BIK (BCL2 interacting killer) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: BIK (BCL2 interacting killer) Canis lupus familiaris
Analyze
Symbol: BIK
Name: BCL2 interacting killer
RGD ID: 12263864
Description: ENCODES a protein that exhibits BH domain binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN apoptotic mitochondrial changes (ortholog); male gonad development (ortholog); positive regulation of protein-containing complex assembly (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH ataxia telangiectasia (ortholog); breast cancer (ortholog); colon cancer (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); mitochondrial envelope (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bcl-2-interacting killer
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11022,417,374 - 22,433,055 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1022,354,097 - 22,370,473 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01023,161,992 - 23,178,391 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11022,881,118 - 22,897,517 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01023,200,499 - 23,217,096 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01023,376,192 - 23,391,652 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BIK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11022,417,374 - 22,433,055 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1022,354,097 - 22,370,473 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01023,161,992 - 23,178,391 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11022,881,118 - 22,897,517 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01023,200,499 - 23,217,096 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01023,376,192 - 23,391,652 (-)NCBIUU_Cfam_GSD_1.0
BIK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382243,110,750 - 43,129,712 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2243,110,750 - 43,129,712 (+)EnsemblGRCh38hg38GRCh38
GRCh372243,506,756 - 43,525,718 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,836,701 - 41,855,662 (+)NCBINCBI36Build 36hg18NCBI36
Build 342241,831,254 - 41,850,215NCBI
Celera2227,417,143 - 27,436,106 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2226,465,060 - 26,484,115 (+)NCBIHuRef
CHM1_12243,466,350 - 43,485,313 (+)NCBICHM1_1
T2T-CHM13v2.02243,591,916 - 43,610,878 (+)NCBIT2T-CHM13v2.0
Bik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391583,410,992 - 83,428,836 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1583,411,063 - 83,428,835 (+)EnsemblGRCm39 Ensembl
GRCm381583,526,790 - 83,544,635 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1583,526,862 - 83,544,634 (+)EnsemblGRCm38mm10GRCm38
MGSCv371583,357,292 - 83,375,065 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361584,321,217 - 84,338,990 (+)NCBIMGSCv36mm8
MGSCv361583,354,628 - 83,372,401 (+)NCBIMGSCv36mm8
Cytogenetic Map15E1NCBI
cM Map1539.4NCBI
Bik
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87116,552,303 - 116,571,317 (+)NCBIGRCr8
mRatBN7.27114,672,277 - 114,691,296 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7114,672,277 - 114,691,296 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7116,427,023 - 116,446,032 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07118,652,801 - 118,671,639 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07118,622,267 - 118,641,107 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07124,390,924 - 124,410,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7124,391,432 - 124,410,447 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07124,379,878 - 124,399,142 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47121,377,004 - 121,396,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17121,411,233 - 121,430,839 (-)NCBI
Celera7110,985,150 - 111,004,412 (+)NCBICelera
Cytogenetic Map7q34NCBI
Bik
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541328,277,727 - 28,294,032 (+)NCBIChiLan1.0ChiLan1.0
BIK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22352,933,764 - 52,952,919 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12255,626,663 - 55,646,548 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02223,994,256 - 24,014,244 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12242,194,353 - 42,213,022 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2242,207,149 - 42,213,022 (+)Ensemblpanpan1.1panPan2
Bik
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049456,050,452 - 6,065,650 (-)NCBIHiC_Itri_2
BIK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11925,632,837 - 25,658,951 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1925,652,945 - 25,658,541 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604599,781,400 - 99,808,922 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bik
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247525,839,422 - 5,856,350 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BIK
242 total Variants

Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_038488383   ⟹   XP_038344311
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11022,881,118 - 22,897,517 (-)NCBI
RefSeq Acc Id: XM_038550297   ⟹   XP_038406225
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01023,376,192 - 23,391,652 (-)NCBI
RefSeq Acc Id: XM_038613510   ⟹   XP_038469438
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01023,200,499 - 23,217,096 (-)NCBI
RefSeq Acc Id: XM_038640669   ⟹   XP_038496597
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1022,354,097 - 22,370,473 (-)NCBI
RefSeq Acc Id: XM_038679616   ⟹   XP_038535544
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01023,161,992 - 23,178,391 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_038344311   ⟸   XM_038488383
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038469438   ⟸   XM_038613510
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038535544   ⟸   XM_038679616
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038496597   ⟸   XM_038640669
- Peptide Label: isoform X3
- UniProtKB: A0A8P0TQZ3 (UniProtKB/TrEMBL),   A0A8I3NT74 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406225   ⟸   XM_038550297
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000054718 UniProtKB/TrEMBL
  ENSCAFG00845014282 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000105544.1 UniProtKB/TrEMBL
  ENSCAFT00845025539.1 UniProtKB/TrEMBL
InterPro Bcl2-int_killer UniProtKB/TrEMBL
NCBI Gene BIK ENTREZGENE
PANTHER BCL-2-INTERACTING KILLER UniProtKB/TrEMBL
  PTHR15018 UniProtKB/TrEMBL
Pfam bcl-2I13 UniProtKB/TrEMBL
UniProt A0A8I3NT74 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TQZ3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38457 ENTREZGENE