Prlr (prolactin receptor) - Rat Genome Database

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Gene: Prlr (prolactin receptor) Rattus norvegicus
Analyze
Symbol: Prlr
Name: prolactin receptor
RGD ID: 3407
Description: Enables prolactin receptor activity and protein kinase binding activity. Involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus and positive regulation of B cell proliferation. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lactogen receptor; MGC105486; PRL-R; RATPRLR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD ; SS.LEW-(Prlr-D2Rat143)/Ayd
QTLs:   Bp99   Smcn1   Bp270  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8260,861,391 - 61,051,883 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl260,861,658 - 61,051,882 (+)EnsemblGRCr8
mRatBN7.2259,134,147 - 59,324,719 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl259,134,588 - 59,324,718 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx266,245,300 - 66,425,431 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0264,366,825 - 64,546,955 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0259,368,154 - 59,548,295 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0260,131,410 - 60,325,686 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl260,131,776 - 60,325,692 (+)Ensemblrn6Rnor6.0
Rnor_5.0284,360,850 - 84,554,681 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4259,507,966 - 59,701,221 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera259,347,111 - 59,534,658 (-)NCBICelera
RGSC_v3.1259,485,049 - 59,629,454 (+)NCBI
Cytogenetic Map2q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azaspiracid  (ISO)
Azoxymethane  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroquine  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (EXP,ISO)
clofibric acid  (EXP)
clothianidin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corn oil  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
cyproterone acetate  (EXP)
D-glucose  (ISO)
DDT  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
ethylenediaminetetraacetic acid  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
herbicide  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
irinotecan  (EXP)
latrunculin A  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP)
magnesium atom  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mercaptopurine  (EXP)
metacetamol  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
methylphenidate  (ISO)
metoclopramide  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
naproxen  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
olanzapine  (EXP)
orphenadrine  (EXP)
oxycodone  (EXP)
paracetamol  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
prednisolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
propiconazole  (EXP,ISO)
prostaglandin F2alpha  (EXP)
purine-6-thiol  (EXP)
senecionine  (ISO)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulpiride  (EXP)
sumatriptan  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A prolactin-dependent immune cell line (Nb2) expresses a mutant form of prolactin receptor. Ali S, etal., J Biol Chem 1991 Oct 25;266(30):20110-7.
2. Modulation of growth factor receptor function by isoform heterodimerization. Chang WP and Clevenger CV, Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5947-52. doi: 10.1073/pnas.93.12.5947.
3. Stoichiometric structure-function analysis of the prolactin receptor signaling domain by receptor chimeras. Chang WP, etal., Mol Cell Biol. 1998 Feb;18(2):896-905. doi: 10.1128/MCB.18.2.896.
4. The protein tyrosine kinase P59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes. Clevenger CV and Medaglia MV, Mol Endocrinol. 1994 Jun;8(6):674-81.
5. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
6. Mapping of rat chromosome 2 markers generated from chromosome-sorted DNA. Deng AY, etal., Mamm Genome 1997 Oct;8(10):731-5.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Sex difference and estrous cycle: expression of prolactin receptor mRNA in rat brain. Pi X and Voogt JL, Brain Res Mol Brain Res 2002 Jun 30;103(1-2):130-9.
13. Detection of prolactin receptor mRNA in the corpus striatum and substantia nigra of the rat. Pi X, etal., J Neurosci Res 2002 Feb 15;67(4):551-8.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Characterization of a rat uterine cell line, U(III) cells: prolactin (PRL) expression and endogenous regulation of PRL-dependent genes; estrogen receptor beta, alpha(2)-macroglobulin, and decidual PRL involving the Jak2 and Stat5 pathway. Prigent-Tessier A, etal., Endocrinology 2001 Mar;142(3):1242-50.
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. Shan L, etal., Toxicol Pathol. 2005;33(7):768-75.
19. Identification of a novel first exon of prolactin receptor gene expressed in the rat brain. Tanaka M, etal., Endocrinology 2002 Jun;143(6):2080-4.
20. Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2. Viengchareun S, etal., PLoS One. 2008 Feb 6;3(2):e1535. doi: 10.1371/journal.pone.0001535.
Additional References at PubMed
PMID:2159291   PMID:2293022   PMID:2832068   PMID:6303755   PMID:7929319   PMID:7984244   PMID:9632658   PMID:10585417   PMID:11445538   PMID:11706048   PMID:11735251   PMID:11862718  
PMID:12040017   PMID:12477932   PMID:12673052   PMID:12782310   PMID:12810576   PMID:12865306   PMID:12914538   PMID:15845620   PMID:16107292   PMID:16280030   PMID:16469767   PMID:16489923  
PMID:17317019   PMID:17322574   PMID:17433256   PMID:17620100   PMID:17785459   PMID:18092198   PMID:18313837   PMID:18372733   PMID:18665386   PMID:18679052   PMID:18765257   PMID:19103603  
PMID:20462969   PMID:21177834   PMID:21508351   PMID:22977841   PMID:23012479   PMID:24114406   PMID:25446202   PMID:26874070   PMID:30500398  


Genomics

Comparative Map Data
Prlr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8260,861,391 - 61,051,883 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl260,861,658 - 61,051,882 (+)EnsemblGRCr8
mRatBN7.2259,134,147 - 59,324,719 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl259,134,588 - 59,324,718 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx266,245,300 - 66,425,431 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0264,366,825 - 64,546,955 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0259,368,154 - 59,548,295 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0260,131,410 - 60,325,686 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl260,131,776 - 60,325,692 (+)Ensemblrn6Rnor6.0
Rnor_5.0284,360,850 - 84,554,681 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4259,507,966 - 59,701,221 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera259,347,111 - 59,534,658 (-)NCBICelera
RGSC_v3.1259,485,049 - 59,629,454 (+)NCBI
Cytogenetic Map2q16NCBI
PRLR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38535,048,756 - 35,230,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl535,048,756 - 35,230,533 (-)Ensemblhg38GRCh38
GRCh37535,048,861 - 35,230,589 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36535,099,985 - 35,266,334 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34535,099,984 - 35,266,334NCBI
Celera534,937,982 - 35,112,885 (-)NCBICelera
Cytogenetic Map5p13.2NCBI
HuRef534,997,595 - 35,179,481 (-)NCBIHuRef
CHM1_1535,051,181 - 35,233,094 (-)NCBICHM1_1
T2T-CHM13v2.0535,295,805 - 35,484,954 (-)NCBIT2T-CHM13v2.0
Prlr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391510,177,324 - 10,349,276 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1510,177,324 - 10,349,266 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381510,177,238 - 10,349,190 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1510,177,238 - 10,349,180 (+)Ensemblmm10GRCm38
MGSCv371510,106,993 - 10,266,775 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361510,122,380 - 10,274,111 (+)NCBIMGSCv36mm8
Celera159,973,912 - 10,134,326 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map155.23NCBI
Prlr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542620,168,830 - 20,326,840 (-)Ensembl
ChiLan1.0NW_00495542620,161,406 - 20,326,688 (-)NCBIChiLan1.0ChiLan1.0
PRLR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2475,107,057 - 75,287,507 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1573,260,795 - 73,441,139 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0575,139,852 - 75,321,695 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1580,420,061 - 80,585,559 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl580,532,058 - 80,600,403 (+)EnsemblpanPan2panpan1.1
PRLR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1473,147,919 - 73,280,970 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl473,110,858 - 73,273,916 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha472,720,596 - 72,897,403 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0473,614,203 - 73,786,894 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl473,614,226 - 73,779,840 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1473,362,835 - 73,534,628 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0473,486,988 - 73,657,508 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0474,020,052 - 74,186,420 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prlr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213224,874,923 - 225,019,820 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365186,473,536 - 6,487,757 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365186,352,133 - 6,495,242 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRLR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1620,618,875 - 20,810,140 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11620,637,568 - 20,655,881 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21621,520,678 - 21,569,349 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRLR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1433,933,601 - 34,108,653 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl433,949,935 - 34,108,619 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607124,243,842 - 24,414,480 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prlr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475919,653,600 - 19,833,848 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475919,653,626 - 19,836,877 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Prlr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13170,375,333 - 170,544,420 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prlr
976 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:350
Count of miRNA genes:208
Interacting mature miRNAs:252
Transcripts:ENSRNOT00000023941, ENSRNOT00000023960, ENSRNOT00000059970, ENSRNOT00000059973
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25838820177302351Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
D2Wox14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2259,324,454 - 59,324,636 (+)MAPPERmRatBN7.2
Rnor_6.0260,325,429 - 60,325,610NCBIRnor6.0
Rnor_5.0284,360,926 - 84,361,107UniSTSRnor5.0
RGSC_v3.4259,700,964 - 59,701,145UniSTSRGSC3.4
RGSC_v3.4259,700,963 - 59,701,145RGDRGSC3.4
Celera259,347,187 - 59,347,368UniSTS
Cytogenetic Map2q16UniSTS
D2Mit24  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8261,051,541 - 61,051,855 (+)Marker Load Pipeline
mRatBN7.2259,324,377 - 59,324,691 (+)MAPPERmRatBN7.2
Rnor_6.0260,325,352 - 60,325,665NCBIRnor6.0
Rnor_5.0284,360,871 - 84,361,184UniSTSRnor5.0
RGSC_v3.4259,700,887 - 59,701,200UniSTSRGSC3.4
RGSC_v3.4259,700,886 - 59,701,200RGDRGSC3.4
Celera259,347,132 - 59,347,445UniSTS
RGSC_v3.1259,629,119 - 59,629,433RGD
RH 3.4 Map2408.7UniSTS
RH 3.4 Map2408.7RGD
Cytogenetic Map2q16UniSTS
D2Arb6  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8261,051,471 - 61,051,826 (+)Marker Load Pipeline
mRatBN7.2259,324,307 - 59,324,662 (+)MAPPERmRatBN7.2
Rnor_6.0260,325,282 - 60,325,636NCBIRnor6.0
Rnor_5.0284,360,900 - 84,361,254UniSTSRnor5.0
RGSC_v3.4259,700,817 - 59,701,171UniSTSRGSC3.4
RGSC_v3.4259,700,816 - 59,701,171RGDRGSC3.4
Celera259,347,161 - 59,347,515UniSTS
RGSC_v3.1259,629,049 - 59,629,404RGD
SHRSP x BN Map227.5198UniSTS
SHRSP x BN Map227.5198RGD
Cytogenetic Map2q16UniSTS
D12Uia2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2259,172,704 - 59,172,974 (+)MAPPERmRatBN7.2
Rnor_6.0260,170,165 - 60,170,434NCBIRnor6.0
Rnor_5.0284,516,208 - 84,516,477UniSTSRnor5.0
RGSC_v3.4259,547,038 - 59,547,307UniSTSRGSC3.4
RGSC_v3.4259,547,040 - 59,547,307RGDRGSC3.4
Celera259,496,188 - 59,496,561UniSTS
RGSC_v3.1259,475,273 - 59,475,540RGD
Cytogenetic Map2q16UniSTS
D2Chm280  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2259,179,853 - 59,180,074 (+)MAPPERmRatBN7.2
Rnor_6.0260,177,314 - 60,177,534NCBIRnor6.0
Rnor_5.0284,509,108 - 84,509,328UniSTSRnor5.0
RGSC_v3.4259,554,187 - 59,554,407UniSTSRGSC3.4
Celera259,489,085 - 59,489,305UniSTS
Cytogenetic Map2q16UniSTS
Prlr  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2259,290,897 - 59,291,032 (+)MAPPERmRatBN7.2
Rnor_6.0260,285,969 - 60,286,103NCBIRnor6.0
Rnor_5.0284,400,544 - 84,400,678UniSTSRnor5.0
RGSC_v3.4259,666,361 - 59,666,495UniSTSRGSC3.4
Celera259,378,767 - 59,378,901UniSTS
Cytogenetic Map2q16UniSTS
Prlr  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2259,306,261 - 59,306,381 (+)MAPPERmRatBN7.2
Rnor_6.0260,307,857 - 60,307,976NCBIRnor6.0
Rnor_6.0260,298,031 - 60,298,150NCBIRnor6.0
Rnor_5.0284,378,241 - 84,378,360UniSTSRnor5.0
Rnor_5.0284,388,496 - 84,388,615UniSTSRnor5.0
RGSC_v3.4259,681,382 - 59,681,501UniSTSRGSC3.4
Celera259,365,410 - 59,365,529UniSTS
Cytogenetic Map2q16UniSTS


Related Rat Strains
The following Strains have been annotated to Prlr
SD     SS.LEW-(Prlr-D2Rat143)/Ayd    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 10 32 146 83 82 51 65 51 6 276 124 7 124 81 90 31 9 9

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001034111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB071022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L48060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M57668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U07567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U34730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z83758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000080786   ⟹   ENSRNOP00000072948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl260,861,658 - 61,033,727 (+)Ensembl
mRatBN7.2 Ensembl259,134,588 - 59,306,557 (+)Ensembl
Rnor_6.0 Ensembl260,131,776 - 60,308,152 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080974   ⟹   ENSRNOP00000074428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl260,861,756 - 61,051,882 (+)Ensembl
mRatBN7.2 Ensembl259,172,057 - 59,324,718 (+)Ensembl
Rnor_6.0 Ensembl260,169,517 - 60,325,692 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084624   ⟹   ENSRNOP00000073622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl259,182,484 - 59,319,599 (+)Ensembl
Rnor_6.0 Ensembl260,180,215 - 60,325,671 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099452   ⟹   ENSRNOP00000081286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl260,861,658 - 61,050,606 (+)Ensembl
mRatBN7.2 Ensembl259,182,484 - 59,323,442 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110246   ⟹   ENSRNOP00000081145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl259,182,484 - 59,324,218 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116300   ⟹   ENSRNOP00000082145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl261,016,004 - 61,033,727 (+)Ensembl
mRatBN7.2 Ensembl259,288,838 - 59,306,559 (+)Ensembl
RefSeq Acc Id: NM_001034111   ⟹   NP_001029283
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,861,765 - 61,033,723 (+)NCBI
mRatBN7.2259,134,588 - 59,306,557 (+)NCBI
Rnor_6.0260,131,776 - 60,308,152 (+)NCBI
Rnor_5.0284,360,850 - 84,554,681 (-)NCBI
RGSC_v3.4259,507,966 - 59,701,221 (+)RGD
Celera259,365,234 - 59,534,658 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012630   ⟹   NP_036762
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,909,659 - 61,051,876 (+)NCBI
mRatBN7.2259,182,484 - 59,324,712 (+)NCBI
Rnor_6.0260,180,215 - 60,325,686 (+)NCBI
Rnor_5.0284,360,850 - 84,554,681 (-)NCBI
RGSC_v3.4259,507,966 - 59,701,221 (+)RGD
Celera259,347,111 - 59,486,679 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101746   ⟹   XP_038957674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,861,391 - 61,051,883 (+)NCBI
mRatBN7.2259,134,147 - 59,316,685 (+)NCBI
RefSeq Acc Id: XM_039101749   ⟹   XP_038957677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,898,820 - 61,051,883 (+)NCBI
mRatBN7.2259,166,190 - 59,316,685 (+)NCBI
RefSeq Acc Id: XM_039101752   ⟹   XP_038957680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,898,845 - 61,051,883 (+)NCBI
mRatBN7.2259,168,868 - 59,324,719 (+)NCBI
RefSeq Acc Id: XM_039101753   ⟹   XP_038957681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,861,512 - 61,051,883 (+)NCBI
mRatBN7.2259,134,150 - 59,324,367 (+)NCBI
RefSeq Acc Id: XM_063281309   ⟹   XP_063137379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,898,821 - 61,051,883 (+)NCBI
RefSeq Acc Id: XM_063281310   ⟹   XP_063137380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,861,467 - 61,051,883 (+)NCBI
RefSeq Acc Id: XM_063281311   ⟹   XP_063137381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,861,467 - 61,051,883 (+)NCBI
RefSeq Acc Id: XM_063281313   ⟹   XP_063137383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,997,943 - 61,051,883 (+)NCBI
RefSeq Acc Id: XM_063281314   ⟹   XP_063137384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,861,391 - 61,051,883 (+)NCBI
RefSeq Acc Id: XM_063281315   ⟹   XP_063137385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,898,845 - 61,051,883 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001029283 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424775 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424777 (Get FASTA)   NCBI Sequence Viewer  
  NP_036762 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957674 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957677 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957680 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957681 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137379 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137380 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137381 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137383 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137384 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137385 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41937 (Get FASTA)   NCBI Sequence Viewer  
  AAA41938 (Get FASTA)   NCBI Sequence Viewer  
  AAA41946 (Get FASTA)   NCBI Sequence Viewer  
  AAA61784 (Get FASTA)   NCBI Sequence Viewer  
  AAA79273 (Get FASTA)   NCBI Sequence Viewer  
  AAA79274 (Get FASTA)   NCBI Sequence Viewer  
  AAA92053 (Get FASTA)   NCBI Sequence Viewer  
  AAH92133 (Get FASTA)   NCBI Sequence Viewer  
  CAB06043 (Get FASTA)   NCBI Sequence Viewer  
  EDL82998 (Get FASTA)   NCBI Sequence Viewer  
  EDL82999 (Get FASTA)   NCBI Sequence Viewer  
  EDL83000 (Get FASTA)   NCBI Sequence Viewer  
  EDL83001 (Get FASTA)   NCBI Sequence Viewer  
  EDL83002 (Get FASTA)   NCBI Sequence Viewer  
  EDL83003 (Get FASTA)   NCBI Sequence Viewer  
  EDL83004 (Get FASTA)   NCBI Sequence Viewer  
  EDL83005 (Get FASTA)   NCBI Sequence Viewer  
  EDL83006 (Get FASTA)   NCBI Sequence Viewer  
  EDL83007 (Get FASTA)   NCBI Sequence Viewer  
  EDL83008 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072948
  ENSRNOP00000072948.2
  ENSRNOP00000074428
  ENSRNOP00000074428.2
  ENSRNOP00000081286
GenBank Protein P05710 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036762   ⟸   NM_012630
- Peptide Label: isoform b precursor
- UniProtKB: Q58DZ7 (UniProtKB/TrEMBL),   A0A0G2K813 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029283   ⟸   NM_001034111
- Peptide Label: isoform a precursor
- UniProtKB: Q64274 (UniProtKB/Swiss-Prot),   Q63723 (UniProtKB/Swiss-Prot),   Q63451 (UniProtKB/Swiss-Prot),   Q62832 (UniProtKB/Swiss-Prot),   P05710 (UniProtKB/Swiss-Prot),   Q63479 (UniProtKB/Swiss-Prot),   A0A0G2K488 (UniProtKB/TrEMBL),   A6KJU2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072948   ⟸   ENSRNOT00000080786
Ensembl Acc Id: ENSRNOP00000073622   ⟸   ENSRNOT00000084624
Ensembl Acc Id: ENSRNOP00000074428   ⟸   ENSRNOT00000080974
RefSeq Acc Id: XP_038957674   ⟸   XM_039101746
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K488 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957681   ⟸   XM_039101753
- Peptide Label: isoform X2
- UniProtKB: Q58DZ7 (UniProtKB/TrEMBL),   A0A0G2K813 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957677   ⟸   XM_039101749
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K488 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957680   ⟸   XM_039101752
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000081145   ⟸   ENSRNOT00000110246
Ensembl Acc Id: ENSRNOP00000081286   ⟸   ENSRNOT00000099452
Ensembl Acc Id: ENSRNOP00000082145   ⟸   ENSRNOT00000116300
RefSeq Acc Id: XP_063137384   ⟸   XM_063281314
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K813 (UniProtKB/TrEMBL),   Q58DZ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137380   ⟸   XM_063281310
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K488 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137381   ⟸   XM_063281311
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K488 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137379   ⟸   XM_063281309
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K488 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137385   ⟸   XM_063281315
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K813 (UniProtKB/TrEMBL),   Q58DZ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137383   ⟸   XM_063281313
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K488 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III   Growth hormone/erythropoietin receptor ligand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05710-F1-model_v2 AlphaFold P05710 1-610 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691181
Promoter ID:EPDNEW_R1706
Type:initiation region
Name:Prlr_1
Description:prolactin receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0260,180,256 - 60,180,316EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3407 AgrOrtholog
BioCyc Gene G2FUF-54086 BioCyc
Ensembl Genes ENSRNOG00000057557 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000080786 ENTREZGENE
  ENSRNOT00000080786.2 UniProtKB/Swiss-Prot
  ENSRNOT00000080974 ENTREZGENE
  ENSRNOT00000080974.2 UniProtKB/Swiss-Prot
  ENSRNOT00000099452 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7310645 IMAGE-MGC_LOAD
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Growth/epo_recpt_lig-bind UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Long_hematopoietin_rcpt_CS UniProtKB/Swiss-Prot
  Type-I_Cytokine_Rcpt UniProtKB/Swiss-Prot
KEGG Report rno:24684 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105486 IMAGE-MGC_LOAD
NCBI Gene 24684 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot
  PTHR23036:SF86 UniProtKB/Swiss-Prot
Pfam EpoR_lig-bind UniProtKB/Swiss-Prot
  fn3 UniProtKB/Swiss-Prot
PhenoGen Prlr PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot
  HEMATOPO_REC_L_F1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000057557 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot
UniProt A0A0G2K488 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K813 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZSH8_RAT UniProtKB/TrEMBL
  A0A8I5ZWH3_RAT UniProtKB/TrEMBL
  A6KJU2 ENTREZGENE, UniProtKB/TrEMBL
  A6KJU7_RAT UniProtKB/TrEMBL
  P05710 ENTREZGENE, UniProtKB/Swiss-Prot
  Q58DZ7 ENTREZGENE, UniProtKB/TrEMBL
  Q62832 ENTREZGENE
  Q63451 ENTREZGENE
  Q63479 ENTREZGENE
  Q63723 ENTREZGENE
  Q64274 ENTREZGENE
  Q7M037_RAT UniProtKB/TrEMBL
UniProt Secondary Q62832 UniProtKB/Swiss-Prot
  Q63451 UniProtKB/Swiss-Prot
  Q63479 UniProtKB/Swiss-Prot
  Q63723 UniProtKB/Swiss-Prot
  Q64274 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Prlr  prolactin receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression levels increased during pregnancy and lactating periods 625741
gene_expression expressed in the brain, liver and mammary gland 625741
gene_expression expressed in the uterine stromal cell line (UIII) 625741
gene_product member of type-1 cytokine receptor superfamily 625741
gene_regulation expression in brain is controlled by the promoter for the E1(4) first exon 625741
gene_regulation expression changed during estrous cycle; may be regulated by PRL or steroid hormones 729535
gene_transcript unlike variants using exons E1(1), E1(2) and E1(3), transcripts which utilize E1(4) lack the usual second exon and are instead spliced to join E1(4) with the third exon 625741
gene_transcript putative transcription factor-binding sites such as CCAAT, Sp1, and glucocorticoid-responsive elements were observed in the upstream regions 625741
gene_transcript the E1(4) first exon consists of two variants, a longer cDNA containing a 243 bp sequence and a shorter variant lacking 139 bp at the 5' end 625741