Jup (junction plakoglobin) - Rat Genome Database

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Gene: Jup (junction plakoglobin) Rattus norvegicus
Analyze
Symbol: Jup
Name: junction plakoglobin
RGD ID: 620412
Description: Enables protein tyrosine kinase binding activity. Predicted to be involved in several processes, including cellular response to indole-3-methanol; positive regulation of protein import into nucleus; and regulation of heart contraction. Predicted to act upstream of or within cell adhesion; desmosome assembly; and skin development. Located in several cellular components, including apicolateral plasma membrane; fascia adherens; and lateral plasma membrane. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin); PARTICIPATES IN E-cadherin signaling pathway; N-cadherin signaling pathway; acute myeloid leukemia pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: gamma-catenin (plakoglobin)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81085,800,812 - 85,827,881 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1085,800,814 - 85,827,429 (-)EnsemblGRCr8
mRatBN7.21085,300,438 - 85,327,378 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,300,440 - 85,327,057 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1090,340,290 - 90,366,730 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01089,818,505 - 89,845,011 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,208,718 - 85,235,336 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,280,517 - 88,307,451 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,279,632 - 88,307,412 (-)Ensemblrn6Rnor6.0
Rnor_5.01088,073,764 - 88,100,700 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41089,307,938 - 89,335,254 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,018,429 - 84,045,045 (-)NCBICelera
RGSC_v3.11089,322,309 - 89,349,624 (-)NCBI
Cytogenetic Map10q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,6-dimethoxyphenol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diethylstilbestrol  (EXP)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furfural  (ISO)
genistein  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
indirubin  (EXP)
indometacin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
lasalocid  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
NCX-4040  (ISO)
nefazodone  (EXP)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitrobenzenes  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-allylcysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers. Aberle H, etal., Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6384-8.
2. Identification and prognostic significance of an epithelial-mesenchymal transition expression profile in human bladder tumors. Baumgart E, etal., Clin Cancer Res. 2007 Mar 15;13(6):1685-94.
3. Methylation of the gamma-catenin gene is associated with poor prognosis of renal cell carcinoma. Breault JE, etal., Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):557-64.
4. Expression of plakoglobin in renal cell carcinoma. Buchner A, etal., Anticancer Res. 1998 Nov-Dec;18(6A):4231-5.
5. Expression of adhesion proteins E-cadherin, alpha-catenin, beta-catenin and gamma-catenin is different in T1 and T2 breast tumours. Bukholm IR, etal., Pathology. 2006 Oct;38(5):403-7.
6. Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Chen YM, etal., Biol Reprod. 2003 Aug;69(2):656-72. Epub 2003 Apr 16.
7. TCDD-dependent downregulation of gamma-catenin in rat liver epithelial cells (WB-F344). Dietrich C, etal., Int J Cancer 2003 Feb 10;103(4):435-9.
8. Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes. Dubash AD, etal., J Cell Biol. 2016 Feb 15;212(4):425-38. doi: 10.1083/jcb.201507018. Epub 2016 Feb 8.
9. The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins. Franke WW, etal., Eur J Cell Biol. 2006 Feb;85(2):69-82. Epub 2006 Jan 9.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations. Gehmlich K, etal., Cardiovasc Res. 2011 Apr 1;90(1):77-87. doi: 10.1093/cvr/cvq353. Epub 2010 Nov 9.
12. Retention of the expression of E-cadherin and catenins is associated with shorter survival in grade III ductal carcinoma of the breast. Gillett CE, etal., J Pathol. 2001 Apr;193(4):433-41.
13. Cell-cell contact changes the dynamics of lamellar activity in nontransformed epitheliocytes but not in their ras-transformed descendants. Gloushankova NA, etal., Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):879-83.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes. Hertig CM, etal., J Cell Sci. 1996 Jan;109 ( Pt 1):11-20.
16. Heterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated disk. Hong M, etal., J Biol Chem. 2012 Nov 30;287(49):41258-67. doi: 10.1074/jbc.M112.412122. Epub 2012 Oct 12.
17. Elevated expression of E-cadherin and alpha-, beta-, and gamma-catenins in metastatic lesions compared with primary epithelial ovarian carcinomas. Imai T, etal., Hum Pathol. 2004 Dec;35(12):1469-76.
18. Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease). McKoy G, etal., Lancet. 2000 Jun 17;355(9221):2119-24.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Abnormalities of E- and P-cadherin and catenin (beta-, gamma-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia. Moreno-Bueno G, etal., J Pathol. 2003 Apr;199(4):471-8.
21. E-cadherin and alpha-, beta- and gamma-catenin expression in prostate cancers: correlation with tumour invasion. Morita N, etal., Br J Cancer. 1999 Apr;79(11-12):1879-83.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Noorman M, etal., Heart Rhythm. 2013 Mar;10(3):412-9. doi: 10.1016/j.hrthm.2012.11.018. Epub 2012 Nov 23.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. Junctional plaque proteins shift to the apical surface of uterine epithelial cells during early pregnancy in the rat. Orchard MD, etal., Acta Histochem. 1999 Apr;101(2):147-56.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Robinson cytologic grading in invasive ductal carcinoma of the breast: correlation with E-cadherin and alpha-, beta- and gamma-catenin expression and regional lymph node metastasis. Robles-Frias A, etal., Acta Cytol. 2006 Mar-Apr;50(2):151-7.
32. [Expresion of E-cadherin and catenins in urothelial carcinomas] San Miguel Fraile P, etal., Actas Urol Esp. 2007 Apr;31(4):355-60.
33. Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc. Sato PY, etal., Circ Res. 2011 Jul 8;109(2):193-201. Epub 2011 May 26.
34. Alterations of beta- and gamma-catenin in N-butyl-N-(-4-hydroxybutyl)nitrosamine-induced murine bladder cancer. Shiina H, etal., Cancer Res. 2001 Oct 1;61(19):7101-9.
35. Functional Loss of the gamma-catenin gene through epigenetic and genetic pathways in human prostate cancer. Shiina H, etal., Cancer Res. 2005 Mar 15;65(6):2130-8.
36. New insights into testicular germ cell tumorigenesis from gene expression profiling. Skotheim RI, etal., Cancer Res. 2002 Apr 15;62(8):2359-64.
37. Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays. Skotheim RI, etal., Neoplasia. 2003 Sep-Oct;5(5):397-404.
38. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:1639850   PMID:2726765   PMID:7650039   PMID:7890674   PMID:7983064   PMID:8582267   PMID:8663237   PMID:8821035   PMID:8853988   PMID:8954745   PMID:9049256   PMID:9847250  
PMID:9864371   PMID:10403777   PMID:10460003   PMID:10662781   PMID:10825188   PMID:10868478   PMID:12847106   PMID:14579029   PMID:14661054   PMID:14673151   PMID:15489334   PMID:15775979  
PMID:16510873   PMID:16917092   PMID:17559062   PMID:17924338   PMID:18261826   PMID:18496566   PMID:18816447   PMID:18937352   PMID:19056867   PMID:19805073   PMID:20859650   PMID:21296051  
PMID:21423176   PMID:21880664   PMID:22781308   PMID:22889254   PMID:23136403   PMID:23376485   PMID:23381804   PMID:23747726   PMID:23979707   PMID:25468996   PMID:28115160   PMID:32357304  


Genomics

Comparative Map Data
Jup
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81085,800,812 - 85,827,881 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1085,800,814 - 85,827,429 (-)EnsemblGRCr8
mRatBN7.21085,300,438 - 85,327,378 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,300,440 - 85,327,057 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1090,340,290 - 90,366,730 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01089,818,505 - 89,845,011 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,208,718 - 85,235,336 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,280,517 - 88,307,451 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,279,632 - 88,307,412 (-)Ensemblrn6Rnor6.0
Rnor_5.01088,073,764 - 88,100,700 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41089,307,938 - 89,335,254 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,018,429 - 84,045,045 (-)NCBICelera
RGSC_v3.11089,322,309 - 89,349,624 (-)NCBI
Cytogenetic Map10q31NCBI
JUP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,754,609 - 41,786,711 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,750,887 - 41,786,931 (-)Ensemblhg38GRCh38
GRCh371739,910,861 - 39,942,963 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,164,390 - 37,196,475 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341737,164,389 - 37,196,475NCBI
Celera1736,562,207 - 36,594,276 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,672,969 - 35,704,921 (-)NCBIHuRef
CHM1_11740,146,477 - 40,178,584 (-)NCBICHM1_1
T2T-CHM13v2.01742,611,153 - 42,643,244 (-)NCBIT2T-CHM13v2.0
Jup
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,259,682 - 100,288,639 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,259,784 - 100,288,589 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811100,368,856 - 100,397,839 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,368,958 - 100,397,763 (-)Ensemblmm10GRCm38
MGSCv3711100,231,933 - 100,259,053 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611100,186,709 - 100,213,829 (-)NCBIMGSCv36mm8
Celera11110,988,014 - 111,016,158 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.47NCBI
Jup
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545115,989,180 - 16,004,155 (-)Ensembl
ChiLan1.0NW_00495545115,993,055 - 16,004,152 (-)NCBIChiLan1.0ChiLan1.0
JUP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21923,195,092 - 23,227,287 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11725,085,219 - 25,117,407 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,527,115 - 15,559,251 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,747,163 - 15,777,479 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,747,163 - 15,777,479 (+)EnsemblpanPan2panpan1.1
JUP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1921,028,773 - 21,053,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl921,028,828 - 21,053,071 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha920,490,821 - 20,515,048 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0921,749,530 - 21,774,004 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,749,494 - 21,776,711 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,535,712 - 20,559,942 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,801,655 - 20,825,888 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,905,422 - 20,929,851 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Jup
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,380,553 - 20,403,963 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,668,575 - 16,694,615 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649016,671,176 - 16,694,552 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JUP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,901,396 - 20,931,210 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11220,902,395 - 20,931,208 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,145,385 - 21,184,606 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JUP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,470,974 - 64,503,085 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,470,959 - 64,503,322 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607735,301,719 - 35,334,347 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jup
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,954,290 - 1,975,018 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247951,954,733 - 1,972,080 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Jup
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1959,673,791 - 59,700,113 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Jup
156 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:314
Count of miRNA genes:160
Interacting mature miRNAs:191
Transcripts:ENSRNOT00000040845
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH128545  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,300,546 - 85,300,704 (+)MAPPERmRatBN7.2
Rnor_6.01088,280,626 - 88,280,783NCBIRnor6.0
Rnor_5.01088,073,873 - 88,074,030UniSTSRnor5.0
RGSC_v3.41089,308,047 - 89,308,204UniSTSRGSC3.4
Celera1084,018,538 - 84,018,695UniSTS
RH 3.4 Map10860.39UniSTS
Cytogenetic Map10q32.1UniSTS
Jup  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,302,010 - 85,302,158 (+)MAPPERmRatBN7.2
Rnor_6.01088,282,090 - 88,282,237NCBIRnor6.0
Rnor_5.01088,075,337 - 88,075,484UniSTSRnor5.0
RGSC_v3.41089,309,511 - 89,309,658UniSTSRGSC3.4
Celera1084,020,002 - 84,020,149UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001439534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC065580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS673478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS690861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB665614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM706826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U58858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000040845   ⟹   ENSRNOP00000043950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1085,800,814 - 85,827,429 (-)Ensembl
mRatBN7.2 Ensembl1085,300,440 - 85,327,057 (-)Ensembl
Rnor_6.0 Ensembl1088,280,519 - 88,307,132 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089933   ⟹   ENSRNOP00000070840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1085,800,814 - 85,827,429 (-)Ensembl
mRatBN7.2 Ensembl1085,300,440 - 85,327,057 (-)Ensembl
Rnor_6.0 Ensembl1088,279,632 - 88,307,412 (-)Ensembl
RefSeq Acc Id: NM_031047   ⟹   NP_112309
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81085,800,812 - 85,827,429 (-)NCBI
mRatBN7.21085,300,438 - 85,327,057 (-)NCBI
Rnor_6.01088,280,517 - 88,307,132 (-)NCBI
Rnor_5.01088,073,764 - 88,100,700 (-)NCBI
RGSC_v3.41089,307,938 - 89,335,254 (-)RGD
Celera1084,018,429 - 84,045,045 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247429   ⟹   XP_006247491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81085,800,812 - 85,827,853 (-)NCBI
mRatBN7.21085,300,438 - 85,327,378 (-)NCBI
Rnor_6.01088,280,517 - 88,307,428 (-)NCBI
Rnor_5.01088,073,764 - 88,100,700 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247430   ⟹   XP_006247492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81085,800,812 - 85,827,881 (-)NCBI
mRatBN7.21085,300,438 - 85,327,372 (-)NCBI
Rnor_6.01088,281,081 - 88,307,437 (-)NCBI
Rnor_5.01088,073,764 - 88,100,700 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063269944   ⟹   XP_063126014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81085,800,812 - 85,827,822 (-)NCBI
RefSeq Acc Id: XM_063269945   ⟹   XP_063126015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81085,800,812 - 85,824,339 (-)NCBI
RefSeq Acc Id: XM_063269946   ⟹   XP_063126016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81085,800,812 - 85,827,119 (-)NCBI
RefSeq Acc Id: NP_112309   ⟸   NM_031047
- UniProtKB: Q6P0K8 (UniProtKB/Swiss-Prot),   A6HJ29 (UniProtKB/TrEMBL),   P70565 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247491   ⟸   XM_006247429
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006247492   ⟸   XM_006247430
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000070840   ⟸   ENSRNOT00000089933
Ensembl Acc Id: ENSRNOP00000043950   ⟸   ENSRNOT00000040845
RefSeq Acc Id: XP_063126014   ⟸   XM_063269944
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063126016   ⟸   XM_063269946
- Peptide Label: isoform X1
- UniProtKB: Q6P0K8 (UniProtKB/Swiss-Prot),   A6HJ29 (UniProtKB/TrEMBL),   P70565 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126015   ⟸   XM_063269945
- Peptide Label: isoform X1
- UniProtKB: Q6P0K8 (UniProtKB/Swiss-Prot),   A6HJ29 (UniProtKB/TrEMBL),   P70565 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P0K8-F1-model_v2 AlphaFold Q6P0K8 1-745 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697719
Promoter ID:EPDNEW_R8241
Type:initiation region
Name:Jup_1
Description:junction plakoglobin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01088,307,439 - 88,307,499EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620412 AgrOrtholog
BioCyc Gene G2FUF-23240 BioCyc
Ensembl Genes ENSRNOG00000015380 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000040845 ENTREZGENE
  ENSRNOT00000040845.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599724 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  Armadillo UniProtKB/Swiss-Prot
  Beta-catenin UniProtKB/Swiss-Prot
KEGG Report rno:81679 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72417 IMAGE-MGC_LOAD
NCBI Gene 81679 ENTREZGENE
PANTHER PTHR45976 UniProtKB/Swiss-Prot
Pfam Arm UniProtKB/Swiss-Prot
PharmGKB JUP RGD
PhenoGen Jup PhenoGen
PRINTS BCATNINFAMLY UniProtKB/Swiss-Prot
PROSITE ARM_REPEAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015380 RatGTEx
SMART ARM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
UniProt A0A8L2R4T1_RAT UniProtKB/TrEMBL
  A6HJ28_RAT UniProtKB/TrEMBL
  A6HJ29 ENTREZGENE, UniProtKB/TrEMBL
  P70565 ENTREZGENE, UniProtKB/TrEMBL
  PLAK_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Jup  junction plakoglobin      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Jup  unction plakoglobin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin)(1 nM)when given to WB-F344 cells, localizes the protein in the cytoplasm and downregulates its activity 633036
gene_process mRNA involved in transcriptional downregulation or destabilization of proteins during tumorigenesis 633036