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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61958
Species: Rattus norvegicus
RGD Object: Gene
Symbol: S1pr1
Name: sphingosine-1-phosphate receptor 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
S1pr1decreases expressionISOS1PR1 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of S1PR1 mRNAPMID:22714537 PMID:29301061
S1pr1increases expressionISOS1pr1 (Mus musculus)6480464CTDsodium arsenite results in increased expression of S1PR1 mRNAPMID:36209798
S1pr1multiple interactionsISOS1PR1 (Homo sapiens)6480464CTDS1PR1 protein affects the reaction [sodium arsenite results in increased activity of RAC1 protein]; S1PR1 protein affects the reaction [sodium arsenite results in increased expression of HGF mRNA]; S1PR1 protein affects the reaction [sodium arsenite results in increased expression of IGF1 mRNA]PMID:19349368
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