Bmp2 (bone morphogenetic protein 2) - Rat Genome Database

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Gene: Bmp2 (bone morphogenetic protein 2) Chinchilla lanigera
Analyze
Symbol: Bmp2
Name: bone morphogenetic protein 2
RGD ID: 8924655
Description: ENCODES a protein that exhibits BMP receptor binding (ortholog); co-receptor binding (ortholog); cytokine activity (ortholog); INVOLVED IN ameloblast differentiation (ortholog); animal organ morphogenesis (ortholog); aortic valve development (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH atrial heart septal defect 1 (ortholog); bone disease (ortholog); Bone Fractures (ortholog); FOUND IN BMP receptor complex (ortholog); cell surface (ortholog); extracellular region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541517,048,030 - 17,060,181 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541517,048,374 - 17,058,172 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ameloblast differentiation  (ISO)
animal organ morphogenesis  (ISO)
aortic valve development  (ISO)
astrocyte differentiation  (ISO)
atrioventricular canal morphogenesis  (ISO)
atrioventricular valve morphogenesis  (ISO)
BMP signaling pathway  (ISO)
bone development  (ISO)
bone mineralization  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cardiac atrium formation  (ISO)
cardiac epithelial to mesenchymal transition  (ISO)
cardiac jelly development  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac muscle tissue morphogenesis  (ISO)
cardiocyte differentiation  (ISO)
cell fate commitment  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
chondrocyte differentiation  (ISO)
corticotropin hormone secreting cell differentiation  (ISO)
embryonic heart tube anterior/posterior pattern specification  (ISO)
endocardial cushion formation  (ISO)
endocardial cushion morphogenesis  (ISO)
endodermal-mesodermal cell signaling  (ISO)
epithelial to mesenchymal transition  (ISO)
gene expression  (ISO)
heart development  (ISO)
heart induction  (ISO)
in utero embryonic development  (ISO)
inflammatory response  (ISO)
inner ear development  (ISO)
lung vasculature development  (ISO)
mesenchymal cell differentiation  (ISO)
mesenchymal cell proliferation involved in ureteric bud development  (ISO)
mesenchyme development  (ISO)
negative regulation of aldosterone biosynthetic process  (ISO)
negative regulation of calcium-independent cell-cell adhesion  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle cell differentiation  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cortisol biosynthetic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of insulin-like growth factor receptor signaling pathway  (ISO)
negative regulation of muscle cell differentiation  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of steroid biosynthetic process  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
Notch signaling pathway  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
osteoblast differentiation  (ISO)
osteoclast differentiation  (ISO)
ovulation cycle  (ISO)
pericardium development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of astrocyte differentiation  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of bone mineralization involved in bone maturation  (ISO)
positive regulation of cartilage development  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell differentiation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of extracellular matrix constituent secretion  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of odontoblast differentiation  (ISO)
positive regulation of odontogenesis  (ISO)
positive regulation of ossification  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of peroxisome proliferator activated receptor signaling pathway  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of Wnt signaling pathway  (ISO)
protein destabilization  (ISO)
proteoglycan metabolic process  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of odontogenesis of dentin-containing tooth  (ISO)
response to bacterium  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (ISO)
response to retinoic acid  (ISO)
telencephalon development  (ISO)
telencephalon regionalization  (ISO)
thyroid-stimulating hormone-secreting cell differentiation  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Bmp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541517,048,030 - 17,060,181 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541517,048,374 - 17,058,172 (+)NCBIChiLan1.0ChiLan1.0
BMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38206,767,686 - 6,780,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl206,767,686 - 6,780,246 (+)EnsemblGRCh38hg38GRCh38
GRCh37206,748,333 - 6,760,893 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36206,696,745 - 6,708,910 (+)NCBINCBI36Build 36hg18NCBI36
Build 34206,697,206 - 6,707,769NCBI
Celera206,819,903 - 6,832,070 (+)NCBICelera
Cytogenetic Map20p12.3NCBI
HuRef206,705,637 - 6,717,811 (+)NCBIHuRef
CHM1_1206,748,804 - 6,760,970 (+)NCBICHM1_1
T2T-CHM13v2.0206,808,871 - 6,821,444 (+)NCBIT2T-CHM13v2.0
Bmp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392133,394,079 - 133,404,816 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2133,394,079 - 133,404,805 (+)EnsemblGRCm39 Ensembl
GRCm382133,552,159 - 133,562,896 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2133,552,159 - 133,562,885 (+)EnsemblGRCm38mm10GRCm38
MGSCv372133,378,935 - 133,388,621 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362133,244,640 - 133,254,326 (+)NCBIMGSCv36mm8
Celera2134,774,971 - 134,784,597 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map265.21NCBI
Bmp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83141,264,648 - 141,275,416 (+)NCBIGRCr8
mRatBN7.23120,812,660 - 120,822,579 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3120,812,882 - 120,821,397 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3124,714,198 - 124,722,859 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03133,321,871 - 133,330,571 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03130,970,379 - 130,979,043 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03126,335,963 - 126,346,771 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3126,335,863 - 126,346,318 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03132,822,005 - 132,832,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43121,372,692 - 121,381,236 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13121,278,264 - 121,286,806 (+)NCBI
Celera3119,596,986 - 119,605,358 (+)NCBICelera
Cytogenetic Map3q36NCBI
BMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2217,692,819 - 7,704,331 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1207,689,639 - 7,701,158 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0206,765,161 - 6,777,728 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1206,546,173 - 6,558,627 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl206,546,173 - 6,558,610 (+)Ensemblpanpan1.1panPan2
BMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12415,199,667 - 15,211,509 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2415,200,291 - 15,212,217 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2415,022,880 - 15,034,779 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02415,603,929 - 15,615,829 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2415,603,981 - 15,615,810 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12415,210,353 - 15,222,261 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02415,320,936 - 15,332,831 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02415,650,158 - 15,662,056 (-)NCBIUU_Cfam_GSD_1.0
Bmp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640163,997,168 - 164,008,273 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648512,428,710 - 12,439,454 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648512,428,765 - 12,439,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1715,749,835 - 15,761,195 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11715,750,487 - 15,762,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21717,052,609 - 17,064,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1231,349,394 - 31,361,227 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl231,348,808 - 31,360,901 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607113,190,629 - 13,202,875 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247417,706,236 - 7,719,484 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247417,706,205 - 7,717,677 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005380857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01016408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCLAT00000021561   ⟹   ENSCLAP00000021358
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541517,048,030 - 17,060,181 (+)Ensembl
RefSeq Acc Id: XM_005380857   ⟹   XP_005380914
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541517,048,374 - 17,058,172 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005380914 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000021358
  ENSCLAP00000021358.1
RefSeq Acc Id: XP_005380914   ⟸   XM_005380857
- UniProtKB: A0A8C2W083 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000021358   ⟸   ENSCLAT00000021561
Protein Domains
TGF-beta family profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014626 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021561 ENTREZGENE
  ENSCLAT00000021561.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/TrEMBL
InterPro BMP2_TGF_beta-like UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
NCBI Gene Bmp2 ENTREZGENE
PANTHER BONE MORPHOGENETIC PROTEIN 2 UniProtKB/TrEMBL
  PTHR11848 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A8C2W083 ENTREZGENE, UniProtKB/TrEMBL