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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62391 Species: Rattus norvegicus RGD Object: Gene Symbol: Ddit3 Name: DNA-damage inducible transcript 3

Acc ID: CHEBI:16856 Term: glutathione Definition: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine. CasRN: 70-18-8 Chemical ID: MESH:D005978

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:69165	6480464	CTD	Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein] Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA] Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of DDIT3 mRNA] Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA]	PMID:17171638
multiple interactions	ISO	RGD:62396	6480464	CTD	Glutathione inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein] Glutathione inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]	PMID:20493918