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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3407 Species: Rattus norvegicus RGD Object: Gene Symbol: Prlr Name: prolactin receptor

Acc ID: CHEBI:34873 Term: N-nitrosodiethylamine Definition: A nitrosamine that has formula C4H10N2O. CasRN: 55-18-5 Chemical ID: MESH:D004052

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of PRLR mRNA	PMID:18164116
multiple interactions	EXP		6480464	CTD	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PRLR mRNA	PMID:17602206
multiple interactions	EXP		6480464	CTD	Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PRLR mRNA] [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PRLR mRNA	PMID:22129741