Gene: Kcnmb1 (potassium large conductance calcium-activated channel, subfamily M, beta member 1)
Mus musculus
Symbol:
Kcnmb1
Name:
potassium large conductance calcium-activated channel, subfamily M, beta member 1
Description:
ENCODES a protein that exhibits calcium-activated potassium channel activity; potassium channel regulator activity (ortholog); INVOLVED IN response to calcium ion (ortholog); ASSOCIATED WITH abnormal muscle contractility; abnormal renal glomerular filtration rate; abnormal vascular smooth muscle physiology; ASSOCIATED WITH Hypertension (ortholog); Hypertension, Diastolic, Resistance to (ortholog); FOUND IN integral to membrane; voltage-gated potassium channel complex; INTERACTS WITH benzo[a]pyrene; bis(2-chloroethyl) sulfide; 17beta-estradiol (ortholog)
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
BK channel beta subunit; BK channel subunit beta-1; BKbeta; BKbeta1; calcium-activated potassium channel subunit beta; calcium-activated potassium channel subunit beta-1; calcium-activated potassium channel, subfamily M subunit beta-1; charybdotoxin receptor subunit beta-1; k(VCA)beta-1; maxi K channel subunit beta-1; OTTMUSP00000005580; slo-beta; slo-beta-1
Orthologs:
Homo sapiens : KCNMB1
(potassium large conductance calcium-activated channel, subfamily M, beta member 1)
HGNC
Rattus norvegicus : Kcnmb1
(potassium large conductance calcium-activated channel, subfamily M, beta member 1)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 11 33,963,013 - 33,973,638 + NCBI Mouse cM Map 11 + NCBI Mouse Celera Assembly 11 36,374,009 - 36,384,630 + NCBI Mouse Genome Assembly Build 37 11 33,863,013 - 33,873,638 + NCBI Mouse Genome Assembly Build 36.1 11 33,863,286 - 33,871,275 + NCBI Mouse Cytogenetic Map 11 A4 NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
17beta-estradiol increases expression ISO RGD:733456 6480464 Estradiol results in increased expression of KCNMB1 mRNA CTD PMID:15849065 5-aza-2'-deoxycytidine multiple interactions ISO RGD:733456 6480464 decitabine inhibits the reaction [Smoke results in decreased expression of KCNMB1 mRNA] CTD PMID:21095227 ammonium chloride affects expression ISO RGD:2961 6480464 Ammonium Chloride affects the expression of KCNMB1 mRNA CTD PMID:16483693 benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to KCNMB1 promoter] CTD PMID:19654925 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of KCNMB1 mRNA CTD PMID:22228805 bis(2-chloroethyl) sulfide increases expression EXP 6480464 Mustard Gas results in increased expression of KCNMB1 mRNA CTD PMID:15674843 cadmium dichloride increases methylation ISO RGD:2961 6480464 Cadmium Chloride results in increased methylation of KCNMB1 promoter CTD PMID:22457795 D-glucose multiple interactions ISO RGD:733456 6480464 Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]; more ... CTD PMID:21413024 dibutyl phthalate increases expression ISO RGD:2961 6480464 Dibutyl Phthalate results in increased expression of KCNMB1 mRNA CTD PMID:21266533 glucose multiple interactions ISO RGD:733456 6480464 Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]; more ... CTD PMID:21413024 tamoxifen multiple interactions ISO RGD:733456 6480464 [[Tamoxifen co-treated with Glucose] results in increased activity of [KCNMA1 protein binds to KCNMB1 protein]] which results in decreased expression of BCL2 protein CTD PMID:21413024 tetrachloromethane decreases expression ISO RGD:2961 6480464 Carbon Tetrachloride results in decreased expression of KCNMB1 protein CTD PMID:17229879 tetraethylammonium multiple interactions ISO RGD:733456 6480464 [Tetraethylammonium co-treated with Glucose] results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein] CTD PMID:21413024 verapamil affects response to substance ISO RGD:733456 6480464 KCNMB1 gene SNP affects the susceptibility to Verapamil CTD PMID:17700361
Biological Process
ion transport IEA UniProtKB-KW:KW-0406 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 potassium ion transport IEA InterPro:IPR003930 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 response to calcium ion ISO UniProtKB:P97678 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 transport IEA UniProtKB-KW:KW-0813 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
Cellular Component
integral to membrane IDA 2290270 MGI:MGI:2450799|PMID:12388098 MGI MGI:MGI:2450799 PMID:12388098 membrane IEA InterPro:IPR003930 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 membrane IEA UniProtKB-KW:KW-0472 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 voltage-gated potassium channel complex IGI MGI:MGI:99923 2290270 MGI:MGI:2450799|PMID:12388098 MGI MGI:MGI:2450799 PMID:12388098
Molecular Function
calcium-activated potassium channel activity IGI MGI:MGI:99923 2290270 MGI:MGI:2450799|PMID:12388098 MGI MGI:MGI:2450799 PMID:12388098 ion channel activity IEA UniProtKB-KW:KW-0407 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 potassium channel regulator activity ISO UniProtKB:P97678 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868
1301426 Desp2_m despair 2 (mouse) Not determined 11 28631256 62631375 Mouse 1357844 Si5lq5_m serum IGFBP-5 level QTL 5 (mouse) Not determined 11 28088548 62088651 Mouse 1558769 Zolw1_m zolpidem withdrawal 1 (mouse) Not determined 11 25407451 59407597 Mouse 1301283 Alcw3_m alcohol withdrawal 3 (mouse) Not determined 11 25407451 59407597 Mouse 1300579 Thypr1_m thymocyte proliferative response 1 (mouse) Not determined 11 19205252 53205390 Mouse 1301814 Bbaa7_m B.burgdorferi-associated arthritis 7 (mouse) Not determined 11 19205252 53205390 Mouse 1300607 Tnbs2_m tri-nitrobenzene sulfonic acid susceptible 2 (mouse) Not determined 11 18049231 52049355 Mouse 4142308 W6q3_m weight 6 weeks QTL 3 (mouse) Not determined 11 12218640 68423006 Mouse 1357898 Fmgty9_m femur geometry 9 (mouse) Not determined 11 11742976 45743105 Mouse 1301718 Pbw3_m pentobarbital withdrawal QTL 3 (mouse) Not determined 11 8961780 42961942 Mouse 4141047 Nilac1_m nicotine induced locomotor activity 1 (mouse) Not determined 11 8961780 42961942 Mouse 1302171 Pgia28_m proteoglycan induced arthritis 28 (mouse) Not determined 11 8856097 42856218 Mouse 1300990 Bits3_m bitterness sensitivity 3 (mouse) Not determined 11 8322121 42322260 Mouse 4141527 Brnvl1_m brain volume 1 (mouse) Not determined 11 8322121 42322260 Mouse 1300604 Mndl1_m mandible length 1 (mouse) Not determined 11 7126273 41126405 Mouse 1558772 Lith23_m lithogenic gene 23 (mouse) Not determined 11 7126273 41126405 Mouse 1301634 Eae6a_m susceptibility to experimental allergic encephalomyelitis 6a (mouse) Not determined 11 1146473 35146596 Mouse 1357842 Hipp5_m hippocampal weight 5 (mouse) Not determined 11 844334 34844436 Mouse 4141955 Hemq4_m hematocrit QTL 4 (mouse) Not determined 11 177055 34177235 Mouse 1558945 Orgwq8_m organ weight QTL 8 (mouse) Not determined 11 6178 34006316 Mouse