RGD Reference Report - Target tissue production and axonal transport of neurotrophin-3 are reduced in streptozotocin-diabetic rats. - Rat Genome Database

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Target tissue production and axonal transport of neurotrophin-3 are reduced in streptozotocin-diabetic rats.

Authors: Fernyhough, P  Diemel, LT  Tomlinson, DR 
Citation: Fernyhough P, etal., Diabetologia. 1998 Mar;41(3):300-6.
RGD ID: 2325654
Pubmed: PMID:9541170   (View Abstract at PubMed)
DOI: DOI:10.1007/s001250050907   (Journal Full-text)

Neurotrophin-3 (NT-3) acts as a target-derived neurotrophic factor for large calibre sensory neurones and plays a role in the maintenance of the adult phenotype of proprioceptive and mechanoreceptive fibres. Large fibre sensory neuropathy is common in diabetes mellitus and the aim of this study was to determine whether endogenous NT-3-dependent neurotrophic support was sub-optimal in the streptozotocin-diabetic rat. NT-3 gene expression was analysed by Northern blotting and ELISA in hindlimb skeletal muscle and found to be decreased by up to 70% (p < 0.05) in rats with 4-6 weeks of diabetes compared to aged-matched controls. Treatment of other diabetic rats with insulin prevented development of deficits of both NT-3 protein and of its mRNA. The deficits in target tissue production of NT-3 were coincident with significant decreases in its anterograde and retrograde axonal transport in sciatic nerve at 6 weeks of diabetes. The mRNA expression in lumbar dorsal root ganglia of the specific receptor for NT-3, trkC, was also down-regulated at 12 weeks of diabetes by 50% (p < 0.05). The observed decreases in NT-3 target tissue production and related axonal transport suggest that large calibre sensory neurones expressing trkC may be receiving sub-optimal neurotrophic support in experimental diabetes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISONtrk3 (Rattus norvegicus)2325654; 2325654mRNA:decreased expression:dorsal root ganglionRGD 
Experimental Diabetes Mellitus  IEP 2325654mRNA:decreased expression:dorsal root ganglionRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ntrk3  (neurotrophic receptor tyrosine kinase 3)

Genes (Mus musculus)
Ntrk3  (neurotrophic tyrosine kinase, receptor, type 3)

Genes (Homo sapiens)
NTRK3  (neurotrophic receptor tyrosine kinase 3)


Additional Information