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Gene: Kcnmb1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1) Rattus norvegicus

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Symbol:

Kcnmb1

Name:

potassium calcium-activated channel subfamily M regulatory beta subunit 1

RGD ID:

2961

Description:

Enables potassium channel regulator activity. Involved in several processes, including cellular response to bile acid; cellular response to ethanol; and cellular response to hypoxia. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Used to study hypertension. Biomarker of hypertension and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acrylamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

BK channel subunit beta-1; BKbeta; BKbeta1; calcium-activated potassium channel beta subunit; calcium-activated potassium channel subunit beta; calcium-activated potassium channel subunit beta-1; calcium-activated potassium channel, subfamily M subunit beta-1; charybdotoxin receptor subunit beta-1; k(VCA)beta-1; LOC60591; maxi K channel subunit beta-1; potassium channel subfamily M regulatory beta subunit 1; potassium large conductance calcium-activated channel, subfamily M, beta member 1; slo-beta; slo-beta-1; slowpoke-beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Kcnmb1^em1Mcwi ; Kcnmb1^em3Mcwi

Genetic Models:

SS-Kcnmb1^em3Mcwi ; SS-Kcnmb1^em1Mcwi

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	19,062,014 - 19,119,005 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	19,062,291 - 19,073,204 (+)	Ensembl				GRCr8
mRatBN7.2	10	18,557,510 - 18,614,824 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	18,557,904 - 18,565,798 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	23,312,979 - 23,320,935 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	22,801,535 - 22,809,494 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	18,280,331 - 18,288,287 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	18,910,586 - 18,922,856 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	18,906,010 - 18,919,639 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	18,790,595 - 18,800,957 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	18,904,902 - 18,912,604 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	18,189,045 - 18,196,906 (+)	NCBI		Celera
RGSC_v3.1	10	18,905,950 - 18,913,652 (+)	NCBI
Cytogenetic Map	10	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Diastolic Hypertension, Resistance to (ISO)

Experimental Diabetes Mellitus (IEP)

hypertension (IDA,IEP,ISO)

Insulin Resistance (IEP)

Myocardial Ischemia (ISO)

type 2 diabetes mellitus (IEP)

Weight Gain (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

17beta-estradiol (ISO)

2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

5-aza-2'-deoxycytidine (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

cadmium dichloride (EXP)

calcium atom (ISO)

calcium(0) (ISO)

D-glucose (ISO)

dibutyl phthalate (EXP)

dimethylarsinic acid (EXP)

doxorubicin (ISO)

flavonoids (EXP)

glucose (ISO)

lithocholic acid (EXP,ISO)

methyl methanesulfonate (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nitrofen (EXP)

NS 1619 (ISO)

paracetamol (EXP)

silicon dioxide (EXP)

sodium dichromate (ISO)

sodium disulfite (EXP)

sulfur dioxide (EXP)

tamoxifen (ISO)

tetrachloromethane (EXP)

tetraethylammonium (ISO)

triclosan (ISO)

verapamil (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to bile acid (IDA)

cellular response to ethanol (IDA)

cellular response to hypoxia (IEP)

detection of calcium ion (IBA)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

positive regulation of potassium ion transmembrane transport (IDA)

potassium ion transmembrane transport (IEA)

potassium ion transport (IEA)

response to calcium ion (IDA)

vasodilation (IDA)

Cellular Component

membrane (IDA,IEA,ISO)

neuronal cell body (IDA)

plasma membrane (TAS)

somatodendritic compartment (IDA)

voltage-gated potassium channel complex (IBA,ISO)

Molecular Function

calcium-activated potassium channel activity (IBA,IEA,ISO)

potassium channel regulator activity (IBA,IDA)

protein binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

increased systemic arterial blood pressure (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Downregulation of the BK channel beta1 subunit in genetic hypertension.	Amberg GC and Santana LF, Circ Res 2003 Nov 14;93(10):965-71. Epub 2003 Oct 9.
2.	Hypoxia inducible factor-2alpha stabilization and maxi-K+ channel beta1-subunit gene repression by hypoxia in cardiac myocytes: role in preconditioning.	Bautista L, etal., Circ Res. 2009 Jun 19;104(12):1364-72. doi: 10.1161/CIRCRESAHA.108.190645. Epub 2009 May 21.
3.	The BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constriction.	Bukiya AN, etal., FEBS Lett. 2009 Sep 3;583(17):2779-84. doi: 10.1016/j.febslet.2009.07.019. Epub 2009 Jul 17.
4.	Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel beta1-subunit by a novel nonsteroidal agent.	Bukiya AN, etal., Mol Pharmacol. 2013 May;83(5):1030-44. doi: 10.1124/mol.112.083519. Epub 2013 Mar 1.
5.	The steroid interaction site in transmembrane domain 2 of the large conductance, voltage- and calcium-gated potassium (BK) channel accessory beta1 subunit.	Bukiya AN, etal., Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20207-12. doi: 10.1073/pnas.1112901108. Epub 2011 Nov 28.
6.	Differential expression of the alpha and beta subunits of the large-conductance calcium-activated potassium channel: implication for channel diversity.	Chang CP, etal., Brain Res Mol Brain Res 1997 Apr;45(1):33-40.
7.	High glucose alters apoptosis and proliferation in HEK293 cells by inhibition of cloned BK Ca channel.	Chang H, etal., J Cell Physiol. 2011 Jun;226(6):1660-75. doi: 10.1002/jcp.22497.
8.	Altered expression of BK channel beta1 subunit in vascular tissues from spontaneously hypertensive rats.	Chang T, etal., Am J Hypertens. 2006 Jul;19(7):678-85.
9.	Developmental regulation of the A-type potassium-channel current in hippocampal neurons: role of the Kvbeta 1.1 subunit.	Falk T, etal., Neuroscience 2003;120(2):387-404.
10.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
12.	Human and rodent MaxiK channel beta-subunit genes: cloning and characterization.	Jiang Z, etal., Genomics 1999 Jan 1;55(1):57-67.
13.	Reduction of large-conductance Ca(2)(+) -activated K(+) channel with compensatory increase of nitric oxide in insulin resistant rats.	Li S, etal., Diabetes Metab Res Rev. 2011 Jul;27(5):461-9. doi: 10.1002/dmrr.1196.
14.	Impaired Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels in the coronary artery smooth muscle cells of Zucker Diabetic Fatty rats.	Lu T, etal., Biophys J. 2008 Dec;95(11):5165-77. doi: 10.1529/biophysj.108.138339. Epub 2008 Sep 12.
15.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
16.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
17.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
18.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	Comprehensive gene review and curation	RGD comprehensive gene curation
21.	BKbeta1 subunits contribute to BK channel diversity in rat hypothalamic neurons.	Salzmann M, etal., Cell Mol Neurobiol. 2010 Aug;30(6):967-76. doi: 10.1007/s10571-010-9527-7. Epub 2010 May 5.
22.	Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk.	Senti M, etal., Circ Res. 2005 Dec 9;97(12):1360-5. Epub 2005 Nov 17.
23.	Aging decreases the contribution of MaxiK channel in regulating vascular tone in mesenteric artery by unparallel downregulation of alpha- and beta1-subunit expression.	Shi L, etal., Mech Ageing Dev. 2013 Sep;134(9):416-25. doi: 10.1016/j.mad.2013.09.001. Epub 2013 Sep 16.
24.	E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients.	Via M, etal., J Hum Genet. 2005;50(11):604-6. Epub 2005 Sep 10.
25.	[Ca(2+)-activated K(+) channel switching in smooth muscle participates in atherosclerosis development in diabetic rats].	Wang Y, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Feb;34(2):188-92.

Additional References at PubMed

PMID:12388098	PMID:14966080	PMID:16113069	PMID:17209121	PMID:17293477	PMID:19321803	PMID:19940072	PMID:20139169	PMID:20334613	PMID:20936291	PMID:21438011	PMID:22660813
PMID:25371198	PMID:28487419	PMID:29040972	PMID:29093563	PMID:30012867	PMID:31738403	PMID:32967457	PMID:33556372	PMID:36717168

Genomics

Comparative Map Data

Kcnmb1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	19,062,014 - 19,119,005 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	19,062,291 - 19,073,204 (+)	Ensembl				GRCr8
mRatBN7.2	10	18,557,510 - 18,614,824 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	18,557,904 - 18,565,798 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	23,312,979 - 23,320,935 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	22,801,535 - 22,809,494 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	18,280,331 - 18,288,287 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	18,910,586 - 18,922,856 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	18,906,010 - 18,919,639 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	18,790,595 - 18,800,957 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	18,904,902 - 18,912,604 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	18,189,045 - 18,196,906 (+)	NCBI		Celera
RGSC_v3.1	10	18,905,950 - 18,913,652 (+)	NCBI
Cytogenetic Map	10	q12	NCBI

KCNMB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	170,374,671 - 170,389,367 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	170,374,671 - 170,389,655 (-)	Ensembl			hg38	GRCh38
GRCh37	5	169,801,675 - 169,816,371 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	169,737,745 - 169,749,216 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	169,737,744 - 169,749,216	NCBI
Celera	5	165,837,099 - 165,848,570 (-)	NCBI		Celera
Cytogenetic Map	5	q35.1	NCBI
HuRef	5	164,904,047 - 164,915,563 (-)	NCBI		HuRef
CHM1_1	5	169,238,046 - 169,249,557 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	170,913,506 - 170,928,202 (-)	NCBI		T2T-CHM13v2.0

Kcnmb1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	33,912,955 - 33,923,641 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	33,913,013 - 33,923,641 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	33,962,955 - 33,973,641 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	33,963,013 - 33,973,641 (+)	Ensembl			mm10	GRCm38
MGSCv37	11	33,863,013 - 33,873,638 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	33,863,286 - 33,871,275 (+)	NCBI		MGSCv36	mm8
Celera	11	36,374,009 - 36,384,630 (+)	NCBI		Celera
Cytogenetic Map	11	A4	NCBI
cM Map	11	19.32	NCBI

Kcnmb1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	23,325,225 - 23,335,298 (-)	Ensembl
ChiLan1.0	NW_004955408	23,306,286 - 23,335,170 (-)	NCBI	ChiLan1.0	ChiLan1.0

KCNMB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	165,531,886 - 165,545,457 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	163,669,031 - 163,685,000 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	165,712,588 - 165,747,948 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	172,495,762 - 172,507,318 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	172,495,762 - 172,507,318 (-)	Ensembl			panPan2	panpan1.1

KCNMB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	41,536,841 - 41,545,523 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	41,537,225 - 41,545,344 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	41,491,752 - 41,497,517 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	41,912,957 - 41,922,108 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	41,912,853 - 41,921,446 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	41,733,152 - 41,738,919 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	41,919,686 - 41,925,451 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	42,430,404 - 42,436,172 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Kcnmb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	95,728,790 - 95,736,033 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936609	4,451,492 - 4,458,712 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936609	4,451,526 - 4,458,665 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KCNMB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	53,618,603 - 53,631,195 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	16	53,616,532 - 53,631,197 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	57,959,628 - 57,972,407 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KCNMB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	72,580,617 - 72,591,070 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	72,577,813 - 72,591,588 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666034	6,070,733 - 6,081,816 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kcnmb1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	19,582,489 - 19,597,722 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624733	19,582,646 - 19,593,581 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Kcnmb1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	6,777,406 - 6,785,101 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Kcnmb1
369 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	266
Count of miRNA genes:	155
Interacting mature miRNAs:	170
Transcripts:	ENSRNOT00000007393, ENSRNOT00000007408
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15776754	60776754	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6660923	73950353	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5893811	50893811	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1250554	64349221	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5893811	50893811	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	14653541	59653541	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15533012	73695498	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6877142	51877142	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35730538	Rat
7387235	Uae41	Urinary albumin excretion QTL 41	5.26	0.1874	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	10	1	30004247	Rat
737823	Alc12	Alcohol consumption QTL 12	4.5		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	17749784	20796344	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	18035782	63035782	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	922197	45922197	Rat
737820	Alc9	Alcohol consumption QTL 9	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	15762230	19737486	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	2103708	47103708	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5893811	50893811	Rat
2298495	Eae23	Experimental allergic encephalomyelitis QTL 23	16.93		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis duration (CMO:0001424)	10	16175525	61175525	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18668419	63668419	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38832698	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6661118	35509383	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	18035782	63035782	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14991535	86964295	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat

Markers in Region

RH142383

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	18,565,193 - 18,565,369 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	18,919,035 - 18,919,210	NCBI	Rnor6.0
Rnor_5.0	10	18,797,692 - 18,797,867	UniSTS	Rnor5.0
RGSC_v3.4	10	18,911,999 - 18,912,174	UniSTS	RGSC3.4
Celera	10	18,196,301 - 18,196,476	UniSTS
Cytogenetic Map	10	q12	UniSTS

Genetic Models

This gene Kcnmb1 is modified in the following models/strains:

SS-Kcnmb1^em3Mcwi SS-Kcnmb1^em1Mcwi

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	10	67	140	50	50	19	82	19	6	296	179	11	119	75	91	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006246089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767563	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767564	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085796	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063268844	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB010963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB050745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF020712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FJ154955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U40602	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U54498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000007393 ⟹ ENSRNOP00000007393

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	10	18,912,865 - 18,919,458 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000007408 ⟹ ENSRNOP00000007408

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	18,557,904 - 18,565,798 (+)	Ensembl
Rnor_6.0 Ensembl	10	18,911,938 - 18,919,639 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090659 ⟹ ENSRNOP00000071161

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	19,063,721 - 19,069,768 (+)	Ensembl
mRatBN7.2 Ensembl	10	18,559,526 - 18,565,576 (+)	Ensembl
Rnor_6.0 Ensembl	10	18,906,010 - 18,919,261 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000159821 ⟹ ENSRNOP00000103628

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	19,062,291 - 19,073,204 (+)	Ensembl

RefSeq Acc Id:

NM_019273 ⟹ NP_062146

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	19,062,099 - 19,069,991 (+)	NCBI
mRatBN7.2	10	18,557,904 - 18,565,799 (+)	NCBI
Rnor_6.0	10	18,911,938 - 18,919,640 (+)	NCBI
Rnor_5.0	10	18,790,595 - 18,800,957 (+)	NCBI
RGSC_v3.4	10	18,904,902 - 18,912,604 (+)	RGD
Celera	10	18,189,045 - 18,196,906 (+)	RGD

Sequence:

show sequence

ATCTGTTTCCCAGGAGACTCTGGAAAACGCAGGGGCAGAGTCCCCAACAGCAGCTGAGGGCTCG
AAGAGACTAGGTACCTGCTTGTGGAGTTTTTTGTCCCGGAGCAAGCTGTGTGCTCAGACTTGAC
CATGTTTGGGCATGGAGGCTCAACCCAGATGGAACTGAAGACTGCTTCCCTAGAGACCAACTGG
AGACCAAACTTCCTGCTAGAGCTCCAAGGCCTGACTTGGGGTGGGGGGGTGGGGGCCAGTGGAG
AGAAACCATCTGCCAGCGGAGACCCAGGGAACTAAATGACTGTTGCCTCCTGTGGCCATGGGGA
AGAAGCTGGTGATGGCCCAGAAGCGCGGAGAGACTCGAGCCCTCTGCCTGGGGGTGGCGATGGT
CGTGTGTGCCGCCATCACTTACTACATCCTGGGTACCACTGTGCTGCCCCTCTACCAGAAAAGT
GTGTGGACCCAGGAATCCACCTGTCACTTGGTTGAAACCAACATCAAGGACCAGGAAGAGCTGG
AGGGCAGGAAGGTGCCCCAGTACCCATGCCTTTGGGTCAATGTATCAGCTGTGGGCAGATGGGC
CATGCTGTATCACACAGAAGACACTCGGGATCAAAACCAACAGTGCTCCTATATCCCCAGGAAC
CTGGACAACTACCAGACAGCCTTGGTTGATGTGAAGAAGGTCAGAGCCAATTTCTACAAACACC
ATAATTTCTATTGCTTTTCTGCACCTCAAGTCAATGAGACCAGTGTTGTGTACCAGCGCCTCTA
TGGGCCCCAAATCCTCCTCTTCTCCTTCTTCTGGCCCACCTTCCTGCTGACTGGTGGCCTTCTT
ATCATTGCCATGGTAAAGCTCAACAGGTCCCTCTCTGTCTTGGCAGCTCAGAAGTAGACCAATC
TCTTCTGCACAGCAGCATGGAGTCACCAGGAACGGCAGGGGTCCCGGGCAGGCATAATTCTCTT
CCTCTTGTCCTCCATTTAATTTGTTCAACCTCTTTGGACAATCATTTCTTGCTCAAGAATGTTT
AACAGCTCTCTCCGGTTGACTTCGAAGGGCAAAGGAACTGCCAGTCACAGCTCTCGATCCCCGG
CTTCAGTTGGCTCACATCTGTTACCTGCTATGTCACTGTCTACTCCCAAGACGATGAATATCGT
CACCTCTGTCCCTATGTGCTCTCTCTTAGTTCCTCAGATACCCACCTTTGACATCCAGGATGCT
GTCCTTGGCCAAATTCAGCTTCTTTGAATTGTCATAAAAGCCATAGCTCTCAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006246089 ⟹ XP_006246151

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	19,062,036 - 19,073,207 (+)	NCBI
mRatBN7.2	10	18,558,206 - 18,569,015 (+)	NCBI
Rnor_6.0	10	18,910,586 - 18,922,856 (+)	NCBI
Rnor_5.0	10	18,790,595 - 18,800,957 (+)	NCBI

Sequence:

show sequence

TCTACCTGCCTCTGCCTCCCGAGTGCTGGGATTAAAGGCGTGTGCCACTGCTGCTCGGCCTAAA
GGTCCTTCATAAGGTGGAGTGTTATGGAACAGAACACCGATGTCTCCCTTTAGTTTCCATGAAT
GTGCACGTGTATGACTATATCAATGACACACACATATACCGAATCTCATACACATATTACACAT
ACTATACCTATCCAAACATACATATACCACACACATGCACAACTCCTTCAGACACCACACACAT
GCAGGCGCATACACACTAATAAATCTCCATTAGCCACGAGGCCCATTAAACAGGTGGTTGACTC
TCTCGTTGGAGTCAGTGAGTGAAGGCGGATGGGATGGTGCCCCCCAGCAGAGTACCAAGGAGCC
TTGAGTGACAATTTTCCTTCTGGGACTTATCAGGCCCTCGGGTGGCAGGCTTAGGTGAGAGGTG
CAAACACTCAATGGGCAAGAATATCTAGGTTGCACCCATTGCCCTCAGCCTGGGGACACCAGAG
GAGACCTCTAGAACTTCAGGTGGCTGGGGACATATCAGTGGGATGAGGGTCAGAAGAGTCCCTT
GGTGGCCAGGGATGTCTGGGATTTATCACTGGGAGGAGGCAACTTCTAATCTGGCTCTGCCCCT
CAAGTAGAGAAACTCTTGACCAGGCATCAAGTCTGCCGGCCTCAGCTCCATGCAAATGCCTAGC
AGGGCACTGAGGTGTGAGCATGGTGGGGGCAGGGTTCTTGTTCTTGCTTTTTCCAGCTCTACTC
TTACTGATCTCTTTATCCACAAGAACATGGAGTGCAGAAGCCAGTTTGTCCCCCTCTCCCCATA
CCAATGTTCAGTTGTCTTATTGGTTGCAACGACTTTCTGCCTATGAAACAGAGTCAGTCTGTGG
GAGGTCCCTAGCATGACACAGTCCCTGGCCCTGGACAGTTGTCTGGAAGCAGCTGTGGGACCCA
CTGTTTCCAGCCTCATCTCCAGTGGTCTTTAAAAGGTAGAATTTCCTCCTTTCTCTGGACTCCA
CCATCTCTAACTTCACAATGCTGAGCAAAGTTTTCAAAATGCTAATGATAGAAGGGAGAAAACA
GAGGTTCAGAGAGGTGCTCTGATTTGTTCCGAGTCACACAGGATGTCACGGACAAAGGTGGGAG
GCTTTGACTGCACTAGTGTGGACAAACCAGGGGCTAGTGACAAGTCCAACCCTTCTACCTCCCT
CCCCTGCACCGCACAAGGAAGACTGTTTCTTCAAACAGGCTTCTCTGCCAGCCTGAGAGACGGA
GTGCAGAAGAAACATTTTGGAATATTTATCAGGATGGTCTTGCGGGGTGGGTAATGAGTTTGGC
TGTTTGACATCTGTTTCCCAGGAGACTCTGGAAAACGCAGGGGCAGAGTCCCCAACAGCAGCTG
AGGGCTGCAAGAGACTAGGTACCTGCTTGTGGAGTTTTTTGTCCCGGAGCAAGCTGTGTGCTCA
GACTTGACCATGTTTGGGCATGGAGGCTCGACCCAGATGGAACTGAAGACTGCTTCCCTAGAGA
CCAACTGGAGACCAAACTTCCTGCTAGAGCTCCAAGGCCTGACTTGGGGTGGGGGGGTGGGGGC
CAGTGGAGAGAAACCATCTGCCAGCGGAGACCCAGGGAACTGTGAGTGCTACATCCCTGAGAGT
TTGGGAAAGGCTTCTGGGAAGCCAGGGCTGAGGGGAGATGGTGGGAGACAGCAGCCTGTGACAG
CATGGATAGGGTGGTGAAAATCCCTACCTCTCCTGCTGCCCATTAGAGTTCTGGCACCGGAGGG
CCTGCCTGGCCTGTTGACCCTGGTCTAGACCTCTCTTCTGTGGCCAGCCAGGAGGTCAGGACCT
GTCTTATCACTTGTCATCAGGATAGGAGTTGACAAACAGGCCTGACAGAGTGTACCAAGCTTCT
TCAGTTCCTCAGTTAATGATAGCTACAGTTTATGGAGGCCTTCAACTGCAGCAAGTAGGTAACG
CCAGCCGTGTTGGTGGGTCTGCCTCAGGACTCTGAGAAATGACTGTTGCCTCCGGTGGCCATGG
GGAAGAAGCTGGTGATGGCCCAGAAGCGCGGAGAGACGCGAGCCCTCTGCCTGGGGGTGGCGAT
GGTCGTGTGTGCCGCCATCACTTACTACATCCTGGGTACCACTGTGCTGCCCCTCTACCAGAAA
AGTGTGTGGACCCAGGAATCCACCTGTCACTTGGTTGAAACCAACATCAAGGACCAGGAAGAGC
TGGAGGGCAGGAAGGTGCCCCAGTACCCATGCCTTTGGGTCAATGTATCAGCTGTGGGCAGATG
GGCCATGCTGTATCACACAGAAGACACTCGGGATCAAAACCAACAGTGCTCCTATATCCCCAGG
AACCTGGACAACTACCAGACAGCCTTGGTTGATGTGAAGAAGGTCAGAGCCAATTTCTACAAAC
ACCATAATTTCTATTGCTTTTCTGCACCTCAAGTCAATGAGACCAGTGTTGTGTACCAGCGCCT
CTATGGGCCCCAAATCCTCCTCTTCTCCTTCTTCTGGCCCACCTTCCTGCTGACTGGTGGCCTT
CTTATCATTGCCATGGTAAAGCTCAACAGGTCCCTCTCTGTCTTGGCAGCTCAGAAGTAGACCA
ATCTCTTCTGCACAGCAGCATGGAGTCACCAGGAACGGCAGGGGTCCCGGGCAGGCATAATTCT
CTTCCTCTTGTCCTCCATTTAATTTGTTCAACCTCTTTGGACAATCATTTCTTGCTCAAGAATG
TTTAACAGCTCTCTCCGGTTGACTTCGAAGGGCAAAGGAACTGCCAGTCACAGCTCTCGATCCC
CGGCTTCAGTTGGCTCACATCTGTTACCTGCTATGTCACTGTCTACTCCCAAGACGATGAATAT
CGTCACCTCTGTCCCTATGTGCTCTCTCTTAGTTCCTCAGATACCCACCTTTGACATCCAGGAT
GCTGTCCTTGGCCAAATTCAGCTTCTTTGAATTGTCATAAAAGCCATAGCTCTCATTTACTGGT
CAACTGAGTAGCACTATTTGTTAAGGACATCAACACACACACACACACACACACACACACACAC
ACACACACACACACACACATTAAAATTTATTCTAAAATTAAAACATAATGCTGTCCTTCAGTAT
CCACCGGGACCAGTTCTGTGACTTGCTCAGATGGCAAAAATCCCTTCTATACAGTGATGCAGTC
TGCGTGGCAGCACTGTCTGCCTTCCTGTGTGCTGCATAGTATCTCCAGATGACCAGTAAACACC
CACTACAGTGTCAATGCCGGAAGTGACTTCATTCTAGGGAGTAATGATGAGGAAGAGTCCATCC
AAGCTCACAGCAGATGCAATTATTACCCAAACACTCTCAATCTGCACTTGATGGAATCCAATGG
GGCAGAACCTGCCGATACATATTTGAGCATATACGCACAGTAACAAAAGTCTGTGAGGAAATAA
ATGCAAGTGCTTCAAATTCTAATCATGAGATGGTGGTTAGTTTTAATTTTCTTCCTTAACCCCG
CTCCTTGTTTCTGTTATTTTCATTCTTCAGTAATAGGAAGATTATACAATGTTTTGTTTGGTTT
TAATGAGAAAAGTAATGCACAGCTGTTATTTTTGGAAAGCATTGAAAGGGGCTACCTCAAGGAG
ATGAGGATGGGCTGCAAGAGGCTCTTTCTCCCGTCAGAGACAAGCAGGGAAGACAGGGTTGTTG
GGCTCCCTGATGGAAGAAAGGCGCTTACTTAGACGAGGTTTGCAGATTCCTGTTCTAGATGCTT
CCAACGTGCCCCCTGTAGACACAGGTGTTGGGCACTTAACACAGTTCGTGTTCATGGCATTCAG
ATATAATTGGAATTAGAATTGTGCCCCCCAAGATGGCACCATTGGCTTTACAGCAACATGGAGA
GAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGCACTGAGGTAACA
TGTTGTGCAGCCTTGCCTTTCAGTGCTCTCTCCACATGCAGATGAACAGCATCATTACATCACC
ACATTGGATTTGACACTCCTGCCCAGAGATCCCAGATACCGTCTGTGGCCTTCGGGTTTCTTAT
CTATGGCCCCTCCTTTCAAGGACAAGTAGCTCATCATTCCCCAAAGCATCCCCCTCCAAGGTCA
GGAACTCCATATTCTGATATTGCGGTATAGTTTGCAAGACACTACTACTGGGTAGCAGGGCTCT
CTCTGTATTATTTCTTACAACAACATATGAATCTATAATTATCTCCCAAACTCGAACTCTATTT
AAAAATAGAAAGCAAAGGTTCCAATAAGGAGTCCGACTTTAAAGGGTTACTGTCTGCAGGTTTC
CAAGTACCTGCATTTGGGACTGAAAGACACAGAAACTCAGAATATCCAAACAGCAGGAGAAGAT
GACACATCCTTCTAGAAGAATTAGTGTGCAGGGATGCCCAGCTCCCTTGCCCCATGCATTAGTC
ATGATGACCTTCATTTTCTTTGGGAGAAATGTTGCCCTCCTGTCAACAAGGACTGGCCTACTTC
CATCAAAAGCCACACCCATCTGTTCTCACAGAACTGCACAGGCAGCCTGAGTGTGAAACCATGG
GCATTTGAGCATGATGGAGTTAGATGTGGGGAAAGATGCTCTTGGCACCAGTGGCTGCCTAGGA
ACGGAGAGGCCTCACCTGCCCTGAACAGGTCACTGCTAATGAGAATTGGATGTTTTCTGTATTC
TTGCACTGGTTCTCATGGCTATGACTCATGTCTGCAAAGGAATACCTGACCCACTCCTCAGGTG
TCCTTTCTCCTAAATCAGACACCACATGGGGATCAGAGGTTACAGGATCCCCAAGCTTCTGATC
TGAAGTAGAAAGGGTCCTTGGGAGACATCCCAGTAGTGCCCGCTCTTCAGCCAAGGCTGTGACT
CAGAGAAAGTAGGTCCCTTCCATGTGTGAATGTTACAAGGGAGAAGCTTGTTCTGCTCTCTCTA
AGGCTGAAGCCTGGAAGGGGCAGGGATATGAGTCAGATACATGGTTGCCTTCAAGGAGCTGTCT
GTCTTCTTGCTCTGCCCTCGACCCCATCACTACCACTGGGGTCTCTTCCTTGTGGTAAAGAACT
CAATTTGTGGGCATCCGAAATCCTGTAATATAGAAACCTTAATTTTTGTGATTCACTAAAATGA
TTTCAGGTTCCTCACTAAATCAGTGGTTCTCAACCTGTGGGTCACAACTCCTCCGGGCATTGAG
CAACCCTTTTCACATTGGAAAAGACCATTGGAAAGCACAGATATTTACATTACAATTCCTAACA
ATAGTAAAATTACAGTTATGAGGTGGCAACAAAAATAATTTTATGGTTGGGGGGTCACCACAAC
ATGAAGAACTGTACTAAGGGGTCACAGCCCTAACCTACATGCTTCACCCCAAGATTCTCCTGCT
GTCAACCACCTTGGATCAGTCGATTGCAAAGTGCATTGCTGACCGTGACAGGTGGTTGGTAAGA
ATGAGCGATGCCCTCCCTTTCCTCTTGTATTTGGAGGAATTTGAATTCTATGAAATATTTGGGA
AGATTCCACTTGAGCAGGAGCAACTGTTGTGTTCCCCACCAGTCAAGGTCTTTTCACAAGCAGA
CGAAGGAGAACCAGCCAATCCAGGCTATAAGCATGGAGAACTTCCCTAGAGTGTAGGGTAGCTG
TTTTTAAACTGCCCTTGGGTAAGGATACTGAGGTGGAAATCATGTCTTTTCTTATTTGTTCTCC
TAAAAACATGTTGGCAGAAATTCCGGATCAAGGCAGTGTGATATACATATCATAGCTGATCAAA
TATGGAACATTGATTGGACTCCAACTGTTTGGTTAAGTAGACATTAAATATATTTTCAAAAAGC
ATTCGACAGAAGCAGGAAAGATGCCTCAGTGGTTAAGGGTGTGTGTGGCTCTTGGAGACAGCCT
GAGTTTGATTCCTAGCTCACATCTGCCTGTAACTCCAGCTCCAAGGGAGTTCCATGGGCACCTG
CACTACTCATTTACACACATTCACGCATATACACACAGACACACAGACACACAGACAAACACAC
ACACACACACTTAAATAAAATATAAAACAATGAGCTTTCTCTTGGTTAATTTTTGGAAGATAAA
ATTATTTTTCACAAAATGCTTTGTAACATGTGATAGATTTATTACTTTAAAATAAAGCAATTGA
AATGAAA

hide sequence

RefSeq Acc Id:

XM_039085796 ⟹ XP_038941724

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	19,062,014 - 19,119,005 (+)	NCBI
mRatBN7.2	10	18,557,510 - 18,614,824 (+)	NCBI

RefSeq Acc Id:

XM_039085797 ⟹ XP_038941725

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	19,062,034 - 19,073,207 (+)	NCBI
mRatBN7.2	10	18,557,519 - 18,569,015 (+)	NCBI

RefSeq Acc Id:

XM_063268844 ⟹ XP_063124914

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	19,062,303 - 19,073,207 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_062146	(Get FASTA)	NCBI Sequence Viewer
	XP_006246151	(Get FASTA)	NCBI Sequence Viewer
	XP_038941724	(Get FASTA)	NCBI Sequence Viewer
	XP_038941725	(Get FASTA)	NCBI Sequence Viewer
	XP_063124914	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB96355	(Get FASTA)	NCBI Sequence Viewer
	AAD11548	(Get FASTA)	NCBI Sequence Viewer
	AAD11858	(Get FASTA)	NCBI Sequence Viewer
	ACH99100	(Get FASTA)	NCBI Sequence Viewer
	BAA33448	(Get FASTA)	NCBI Sequence Viewer
	BAB17678	(Get FASTA)	NCBI Sequence Viewer
	EDM04079	(Get FASTA)	NCBI Sequence Viewer
	EDM04080	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000007408.3
	ENSRNOP00000071161
	ENSRNOP00000071161.2
	ENSRNOP00000103628
GenBank Protein	P97678	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_062146 ⟸ NM_019273
- UniProtKB:	Q9ESK7 (UniProtKB/Swiss-Prot), O88805 (UniProtKB/Swiss-Prot), O35337 (UniProtKB/Swiss-Prot), Q9QWI7 (UniProtKB/Swiss-Prot), P97678 (UniProtKB/Swiss-Prot), A6HDH5 (UniProtKB/TrEMBL), B5U130 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGKKLVMAQKRGETRALCLGVAMVVCAAITYYILGTTVLPLYQKSVWTQESTCHLVETNIKDQE ELEGRKVPQYPCLWVNVSAVGRWAMLYHTEDTRDQNQQCSYIPRNLDNYQTALVDVKKVRANFY KHHNFYCFSAPQVNETSVVYQRLYGPQILLFSFFWPTFLLTGGLLIIAMVKLNRSLSVLAAQK hide sequence

RefSeq Acc Id:	XP_006246151 ⟸ XM_006246089
- Peptide Label:	isoform X1
- UniProtKB:	Q9ESK7 (UniProtKB/Swiss-Prot), O88805 (UniProtKB/Swiss-Prot), O35337 (UniProtKB/Swiss-Prot), Q9QWI7 (UniProtKB/Swiss-Prot), P97678 (UniProtKB/Swiss-Prot), A6HDH5 (UniProtKB/TrEMBL), B5U130 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGKKLVMAQKRGETRALCLGVAMVVCAAITYYILGTTVLPLYQKSVWTQESTCHLVETNIKDQE ELEGRKVPQYPCLWVNVSAVGRWAMLYHTEDTRDQNQQCSYIPRNLDNYQTALVDVKKVRANFY KHHNFYCFSAPQVNETSVVYQRLYGPQILLFSFFWPTFLLTGGLLIIAMVKLNRSLSVLAAQK hide sequence

Ensembl Acc Id:

ENSRNOP00000071161 ⟸ ENSRNOT00000090659

Ensembl Acc Id:

ENSRNOP00000007408 ⟸ ENSRNOT00000007408

Ensembl Acc Id:

ENSRNOP00000007393 ⟸ ENSRNOT00000007393

RefSeq Acc Id:	XP_038941724 ⟸ XM_039085796
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038941725 ⟸ XM_039085797
- Peptide Label:	isoform X3
- UniProtKB:	A6HDH4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063124914 ⟸ XM_063268844
- Peptide Label:	isoform X3
- UniProtKB:	A6HDH4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000103628 ⟸ ENSRNOT00000159821

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P97678-F1-model_v2	AlphaFold	P97678	1-191	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697097

Promoter ID:

EPDNEW_R7622

Type:

initiation region

Name:

Kcnmb1_1

Description:

potassium calcium-activated channel subfamily M regulatory betasubunit 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	18,912,187 - 18,912,247	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2961	AgrOrtholog
BioCyc Gene	G2FUF-25591	BioCyc
Ensembl Genes	ENSRNOG00000005465	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000007408.7	UniProtKB/Swiss-Prot
	ENSRNOT00000090659	ENTREZGENE
	ENSRNOT00000090659.2	UniProtKB/Swiss-Prot
	ENSRNOT00000159821	ENTREZGENE
InterPro	K_chnl_Ca-activ_BK_bsu	UniProtKB/Swiss-Prot
KEGG Report	rno:29747	UniProtKB/Swiss-Prot
NCBI Gene	29747	ENTREZGENE
PANTHER	CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-1	UniProtKB/Swiss-Prot
	PTHR10258	UniProtKB/Swiss-Prot
Pfam	CaKB	UniProtKB/Swiss-Prot
PhenoGen	Kcnmb1	PhenoGen
PRINTS	BKCHANNELB	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000005465	RatGTEx
UniProt	A6HDH4	ENTREZGENE, UniProtKB/TrEMBL
	A6HDH5	ENTREZGENE, UniProtKB/TrEMBL
	B5U130	ENTREZGENE, UniProtKB/TrEMBL
	KCMB1_RAT	UniProtKB/Swiss-Prot
	O35337	ENTREZGENE
	O88805	ENTREZGENE
	P97678	ENTREZGENE
	Q9ESK7	ENTREZGENE
	Q9QWI7	ENTREZGENE
UniProt Secondary	O35337	UniProtKB/Swiss-Prot
	O88805	UniProtKB/Swiss-Prot
	Q9ESK7	UniProtKB/Swiss-Prot
	Q9QWI7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-04-26	Kcnmb1	potassium large conductance calcium-activated channel, subfamily M, beta member 1	LOC60591	calcium-activated potassium channel beta subunit	Data merged from RGD:708570	737654	APPROVED
2002-06-10	Kcnmb1	potassium large conductance calcium-activated channel, subfamily M, beta member 1			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	expression is decreased during hypertension	1298970
gene_expression	expressed in a few discrete populations of neurons	1298969
gene_process	modulates the channel activity	1298969

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Mammalian Phenotype

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Mammalian Phenotype