S1pr1 (sphingosine-1-phosphate receptor 1) - Rat Genome Database

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Gene: S1pr1 (sphingosine-1-phosphate receptor 1) Rattus norvegicus
Analyze
Symbol: S1pr1
Name: sphingosine-1-phosphate receptor 1
RGD ID: 61958
Description: Enables G protein-coupled receptor activity and sphingolipid binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of stress fiber assembly; and positive regulation of smooth muscle cell proliferation. Predicted to be located in external side of plasma membrane. Predicted to be active in cytoplasm; plasma membrane; and presynapse. Used to study hypertension. Orthologous to human S1PR1 (sphingosine-1-phosphate receptor 1); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Edg1; EDG1 (Edg1); endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; S1P receptor 1; S1P receptor Edg-1; S1P1; sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor Edg-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc ; SHRSP.WKY-(D2Mit21-D2Rat157)/Gcrc
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82206,309,715 - 206,314,070 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2205,900,836 - 206,328,689 (-)EnsemblGRCr8
mRatBN7.22203,624,752 - 203,629,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2203,621,587 - 203,629,681 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2211,288,334 - 211,292,535 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02209,178,280 - 209,182,489 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02203,995,309 - 203,999,518 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02218,654,406 - 218,658,761 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2218,654,554 - 218,658,761 (-)Ensemblrn6Rnor6.0
Rnor_5.02236,742,193 - 236,746,400 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42211,851,304 - 211,855,511 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2196,132,649 - 196,136,856 (-)NCBICelera
RGSC_v3.12211,814,057 - 211,818,265 (-)NCBI
Cytogenetic Map2q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
7,8-dihydroxycoumarin  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
apigenin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP,ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP)
DDE  (ISO)
DDT  (EXP)
diallyl trisulfide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fentin chloride  (EXP)
fingolimod hydrochloride  (ISO)
flutamide  (EXP)
fonofos  (ISO)
furan  (EXP)
furosemide  (EXP)
gentamycin  (EXP)
glucose  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP)
isoprenaline  (ISO)
kaempferol  (ISO)
kainic acid  (ISO)
L-ethionine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naphthalenes  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentane-2,3-dione  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (ISO)
PhIP  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium cyanide  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
scopolamine  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sphingosine 1-phosphate  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
endosome  (IEA)
external side of plasma membrane  (IEA,ISO)
membrane  (IEA)
membrane raft  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)
presynapse  (IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. Awad AS, etal., Am J Physiol Renal Physiol. 2006 Jun;290(6):F1516-24. Epub 2006 Jan 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Candidate Genes That Determine Response to Salt in the Stroke-Prone Spontaneously Hypertensive Rat. Congenic Analysis. Graham D, etal., Hypertension. 2007 Oct 15;.
5. Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. Kluk MJ and Hla T, Circ Res. 2001 Sep 14;89(6):496-502.
6. Cloning of the rat edg-1 immediate-early gene: expression pattern suggests diverse functions. Lado DC, etal., Gene 1994 Nov 18;149(2):331-6.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. Okamoto H, etal., J Biol Chem. 1998 Oct 16;273(42):27104-10.
10. Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Okamoto H, etal., Mol Cell Biol. 2000 Dec;20(24):9247-61.
11. Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate. Parrill AL, etal., J Biol Chem 2000 Dec 15;275(50):39379-84.
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. Robert P, etal., J Mol Cell Cardiol 2001 Sep;33(9):1589-606.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. Usui S, etal., J Biol Chem 2004 Mar 26;279(13):12300-11. Epub 2004 Jan 07.
Additional References at PubMed
PMID:11032855   PMID:11214319   PMID:11443127   PMID:11726541   PMID:12477932   PMID:14732704   PMID:15371328   PMID:16314531   PMID:16990586   PMID:18535287   PMID:18836449   PMID:19204730  
PMID:19493165   PMID:20032465   PMID:20729401   PMID:20844107   PMID:21289599   PMID:21605625   PMID:21613209   PMID:21668976   PMID:21719706   PMID:22104144   PMID:22344443   PMID:22445889  
PMID:22805346   PMID:22828274   PMID:23969695   PMID:24851274   PMID:24876379   PMID:25255053   PMID:25348153   PMID:26543024   PMID:27697711   PMID:27881715   PMID:28018679   PMID:28104351  
PMID:28493876   PMID:29266713   PMID:31276786   PMID:31476348   PMID:31802363   PMID:32487716   PMID:32924718   PMID:34296288   PMID:34310896   PMID:34347342   PMID:34516079   PMID:34773542  
PMID:37083109   PMID:37851113   PMID:37880240  


Genomics

Comparative Map Data
S1pr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82206,309,715 - 206,314,070 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2205,900,836 - 206,328,689 (-)EnsemblGRCr8
mRatBN7.22203,624,752 - 203,629,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2203,621,587 - 203,629,681 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2211,288,334 - 211,292,535 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02209,178,280 - 209,182,489 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02203,995,309 - 203,999,518 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02218,654,406 - 218,658,761 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2218,654,554 - 218,658,761 (-)Ensemblrn6Rnor6.0
Rnor_5.02236,742,193 - 236,746,400 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42211,851,304 - 211,855,511 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2196,132,649 - 196,136,856 (-)NCBICelera
RGSC_v3.12211,814,057 - 211,818,265 (-)NCBI
Cytogenetic Map2q42NCBI
S1PR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381101,236,899 - 101,242,313 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1101,235,366 - 101,243,713 (+)Ensemblhg38GRCh38
GRCh371101,702,455 - 101,707,869 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361101,475,043 - 101,479,662 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341101,414,596 - 101,419,094NCBI
Celera199,964,008 - 99,968,779 (+)NCBICelera
Cytogenetic Map1p21.2NCBI
HuRef199,828,430 - 99,833,201 (+)NCBIHuRef
CHM1_11101,818,158 - 101,822,929 (+)NCBICHM1_1
T2T-CHM13v2.01101,085,760 - 101,091,176 (+)NCBIT2T-CHM13v2.0
S1pr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393115,504,082 - 115,508,704 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3115,504,082 - 115,508,721 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383115,710,433 - 115,715,055 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3115,710,433 - 115,715,072 (-)Ensemblmm10GRCm38
MGSCv373115,413,351 - 115,417,973 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363115,702,443 - 115,707,051 (-)NCBIMGSCv36mm8
Celera3122,144,261 - 122,148,908 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map350.0NCBI
S1pr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554355,880,288 - 5,881,436 (+)Ensembl
ChiLan1.0NW_0049554355,880,266 - 5,882,823 (+)NCBIChiLan1.0ChiLan1.0
S1PR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21125,787,394 - 125,793,033 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11124,945,604 - 124,950,317 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01103,893,199 - 103,898,381 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11102,606,608 - 102,611,373 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1102,608,839 - 102,609,987 (+)EnsemblpanPan2panpan1.1
S1PR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1648,897,320 - 48,902,206 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl648,897,449 - 48,900,037 (-)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0649,235,333 - 49,239,909 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1648,928,661 - 48,930,939 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0648,908,285 - 48,910,563 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0649,337,617 - 49,339,895 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
S1pr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058111,439,836 - 111,445,001 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367481,245,538 - 1,250,093 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367481,244,962 - 1,250,093 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
S1PR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4117,064,755 - 117,069,650 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14117,064,632 - 117,069,724 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
S1PR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12032,109,436 - 32,117,015 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2032,110,819 - 32,111,967 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603825,954,820 - 25,959,741 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
S1pr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248574,143,270 - 4,147,877 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248574,143,269 - 4,147,877 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
S1pr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1343,899,228 - 43,903,851 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in S1pr1
34 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:574
Count of miRNA genes:276
Interacting mature miRNAs:340
Transcripts:ENSRNOT00000018318
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2205135267225627153Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
RH129877  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22203,624,810 - 203,624,994 (+)MAPPERmRatBN7.2
Rnor_6.02218,654,464 - 218,654,647NCBIRnor6.0
Rnor_5.02236,742,103 - 236,742,286UniSTSRnor5.0
RGSC_v3.42211,851,214 - 211,851,397UniSTSRGSC3.4
Celera2196,132,559 - 196,132,742UniSTS
RH 3.4 Map21451.6UniSTS
Cytogenetic Map2q41UniSTS
EDG1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22203,626,108 - 203,627,168 (+)MAPPERmRatBN7.2
Rnor_6.02218,655,762 - 218,656,821NCBIRnor6.0
Rnor_5.02236,743,401 - 236,744,460UniSTSRnor5.0
RGSC_v3.42211,852,512 - 211,853,571UniSTSRGSC3.4
Celera2196,133,857 - 196,134,916UniSTS
Cytogenetic Map2q41UniSTS


Related Rat Strains
The following Strains have been annotated to S1pr1
SHRSP.WKY-(D2Mit21-D2Rat157)/Gcrc     SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018318   ⟹   ENSRNOP00000052627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2205,900,836 - 206,315,237 (-)Ensembl
mRatBN7.2 Ensembl2203,621,587 - 203,629,681 (-)Ensembl
Rnor_6.0 Ensembl2218,654,554 - 218,658,761 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125679   ⟹   ENSRNOP00000101281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2206,309,674 - 206,328,689 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140136   ⟹   ENSRNOP00000107206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2206,309,944 - 206,328,689 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142036   ⟹   ENSRNOP00000098635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2206,309,639 - 206,315,218 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144764   ⟹   ENSRNOP00000100933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2206,150,312 - 206,315,237 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000172725   ⟹   ENSRNOP00000108446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2206,309,751 - 206,328,689 (-)Ensembl
RefSeq Acc Id: NM_017301   ⟹   NP_058997
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82206,309,863 - 206,314,070 (-)NCBI
mRatBN7.22203,624,901 - 203,629,110 (-)NCBI
Rnor_6.02218,654,554 - 218,658,761 (-)NCBI
Rnor_5.02236,742,193 - 236,746,400 (-)NCBI
RGSC_v3.42211,851,304 - 211,855,511 (-)RGD
Celera2196,132,649 - 196,136,856 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761459   ⟹   XP_008759681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82206,309,715 - 206,313,936 (-)NCBI
mRatBN7.22203,624,752 - 203,628,956 (-)NCBI
Rnor_6.02218,654,406 - 218,658,694 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_058997 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759681 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA83418 (Get FASTA)   NCBI Sequence Viewer  
  AAH97938 (Get FASTA)   NCBI Sequence Viewer  
  EDL82014 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052627
  ENSRNOP00000052627.1
  ENSRNOP00000098635
GenBank Protein P48303 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058997   ⟸   NM_017301
- UniProtKB: Q4V7F6 (UniProtKB/Swiss-Prot),   P48303 (UniProtKB/Swiss-Prot),   A6HV78 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759681   ⟸   XM_008761459
- Peptide Label: isoform X1
- UniProtKB: Q4V7F6 (UniProtKB/Swiss-Prot),   P48303 (UniProtKB/Swiss-Prot),   A6HV78 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052627   ⟸   ENSRNOT00000018318
Ensembl Acc Id: ENSRNOP00000098635   ⟸   ENSRNOT00000142036
Ensembl Acc Id: ENSRNOP00000107206   ⟸   ENSRNOT00000140136
Ensembl Acc Id: ENSRNOP00000108446   ⟸   ENSRNOT00000172725
Ensembl Acc Id: ENSRNOP00000100933   ⟸   ENSRNOT00000144764
Ensembl Acc Id: ENSRNOP00000101281   ⟸   ENSRNOT00000125679
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48303-F1-model_v2 AlphaFold P48303 1-383 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691699
Promoter ID:EPDNEW_R2223
Type:single initiation site
Name:S1pr1_1
Description:sphingosine-1-phosphate receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02218,658,781 - 218,658,841EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61958 AgrOrtholog
BioCyc Gene G2FUF-51520 BioCyc
Ensembl Genes ENSRNOG00000013683 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018318 ENTREZGENE
  ENSRNOT00000018318.4 UniProtKB/Swiss-Prot
  ENSRNOT00000142036 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7460011 IMAGE-MGC_LOAD
InterPro EDG1_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  S1P_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:29733 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116057 IMAGE-MGC_LOAD
NCBI Gene 29733 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen S1pr1 PhenoGen
PRINTS EDG1RECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
  S1PRECEPTOR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013683 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC210588
UniProt A6HV78 ENTREZGENE, UniProtKB/TrEMBL
  P48303 ENTREZGENE
  Q4V7F6 ENTREZGENE
  S1PR1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q4V7F6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-20 S1pr1  sphingosine-1-phosphate receptor 1  Edg1  endothelial differentiation sphingolipid G-protein-coupled receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Edg1  endothelial differentiation sphingolipid G-protein-coupled receptor 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression widely expressed 61573