress-induced GADD153 gene expression in vascular smooth muscle cells. Tang JR, etal., Biochem Biophys Res Commun. 2002 Feb 1;290(4):1255-9.
38. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
39. Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Ubeda M, etal., Mol Cell Biol. 1996 Apr;16(4):1479-89.
40. LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis. Wang S, etal., Aging (Albany NY). 2022 Aug 30;14(16):6809-6828. doi: 10.18632/aging.204256. Epub 2022 Aug 30.
41. Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus. Williams BL and Lipkin WI, J Virol. 2006 Sep;80(17):8613-26. doi: 10.1128/JVI.00836-06.
42. alpha-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Xu B, etal., Mol Neurobiol. 2014 Feb;49(1):399-412. doi: 10.1007/s12035-013-8527-2. Epub 2013 Aug 10.
43. Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway. Xu X, etal., Front Mol Neurosci. 2017 Jun 26;10:203. doi: 10.3389/fnmol.2017.00203. eCollection 2017.
44. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
45. Endoplasmic reticulum stress-mediated apoptotic pathway is involved in corpus luteum regression in rats. Yang Y, etal., Reprod Sci. 2015 May;22(5):572-84. doi: 10.1177/1933719114553445. Epub 2014 Oct 20.
46. Hepatocyte autophagy is linked to C/EBP-homologous protein, Bcl2-interacting mediator of cell death, and BH3-interacting domain death agonist gene expression. Zhang J, etal., J Surg Res. 2015 May 15;195(2):588-95. doi: 10.1016/j.jss.2015.01.039. Epub 2015 Jan 28.
47. The induction of cell cycle regulatory and DNA repair proteins in cisplatin-induced acute renal failure. Zhou H, etal., Toxicol Appl Pharmacol. 2004 Oct 15;200(2):111-20.
Additional References at PubMed
PMID:1547942   PMID:8622660   PMID:9531536   PMID:9930704   PMID:10523647   PMID:10820183   PMID:11478948   PMID:11691921   PMID:11854325   PMID:12477932   PMID:12907753   PMID:14667815  
PMID:14729979   PMID:14752510   PMID:15277470   PMID:15322075   PMID:15601821   PMID:15694370   PMID:15775988   PMID:16434966   PMID:17113167   PMID:17395747   PMID:17715997   PMID:17872950  
PMID:17911345   PMID:18006442   PMID:18534616   PMID:18940792   PMID:19061639   PMID:19175159   PMID:19215662   PMID:19218986   PMID:19299913   PMID:19424493   PMID:19614958   PMID:19752026  
PMID:19769458   PMID:19890920   PMID:20109102   PMID:20829347   PMID:21068199   PMID:21159964   PMID:21225541   PMID:21479580   PMID:21767604   PMID:22065586   PMID:22083547   PMID:22180248  
PMID:22242125   PMID:22265908   PMID:22441668   PMID:22496745   PMID:22653339   PMID:22705154   PMID:22761832   PMID:22815481   PMID:23028046   PMID:23074209   PMID:23239445   PMID:23555658  
PMID:24133119   PMID:24668805   PMID:24939851   PMID:25012492   PMID:25412307   PMID:25902191   PMID:26027784   PMID:26099737   PMID:27278525   PMID:27322831   PMID:27484784   PMID:27957794  
PMID:28667101   PMID:28893685   PMID:29414031   PMID:29653943   PMID:29901175   PMID:29958740   PMID:30188326   PMID:30456794   PMID:30486828   PMID:30561076   PMID:31084986   PMID:31914690  
PMID:32304741   PMID:33725228   PMID:34676402   PMID:35315506   PMID:35456517   PMID:37499993  


Genomics

Comparative Map Data
Ddit3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,001,695 - 65,006,517 (+)NCBIGRCr8
mRatBN7.2763,115,645 - 63,121,203 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,116,380 - 63,121,201 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,005,654 - 65,010,476 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,208,074 - 67,212,896 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,009,429 - 67,014,244 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,578,564 - 70,585,074 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,580,198 - 70,585,084 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,753,800 - 70,759,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,247,749 - 67,252,571 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,268,487 - 67,273,294 (+)NCBI
Celera760,256,651 - 60,261,474 (+)NCBICelera
Cytogenetic Map7q22NCBI
DDIT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,516,588 - 57,520,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,516,588 - 57,521,737 (-)EnsemblGRCh38hg38GRCh38
GRCh371257,910,371 - 57,914,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,196,638 - 56,200,567 (-)NCBINCBI36Build 36hg18NCBI36
Build 341256,196,639 - 56,200,567NCBI
Celera1257,566,204 - 57,570,133 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,948,369 - 54,952,298 (-)NCBIHuRef
CHM1_11257,878,226 - 57,882,156 (-)NCBICHM1_1
T2T-CHM13v2.01257,484,816 - 57,488,745 (-)NCBIT2T-CHM13v2.0
Ddit3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,126,662 - 127,132,160 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,126,698 - 127,129,622 (+)EnsemblGRCm39 Ensembl
GRCm39 Ensembl10127,126,643 - 127,132,157 (+)EnsemblGRCm39 Ensembl
GRCm3810127,290,793 - 127,296,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,829 - 127,293,753 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,774 - 127,296,288 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,727,849 - 126,733,344 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,693,759 - 126,699,235 (+)NCBIMGSCv36mm8
Celera10129,683,104 - 129,688,599 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
Ddit3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,232,979 - 5,238,513 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,232,979 - 5,238,513 (-)NCBIChiLan1.0ChiLan1.0
DDIT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21036,823,643 - 36,824,526 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11236,820,414 - 36,821,297 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,406,332 - 31,410,293 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,664,766 - 31,668,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,664,743 - 31,668,701 (+)Ensemblpanpan1.1panPan2
DDIT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,606,693 - 1,612,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,606,693 - 1,611,303 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,669,927 - 1,675,567 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,615,759 - 1,621,400 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,615,759 - 1,620,369 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,593,774 - 1,599,407 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,835,463 - 1,841,297 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,960,652 - 1,966,292 (-)NCBIUU_Cfam_GSD_1.0
Ddit3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,201,026 - 57,205,216 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366461,665,019 - 1,669,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDIT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,785,445 - 22,789,829 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,785,441 - 22,789,867 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DDIT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,424,693 - 53,429,094 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,424,868 - 53,425,576 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,535,088 - 192,539,471 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddit3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480210,437,998 - 10,443,278 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ddit3
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:145
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000008941
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat

Markers in Region
RH128750  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,121,211 - 63,121,513 (+)MAPPERmRatBN7.2
Rnor_6.0770,585,083 - 70,585,384NCBIRnor6.0
Rnor_5.0770,759,229 - 70,759,530UniSTSRnor5.0
RGSC_v3.4767,252,580 - 67,252,881UniSTSRGSC3.4
Celera760,261,483 - 60,261,784UniSTS
Cytogenetic Map7q22UniSTS
PMC152658P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,120,257 - 63,120,975 (+)MAPPERmRatBN7.2
Rnor_6.0770,584,129 - 70,584,846NCBIRnor6.0
Rnor_5.0770,758,275 - 70,758,992UniSTSRnor5.0
RGSC_v3.4767,251,626 - 67,252,343UniSTSRGSC3.4
Celera760,260,528 - 60,261,246UniSTS
Cytogenetic Map7q22UniSTS
RH140361  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,119,865 - 63,120,070 (+)MAPPERmRatBN7.2
Rnor_6.0770,583,737 - 70,583,941NCBIRnor6.0
Rnor_5.0770,757,883 - 70,758,087UniSTSRnor5.0
RGSC_v3.4767,251,234 - 67,251,438UniSTSRGSC3.4
Celera760,260,136 - 60,260,340UniSTS
Cytogenetic Map7q22UniSTS
RH141558  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,120,873 - 63,121,092 (+)MAPPERmRatBN7.2
Rnor_6.0770,584,745 - 70,584,963NCBIRnor6.0
Rnor_5.0770,758,891 - 70,759,109UniSTSRnor5.0
RGSC_v3.4767,252,242 - 67,252,460UniSTSRGSC3.4
Celera760,261,145 - 60,261,363UniSTS
Cytogenetic Map7q22UniSTS
PMC150726P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2763,120,763 - 63,121,067 (+)MAPPERmRatBN7.2
Rnor_6.0770,584,635 - 70,584,938NCBIRnor6.0
Rnor_5.0770,758,781 - 70,759,084UniSTSRnor5.0
RGSC_v3.4767,252,132 - 67,252,435UniSTSRGSC3.4
Celera760,261,035 - 60,261,338UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 34 18 19 18 4 7 72 35 41 11 4
Low 23 23 23 4 4 2 4
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000008941   ⟹   ENSRNOP00000008941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,116,380 - 63,121,201 (+)Ensembl
Rnor_6.0 Ensembl770,580,252 - 70,585,074 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083472   ⟹   ENSRNOP00000071840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,116,391 - 63,121,140 (+)Ensembl
Rnor_6.0 Ensembl770,580,198 - 70,585,084 (+)Ensembl
RefSeq Acc Id: NM_001109986   ⟹   NP_001103456
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8765,001,695 - 65,006,517 (+)NCBI
mRatBN7.2763,116,380 - 63,121,203 (+)NCBI
Rnor_6.0770,580,252 - 70,585,074 (+)NCBI
Rnor_5.0770,753,800 - 70,759,220 (+)NCBI
RGSC_v3.4767,247,749 - 67,252,571 (+)RGD
Celera760,256,651 - 60,261,474 (+)RGD
Sequence:
RefSeq Acc Id: NM_024134   ⟹   NP_077048
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8765,001,695 - 65,006,517 (+)NCBI
mRatBN7.2763,116,380 - 63,121,203 (+)NCBI
Rnor_6.0770,580,252 - 70,585,074 (+)NCBI
Rnor_5.0770,753,800 - 70,759,220 (+)NCBI
RGSC_v3.4767,247,749 - 67,252,571 (+)RGD
Celera760,256,651 - 60,261,474 (+)RGD
Sequence:
RefSeq Acc Id: NP_077048   ⟸   NM_024134
- UniProtKB: Q62857 (UniProtKB/Swiss-Prot),   Q496Y7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001103456   ⟸   NM_001109986
- UniProtKB: Q62857 (UniProtKB/Swiss-Prot),   Q496Y7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008941   ⟸   ENSRNOT00000008941
RefSeq Acc Id: ENSRNOP00000071840   ⟸   ENSRNOT00000083472
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62857-F1-model_v2 AlphaFold Q62857 1-168 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695256
Promoter ID:EPDNEW_R5781
Type:single initiation site
Name:Ddit3_1
Description:DNA-damage inducible transcript 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0770,580,256 - 70,580,316EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62391 AgrOrtholog
BioCyc Gene G2FUF-33754 BioCyc
Ensembl Genes ENSRNOG00000006789 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008941.6 UniProtKB/TrEMBL
  ENSRNOT00000083472.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7932840 IMAGE-MGC_LOAD
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_damage_induc_transcript_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29467 UniProtKB/TrEMBL
MGC_CLONE MGC:124604 IMAGE-MGC_LOAD
NCBI Gene 29467 ENTREZGENE
PANTHER DNA DAMAGE-INDUCIBLE TRANSCRIPT 3 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_2 UniProtKB/TrEMBL
PharmGKB DDIT3 RGD
PhenoGen Ddit3 PhenoGen
PIRSF C/EBPzeta_CHOP_DDIT3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006789 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217079
UniProt A0A0G2K1H3_RAT UniProtKB/TrEMBL
  DDIT3_RAT UniProtKB/Swiss-Prot
  F7EU90_RAT UniProtKB/TrEMBL
  Q496Y7 ENTREZGENE, UniProtKB/TrEMBL
  Q62804_RAT UniProtKB/TrEMBL
  Q62857 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ddit3  DNA-damage inducible transcript 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed at high level in response to stress 70575
gene_function leucine zipper transcription factor 62382
gene_function leucine zipper transcription factor 70575
gene_mutations_overexpression high level reduces Bcl2 expression and depletes glutathione in cells 62382
gene_mutations_overexpression high level reduces Bcl2 expression and depletes glutathione in cells 70575
gene_process sensitizes cells to killing by stress 62382
gene_process sensitizes cells to killing by stress 70575