Bik (BCL2-interacting killer) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Bik (BCL2-interacting killer) Rattus norvegicus
Analyze
Symbol: Bik
Name: BCL2-interacting killer
RGD ID: 621547
Description: Enables BH domain binding activity. Involved in response to cisplatin. Predicted to be located in mitochondrial envelope. Predicted to be part of Bcl-2 family protein complex. Human ortholog(s) of this gene implicated in ataxia telangiectasia; breast cancer; colon cancer; and prostate cancer. Orthologous to human BIK (BCL2 interacting killer); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: bcl-2-interacting killer; BCL2-interacting killer (apoptosis-inducing); Bcl2-interacting killer-like; Biklk; Blk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87116,552,303 - 116,571,317 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7116,552,303 - 116,571,317 (+)EnsemblGRCr8
mRatBN7.27114,672,277 - 114,691,296 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7114,672,277 - 114,691,296 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7116,427,023 - 116,446,032 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07118,652,801 - 118,671,639 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07118,622,267 - 118,641,107 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07124,390,924 - 124,410,449 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7124,391,432 - 124,410,447 (+)Ensemblrn6Rnor6.0
Rnor_5.07124,379,878 - 124,399,142 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47121,377,004 - 121,396,609 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7110,985,150 - 111,004,412 (+)NCBICelera
RGSC_v3.17121,411,233 - 121,430,839 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(Z)-3-butylidenephthalide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
17beta-estradiol  (ISO)
1H-pyrazole  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorambucil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
cisplatin  (ISO)
clozapine  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (EXP)
depsipeptide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
dinophysistoxin 1  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (EXP,ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
flavonoids  (EXP)
fonofos  (ISO)
furan  (EXP,ISO)
furosemide  (EXP)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
maneb  (ISO)
menadione  (ISO)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
olanzapine  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
pentanal  (ISO)
permethrin  (EXP)
PF-3758309  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP,ISO)
urethane  (EXP,ISO)
usnic acid  (ISO)
valproic acid  (ISO)
VX nerve agent  (ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu SY, etal., Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12401-6.
3. BAK, BAX, and NBK/BIK proapoptotic gene alterations in Iranian patients with ataxia telangiectasia. Isaian A, etal., J Clin Immunol. 2010 Jan;30(1):132-7. doi: 10.1007/s10875-009-9340-6. Epub 2009 Nov 7.
4. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
5. Mutant Bik gene transferred by cationic liposome inhibits peritoneal disseminated murine colon cancer. Lan KL, etal., Clin Exp Metastasis. 2007;24(6):461-70. doi: 10.1007/s10585-007-9083-9. Epub 2007 Jul 18.
6. Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary. Leo CP, etal., Endocrinology 1999 Dec;140(12):5469-77.
7. Enhancement of Bik antitumor effect by Bik mutants. Li YM, etal., Cancer Res. 2003 Nov 15;63(22):7630-3.
8. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
9. Cisplatin inhibits hippocampal cell proliferation and alters the expression of apoptotic genes. Manohar S, etal., Neurotox Res. 2014 May;25(4):369-80. doi: 10.1007/s12640-013-9443-y. Epub 2013 Nov 26.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma. Sturm I, etal., Cell Death Differ. 2006 Apr;13(4):619-27. doi: 10.1038/sj.cdd.4401782.
14. Amplification of D22S283 as a favorable prognostic indicator in liver fluke related cholangiocarcinoma. Thanasai J, etal., World J Gastroenterol. 2006 Jul 21;12(27):4338-44.
Additional References at PubMed
PMID:9525867   PMID:16270031   PMID:21041309   PMID:27262843   PMID:34517787  


Genomics

Comparative Map Data
Bik
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87116,552,303 - 116,571,317 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7116,552,303 - 116,571,317 (+)EnsemblGRCr8
mRatBN7.27114,672,277 - 114,691,296 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7114,672,277 - 114,691,296 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7116,427,023 - 116,446,032 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07118,652,801 - 118,671,639 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07118,622,267 - 118,641,107 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07124,390,924 - 124,410,449 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7124,391,432 - 124,410,447 (+)Ensemblrn6Rnor6.0
Rnor_5.07124,379,878 - 124,399,142 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47121,377,004 - 121,396,609 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7110,985,150 - 111,004,412 (+)NCBICelera
RGSC_v3.17121,411,233 - 121,430,839 (-)NCBI
Cytogenetic Map7q34NCBI
BIK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382243,110,750 - 43,129,712 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2243,110,748 - 43,129,712 (+)Ensemblhg38GRCh38
GRCh372243,506,756 - 43,525,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,836,701 - 41,855,662 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342241,831,254 - 41,850,215NCBI
Celera2227,417,143 - 27,436,106 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2226,465,060 - 26,484,115 (+)NCBIHuRef
CHM1_12243,466,350 - 43,485,313 (+)NCBICHM1_1
T2T-CHM13v2.02243,591,916 - 43,610,878 (+)NCBIT2T-CHM13v2.0
Bik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391583,410,992 - 83,428,836 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1583,411,063 - 83,428,835 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381583,526,790 - 83,544,635 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1583,526,862 - 83,544,634 (+)Ensemblmm10GRCm38
MGSCv371583,357,292 - 83,375,065 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361584,321,217 - 84,338,990 (+)NCBIMGSCv36mm8
MGSCv361583,354,628 - 83,372,401 (+)NCBIMGSCv36mm8
Cytogenetic Map15E1NCBI
cM Map1539.4NCBI
Bik
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541328,277,727 - 28,294,032 (+)NCBIChiLan1.0ChiLan1.0
BIK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22352,933,764 - 52,952,919 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12255,626,663 - 55,646,548 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02223,994,256 - 24,014,244 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12242,194,353 - 42,213,022 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2242,207,149 - 42,213,022 (+)EnsemblpanPan2panpan1.1
BIK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11022,417,374 - 22,433,055 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1022,354,097 - 22,370,473 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01023,161,992 - 23,178,391 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1023,161,979 - 23,178,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11022,881,118 - 22,897,517 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01023,200,499 - 23,217,096 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01023,376,192 - 23,391,652 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bik
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049456,050,452 - 6,065,650 (-)NCBIHiC_Itri_2
BIK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11925,632,837 - 25,658,951 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1925,652,945 - 25,658,541 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604599,781,400 - 99,808,922 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bik
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247525,839,422 - 5,856,350 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Bik
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11252,943,683 - 252,962,196 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bik
74 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:43
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000013977
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7116269196132020414Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 148 88 87 56 92 56 6 342 186 8 125 76 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000013977   ⟹   ENSRNOP00000013977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7116,552,303 - 116,571,317 (+)Ensembl
mRatBN7.2 Ensembl7114,672,277 - 114,691,296 (+)Ensembl
Rnor_6.0 Ensembl7124,391,432 - 124,410,447 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113031   ⟹   ENSRNOP00000085980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7116,552,667 - 116,571,317 (+)Ensembl
mRatBN7.2 Ensembl7114,672,671 - 114,691,296 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134722   ⟹   ENSRNOP00000112853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7116,556,855 - 116,571,317 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000170889   ⟹   ENSRNOP00000101761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7116,552,678 - 116,571,317 (+)Ensembl
RefSeq Acc Id: NM_053704   ⟹   NP_446156
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87116,552,303 - 116,571,317 (+)NCBI
mRatBN7.27114,672,277 - 114,691,296 (+)NCBI
Rnor_6.07124,391,432 - 124,410,447 (+)NCBI
Rnor_5.07124,379,878 - 124,399,142 (+)NCBI
RGSC_v3.47121,377,004 - 121,396,609 (-)RGD
Celera7110,985,150 - 111,004,412 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446156 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK53820 (Get FASTA)   NCBI Sequence Viewer  
  EDM15624 (Get FASTA)   NCBI Sequence Viewer  
  EDM15625 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013977
  ENSRNOP00000013977.1
  ENSRNOP00000085980.1
  ENSRNOP00000101761.1
  ENSRNOP00000112853.1
RefSeq Acc Id: NP_446156   ⟸   NM_053704
- UniProtKB: Q925D2 (UniProtKB/TrEMBL),   A6HT97 (UniProtKB/TrEMBL),   A0A8I6GEH5 (UniProtKB/TrEMBL),   A6HT98 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013977   ⟸   ENSRNOT00000013977
Ensembl Acc Id: ENSRNOP00000085980   ⟸   ENSRNOT00000113031
Ensembl Acc Id: ENSRNOP00000101761   ⟸   ENSRNOT00000170889
Ensembl Acc Id: ENSRNOP00000112853   ⟸   ENSRNOT00000134722

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q925D2-F1-model_v2 AlphaFold Q925D2 1-158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621547 AgrOrtholog
BioCyc Gene G2FUF-32600 BioCyc
Ensembl Genes ENSRNOG00000010359 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013977 ENTREZGENE
  ENSRNOT00000013977.4 UniProtKB/TrEMBL
  ENSRNOT00000113031.2 UniProtKB/TrEMBL
  ENSRNOT00000134722.1 UniProtKB/TrEMBL
  ENSRNOT00000170889.1 UniProtKB/TrEMBL
InterPro Bcl2-int_killer UniProtKB/TrEMBL
KEGG Report rno:114496 UniProtKB/TrEMBL
NCBI Gene 114496 ENTREZGENE
PANTHER BCL-2-INTERACTING KILLER UniProtKB/TrEMBL
  PTHR15018 UniProtKB/TrEMBL
Pfam bcl-2I13 UniProtKB/TrEMBL
PhenoGen Bik PhenoGen
RatGTEx ENSRNOG00000010359 RatGTEx
UniProt A0A8I6GEH5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LIS1_RAT UniProtKB/TrEMBL
  A0ABK0M1N3_RAT UniProtKB/TrEMBL
  A6HT97 ENTREZGENE, UniProtKB/TrEMBL
  A6HT98 ENTREZGENE, UniProtKB/TrEMBL
  Q925D2 ENTREZGENE
UniProt Secondary Q925D2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Bik  BCL2-interacting killer  Bik  BCL2-interacting killer (apoptosis-inducing)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Bik  BCL2-interacting killer (apoptosis-inducing)  Bik  Bcl2-interacting killer  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Bik  Bcl2-interacting killer  Biklk  Bcl2-interacting killer-like  Symbol and Name updated 1299863 APPROVED
2005-01-20 Biklk  Bcl2-interacting killer-like      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Biklk  Bcl2-interacting killer-like      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a BH3 domain 631874