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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62391 Species: Rattus norvegicus RGD Object: Gene Symbol: Ddit3 Name: DNA-damage inducible transcript 3

Acc ID: CHEBI:3374 Term: capsaicin Definition: A capsaicinoid that has formula C18H27NO3. CasRN: 404-86-4 Chemical ID: MESH:D002211

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:69165	6480464	CTD	Capsaicin results in increased expression of DDIT3	PMID:21859781
increases expression	ISO	RGD:69165	6480464	CTD	Capsaicin results in increased expression of DDIT3 protein	PMID:19939880 PMID:18533110 PMID:19699254 PMID:19139269 PMID:19331147
increases expression	ISO	RGD:69165	6480464	CTD	Capsaicin results in increased expression of DDIT3 mRNA	PMID:18533110 PMID:19939880
increases expression	ISO	RGD:69165	6480464	CTD	Capsaicin results in increased expression of DDIT3 mRNA Capsaicin results in increased expression of DDIT3 protein	PMID:18533110
increases expression	EXP		6480464	CTD	Capsaicin results in increased expression of DDIT3 protein	PMID:19285962
increases expression	ISO	RGD:69165	6480464	CTD	Capsaicin results in increased expression of DDIT3 protein	PMID:19139269 PMID:19939880 PMID:19699254 PMID:18533110 PMID:19331147
increases expression	ISO	RGD:69165	6480464	CTD	Capsaicin results in increased expression of DDIT3 protein	PMID:19699254 PMID:19939880 PMID:18533110 PMID:19139269 PMID:19331147
increases expression	ISO	RGD:69165	6480464	CTD	Capsaicin results in increased expression of DDIT3 mRNA	PMID:19939880 PMID:18533110
increases expression	ISO	RGD:69165	6480464	CTD	Capsaicin results in increased expression of DDIT3 protein	PMID:18533110 PMID:19139269 PMID:19331147 PMID:19699254 PMID:19939880
increases expression	ISO	RGD:69165	6480464	CTD	Capsaicin analog results in increased expression of DDIT3 mRNA	PMID:21343315
affects localization	ISO	RGD:69165	6480464	CTD	Capsaicin affects the localization of DDIT3 protein	PMID:20925121