Ntrk3 (neurotrophic receptor tyrosine kinase 3) - Rat Genome Database

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Gene: Ntrk3 (neurotrophic receptor tyrosine kinase 3) Rattus norvegicus
Analyze
Symbol: Ntrk3
Name: neurotrophic receptor tyrosine kinase 3
RGD ID: 3214
Description: Enables GPI-linked ephrin receptor activity. Involved in several processes, including negative regulation of astrocyte differentiation; nervous system development; and response to corticosterone. Is active in glutamatergic synapse and postsynaptic membrane. Biomarker of borna disease. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3); PARTICIPATES IN neurotrophic factor signaling pathway; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GP145-TrkC; neural receptor protein-tyrosine kinase; neural receptor protein-tyrosine kinase (trkC); neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; trk-C; trkC; trkC tyrosine kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp138
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81141,526,192 - 141,913,575 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1141,542,569 - 141,913,004 (-)EnsemblGRCr8
mRatBN7.21132,116,472 - 132,503,849 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,132,849 - 132,503,286 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1140,038,778 - 140,410,193 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01147,208,513 - 147,579,935 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01140,126,320 - 140,497,270 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01139,890,537 - 140,262,503 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1139,890,560 - 140,262,503 (-)Ensemblrn6Rnor6.0
Rnor_5.01140,868,261 - 141,239,954 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41133,925,530 - 134,302,139 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1124,206,109 - 124,576,015 (-)NCBICelera
RGSC_v3.11134,003,872 - 134,380,482 (-)NCBI
Cytogenetic Map1q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium silicate  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
doxorubicin  (ISO)
enzacamene  (EXP)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (EXP,ISO)
nitrofen  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentobarbital  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
ponatinib  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sarin  (ISO)
scopolamine  (EXP)
silicon dioxide  (ISO)
terbufos  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
trimethyltin  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IEA)
cell differentiation  (IEA)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA,IEA,ISO)
cellular response to nerve growth factor stimulus  (IBA)
cellular response to retinoic acid  (IEP)
circadian rhythm  (IEA,ISO)
cochlea development  (IEP)
ephrin receptor signaling pathway  (IEA)
heart development  (IEA,ISO,ISS)
lens fiber cell differentiation  (ISO)
mechanoreceptor differentiation  (ISO)
myelination in peripheral nervous system  (ISO)
negative regulation of astrocyte differentiation  (IMP)
nervous system development  (IEA)
neuron fate specification  (IMP)
neuron migration  (IMP)
neuronal action potential propagation  (ISO)
neurotrophin signaling pathway  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of axon extension involved in regeneration  (ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neuron projection development  (IBA,IDA,IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IEA,ISO)
positive regulation of positive chemotaxis  (IEA,ISO)
positive regulation of synapse assembly  (ISO)
postsynaptic density assembly  (EXP,IDA)
regulation of neural precursor cell proliferation  (IMP)
regulation of presynapse assembly  (IDA,IMP)
response to axon injury  (IEA,IEP)
response to corticosterone  (IEP)
response to ethanol  (IEP)
system development  (IEA)

Cellular Component
axon  (IBA)
cytoplasm  (IEA,ISO)
glutamatergic synapse  (EXP,IDA,IMP)
Golgi membrane  (TAS)
membrane  (IEA)
nucleolus  (IEA,ISO)
plasma membrane  (IBA,IEA,TAS)
postsynaptic membrane  (IDA,IMP)
receptor complex  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Detection of aberrant methylated SEPT9 and NTRK3 genes in sporadic colorectal cancer patients as a potential diagnostic biomarker. Behrouz Sharif S, etal., Oncol Lett. 2016 Dec;12(6):5335-5343. doi: 10.3892/ol.2016.5327. Epub 2016 Oct 31.
2. Long non-coding RNA LINC00978 promotes cell proliferation and tumorigenesis via regulating microRNA-497/NTRK3 axis in gastric cancer. Bu JY, etal., Int J Biol Macromol. 2019 Feb 15;123:1106-1114. doi: 10.1016/j.ijbiomac.2018.11.162. Epub 2018 Nov 17.
3. TrkC overexpression enhances survival and migration of neural stem cell transplants in the rat spinal cord. Castellanos DA, etal., Cell Transplant. 2002;11(3):297-307.
4. Genome-wide analysis identifies critical DNA methylations within NTRKs genes in colorectal cancer. Chen Z, etal., J Transl Med. 2021 Feb 16;19(1):73. doi: 10.1186/s12967-021-02740-6.
5. Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. Cheung ZH, etal., PLoS Biol. 2007 Apr;5(4):e63.
6. Target tissue production and axonal transport of neurotrophin-3 are reduced in streptozotocin-diabetic rats. Fernyhough P, etal., Diabetologia. 1998 Mar;41(3):300-6.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Differential expression of trkB.T1 and trkB.T2, truncated trkC, and p75(NGFR) in the cochlea prior to hearing function. Gestwa G, etal., J Comp Neurol. 1999 Nov 8;414(1):33-49.
9. Presence and localization of neurotrophins and neurotrophin receptors in rat lacrimal gland. Ghinelli E, etal., Invest Ophthalmol Vis Sci. 2003 Aug;44(8):3352-7.
10. Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion. Hajebrahimi Z, etal., Neurosci Lett. 2008 Aug 29;441(3):261-6. Epub 2008 Jun 21.
11. TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIalpha in rat hippocampal neurons. He Z, etal., J Neurosci. 2012 Jul 4;32(27):9383-95. doi: 10.1523/JNEUROSCI.6363-11.2012.
12. JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1. Huang SH, etal., J Neurosci. 2011 Jul 20;31(29):10602-14. doi: 10.1523/JNEUROSCI.0436-11.2011.
13. TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior. Ivanov SV, etal., Oncogene. 2013 Aug 8;32(32):3698-710. doi: 10.1038/onc.2012.377. Epub 2012 Oct 1.
14. TrkC plays an essential role in breast tumor growth and metastasis. Jin W, etal., Carcinogenesis. 2010 Nov;31(11):1939-47. doi: 10.1093/carcin/bgq180. Epub 2010 Aug 28.
15. Neurotrophin-3 administration alters neurotrophin, neurotrophin receptor and nestin mRNA expression in rat dorsal root ganglia following axotomy. Kuo LT, etal., Neuroscience. 2007 Jun 29;147(2):491-507. Epub 2007 May 29.
16. Ethanol-induced alterations of neurotrophin receptor expression on Purkinje cells in the neonatal rat cerebellum. Light KE, etal., Brain Res. 2002 Jan 4;924(1):71-81.
17. A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis. Marler KJ, etal., J Neurosci. 2008 Nov 26;28(48):12700-12. doi: 10.1523/JNEUROSCI.1915-08.2008.
18. Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system. Merlio JP, etal., Neuroscience 1992 Dec;51(3):513-32.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior. Miknyoczki SJ, etal., Int J Cancer. 1999 May 5;81(3):417-27.
21. Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of prenatal exposure. Moore DB, etal., J Neurobiol. 2004 Jul;60(1):101-13. doi: 10.1002/neu.20009.
22. Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of neonatal exposure. Moore DB, etal., J Neurobiol. 2004 Jul;60(1):114-26. doi: 10.1002/neu.20010.
23. Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Moqrich A, etal., Nat Neurosci. 2004 Aug;7(8):812-8. Epub 2004 Jul 11.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Neurotrophin NT3 promotes ovarian primordial to primary follicle transition. Nilsson E, etal., Reproduction. 2009 Oct;138(4):697-707. doi: 10.1530/REP-09-0179. Epub 2009 Jul 7.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. Gangliosides activate Trk receptors by inducing the release of neurotrophins. Rabin SJ, etal., J Biol Chem 2002 Dec 20;277(51):49466-72.
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA. Robinson KN, etal., J Biol Chem. 2005 Jan 7;280(1):225-35. Epub 2004 Oct 28.
31. Early postnatal corticosterone administration regulates neurotrophins and their receptors in septum and hippocampus of the rat. Roskoden T, etal., Exp Brain Res. 2004 Jan;154(2):183-91. Epub 2003 Oct 14.
32. Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma. Sakamoto Y, etal., Oncol Rep. 2001 May-Jun;8(3):477-84.
33. Effects of coffee bean aroma on the rat brain stressed by sleep deprivation: a selected transcript- and 2D gel-based proteome analysis. Seo HS, etal., J Agric Food Chem. 2008 Jun 25;56(12):4665-73. Epub 2008 Jun 3.
34. Differential tyrosine kinase C mRNA distribution in extensor digitorum longus and soleus motoneurons in adult rats: effect of axotomy and neurotrophin-3 treatment. Simon M, etal., Neurosci Lett 2002 Mar 1;320(1-2):9-12.
35. Postsynaptic TrkC and presynaptic PTPs function as a bidirectional excitatory synaptic organizing complex. Takahashi H, etal., Neuron. 2011 Jan 27;69(2):287-303. doi: 10.1016/j.neuron.2010.12.024.
36. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. Takahashi J, etal., J Neurobiol. 1999 Jan;38(1):65-81.
37. Alternative forms of rat TrkC with different functional capabilities. Valenzuela DM, etal., Neuron 1993 May;10(5):963-74.
38. Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. Wood LD, etal., Hum Mutat. 2006 Oct;27(10):1060-1.
39. Alterations in neurotrophin and neurotrophin receptor gene expression patterns in the rat central nervous system following perinatal Borna disease virus infection. Zocher M, etal., J Neurovirol. 2000 Dec;6(6):462-77.
Additional References at PubMed
PMID:8494648   PMID:9856458   PMID:10207144   PMID:10486198   PMID:10908605   PMID:11248116   PMID:12471037   PMID:12477932   PMID:12605901   PMID:12858046   PMID:12882335   PMID:12944916  
PMID:14499950   PMID:15304335   PMID:15376326   PMID:16142215   PMID:17072373   PMID:17316612   PMID:17584746   PMID:17686986   PMID:17967490   PMID:18957307   PMID:19141250   PMID:19549834  
PMID:20553714   PMID:21221027   PMID:21441969   PMID:21456016   PMID:21783247   PMID:23136392   PMID:23382219   PMID:23785138   PMID:23954828   PMID:24198040   PMID:24316227   PMID:24484474  
PMID:24613359   PMID:24753016   PMID:25196463   PMID:25398493   PMID:25624497   PMID:27830679   PMID:28614398   PMID:34970951  


Genomics

Comparative Map Data
Ntrk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81141,526,192 - 141,913,575 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1141,542,569 - 141,913,004 (-)EnsemblGRCr8
mRatBN7.21132,116,472 - 132,503,849 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,132,849 - 132,503,286 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1140,038,778 - 140,410,193 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01147,208,513 - 147,579,935 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01140,126,320 - 140,497,270 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01139,890,537 - 140,262,503 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1139,890,560 - 140,262,503 (-)Ensemblrn6Rnor6.0
Rnor_5.01140,868,261 - 141,239,954 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41133,925,530 - 134,302,139 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1124,206,109 - 124,576,015 (-)NCBICelera
RGSC_v3.11134,003,872 - 134,380,482 (-)NCBI
Cytogenetic Map1q31NCBI
NTRK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381587,859,751 - 88,256,739 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1587,859,751 - 88,256,993 (-)Ensemblhg38GRCh38
GRCh371588,402,982 - 88,799,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361586,220,992 - 86,600,665 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341586,220,991 - 86,600,665NCBI
Celera1564,821,267 - 65,200,916 (-)NCBICelera
Cytogenetic Map15q25.3NCBI
HuRef1564,532,241 - 64,911,404 (-)NCBIHuRef
CHM1_11588,261,800 - 88,641,816 (-)NCBICHM1_1
T2T-CHM13v2.01585,614,323 - 86,011,407 (-)NCBIT2T-CHM13v2.0
Ntrk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39777,825,711 - 78,228,865 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl777,825,707 - 78,387,760 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38778,179,986 - 78,581,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl778,175,959 - 78,738,012 (-)Ensemblmm10GRCm38
MGSCv37785,337,000 - 85,722,724 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36778,066,072 - 78,451,488 (-)NCBIMGSCv36mm8
Celera775,610,791 - 75,991,488 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map744.01NCBI
Ntrk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541616,652,791 - 17,018,188 (+)Ensembl
ChiLan1.0NW_00495541616,652,931 - 17,018,188 (+)NCBIChiLan1.0ChiLan1.0
NTRK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21677,421,258 - 77,808,559 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11581,101,703 - 81,513,473 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01566,566,219 - 66,953,279 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11585,776,819 - 86,157,209 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1585,776,832 - 86,157,204 (-)EnsemblpanPan2panpan1.1
NTRK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1351,131,470 - 51,491,112 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl351,138,751 - 51,513,024 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha353,770,192 - 54,150,627 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0351,548,386 - 51,933,727 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl351,554,220 - 51,933,726 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1351,071,744 - 51,456,495 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0351,281,270 - 51,665,830 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0351,620,674 - 52,005,592 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ntrk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640132,042,602 - 132,426,830 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648313,909,109 - 14,291,887 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648313,912,904 - 14,291,881 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTRK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1191,535,301 - 191,925,327 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11191,535,262 - 191,941,675 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,938,371 - 213,258,768 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NTRK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1296,441,824 - 6,831,029 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl296,447,256 - 6,830,526 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605940,018,915 - 40,410,728 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntrk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476815,252,354 - 15,619,601 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476815,239,111 - 15,619,979 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ntrk3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12121,789,479 - 122,159,303 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ntrk3
2769 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:613
Count of miRNA genes:207
Interacting mature miRNAs:231
Transcripts:ENSRNOT00000025536, ENSRNOT00000041839, ENSRNOT00000045165, ENSRNOT00000046080, ENSRNOT00000046849, ENSRNOT00000047776
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760602142582180Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1111404407142582336Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
D1Uia12  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81141,624,120 - 141,624,267 (+)Marker Load Pipeline
mRatBN7.21132,214,399 - 132,214,546 (+)MAPPERmRatBN7.2
Rnor_6.01139,972,085 - 139,972,231NCBIRnor6.0
Rnor_5.01140,949,643 - 140,949,789UniSTSRnor5.0
RGSC_v3.41134,007,904 - 134,008,050UniSTSRGSC3.4
RGSC_v3.41134,007,903 - 134,008,050RGDRGSC3.4
Celera1124,287,809 - 124,287,955UniSTS
RGSC_v3.11134,086,246 - 134,086,393RGD
Cytogenetic Map1q31UniSTS
D1Mco67  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21132,256,726 - 132,256,925 (+)MAPPERmRatBN7.2
Rnor_6.01140,014,403 - 140,014,601NCBIRnor6.0
Rnor_5.01140,992,120 - 140,992,318UniSTSRnor5.0
RGSC_v3.41134,051,455 - 134,051,653UniSTSRGSC3.4
Celera1124,330,125 - 124,330,323UniSTS
Cytogenetic Map1q31UniSTS
BE106688  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21132,132,876 - 132,133,043 (+)MAPPERmRatBN7.2
Rnor_6.01139,890,565 - 139,890,731NCBIRnor6.0
Rnor_5.01140,868,289 - 140,868,455UniSTSRnor5.0
RGSC_v3.41133,925,533 - 133,925,699UniSTSRGSC3.4
Celera1124,206,137 - 124,206,303UniSTS
RH 3.4 Map11053.3UniSTS
Cytogenetic Map1q31UniSTS
Ntrk3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21132,383,823 - 132,383,927 (+)MAPPERmRatBN7.2
Rnor_6.01140,141,474 - 140,141,577NCBIRnor6.0
Rnor_5.01141,118,729 - 141,118,832UniSTSRnor5.0
RGSC_v3.41134,180,066 - 134,180,169UniSTSRGSC3.4
Celera1124,456,732 - 124,456,835UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 11 67 162 78 77 46 33 46 6 277 132 11 141 79 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC078844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L03813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L14445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L14446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L14447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S60953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S62924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S62933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000025536   ⟹   ENSRNOP00000025536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,234,519 - 132,503,286 (-)Ensembl
Rnor_6.0 Ensembl1139,992,204 - 140,262,452 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000041839   ⟹   ENSRNOP00000046059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1141,542,569 - 141,913,004 (-)Ensembl
mRatBN7.2 Ensembl1132,132,849 - 132,503,286 (-)Ensembl
Rnor_6.0 Ensembl1139,890,560 - 140,262,503 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000045165   ⟹   ENSRNOP00000049463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1141,542,569 - 141,913,004 (-)Ensembl
mRatBN7.2 Ensembl1132,132,849 - 132,503,286 (-)Ensembl
Rnor_6.0 Ensembl1139,890,715 - 140,262,452 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000046849   ⟹   ENSRNOP00000044402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1141,542,569 - 141,913,004 (-)Ensembl
mRatBN7.2 Ensembl1132,132,849 - 132,503,286 (-)Ensembl
Rnor_6.0 Ensembl1139,890,715 - 140,262,452 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110436   ⟹   ENSRNOP00000094926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1141,643,239 - 141,913,004 (-)Ensembl
mRatBN7.2 Ensembl1132,234,193 - 132,503,286 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114826   ⟹   ENSRNOP00000096233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1132,260,318 - 132,503,286 (-)Ensembl
RefSeq Acc Id: NM_001270655   ⟹   NP_001257584
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,542,569 - 141,913,004 (-)NCBI
mRatBN7.21132,132,849 - 132,503,286 (-)NCBI
Rnor_6.01139,890,537 - 140,262,503 (-)NCBI
Rnor_5.01140,868,261 - 141,239,954 (-)NCBI
Celera1124,206,109 - 124,576,015 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270656   ⟹   NP_001257585
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,542,569 - 141,913,004 (-)NCBI
mRatBN7.21132,132,849 - 132,503,286 (-)NCBI
Rnor_6.01139,890,537 - 140,262,503 (-)NCBI
Rnor_5.01140,868,261 - 141,239,954 (-)NCBI
Celera1124,206,109 - 124,576,015 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019248   ⟹   NP_062121
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,542,569 - 141,913,004 (-)NCBI
mRatBN7.21132,132,849 - 132,503,286 (-)NCBI
Rnor_6.01139,890,537 - 140,262,503 (-)NCBI
Rnor_5.01140,868,261 - 141,239,954 (-)NCBI
RGSC_v3.41133,925,530 - 134,302,139 (-)RGD
Celera1124,206,109 - 124,576,015 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759513   ⟹   XP_008757735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,642,292 - 141,913,575 (-)NCBI
mRatBN7.21132,232,568 - 132,503,829 (-)NCBI
Rnor_6.01139,990,256 - 140,262,498 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109631   ⟹   XP_038965559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,600,598 - 141,913,549 (-)NCBI
mRatBN7.21132,190,886 - 132,503,829 (-)NCBI
RefSeq Acc Id: XM_039109638   ⟹   XP_038965566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,600,132 - 141,913,549 (-)NCBI
mRatBN7.21132,189,358 - 132,503,829 (-)NCBI
RefSeq Acc Id: XM_063287704   ⟹   XP_063143774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,526,192 - 141,913,568 (-)NCBI
RefSeq Acc Id: XM_063287717   ⟹   XP_063143787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81141,642,292 - 141,913,568 (-)NCBI
RefSeq Acc Id: NP_062121   ⟸   NM_019248
- Peptide Label: isoform 3 precursor
- UniProtKB: A0A8L2ULV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257584   ⟸   NM_001270655
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A8L2ULV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257585   ⟸   NM_001270656
- Peptide Label: isoform 1 precursor
- UniProtKB: Q03351 (UniProtKB/Swiss-Prot),   A0A8L2ULV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757735   ⟸   XM_008759513
- Peptide Label: isoform X3
- UniProtKB: Q68G04 (UniProtKB/TrEMBL),   A0A8I6ALQ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049463   ⟸   ENSRNOT00000045165
Ensembl Acc Id: ENSRNOP00000046059   ⟸   ENSRNOT00000041839
Ensembl Acc Id: ENSRNOP00000044402   ⟸   ENSRNOT00000046849
Ensembl Acc Id: ENSRNOP00000025536   ⟸   ENSRNOT00000025536
RefSeq Acc Id: XP_038965566   ⟸   XM_039109638
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ALQ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965559   ⟸   XM_039109631
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ALQ4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094926   ⟸   ENSRNOT00000110436
Ensembl Acc Id: ENSRNOP00000096233   ⟸   ENSRNOT00000114826
RefSeq Acc Id: XP_063143774   ⟸   XM_063287704
- Peptide Label: isoform X1
- UniProtKB: A0A8L2ULV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143787   ⟸   XM_063287717
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ALQ4 (UniProtKB/TrEMBL),   Q68G04 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Ig-like C2-type   LRRCT   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03351-F1-model_v2 AlphaFold Q03351 1-864 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3214 AgrOrtholog
BioCyc Gene G2FUF-58842 BioCyc
Ensembl Genes ENSRNOG00000018674 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025536.6 UniProtKB/Swiss-Prot
  ENSRNOT00000041839 ENTREZGENE
  ENSRNOT00000041839.4 UniProtKB/Swiss-Prot
  ENSRNOT00000045165 ENTREZGENE
  ENSRNOT00000045165.4 UniProtKB/Swiss-Prot
  ENSRNOT00000046849 ENTREZGENE
  ENSRNOT00000110436 ENTREZGENE
  ENSRNOT00000114826.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7121171 IMAGE-MGC_LOAD
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Immunoglobulin UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
  NTRK_C2 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RTK UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kin_neurotrophic_rcpt_3 UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_NGF_rcpt UniProtKB/Swiss-Prot
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot
KEGG Report rno:29613 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93481 IMAGE-MGC_LOAD
NCBI Gene 29613 ENTREZGENE
PANTHER NT-3 GROWTH FACTOR RECEPTOR UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot
Pfam I-set UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
  PF00047 UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  TPKR_C2 UniProtKB/Swiss-Prot
PhenoGen Ntrk3 PhenoGen
PRINTS NTKRECEPTOR UniProtKB/Swiss-Prot
  NTKRECEPTOR3 UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  LRR UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_II UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018674 RatGTEx
SMART LRRCT UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
  SSF48726 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6ALQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2ULV7 ENTREZGENE, UniProtKB/TrEMBL
  NTRK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q68G04 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Ntrk3  neurotrophic receptor tyrosine kinase 3  Ntrk3  neurotrophic tyrosine kinase, receptor, type 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ntrk3  neurotrophic tyrosine kinase, receptor, type 3    neural receptor protein-tyrosine kinase  Name updated 1299863 APPROVED
2002-06-10 Ntrk3  neural receptor protein-tyrosine kinase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation activated by GM1 gangliosides 727459
gene_transcript multiple alternative splice forms exist and may have different functional capabilities 729049