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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61958
Species: Rattus norvegicus
RGD Object: Gene
Symbol: S1pr1
Name: sphingosine-1-phosphate receptor 1
Acc ID: CHEBI:50845
Term: doxycycline
Definition: Tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis.
Chemical ID: MESH:D004318
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
S1pr1multiple interactionsISOS1pr1 (Mus musculus)6480464CTDDoxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 mRNA]; Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 protein]PMID:18089841
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