Cttn (cortactin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cttn (cortactin) Rattus norvegicus
Analyze
Symbol: Cttn
Name: cortactin
RGD ID: 619839
Description: Enables Arp2/3 complex binding activity and proline-rich region binding activity. Involved in several processes, including focal adhesion assembly; modification of postsynaptic actin cytoskeleton; and plasma membrane bounded cell projection organization. Located in cell junction and clathrin-coated pit. Part of voltage-gated potassium channel complex. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Colocalizes with actin filament; focal adhesion; and growth cone. Orthologous to human CTTN (cortactin); PARTICIPATES IN E-cadherin signaling pathway; fibroblast growth factor signaling pathway; N-cadherin signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cortactin isoform B; Cttnb; MGC93456; src substrate cortactin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,029,048 - 209,064,577 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1209,029,048 - 209,058,211 (-)EnsemblGRCr8
mRatBN7.21199,599,710 - 199,635,254 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,599,710 - 199,635,164 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1207,983,053 - 208,018,518 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,067,268 - 215,102,680 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,741,446 - 207,776,858 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,602,698 - 217,638,196 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01215,255,385 - 215,290,882 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,255,381 - 215,290,845 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1217,602,698 - 217,638,152 (-)Ensemblrn6Rnor6.0
Rnor_5.01224,459,485 - 224,494,974 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01222,159,088 - 222,194,579 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41204,865,768 - 204,901,221 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1197,159,379 - 197,194,704 (-)NCBICelera
RGSC_v3.11205,020,464 - 205,048,384 (-)NCBI
RH 3.4 Map11561.5RGD
Cytogenetic Map1q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dimethoxyphenol  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenpyroximate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hexadecanoic acid  (ISO)
ifosfamide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
metformin  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
methylparaben  (ISO)
microcystin-LR  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel subsulfide  (ISO)
ochratoxin A  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
potassium dichromate  (ISO)
probucol  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
Sunset Yellow FCF  (ISO)
tanespimycin  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. Cai L, etal., Cell. 2008 Sep 5;134(5):828-42. doi: 10.1016/j.cell.2008.06.054.
2. Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis. Cao H, etal., Mol Cell Biol 2003 Mar;23(6):2162-70.
3. SRC-mediated phosphorylation of dynamin and cortactin regulates the "constitutive" endocytosis of transferrin. Cao H, etal., Mol Cell Biol. 2010 Feb;30(3):781-92. doi: 10.1128/MCB.00330-09. Epub 2009 Dec 7.
4. N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells. Desmarais V, etal., Cell Motil Cytoskeleton. 2009 Jun;66(6):303-16. doi: 10.1002/cm.20361.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. A dynamin-3 spliced variant modulates the actin/cortactin-dependent morphogenesis of dendritic spines. Gray NW, etal., J Cell Sci. 2005 Mar 15;118(Pt 6):1279-90. Epub 2005 Mar 1.
8. Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin. Hattan D, etal., J Biol Chem. 2002 Oct 11;277(41):38596-606. Epub 2002 Jul 31.
9. Activity-dependent redistribution and essential role of cortactin in dendritic spine morphogenesis. Hering H and Sheng M, J Neurosci. 2003 Dec 17;23(37):11759-69.
10. Artificial dental pulp exposure injury up-regulates antigen-presenting cell-related molecules in rat central nervous system. Kaneko T, etal., J Endod. 2010 Mar;36(3):459-64.
11. Distinct phospho-forms of cortactin differentially regulate actin polymerization and focal adhesions. Kruchten AE, etal., Am J Physiol Cell Physiol. 2008 Nov;295(5):C1113-22. doi: 10.1152/ajpcell.00238.2008. Epub 2008 Sep 3.
12. Growth cone morphology and spreading are regulated by a dynamin-cortactin complex at point contacts in hippocampal neurons. Kurklinsky S, etal., J Neurochem. 2011 Apr;117(1):48-60. doi: 10.1111/j.1471-4159.2011.07169.x. Epub 2011 Feb 9.
13. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Dynamin2 GTPase and cortactin remodel actin filaments. Mooren OL, etal., J Biol Chem. 2009 Sep 4;284(36):23995-4005. doi: 10.1074/jbc.M109.024398. Epub 2009 Jul 15.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90. Ohoka Y and Takai Y, Genes Cells 1998 Sep;3(9):603-12.
18. Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. Ortiz DF, etal., J Biol Chem 2004 Jul 30;279(31):32761-70. Epub 2004 May 24.
19. Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. Oser M, etal., J Cell Biol. 2009 Aug 24;186(4):571-87. doi: 10.1083/jcb.200812176.
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. The subcellular organization of cortactin in hippocampus. Racz B and Weinberg RJ, J Neurosci. 2004 Nov 17;24(46):10310-7.
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10637315   PMID:10760273   PMID:11583995   PMID:12853475   PMID:12913069   PMID:14742709   PMID:15383621   PMID:15522889   PMID:15821732   PMID:16162656   PMID:16533564   PMID:17893324  
PMID:17959782   PMID:17959830   PMID:18353971   PMID:19414610   PMID:19540230   PMID:19684413   PMID:20457763   PMID:21423176   PMID:21725361   PMID:22282019   PMID:22660580   PMID:23038781  
PMID:23365224   PMID:23376485   PMID:23536706   PMID:24700464   PMID:25468996   PMID:26261183   PMID:28131823   PMID:28235806   PMID:29515177   PMID:32357304   PMID:32711564   PMID:33446758  
PMID:34426822   PMID:35352799  


Genomics

Comparative Map Data
Cttn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,029,048 - 209,064,577 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1209,029,048 - 209,058,211 (-)EnsemblGRCr8
mRatBN7.21199,599,710 - 199,635,254 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,599,710 - 199,635,164 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1207,983,053 - 208,018,518 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,067,268 - 215,102,680 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,741,446 - 207,776,858 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,602,698 - 217,638,196 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01215,255,385 - 215,290,882 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,255,381 - 215,290,845 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1217,602,698 - 217,638,152 (-)Ensemblrn6Rnor6.0
Rnor_5.01224,459,485 - 224,494,974 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01222,159,088 - 222,194,579 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41204,865,768 - 204,901,221 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1197,159,379 - 197,194,704 (-)NCBICelera
RGSC_v3.11205,020,464 - 205,048,384 (-)NCBI
RH 3.4 Map11561.5RGD
Cytogenetic Map1q42NCBI
CTTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381170,398,529 - 70,436,575 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1170,398,404 - 70,436,584 (+)Ensemblhg38GRCh38
GRCh371170,244,635 - 70,282,681 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,922,292 - 69,960,338 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341169,922,291 - 69,960,337NCBI
Celera1167,505,807 - 67,543,876 (+)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1166,505,811 - 66,543,873 (+)NCBIHuRef
CHM1_11170,128,086 - 70,166,161 (+)NCBICHM1_1
T2T-CHM13v2.01170,418,951 - 70,456,993 (+)NCBIT2T-CHM13v2.0
Cttn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397143,989,468 - 144,024,743 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7143,989,470 - 144,024,746 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387144,435,724 - 144,471,560 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7144,435,733 - 144,471,009 (-)Ensemblmm10GRCm38
MGSCv377151,621,629 - 151,656,646 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367144,245,114 - 144,280,131 (-)NCBIMGSCv36mm8
Celera7144,198,389 - 144,233,423 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.84NCBI
Cttn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542215,835,145 - 15,874,108 (-)Ensembl
ChiLan1.0NW_00495542215,838,036 - 15,874,067 (-)NCBIChiLan1.0ChiLan1.0
CTTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2971,369,726 - 71,408,804 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11172,413,941 - 72,453,030 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01165,500,074 - 65,539,158 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11168,792,135 - 68,823,859 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1168,794,162 - 68,823,857 (+)EnsemblpanPan2panpan1.1
CTTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11847,932,367 - 47,960,732 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1847,916,632 - 47,960,674 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1846,539,259 - 46,571,258 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01848,606,497 - 48,638,577 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1848,590,898 - 48,637,751 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11848,053,474 - 48,085,478 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01847,639,312 - 47,671,323 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01848,385,244 - 48,417,504 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cttn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,038,885 - 4,063,551 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936599481,243 - 501,743 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936599481,234 - 503,857 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl23,031,103 - 3,060,813 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.123,031,103 - 3,060,796 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.221,444,656 - 1,455,002 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114,139,045 - 4,176,962 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14,137,814 - 4,176,446 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038101,394,443 - 101,445,469 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cttn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476716,847,459 - 16,880,183 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476716,842,341 - 16,884,449 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cttn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v125,258,955 - 5,289,210 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cttn
282 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:903
Count of miRNA genes:210
Interacting mature miRNAs:244
Transcripts:ENSRNOT00000028283, ENSRNOT00000047669, ENSRNOT00000054859
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
6480773Gluco64Glucose level QTL 645.09blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811209116975Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
RH142385  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11561.5UniSTS
Cytogenetic Map1q41-q42UniSTS
RH126596  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21199,599,777 - 199,599,987 (+)MAPPERmRatBN7.2
Rnor_6.01215,255,453 - 215,255,662NCBIRnor6.0
Rnor_6.01217,602,766 - 217,602,975NCBIRnor6.0
Rnor_5.01222,159,156 - 222,159,365UniSTSRnor5.0
Rnor_5.01224,459,553 - 224,459,762UniSTSRnor5.0
RGSC_v3.41204,865,836 - 204,866,045UniSTSRGSC3.4
Celera1197,159,447 - 197,159,656UniSTS
Cytogenetic Map1q41-q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
19 1 62 175 98 92 66 79 66 12 340 175 11 150 80 102 26 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001398643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001398644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC125304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF054618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF054619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000028283   ⟹   ENSRNOP00000028283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1209,029,048 - 209,058,211 (-)Ensembl
mRatBN7.2 Ensembl1199,599,711 - 199,628,877 (-)Ensembl
Rnor_6.0 Ensembl1215,255,386 - 215,290,838 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000047669   ⟹   ENSRNOP00000050255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1209,029,048 - 209,058,211 (-)Ensembl
mRatBN7.2 Ensembl1199,599,712 - 199,628,877 (-)Ensembl
Rnor_6.0 Ensembl1215,255,381 - 215,290,845 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000054859   ⟹   ENSRNOP00000051742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1209,029,048 - 209,058,211 (-)Ensembl
mRatBN7.2 Ensembl1199,599,717 - 199,628,877 (-)Ensembl
Rnor_6.0 Ensembl1217,602,698 - 217,638,118 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078514   ⟹   ENSRNOP00000070873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1217,603,942 - 217,631,862 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079805   ⟹   ENSRNOP00000072540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1209,029,048 - 209,058,211 (-)Ensembl
mRatBN7.2 Ensembl1199,599,718 - 199,628,877 (-)Ensembl
Rnor_6.0 Ensembl1217,603,942 - 217,631,862 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090375   ⟹   ENSRNOP00000073253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1199,599,710 - 199,635,164 (-)Ensembl
Rnor_6.0 Ensembl1215,256,629 - 215,284,548 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092783   ⟹   ENSRNOP00000076003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1217,604,892 - 217,620,420 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092916   ⟹   ENSRNOP00000075952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1209,029,048 - 209,058,211 (-)Ensembl
mRatBN7.2 Ensembl1199,599,719 - 199,628,877 (-)Ensembl
Rnor_6.0 Ensembl1217,602,698 - 217,638,152 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1217,603,922 - 217,605,397 (-)Ensembl
RefSeq Acc Id: NM_001398643   ⟹   NP_001385572
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,029,048 - 209,064,516 (-)NCBI
mRatBN7.21199,599,710 - 199,635,183 (-)NCBI
RefSeq Acc Id: NM_001398644   ⟹   NP_001385573
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,029,048 - 209,064,516 (-)NCBI
mRatBN7.21199,599,710 - 199,635,183 (-)NCBI
RefSeq Acc Id: NM_021868   ⟹   NP_068640
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,029,048 - 209,064,516 (-)NCBI
mRatBN7.21199,599,710 - 199,635,183 (-)NCBI
Rnor_6.01217,602,698 - 217,638,152 (-)NCBI
Rnor_5.01224,459,485 - 224,494,974 (-)NCBI
RGSC_v3.41204,865,768 - 204,901,221 (-)RGD
Celera1197,159,379 - 197,194,704 (-)RGD
Sequence:
RefSeq Acc Id: XM_063272517   ⟹   XP_063128587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,029,048 - 209,064,514 (-)NCBI
RefSeq Acc Id: XM_063272519   ⟹   XP_063128589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,029,048 - 209,064,371 (-)NCBI
RefSeq Acc Id: XM_063272521   ⟹   XP_063128591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,029,048 - 209,064,533 (-)NCBI
RefSeq Acc Id: XM_063272523   ⟹   XP_063128593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,029,048 - 209,064,346 (-)NCBI
RefSeq Acc Id: XM_063272525   ⟹   XP_063128595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,029,048 - 209,064,514 (-)NCBI
RefSeq Acc Id: XM_063272527   ⟹   XP_063128597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,036,003 - 209,064,577 (-)NCBI
RefSeq Acc Id: XM_063272530   ⟹   XP_063128600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,036,003 - 209,064,577 (-)NCBI
RefSeq Acc Id: XM_063272532   ⟹   XP_063128602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81209,044,116 - 209,064,576 (-)NCBI
RefSeq Acc Id: NP_068640   ⟸   NM_021868
- Peptide Label: isoform 2
- UniProtKB: D3ZRB0 (UniProtKB/Swiss-Prot),   Q66HL2 (UniProtKB/Swiss-Prot),   A0A140TAH0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000076003   ⟸   ENSRNOT00000092783
Ensembl Acc Id: ENSRNOP00000028283   ⟸   ENSRNOT00000028283
Ensembl Acc Id: ENSRNOP00000072540   ⟸   ENSRNOT00000079805
Ensembl Acc Id: ENSRNOP00000050255   ⟸   ENSRNOT00000047669
Ensembl Acc Id: ENSRNOP00000075952   ⟸   ENSRNOT00000092916
Ensembl Acc Id: ENSRNOP00000073253   ⟸   ENSRNOT00000090375
Ensembl Acc Id: ENSRNOP00000070873   ⟸   ENSRNOT00000078514
Ensembl Acc Id: ENSRNOP00000051742   ⟸   ENSRNOT00000054859
RefSeq Acc Id: NP_001385573   ⟸   NM_001398644
- Peptide Label: isoform 3
- UniProtKB: O70419 (UniProtKB/TrEMBL),   A0A8L2URS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385572   ⟸   NM_001398643
- Peptide Label: isoform 1
- UniProtKB: D3ZGE6 (UniProtKB/TrEMBL),   A6HYF4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128591   ⟸   XM_063272521
- Peptide Label: isoform X2
- UniProtKB: Q66HL2 (UniProtKB/Swiss-Prot),   D3ZRB0 (UniProtKB/Swiss-Prot),   A0A140TAH0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128595   ⟸   XM_063272525
- Peptide Label: isoform X3
- UniProtKB: O70419 (UniProtKB/TrEMBL),   A0A8L2URS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128587   ⟸   XM_063272517
- Peptide Label: isoform X1
- UniProtKB: D3ZGE6 (UniProtKB/TrEMBL),   A6HYF4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128589   ⟸   XM_063272519
- Peptide Label: isoform X1
- UniProtKB: D3ZGE6 (UniProtKB/TrEMBL),   A6HYF4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128593   ⟸   XM_063272523
- Peptide Label: isoform X2
- UniProtKB: Q66HL2 (UniProtKB/Swiss-Prot),   D3ZRB0 (UniProtKB/Swiss-Prot),   A0A140TAH0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128600   ⟸   XM_063272530
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063128597   ⟸   XM_063272527
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063128602   ⟸   XM_063272532
- Peptide Label: isoform X6
Protein Domains
SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HL2-F1-model_v2 AlphaFold Q66HL2 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690558
Promoter ID:EPDNEW_R1081
Type:initiation region
Name:Cttn_2
Description:cortactin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1108  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01215,290,822 - 215,290,882EPDNEW
RGD ID:13690584
Promoter ID:EPDNEW_R1108
Type:multiple initiation site
Name:Cttn_1
Description:cortactin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1081  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01217,638,167 - 217,638,227EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619839 AgrOrtholog
BioCyc Gene G2FUF-56851 BioCyc
Ensembl Genes ENSRNOG00000047280 Ensembl
  ENSRNOG00000050994 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000047669 ENTREZGENE
  ENSRNOT00000054859 ENTREZGENE
  ENSRNOT00000092916 ENTREZGENE
Gene3D-CATH SH3 Domains UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107292 IMAGE-MGC_LOAD
InterPro Cortactin_SH3 UniProtKB/Swiss-Prot
  Hs1_Cortactin UniProtKB/Swiss-Prot
  SH3-like_dom UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:60465 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93456 IMAGE-MGC_LOAD
NCBI Gene 60465 ENTREZGENE
PANTHER CORTACTIN AND DREBRIN UniProtKB/Swiss-Prot
  PTHR10829:SF15 UniProtKB/Swiss-Prot
Pfam HS1_rep UniProtKB/Swiss-Prot
  SH3_9 UniProtKB/Swiss-Prot
PhenoGen Cttn PhenoGen
PRINTS P67PHOX UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE CORTACTIN UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047280 RatGTEx
  ENSRNOG00000050994 RatGTEx
SMART SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
UniProt A0A140TAH0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QFA3_RAT UniProtKB/TrEMBL
  A0A8L2R7C5_RAT UniProtKB/TrEMBL
  A0A8L2URS9 ENTREZGENE, UniProtKB/TrEMBL
  A6HYF4 ENTREZGENE, UniProtKB/TrEMBL
  A6HYF5_RAT UniProtKB/TrEMBL
  A6HYF6_RAT UniProtKB/TrEMBL
  A6HYF7_RAT UniProtKB/TrEMBL
  D3ZGE6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZRB0 ENTREZGENE
  O70419 ENTREZGENE, UniProtKB/TrEMBL
  Q66HL2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary D3ZRB0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Cttn  cortactin    cortactin isoform B  Name updated 1299863 APPROVED
2004-09-10 Cttn  cortactin isoform B  Cttnb    Symbol and Name updated 1299863 APPROVED
2002-08-07 Cttnb  cortactin isoform B      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to plasma membrane ruffles 727733
gene_physical_interaction binds to large GTPase dynamin 727733