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Gene: Chrna2 (cholinergic receptor nicotinic alpha 2 subunit) Rattus norvegicus

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Symbol:

Chrna2

Name:

cholinergic receptor nicotinic alpha 2 subunit

RGD ID:

621533

Description:

Enables acetylcholine-gated monoatomic cation-selective channel activity; heterocyclic compound binding activity; and quaternary ammonium group binding activity. Involved in cellular response to nicotine; modulation of inhibitory postsynaptic potential; and response to acetylcholine. Located in neuron projection cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 4. Orthologous to human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH 1,1-dimethyl-4-phenylpiperazinium iodide; 1-naphthyl isothiocyanate; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ACHR; cholinergic receptor, nicotinic, alpha 2; cholinergic receptor, nicotinic, alpha 2 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal); neuronal acetylcholine receptor subunit alpha-2; nicotinic acetylcholine receptor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Chrna2 (cholinergic receptor nicotinic alpha 2 subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Chrna2 (cholinergic receptor nicotinic alpha 2 subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Chrna2 (cholinergic receptor nicotinic alpha 2 subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Chrna2 (cholinergic receptor nicotinic alpha 2 subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Chrna2 (cholinergic receptor nicotinic alpha 2 subunit)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	AASDH (aminoadipate-semialdehyde dehydrogenase)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Chrna2 (cholinergic receptor nicotinic alpha 2 subunit)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	chrna2a (cholinergic receptor, nicotinic, alpha 2a (neuronal))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	chrna2a (cholinergic receptor, nicotinic, alpha 2a (neuronal))	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	chrna2b (cholinergic receptor, nicotinic, alpha 2b (neuronal))	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	acr-8	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	nAChRalpha1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	nAChRalpha2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	nAChRalpha2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	nAChRbeta1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	nAChRbeta2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	nAChRbeta2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	nAChRalpha3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	nAChRalpha4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	nAChRalpha4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	unc-63	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	unc-63	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	chrna2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	chrna2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	44,517,862 - 44,534,144 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	44,517,862 - 44,534,144 (+)	Ensembl				GRCr8
mRatBN7.2	15	40,342,317 - 40,358,601 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	40,342,317 - 40,358,601 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	42,209,601 - 42,225,892 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	43,359,798 - 43,376,089 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	41,802,620 - 41,818,906 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	42,808,897 - 42,825,179 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	42,808,897 - 42,825,179 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	48,768,230 - 48,785,192 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	45,570,809 - 45,587,091 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	40,015,644 - 40,031,870 (+)	NCBI		Celera
RGSC_v3.1	15	45,586,588 - 45,602,871 (+)	NCBI
Cytogenetic Map	15	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant nocturnal frontal lobe epilepsy (ISO)

autosomal dominant nocturnal frontal lobe epilepsy 4 (ISO)

benign familial infantile epilepsy (ISO)

benign familial infantile seizures 6 (ISO)

epilepsy (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Lung Neoplasms (ISO)

Myoclonic Epilepsies (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(S)-nicotine (ISO)

1,1-dimethyl-4-phenylpiperazinium iodide (EXP,ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,7-dihydropurine-6-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acetylcholine (EXP,ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

Aroclor 1254 (ISO)

atrazine (ISO)

Azoxymethane (ISO)

barium(0) (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bexarotene (EXP)

bifenthrin (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butan-1-ol (ISO)

butan-2-ol (ISO)

cadmium dichloride (EXP)

calcitriol (ISO)

cannabidiol (ISO)

carbachol (EXP)

carbamazepine (ISO)

carbon nanotube (ISO)

clofibrate (EXP,ISO)

clofibric acid (EXP)

crotyl alcohol (ISO)

cytisine (EXP,ISO)

D-glucose (ISO)

dextran sulfate (ISO)

diazinon (EXP)

dichloroacetic acid (ISO)

dieldrin (EXP)

dihydro-beta-erythroidine (EXP)

diquat (ISO)

epibatidine (EXP,ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenofibrate (EXP)

flavonoids (EXP)

folic acid (ISO)

fructose (ISO)

glucose (ISO)

glyphosate (EXP)

isobutanol (ISO)

mercaptopurine (EXP)

methapyrilene (ISO)

methyllycaconitine (EXP)

methylmercury chloride (ISO)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP)

nickel atom (EXP)

nicotine (EXP,ISO)

paracetamol (EXP)

pentan-1-ol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

permethrin (ISO)

phenethyl caffeate (EXP)

phenobarbital (ISO)

pirinixic acid (EXP,ISO)

propan-1-ol (ISO)

propan-2-ol (ISO)

purine-6-thiol (EXP)

sodium arsenite (ISO)

sodium fluoride (ISO)

tert-butanol (ISO)

Tesaglitazar (EXP)

testosterone (ISO)

titanium dioxide (ISO)

trichloroethene (EXP,ISO)

triphenyl phosphate (ISO)

troglitazone (EXP,ISO)

tubocurarine (EXP)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetylcholine receptor signaling pathway (IBA,IEA,ISO)

cellular response to nicotine (IDA)

cerebral cortex GABAergic interneuron development (IEP)

excitatory postsynaptic potential (IEA)

hippocampus development (IEP)

membrane depolarization (IBA,ISO)

modulation of inhibitory postsynaptic potential (IDA)

monoatomic ion transmembrane transport (IBA,IEA)

monoatomic ion transport (IEA)

neuromuscular synaptic transmission (IBA)

presynaptic modulation of chemical synaptic transmission (IBA)

regulation of postsynaptic membrane potential (IEA)

regulation of synaptic plasticity (ISO)

response to acetylcholine (IDA,IEA)

response to nicotine (IBA)

signal transduction (IEA,ISO)

synaptic transmission, cholinergic (IBA)

Cellular Component

acetylcholine-gated channel complex (IBA,IEA,ISO,ISS)

cell periphery (IEA,ISO)

membrane (IEA)

neuron projection (IBA)

neuron projection cytoplasm (IDA)

plasma membrane (IBA,IEA,ISO)

postsynaptic membrane (IEA)

presynapse (IEA)

protein-containing complex (IDA)

synapse (IBA,IEA,ISO)

synaptic membrane (IEA)

Molecular Function

acetylcholine receptor activity (IBA,IEA,ISO)

acetylcholine-gated monoatomic cation-selective channel activity (IBA,IDA,IEA,ISO)

extracellular ligand-gated monoatomic ion channel activity (IEA)

heterocyclic compound binding (IDA,IPI)

monoatomic ion channel activity (IEA)

quaternary ammonium group binding (IDA,IEA)

transmembrane signaling receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via nicotinic acetylcholine receptor (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Mammalian nicotinic acetylcholine receptors: from structure to function.	Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Alpha2 nicotine receptors function as a molecular switch to continuously excite a subset of interneurons in rat hippocampal circuits.	Jia Y, etal., Eur J Neurosci. 2009 Apr;29(8):1588-603. doi: 10.1111/j.1460-9568.2009.06706.x.
5.	Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes.	Marritt AM, etal., Mol Pharmacol. 2005 Dec;68(6):1656-68. Epub 2005 Aug 29.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Postnatal expression of alpha2 nicotinic acetylcholine receptor subunit mRNA in developing cortex and hippocampus.	Son JH and Winzer-Serhan UH, J Chem Neuroanat. 2006 Dec;32(2-4):179-90. doi: 10.1016/j.jchemneu.2006.09.001. Epub 2006 Oct 12.
13.	Functional expression of a new pharmacological subtype of brain nicotinic acetylcholine receptor.	Wada K, etal., Science 1988 Apr 15;240(4850):330-4.
14.	The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells.	Xiao Y and Kellar KJ, J Pharmacol Exp Ther. 2004 Jul;310(1):98-107. Epub 2004 Mar 11.

Additional References at PubMed

PMID:8906617	PMID:15026122	PMID:21884692

Genomics

Comparative Map Data

Chrna2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	44,517,862 - 44,534,144 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	44,517,862 - 44,534,144 (+)	Ensembl				GRCr8
mRatBN7.2	15	40,342,317 - 40,358,601 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	40,342,317 - 40,358,601 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	42,209,601 - 42,225,892 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	43,359,798 - 43,376,089 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	41,802,620 - 41,818,906 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	42,808,897 - 42,825,179 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	42,808,897 - 42,825,179 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	48,768,230 - 48,785,192 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	45,570,809 - 45,587,091 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	40,015,644 - 40,031,870 (+)	NCBI		Celera
RGSC_v3.1	15	45,586,588 - 45,602,871 (+)	NCBI
Cytogenetic Map	15	p12	NCBI

CHRNA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	27,459,756 - 27,479,261 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	27,459,756 - 27,479,883 (-)	Ensembl			hg38	GRCh38
GRCh37	8	27,317,273 - 27,336,778 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	27,373,195 - 27,392,730 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	8	27,374,181 - 27,392,675	NCBI
Celera	8	26,277,396 - 26,296,925 (-)	NCBI		Celera
Cytogenetic Map	8	p21.2	NCBI
HuRef	8	25,862,340 - 25,881,872 (-)	NCBI		HuRef
CHM1_1	8	27,519,147 - 27,538,678 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	27,737,110 - 27,756,814 (-)	NCBI		T2T-CHM13v2.0

Chrna2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	66,370,685 - 66,390,397 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	66,372,488 - 66,390,397 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	14	66,133,236 - 66,152,948 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	66,135,039 - 66,152,948 (+)	Ensembl			mm10	GRCm38
MGSCv37	14	66,759,797 - 66,771,785 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	14	65,095,070 - 65,107,058 (+)	NCBI		MGSCv36	mm8
Celera	14	63,889,359 - 63,901,395 (+)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI
cM Map	14	34.36	NCBI

Chrna2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	49,970,398 - 49,989,137 (-)	Ensembl
ChiLan1.0	NW_004955403	49,970,398 - 49,989,095 (-)	NCBI	ChiLan1.0	ChiLan1.0

CHRNA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	45,990,058 - 46,009,764 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	21,704,317 - 21,723,990 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	26,729,767 - 26,749,277 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	23,932,846 - 23,952,377 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	23,932,846 - 23,952,377 (-)	Ensembl			panPan2	panpan1.1

CHRNA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	30,117,384 - 30,137,223 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	30,117,239 - 30,135,599 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	30,711,637 - 30,723,506 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	30,316,301 - 30,326,148 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	30,307,340 - 30,325,726 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	30,245,712 - 30,257,580 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	30,126,596 - 30,137,323 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	30,292,990 - 30,304,860 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Chrna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	8,251,532 - 8,258,650 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936675	327,501 - 334,581 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936675	327,501 - 334,493 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHRNA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	11,195,228 - 11,207,650 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	11,193,732 - 11,204,334 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	12,374,481 - 12,388,291 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CHRNA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	25,571,958 - 25,591,982 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	25,571,863 - 25,591,788 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666052	16,552,356 - 16,572,243 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Chrna2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	22,182,951 - 22,200,063 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624758	22,182,468 - 22,200,076 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Chrna2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	12	58,302,739 - 58,319,576 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Chrna2
68 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	112
Count of miRNA genes:	91
Interacting mature miRNAs:	93
Transcripts:	ENSRNOT00000023475
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1641913	Colcr2	Colorectal carcinoma resistance QTL 2	6.57	0.0197	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	15	2315759	47315759	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	44836456	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2315759	53331089	Rat
152025253	Hrtrt24	Heart rate QTL 24	3.82		heart pumping trait (VT:2000009)		15	31855803	92671517	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	43677244	88677244	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	28527732	73527732	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	43677244	88677244	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	25285835	104695021	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	22336351	52597086	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	25285835	104695021	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	19155762	87086765	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	2785923	47785923	Rat
1598828	Glom14	Glomerulus QTL 14	2.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	15	40463152	85463152	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	14926594	71614418	Rat
631550	Bw7	Body weight QTL 7	3.6		body mass (VT:0001259)	body weight (CMO:0000012)	15	22336351	67336351	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	43677244	88677244	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	43677244	88677244	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	25285835	104695021	Rat
7411725	Strs7	Sensitivity to stroke QTL 7	3.8		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	15	44465447	56583797	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	43677244	88677244	Rat

Markers in Region

D15Wox3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	15	44,529,522 - 44,529,639 (+)	Marker Load Pipeline
mRatBN7.2	15	40,353,977 - 40,354,096 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	42,820,558 - 42,820,674	NCBI	Rnor6.0
Rnor_5.0	15	48,773,415 - 48,773,531	UniSTS	Rnor5.0
RGSC_v3.4	15	45,582,469 - 45,582,586	RGD	RGSC3.4
RGSC_v3.4	15	45,582,470 - 45,582,586	UniSTS	RGSC3.4
Celera	15	40,027,310 - 40,027,432	UniSTS
RGSC_v3.1	15	45,598,249 - 45,598,366	RGD
RH 2.0 Map	15	296.8	RGD
Cytogenetic Map	15	p12	UniSTS

Chrna2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	40,356,876 - 40,357,168 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	42,823,455 - 42,823,746	NCBI	Rnor6.0
Rnor_5.0	15	48,770,343 - 48,770,634	UniSTS	Rnor5.0
RGSC_v3.4	15	45,585,367 - 45,585,658	UniSTS	RGSC3.4
Celera	15	40,030,146 - 40,030,437	UniSTS
Cytogenetic Map	15	p12	UniSTS

UniSTS:496005

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	40,356,280 - 40,356,378 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	42,822,859 - 42,822,956	NCBI	Rnor6.0
Rnor_5.0	15	48,771,133 - 48,771,230	UniSTS	Rnor5.0
RGSC_v3.4	15	45,584,771 - 45,584,868	UniSTS	RGSC3.4
Celera	15	40,029,550 - 40,029,647	UniSTS
Cytogenetic Map	15	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	6	33	131	79	78	47	85	47	6	276	147	10	102	61	52	31	13	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133420	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC112574	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH002124	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY574253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L10077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023475 ⟹ ENSRNOP00000023475

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	44,517,862 - 44,534,144 (+)	Ensembl
mRatBN7.2 Ensembl	15	40,342,317 - 40,358,601 (+)	Ensembl
Rnor_6.0 Ensembl	15	42,808,897 - 42,825,179 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000124226 ⟹ ENSRNOP00000109692

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	44,525,347 - 44,534,144 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000127420 ⟹ ENSRNOP00000100895

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	44,517,862 - 44,534,144 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000139751 ⟹ ENSRNOP00000105569

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	44,517,862 - 44,533,813 (+)	Ensembl

RefSeq Acc Id:

NM_133420 ⟹ NP_596911

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	44,517,862 - 44,534,144 (+)	NCBI
mRatBN7.2	15	40,342,317 - 40,358,601 (+)	NCBI
Rnor_6.0	15	42,808,897 - 42,825,179 (+)	NCBI
Rnor_5.0	15	48,768,230 - 48,785,192 (-)	NCBI
RGSC_v3.4	15	45,570,809 - 45,587,091 (+)	RGD
Celera	15	40,015,644 - 40,031,870 (+)	RGD

Sequence:

show sequence

ACTGAGCATTCTGTTGAACTCGGATCACCTATCTCCAGGAAGCTAGCCTGAATCCCTCATCCCA
ACAGTGCCTCCCAAACCTTGCAGGTTCTGTGTCTGGGCAACCATGAGCTGAAGCAACTGAGCTC
TGTTCTGCACCTGTCACTGCTTCCGAGGGACCCTCGTCAGCCACCCCAGGTCTCCAGCCGGTTG
GTTCTCTGCATCCCTTGAGGGGCCTGTCTTCTTCTATGACAATTGCAGAGAGACAGTGCCTCAA
AGAAGCCAGCTCTTGGTAGTCCAAGGGAAACCAGGACCCTCTGAAGCCATGACCCTTTCCCATT
CTGCTCTCCAGTTCTGGACACATCTTTATCTCTGGTGTCTCCTTCTGGTGCCAGCAGTGTTGAC
CCAGCAAGGCTCACACACCCATGCTGAGGACCGCCTGTTCAAACACCTGTTTGGAGGCTACAAT
CGCTGGGCACGGCCAGTGCCCAACACTTCTGATGTGGTCATCGTGCGCTTTGGATTATCCATTG
CTCAGCTCATAGATGTGGATGAGAAGAATCAAATGATGACCACCAATGTCTGGCTAAAGCAGGA
ATGGAATGACTACAAGCTGCGCTGGGACCCGGCTGAGTTTGGCAATGTCACCTCCCTGCGCGTC
CCTTCAGAGATGATCTGGATCCCAGACATTGTCCTCTACAACAATGCAGATGGGGAGTTTGCGG
TGACCCACATGACCAAGGCTCACCTCTTCTTCACGGGCACTGTGCACTGGGTGCCCCCAGCCAT
CTACAAGAGCTCCTGCAGCATCGATGTGACCTTCTTCCCCTTCGACCAGCAGAACTGCAAGATG
AAGTTTGGCTCCTGGACATATGACAAGGCCAAGATCGATCTGGAGCAGATGGAGAGGACAGTGG
ACCTGAAGGACTACTGGGAGAGTGGCGAGTGGGCCATTATCAATGCCACCGGAACCTATAACAG
TAAGAAGTACGACTGCTGCGCGGAGATCTACCCCGATGTCACCTACTACTTTGTGATCCGCCGG
CTGCCGCTGTTCTATACCATCAACCTCATCATCCCATGCCTGCTCATCTCCTGCCTCACTGTGC
TCGTGTTCTACCTGCCTTCCGAGTGTGGAGAGAAGATCACGCTGTGCATCTCGGTGCTGCTATC
TCTCACTGTCTTCCTGCTGCTCATCACGGAGATCATCCCGTCCACCTCGCTGGTCATCCCACTC
ATCGGCGAGTACCTGCTCTTCACCATGATCTTTGTCACCCTCTCTATCGTTATCACAGTCTTCG
TGCTCAATGTACACCACCGCTCCCCCAGCACCCACAACATGCCCAACTGGGTAAGGGTAGCCCT
GCTAGGCCGGGTGCCCAGGTGGCTGATGATGAACCGGCCCCTGCCACCTATGGAGCTCCATGGC
TCCCCGGATCTGAAGCTCAGCCCCTCATACCATTGGCTAGAGACTAACATGGATGCTGGAGAAA
GGGAGGAGACAGAGGAAGAGGAGGAAGAAGAAGATGAAAACATATGTGTGTGTGCAGGCCTTCC
AGACTCTTCGATGGGTGTCCTCTATGGCCATGGCGGCCTGCATCTGAGAGCCATGGAGCCTGAG
ACCAAGACTCCATCCCAGGCTAGCGAGATTCTGCTGTCACCTCAAATACAGAAAGCACTAGAAG
GTGTACACTACATTGCTGACCGTCTGAGGTCTGAGGATGCTGACTCTTCGGTGAAGGAAGACTG
GAAGTATGTGGCCATGGTGGTAGACCGGATATTCCTCTGGCTGTTCATTATCGTCTGCTTCCTG
GGGACCATCGGACTCTTCCTTCCTCCATTCCTGGCTGGAATGATCTAACTTCATGTCCTTCATG
TTGGCTCCAAGGTGGCCTTCGTAACTATCTTCTAGTCTTCTGTGAATGGAGCCATCTCTAGAAT
ACTCTTTTGAC

hide sequence

Protein Sequences


Protein RefSeqs	NP_596911	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA40664	(Get FASTA)	NCBI Sequence Viewer
	AAB60900	(Get FASTA)	NCBI Sequence Viewer
	AAS90349	(Get FASTA)	NCBI Sequence Viewer
	EDL85379	(Get FASTA)	NCBI Sequence Viewer
	EDL85380	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023475
	ENSRNOP00000023475.2
GenBank Protein	P12389	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_596911 ⟸ NM_133420
- Peptide Label:	precursor
- UniProtKB:	O08952 (UniProtKB/Swiss-Prot), Q53YK3 (UniProtKB/Swiss-Prot), P12389 (UniProtKB/Swiss-Prot), A6K6M0 (UniProtKB/TrEMBL), A6K6L9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTLSHSALQFWTHLYLWCLLLVPAVLTQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVR FGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIPDIVLYNNA DGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQ MERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLI SCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSI VITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRPLPPMELHGSPDLKLSPSYHWLETN MDAGEREETEEEEEEEDENICVCAGLPDSSMGVLYGHGGLHLRAMEPETKTPSQASEILLSPQI QKALEGVHYIADRLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI hide sequence

Ensembl Acc Id:

ENSRNOP00000023475 ⟸ ENSRNOT00000023475

Ensembl Acc Id:

ENSRNOP00000100895 ⟸ ENSRNOT00000127420

Ensembl Acc Id:

ENSRNOP00000109692 ⟸ ENSRNOT00000124226

Ensembl Acc Id:

ENSRNOP00000105569 ⟸ ENSRNOT00000139751

Protein Domains

Neurotransmitter-gated ion-channel ligand-binding Neurotransmitter-gated ion-channel transmembrane

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P12389-F1-model_v2	AlphaFold	P12389	1-511	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621533	AgrOrtholog
BioCyc Gene	G2FUF-13331	BioCyc
Ensembl Genes	ENSRNOG00000017424	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000023475	ENTREZGENE
	ENSRNOT00000023475.3	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.58.390	UniProtKB/Swiss-Prot
	2.70.170.10	UniProtKB/Swiss-Prot
InterPro	Neur_chan_lig-bd	UniProtKB/Swiss-Prot
	Neur_chan_lig-bd_sf	UniProtKB/Swiss-Prot
	Neur_channel	UniProtKB/Swiss-Prot
	Neuro-gated_channel_TM_sf	UniProtKB/Swiss-Prot
	Neuro_actylchol_rec	UniProtKB/Swiss-Prot
	Neurotrans-gated_channel_TM	UniProtKB/Swiss-Prot
	Neurotransmitter_ion_chnl_CS	UniProtKB/Swiss-Prot
	Nicotinic_acetylcholine_rcpt	UniProtKB/Swiss-Prot
KEGG Report	rno:170945	UniProtKB/Swiss-Prot
NCBI Gene	170945	ENTREZGENE
PANTHER	PTHR18945	UniProtKB/Swiss-Prot
Pfam	Neur_chan_LBD	UniProtKB/Swiss-Prot
	Neur_chan_memb	UniProtKB/Swiss-Prot
PharmGKB	CHRNA2	RGD
PhenoGen	Chrna2	PhenoGen
PRINTS	NICOTINICR	UniProtKB/Swiss-Prot
	NRIONCHANNEL	UniProtKB/Swiss-Prot
PROSITE	NEUROTR_ION_CHANNEL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000017424	RatGTEx
Superfamily-SCOP	SSF63712	UniProtKB/Swiss-Prot
	SSF90112	UniProtKB/Swiss-Prot
UniProt	A0ABK0LFX2_RAT	UniProtKB/TrEMBL
	A0ABK0LI81_RAT	UniProtKB/TrEMBL
	A0ABK0LUD5_RAT	UniProtKB/TrEMBL
	A6K6L9	ENTREZGENE, UniProtKB/TrEMBL
	A6K6M0	ENTREZGENE, UniProtKB/TrEMBL
	ACHA2_RAT	UniProtKB/Swiss-Prot
	O08952	ENTREZGENE
	P12389	ENTREZGENE
	Q53YK3	ENTREZGENE
UniProt Secondary	O08952	UniProtKB/Swiss-Prot
	Q53YK3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Chrna2	cholinergic receptor nicotinic alpha 2 subunit	Chrna2	cholinergic receptor, nicotinic, alpha 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-11-12	Chrna2	cholinergic receptor, nicotinic, alpha 2	Chrna2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Chrna2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	Chrna2	cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-26	Chrna2	cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Chrna2	cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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RGD Manual Annotations