Bmp2 (bone morphogenetic protein 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Bmp2 (bone morphogenetic protein 2) Rattus norvegicus
Analyze
Symbol: Bmp2
Name: bone morphogenetic protein 2
RGD ID: 2211
Description: Enables growth factor activity; identical protein binding activity; and protein domain specific binding activity. Involved in several processes, including BMP signaling pathway; cardiac muscle hypertrophy in response to stress; and cellular response to mechanical stimulus. Acts upstream of or within positive regulation of neurogenesis and positive regulation of transcription by RNA polymerase II. Located in extracellular space and vesicle. Part of protein-containing complex. Biomarker of hypertension and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); hemochromatosis type 1; otosclerosis; short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1; and tooth agenesis. Orthologous to human BMP2 (bone morphogenetic protein 2); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; basal cell carcinoma pathway; Hedgehog signaling pathway; INTERACTS WITH (20S)-ginsenoside Rg3; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BMP-2; BMP-2A; bone morphogenetic protein 2A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83141,264,648 - 141,275,416 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3141,264,646 - 141,274,760 (+)EnsemblGRCr8
mRatBN7.23120,812,660 - 120,822,579 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3120,812,882 - 120,821,397 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3124,714,198 - 124,722,859 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03133,321,871 - 133,330,571 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03130,970,379 - 130,979,043 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03126,335,963 - 126,346,771 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3126,335,863 - 126,346,318 (+)Ensemblrn6Rnor6.0
Rnor_5.03132,822,005 - 132,832,789 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43121,372,692 - 121,381,236 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3119,596,986 - 119,605,358 (+)NCBICelera
RGSC_v3.13121,278,264 - 121,286,806 (+)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(20S)-ginsenoside Rg3  (EXP)
(R)-adrenaline  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methyladenine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxypsoralen  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (EXP)
acetamide  (EXP)
adenosine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
angiotensin II  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP)
atorvastatin calcium  (EXP,ISO)
aucubin  (ISO)
azadirachtin A  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
beta-D-glucosamine  (EXP)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cerivastatin  (ISO)
chloroquine  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
corn oil  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dichromium trioxide  (ISO)
Didecyldimethylammonium  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
equol  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
farnesyl diphosphate  (ISO)
ferric oxide  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
Fulvic acid  (ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
gamma-aminobutyric acid  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
ginsenoside Rb1  (EXP)
glucose  (EXP,ISO)
glycerol 2-phosphate  (EXP,ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (EXP)
Harpagoside  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
icariin  (EXP,ISO)
imperatorin  (ISO)
isoprenaline  (EXP)
kaempferol  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP,ISO)
letrozole  (ISO)
lipopolysaccharide  (EXP,ISO)
loliolide  (ISO)
losartan  (EXP)
LY294002  (ISO)
maneb  (ISO)
menaquinone  (EXP)
menaquinone-4  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mevalonic acid  (EXP,ISO)
mevastatin  (ISO)
microcystin-LR  (EXP)
mitomycin C  (ISO)
Morroniside  (EXP,ISO)
Muraglitazar  (EXP)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (EXP)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naringin  (EXP,ISO)
neohesperidin  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
octreotide  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pasireotide  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phylloquinone  (EXP)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
Rebamipide  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tadalafil  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tricetin  (ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tripotassium phosphate  (EXP)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vorinostat  (ISO)
warfarin  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
aortic valve development  (ISO)
atrioventricular canal morphogenesis  (IEA,ISO)
atrioventricular valve morphogenesis  (ISO)
BMP signaling pathway  (IBA,IDA,IEA,ISO,ISS)
bone development  (IEA,ISO)
bone mineralization  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cardiac atrium formation  (IEA,ISO)
cardiac epithelial to mesenchymal transition  (IEA,ISO)
cardiac jelly development  (IEA,ISO)
cardiac muscle cell differentiation  (IEA,ISO)
cardiac muscle hypertrophy in response to stress  (IEA,IMP)
cardiac muscle tissue morphogenesis  (ISO)
cardiocyte differentiation  (ISO)
cartilage development  (IEA)
cell differentiation  (IEA)
cell fate commitment  (ISO)
cellular response to BMP stimulus  (IEA,IEP,ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (IEP)
chondrocyte differentiation  (IEA,ISO)
corticotropin hormone secreting cell differentiation  (ISO)
embryonic heart tube anterior/posterior pattern specification  (ISO)
endocardial cushion formation  (IEA,ISO)
endocardial cushion morphogenesis  (ISO)
endodermal-mesodermal cell signaling  (IEA,ISO)
epithelial to mesenchymal transition  (IEA,ISO,ISS)
gene expression  (IEA,ISO)
heart development  (IEA,ISO,ISS)
heart induction  (IEA,ISO,ISS)
heart morphogenesis  (IBA)
in utero embryonic development  (ISO)
inflammatory response  (IEA,ISO)
inner ear development  (ISO)
intracellular iron ion homeostasis  (IEA,ISO)
lung vasculature development  (IEA,ISO,ISS)
mesenchymal cell differentiation  (IEA,ISO,ISS)
mesenchymal cell proliferation involved in ureteric bud development  (IEA,ISO)
mesenchyme development  (IEA,ISO)
negative regulation of aldosterone biosynthetic process  (IEA,ISO)
negative regulation of calcium-independent cell-cell adhesion  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cardiac muscle cell differentiation  (IEA,ISO,ISS)
negative regulation of cell cycle  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of cortisol biosynthetic process  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO,ISS)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of insulin-like growth factor receptor signaling pathway  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (IEA,ISO)
negative regulation of steroid biosynthetic process  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
Notch signaling pathway  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
ossification  (IEA)
osteoblast differentiation  (IBA,ISO)
osteoclast differentiation  (IEA,ISO)
ovulation cycle  (IEP)
pericardium development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of astrocyte differentiation  (ISO)
positive regulation of bone mineralization  (IEA,ISO,ISS)
positive regulation of bone mineralization involved in bone maturation  (IEA,ISO,ISS)
positive regulation of cartilage development  (ISO)
positive regulation of cell differentiation  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of extracellular matrix constituent secretion  (IEA,ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of multicellular organismal process  (IEA)
positive regulation of neurogenesis  (IDA)
positive regulation of neuron differentiation  (ISO)
positive regulation of odontoblast differentiation  (IEA,ISO,ISS)
positive regulation of odontogenesis  (ISO)
positive regulation of ossification  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of osteoblast proliferation  (IEA,ISO)
positive regulation of p38MAPK cascade  (IEA,ISO)
positive regulation of peroxisome proliferator activated receptor signaling pathway  (ISO)
positive regulation of phosphatase activity  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO,ISS)
positive regulation of Wnt signaling pathway  (ISO)
protein destabilization  (ISO)
proteoglycan metabolic process  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of multicellular organismal development  (IEA)
regulation of odontogenesis of dentin-containing tooth  (ISO)
response to bacterium  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (IEP)
response to retinoic acid  (IEP)
telencephalon development  (ISO)
telencephalon regionalization  (ISO)
thyroid-stimulating hormone-secreting cell differentiation  (ISO)

Cellular Component
BMP receptor complex  (IEA,ISO)
cell surface  (IEA,ISO,ISS)
extracellular region  (IEA,ISO)
extracellular space  (IBA,IDA,IEA,ISO)
plasma membrane  (IEA,ISO)
protein-containing complex  (IDA,IEA,ISO)
vesicle  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Enhancement of bone repair with a helper-dependent adenoviral transfer of bone morphogenetic protein-2. Abe N, etal., Biochem Biophys Res Commun 2002 Sep 27;297(3):523-7.
2. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
3. Bone morphogenetic protein-2 and -4 limit the number of enteric neurons but promote development of a TrkC-expressing neurotrophin-3-dependent subset. Chalazonitis A, etal., J Neurosci 2004 Apr 28;24(17):4266-82.
4. Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer. Doak SH, etal., Cancer Genet Cytogenet. 2007 Jul 15;176(2):161-5.
5. Effect of stretching stress on gene transcription related to early-phase differentiation in rat periodontal ligament cells. Enokiya Y, etal., Bull Tokyo Dent Coll. 2010;51(3):129-37.
6. Recombinant bone morphogenetic protein (BMP)-2 regulates costochondral growth plate chondrocytes and induces expression of BMP-2 and BMP-4 in a cell maturation-dependent manner. Erickson DM, etal., J Orthop Res. 1997 May;15(3):371-80.
7. Analysis of spatial and temporal expression patterns of bone morphogenetic protein family members in the rat uterus over the estrous cycle. Erickson GF, etal., J Endocrinol. 2004 Aug;182(2):203-17.
8. Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): comparison of the structures and promoter regions of BMP-2 and BMP-4 genes. Feng JQ, etal., Biochim Biophys Acta 1994 Jun 21;1218(2):221-4.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells. Gazit D, etal., Mol Endocrinol. 1993 Feb;7(2):189-98.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Horvath LG, etal., Prostate. 2004 May 15;59(3):234-42.
13. Fibrodysplasia ossificans progressiva: a clue from the fly? Kaplan FS, etal., Calcif Tissue Int 1990 Aug;47(2):117-25.
14. Synergistic effect of fibroblast growth factor-4 in ectopic bone formation induced by bone morphogenetic protein-2. Kubota K, etal., Bone 2002 Oct;31(4):465-71.
15. BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression. Lee MH, etal., J Biol Chem 2003 Sep 5;278(36):34387-94. Epub 2003 Jun 18.
16. Zhonghua nan ke xue = National journal of andrology Li ZL, etal., Zhonghua Nan Ke Xue. 2006 Feb;12(2):126-8, 132.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Phenotype characterization and sequence analysis of BMP2 and BMP4 variants in two Mexican families with oligodontia. Mu Y, etal., Genet Mol Res. 2012 Nov 28;11(4):4110-20. doi: 10.4238/2012.September.25.5.
19. Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins. Nahar NN, etal., J Bone Miner Metab. 2008;26(5):514-9. Epub 2008 Aug 30.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Expression of bone morphogenic proteins and receptors at the injured growth plate cartilage in young rats. Ngo TQ, etal., J Histochem Cytochem. 2006 Aug;54(8):945-54. Epub 2006 May 1.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord. Sandner B, etal., Stem Cell Res. 2013 Sep;11(2):758-71. doi: 10.1016/j.scr.2013.05.003. Epub 2013 May 16.
29. Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis. Sato M, etal., J Bone Miner Res. 1999 Jul;14(7):1084-95.
30. Association of bone morphogenetic proteins with otosclerosis. Schrauwen I, etal., J Bone Miner Res. 2008 Apr;23(4):507-16.
31. Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Shah NM, etal., Cell. 1996 May 3;85(3):331-43.
32. BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Shahid M, etal., Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. doi: 10.1152/ajpheart.00879.2015. Epub 2016 Feb 12.
33. Localization of bone morphogenetic proteins (BMPs)-2, -4, and -6 within megakaryocytes and platelets. Sipe JB, etal., Bone. 2004 Dec;35(6):1316-22.
34. Matrix Gla protein (MGP) and bone morphogenetic protein-2 in aortic calcified lesions of aging rats. Sweatt A, etal., J Thromb Haemost. 2003 Jan;1(1):178-85.
35. Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Takahashi H, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L450-8. Epub 2005 Dec 16.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Valdes AM, etal., Arthritis Rheum. 2004 Aug;50(8):2497-507.
38. Icariin Restores Bone Structure and Strength in a Rat Model of Chronic High-Dose Alcohol-Induced Osteopenia. Wu JZ, etal., Cell Physiol Biochem. 2018;46(4):1727-1736. doi: 10.1159/000489248. Epub 2018 Apr 23.
39. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. Xiong DH, etal., J Bone Miner Res. 2006 Nov;21(11):1678-95.
Additional References at PubMed
PMID:1468569   PMID:3201241   PMID:7811286   PMID:7848824   PMID:8653785   PMID:8769660   PMID:8898212   PMID:9187146   PMID:9213002   PMID:9244299   PMID:9463347   PMID:9585504  
PMID:9693150   PMID:9769173   PMID:9786991   PMID:10391928   PMID:10486560   PMID:10684250   PMID:11502704   PMID:11719201   PMID:12151307   PMID:12421925   PMID:12782312   PMID:14623234  
PMID:14627707   PMID:15110716   PMID:15150273   PMID:15175325   PMID:15254224   PMID:15322112   PMID:15358784   PMID:15383550   PMID:15525533   PMID:15565649   PMID:15657444   PMID:15671031  
PMID:15695507   PMID:15820682   PMID:15851600   PMID:15882580   PMID:15886483   PMID:15925496   PMID:15975920   PMID:16049014   PMID:16099986   PMID:16109715   PMID:16194878   PMID:16243309  
PMID:16314491   PMID:16433617   PMID:16604073   PMID:16935278   PMID:16996588   PMID:17001659   PMID:17158861   PMID:17171790   PMID:17202865   PMID:17244894   PMID:17415742   PMID:17472960  
PMID:17473173   PMID:17953369   PMID:17992660   PMID:18070548   PMID:18184661   PMID:18295562   PMID:18313401   PMID:18326817   PMID:18335997   PMID:18380969   PMID:18436533   PMID:18545679  
PMID:18600149   PMID:18832104   PMID:19103752   PMID:19208758   PMID:19213727   PMID:19584291   PMID:19617624   PMID:19664780   PMID:19669850   PMID:19736317   PMID:19852960   PMID:20019778  
PMID:20042692   PMID:20048761   PMID:20065295   PMID:20576608   PMID:20675382   PMID:20843790   PMID:20882582   PMID:20886619   PMID:20890042   PMID:20926379   PMID:20936960   PMID:20939479  
PMID:21043834   PMID:21049555   PMID:21145505   PMID:21157119   PMID:21311046   PMID:21324897   PMID:21350216   PMID:21415150   PMID:21520255   PMID:21590708   PMID:21592969   PMID:21624478  
PMID:21636885   PMID:21737358   PMID:21795542   PMID:21873793   PMID:22227436   PMID:22363399   PMID:22450430   PMID:22508088   PMID:22540193   PMID:22556155   PMID:22579779   PMID:22674456  
PMID:22705305   PMID:22829700   PMID:22861354   PMID:22994418   PMID:23010719   PMID:23012479   PMID:23088504   PMID:23238867   PMID:23359400   PMID:23447035   PMID:23620751   PMID:23632743  
PMID:23821199   PMID:23822814   PMID:24111806   PMID:24167632   PMID:24306516   PMID:24406215   PMID:24416413   PMID:24464097   PMID:24648278   PMID:24682653   PMID:24866243   PMID:25100727  
PMID:25218476   PMID:25446167   PMID:25659106   PMID:25677945   PMID:25725805   PMID:25823394   PMID:25896232   PMID:26308798   PMID:26345843   PMID:26352281   PMID:26404484   PMID:26763079  
PMID:26772960   PMID:26797522   PMID:26931551   PMID:27178636   PMID:27477499   PMID:27771997   PMID:27885436   PMID:28124060   PMID:28256809   PMID:28457943   PMID:28595186   PMID:28642034  
PMID:29785051   PMID:29850574   PMID:30700748   PMID:30937700   PMID:31002144   PMID:31432121   PMID:31694396   PMID:31737960   PMID:31746352   PMID:32131378   PMID:32830897   PMID:34266353  
PMID:35594008   PMID:35981926   PMID:36421043   PMID:36613483   PMID:37331163   PMID:38063098  


Genomics

Comparative Map Data
Bmp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83141,264,648 - 141,275,416 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3141,264,646 - 141,274,760 (+)EnsemblGRCr8
mRatBN7.23120,812,660 - 120,822,579 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3120,812,882 - 120,821,397 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3124,714,198 - 124,722,859 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03133,321,871 - 133,330,571 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03130,970,379 - 130,979,043 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03126,335,963 - 126,346,771 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3126,335,863 - 126,346,318 (+)Ensemblrn6Rnor6.0
Rnor_5.03132,822,005 - 132,832,789 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43121,372,692 - 121,381,236 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3119,596,986 - 119,605,358 (+)NCBICelera
RGSC_v3.13121,278,264 - 121,286,806 (+)NCBI
Cytogenetic Map3q36NCBI
BMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38206,767,686 - 6,780,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl206,767,686 - 6,780,251 (+)Ensemblhg38GRCh38
GRCh37206,748,333 - 6,760,893 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36206,696,745 - 6,708,910 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34206,697,206 - 6,707,769NCBI
Celera206,819,903 - 6,832,070 (+)NCBICelera
Cytogenetic Map20p12.3NCBI
HuRef206,705,637 - 6,717,811 (+)NCBIHuRef
CHM1_1206,748,804 - 6,760,970 (+)NCBICHM1_1
T2T-CHM13v2.0206,808,871 - 6,821,444 (+)NCBIT2T-CHM13v2.0
Bmp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392133,394,079 - 133,404,816 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2133,394,079 - 133,404,805 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382133,552,159 - 133,562,896 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2133,552,159 - 133,562,885 (+)Ensemblmm10GRCm38
MGSCv372133,378,935 - 133,388,621 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362133,244,640 - 133,254,326 (+)NCBIMGSCv36mm8
Celera2134,774,971 - 134,784,597 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map265.21NCBI
Bmp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541517,048,030 - 17,060,181 (+)Ensembl
ChiLan1.0NW_00495541517,048,374 - 17,058,172 (+)NCBIChiLan1.0ChiLan1.0
BMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2217,692,819 - 7,704,331 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1207,689,639 - 7,701,158 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0206,765,161 - 6,777,728 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1206,546,173 - 6,558,627 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl206,546,173 - 6,558,610 (+)EnsemblpanPan2panpan1.1
BMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12415,199,667 - 15,211,509 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2415,200,291 - 15,212,217 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2415,022,880 - 15,034,779 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02415,603,929 - 15,615,829 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2415,603,981 - 15,615,810 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12415,210,353 - 15,222,261 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02415,320,936 - 15,332,831 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02415,650,158 - 15,662,056 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bmp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640163,997,168 - 164,008,273 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648512,428,710 - 12,439,454 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648512,428,765 - 12,439,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1715,749,835 - 15,761,195 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11715,750,487 - 15,762,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21717,052,609 - 17,064,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1231,349,394 - 31,361,227 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl231,348,808 - 31,360,901 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607113,190,629 - 13,202,875 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247417,706,236 - 7,719,484 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247417,706,205 - 7,717,677 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bmp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15113,267,883 - 113,277,716 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bmp2
56 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:85
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000028904, ENSRNOT00000073728
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH131457  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23120,821,085 - 120,821,279 (+)MAPPERmRatBN7.2
Rnor_6.03126,344,388 - 126,344,581NCBIRnor6.0
Rnor_5.03132,830,406 - 132,830,599UniSTSRnor5.0
RGSC_v3.43121,380,922 - 121,381,115UniSTSRGSC3.4
Celera3119,605,044 - 119,605,237UniSTS
RH 3.4 Map31052.5UniSTS
Cytogenetic Map3q36UniSTS
UniSTS:464654  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23120,820,845 - 120,820,970 (+)MAPPERmRatBN7.2
Rnor_6.03126,344,148 - 126,344,272NCBIRnor6.0
Rnor_5.03132,830,166 - 132,830,290UniSTSRnor5.0
RGSC_v3.43121,380,682 - 121,380,806UniSTSRGSC3.4
Celera3119,604,804 - 119,604,928UniSTS
Cytogenetic Map3q36UniSTS
UniSTS:496639  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23120,820,783 - 120,821,024 (+)MAPPERmRatBN7.2
Rnor_6.03126,344,086 - 126,344,326NCBIRnor6.0
Rnor_5.03132,830,104 - 132,830,344UniSTSRnor5.0
RGSC_v3.43121,380,620 - 121,380,860UniSTSRGSC3.4
Celera3119,604,742 - 119,604,982UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 56 59 6 319 156 11 140 80 91 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028904   ⟹   ENSRNOP00000028904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3126,335,863 - 126,346,318 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108290   ⟹   ENSRNOP00000081600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3141,264,646 - 141,274,760 (+)Ensembl
mRatBN7.2 Ensembl3120,812,882 - 120,821,397 (+)Ensembl
RefSeq Acc Id: NM_017178   ⟹   NP_058874
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83141,265,524 - 141,274,237 (+)NCBI
mRatBN7.23120,812,687 - 120,821,400 (+)NCBI
Rnor_6.03126,336,185 - 126,344,702 (+)NCBI
Rnor_5.03132,822,005 - 132,832,789 (+)NCBI
RGSC_v3.43121,372,692 - 121,381,236 (+)RGD
Celera3119,596,986 - 119,605,358 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104435   ⟹   XP_038960363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83141,264,648 - 141,275,416 (+)NCBI
mRatBN7.23120,812,660 - 120,822,579 (+)NCBI
Protein Sequences
Protein RefSeqs NP_058874 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960363 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA81088 (Get FASTA)   NCBI Sequence Viewer  
  EDL80282 (Get FASTA)   NCBI Sequence Viewer  
  EDL80283 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000081600
GenBank Protein P49001 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058874   ⟸   NM_017178
- Peptide Label: precursor
- UniProtKB: P49001 (UniProtKB/Swiss-Prot),   G3V8W4 (UniProtKB/TrEMBL),   A6HQI1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028904   ⟸   ENSRNOT00000028904
RefSeq Acc Id: XP_038960363   ⟸   XM_039104435
- Peptide Label: isoform X1
- UniProtKB: P49001 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000081600   ⟸   ENSRNOT00000108290
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49001-F1-model_v2 AlphaFold P49001 1-393 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692461
Promoter ID:EPDNEW_R2984
Type:single initiation site
Name:Bmp2_1
Description:bone morphogenetic protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03126,335,794 - 126,335,854EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2211 AgrOrtholog
BioCyc Gene G2FUF-47749 BioCyc
Ensembl Genes ENSRNOG00000021276 Ensembl
  ENSRNOG00000071010 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000108290 ENTREZGENE
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
  2.60.120.970 UniProtKB/Swiss-Prot
InterPro BMP2_TGF_beta-like UniProtKB/Swiss-Prot
  Cystine-knot_cytokine UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGF-b_propeptide UniProtKB/Swiss-Prot
  TGF-beta-rel UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report rno:29373 UniProtKB/Swiss-Prot
NCBI Gene 29373 ENTREZGENE
PANTHER BONE MORPHOGENETIC PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR11848 UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
  TGFb_propeptide UniProtKB/Swiss-Prot
PhenoGen Bmp2 PhenoGen
PRINTS INHIBINA UniProtKB/Swiss-Prot
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021276 RatGTEx
  ENSRNOG00000071010 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
TIGR TC217827
UniProt A6HQI1 ENTREZGENE, UniProtKB/TrEMBL
  A6HQI2_RAT UniProtKB/TrEMBL
  BMP2_RAT UniProtKB/Swiss-Prot
  G3V8W4 ENTREZGENE, UniProtKB/TrEMBL
  P49001 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Bmp2  bone morphogenetic protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in spleen 69777
gene_function growth factor 631753
gene_homology has 90% identity to human protein 69777
gene_process induces ectopic bone formation 631753
gene_product member of the transforming growth factor beta superfamily 69777
gene_transcript transcript has 3 exons 69777
gene_transcript 11kb 69777