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Gene: Apobec1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1) Rattus norvegicus

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Symbol:

Apobec1

Name:

apolipoprotein B mRNA editing enzyme catalytic subunit 1

RGD ID:

2133

Description:

Enables several functions, including cytidine deaminase activity; enzyme activator activity; and ribonucleoprotein complex binding activity. Involved in several processes, including DNA cytosine deamination; RNA modification; and positive regulation of mRNA modification. Predicted to be part of apolipoprotein B mRNA editing enzyme complex. Predicted to be active in cytoplasm and nucleus. Used to study familial hyperlipidemia and liver benign neoplasm. Biomarker of colon cancer and obesity. Orthologous to human APOBEC1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1); PARTICIPATES IN lipoprotein metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

apobec-1; apolipoprotein B editing complex 1; Apolipoprotein B editing protein; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; apolipoprotein B mRNA-editing enzyme 1; C->U-editing enzyme APOBEC-1; mRNA(cytosine(6666)) deaminase 1; REPR

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	157,472,879 - 157,500,496 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	157,472,868 - 157,498,909 (-)	Ensembl				GRCr8
mRatBN7.2	4	155,800,030 - 155,828,515 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	155,800,887 - 155,827,390 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	162,064,076 - 162,078,798 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	157,847,296 - 157,862,008 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	156,493,855 - 156,508,527 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	155,386,367 - 155,414,034 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	155,386,711 - 155,401,480 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	222,409,798 - 222,438,051 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	159,033,170 - 159,048,108 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	144,620,263 - 144,634,783 (-)	NCBI		Celera
RGSC_v3.1	4	159,278,107 - 159,293,044 (-)	NCBI
Cytogenetic Map	4	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

colon cancer (IEP)

Experimental Liver Cirrhosis (ISO)

familial hyperlipidemia (IDA)

liver benign neoplasm (IMP)

obesity (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

4,4'-diaminodiphenylmethane (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (ISO)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

aconitine (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

Butylbenzyl phthalate (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

cisplatin (ISO)

clofibric acid (EXP)

Cuprizon (EXP)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

diiodine (ISO)

diuron (EXP)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

flutamide (EXP)

folic acid (ISO)

glycidol (EXP)

kojic acid (ISO)

lead diacetate (EXP)

lidocaine (EXP)

N-nitrosodimethylamine (EXP)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

perfluorobutanesulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (EXP)

pirinixic acid (EXP,ISO)

pregnenolone 16alpha-carbonitrile (EXP)

propiconazole (ISO)

sodium arsenite (ISO)

Soman (EXP)

succimer (ISO)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

triptonide (ISO)

tungsten (ISO)

valproic acid (ISO)

zearalenone (EXP)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to insulin stimulus (IEP)

cytidine metabolic process (IC)

cytidine to uridine editing (IBA,IDA,IEA,ISO)

defense response to virus (IDA)

DNA cytosine deamination (IDA)

lipoprotein biosynthetic process (ISO)

lipoprotein metabolic process (ISO)

lipoprotein transport (ISO)

mRNA modification (IDA,IEA,ISO)

mRNA processing (IEA)

mRNA stabilization (ISO)

negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (IEA,ISO)

negative regulation of triglyceride metabolic process (ISO)

positive regulation of gene expression via chromosomal CpG island demethylation (IEA,ISO,ISS)

positive regulation of macromolecule metabolic process (IEA)

positive regulation of mRNA modification (IDA)

regulation of cell population proliferation (ISO)

regulation of mRNA metabolic process (IEA)

response to calcium ion (IDA)

response to ethanol (IDA)

response to gamma radiation (ISO)

response to xenobiotic stimulus (IDA)

response to zinc ion (IEP)

triglyceride metabolic process (ISO)

Cellular Component

apolipoprotein B mRNA editing enzyme complex (IEA,ISO)

cytoplasm (IBA,IEA,ISO,ISS)

nucleus (IBA,IEA,ISO,NAS)

Molecular Function

catalytic activity (IEA)

cytidine deaminase activity (IBA,IDA,NAS)

cytosine deaminase activity (IDA)

enzyme activator activity (IDA)

hydrolase activity (IEA)

metal ion binding (IEA)

mRNA 3'-UTR AU-rich region binding (IEA,ISO)

mRNA binding (IDA,IEA)

protein binding (IPI,ISO)

protein domain specific binding (IPI)

ribonucleoprotein complex binding (IPI)

RNA binding (IBA,NAS)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

lipoprotein metabolic pathway (ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Apobec-1 transcription in rat colon cancer: decreased apobec-1 protein production through alterations in polysome distribution and mRNA translation associated with upstream AUGs.	Anant S, etal., Biochim Biophys Acta 2002 May 3;1575(1-3):54-62.
2.	Cytidine deamination of retroviral DNA by diverse APOBEC proteins.	Bishop KN, etal., Curr Biol. 2004 Aug 10;14(15):1392-6.
3.	Calcium increases apolipoprotein B mRNA editing.	Chen Z, etal., Biochem Biophys Res Commun. 2000 Oct 14;277(1):221-7.
4.	SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors.	Corella D and Ordovas JM, Annu Rev Nutr. 2005;25:341-90.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	Inhibition of the apolipoprotein B mRNA editing enzyme-complex by hnRNP C1 protein and 40S hnRNP complexes.	Greeve J, etal., Biol Chem. 1998 Aug-Sep;379(8-9):1063-73.
8.	Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex.	Lellek H, etal., J Biol Chem. 2000 Jun 30;275(26):19848-56.
9.	Acute modulation of the extent of apoB mRNA editing and the relative rates of syntheses of apoB48 and apoB100 in cultured rat hepatocytes by osmotic and other stress stimuli.	McCahill A, etal., Mol Cell Biochem. 2000 May;208(1-2):77-87.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming.	Morgan HD, etal., J Biol Chem. 2004 Dec 10;279(50):52353-60. Epub 2004 Sep 24.
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1).	Petersen-Mahrt SK and Neuberger MS, J Biol Chem 2003 May 30;278(22):19583-6. Epub 2003 Apr 14.
14.	Regulation of hepatic apolipoprotein B RNA editing in the genetically obese Zucker rat.	Phung TL, etal., Metabolism. 1996 Sep;45(9):1056-8.
15.	Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors.	Qian X, etal., Arterioscler Thromb Vasc Biol. 1998 Jun;18(6):1013-20.
16.	Plasma apolipoprotein B-48, hepatic apolipoprotein B mRNA editing and apolipoprotein B mRNA editing catalytic subunit-1 mRNA levels are altered in zinc-deficient rats.	Reaves SK, etal., J Nutr. 1999 Oct;129(10):1855-61.
17.	GOA pipeline	RGD automated data pipeline
18.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	Molecular cloning of an apolipoprotein B messenger RNA editing protein.	Teng B, etal., Science 1993 Jun 18;260(5115):1816-9.
21.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22.	Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells.	Van Mater D, etal., Biochem Biophys Res Commun. 1998 Nov 18;252(2):334-9.
23.	Insulin increases expression of apobec-1, the catalytic subunit of the apolipoprotein B mRNA editing complex in rat hepatocytes.	von Wronski MA, etal., Metabolism. 1998 Jul;47(7):869-73.
24.	Effects of a thyromimetic on apolipoprotein B-100 in rats.	Wada Y, etal., J Mol Endocrinol. 2000 Dec;25(3):299-308.
25.	Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing.	Yang Y, etal., Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13075-80.

Additional References at PubMed

PMID:8626621	PMID:8692961	PMID:9240444	PMID:10403781	PMID:12477932	PMID:13130124	PMID:15286366	PMID:15480992	PMID:15489334	PMID:15963568	PMID:17875695	PMID:21496894
PMID:21775448	PMID:22326345	PMID:22580899	PMID:23609497	PMID:24916387	PMID:25085003	PMID:29553573

Genomics

Comparative Map Data

Apobec1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	157,472,879 - 157,500,496 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	157,472,868 - 157,498,909 (-)	Ensembl				GRCr8
mRatBN7.2	4	155,800,030 - 155,828,515 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	155,800,887 - 155,827,390 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	162,064,076 - 162,078,798 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	157,847,296 - 157,862,008 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	156,493,855 - 156,508,527 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	155,386,367 - 155,414,034 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	155,386,711 - 155,401,480 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	222,409,798 - 222,438,051 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	159,033,170 - 159,048,108 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	144,620,263 - 144,634,783 (-)	NCBI		Celera
RGSC_v3.1	4	159,278,107 - 159,293,044 (-)	NCBI
Cytogenetic Map	4	q42	NCBI

APOBEC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	7,649,400 - 7,670,599 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	7,649,400 - 7,665,908 (-)	Ensembl			hg38	GRCh38
GRCh37	12	7,801,996 - 7,823,195 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	7,693,263 - 7,709,769 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	7,693,263 - 7,709,765	NCBI
Celera	12	9,377,416 - 9,393,928 (-)	NCBI		Celera
Cytogenetic Map	12	p13.31	NCBI
HuRef	12	7,615,551 - 7,632,073 (-)	NCBI		HuRef
CHM1_1	12	7,801,108 - 7,817,585 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	7,663,658 - 7,684,886 (-)	NCBI		T2T-CHM13v2.0

Apobec1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	122,554,755 - 122,580,068 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	122,554,751 - 122,579,403 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	122,577,792 - 122,603,024 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	122,577,792 - 122,602,444 (-)	Ensembl			mm10	GRCm38
MGSCv37	6	122,527,810 - 122,552,462 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	122,543,411 - 122,568,063 (-)	NCBI		MGSCv36	mm8
Celera	6	124,372,038 - 124,397,549 (-)	NCBI		Celera
Cytogenetic Map	6	F1	NCBI
cM Map	6	57.68	NCBI

Apobec1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	6,471,953 - 6,480,469 (-)	Ensembl
ChiLan1.0	NW_004955413	6,471,933 - 6,480,475 (-)	NCBI	ChiLan1.0	ChiLan1.0

APOBEC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	13,212,602 - 13,225,890 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	13,209,214 - 13,223,660 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	7,777,734 - 7,793,960 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	7,939,115 - 7,950,315 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	7,939,262 - 7,944,203 (-)	Ensembl			panPan2	panpan1.1

APOBEC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	37,102,728 - 37,114,084 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	37,103,016 - 37,114,556 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	9,502,214 - 9,513,600 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	37,452,077 - 37,463,466 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	37,452,249 - 37,463,777 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	37,333,157 - 37,344,537 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	37,368,031 - 37,379,426 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	8,988,480 - 8,999,873 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Apobec1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	98,775,264 - 98,783,978 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004939393	628 - 6,201 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004939393	628 - 6,234 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

APOBEC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	62,810,879 - 62,820,173 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	62,811,819 - 62,820,532 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	65,642,017 - 65,650,615 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

APOBEC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	7,696,571 - 7,700,424 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	7,696,259 - 7,700,643 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666063	490,767 - 508,119 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Apobec1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624860	4,938,001 - 4,957,236 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624860	4,938,001 - 4,957,640 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Apobec1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	24,511,783 - 24,523,110 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Apobec1
175 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	32
Count of miRNA genes:	31
Interacting mature miRNAs:	32
Transcripts:	ENSRNOT00000020735
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	146370897	184426481	Rat
724558	Plsm2	Polydactyly-luxate syndrome (PLS) morphotypes QTL 2		0.0003	hindlimb integrity trait (VT:0010563)	hind foot phalanges count (CMO:0001949)	4	134095016	179095016	Rat
1582237	Kidm34	Kidney mass QTL 34	4	0.0001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	4	149763204	169799698	Rat
61446	Coreg2	Compensatory renal growth QTL 2	3.5		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	4	150095743	159267220	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	146370897	184426481	Rat
6478757	Anxrr44	Anxiety related response QTL 44		0.01087	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
1358364	Sradr4	Stress Responsive Adrenal Weight QTL 4	4.92		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	131384565	176384565	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
61451	Ciaa4	CIA Autoantibody QTL 4	3.1		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	4	123870974	168870974	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	117559384	162559384	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	140059299	181024663	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	157292416	184426481	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	94638356	168870820	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	106848959	168870974	Rat
7411558	Bw133	Body weight QTL 133	13.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	127263297	172263297	Rat
6478778	Anxrr51	Anxiety related response QTL 51		0.25384	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	126334185	171334185	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	147299608	184426481	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
6478782	Anxrr52	Anxiety related response QTL 52		0.02091	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
631511	Pia7	Pristane induced arthritis QTL 7	4.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	124700988	169700988	Rat
6478720	Alc23	Alcohol consumption QTL 23		0.00509	drinking behavior trait (VT:0001422)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	155834926	184426481	Rat
6478785	Anxrr53	Anxiety related response QTL 53		0.01397	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	100752691	179366077	Rat
1581566	Eae21	Experimental allergic encephalomyelitis QTL 21	6.2		body mass (VT:0001259)	maximum body weight loss to initial body weight ratio (CMO:0001400)	4	137447185	182447185	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	137430611	182430611	Rat
6478728	Anxrr36	Anxiety related response QTL 36		0.01061	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	86709649	168870974	Rat
61422	Cia13	Collagen induced arthritis QTL 13	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	134199006	168870974	Rat
634342	Cia24	Collagen induced arthritis QTL 24	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	148121375	176967367	Rat
6478733	Anxrr37	Anxiety related response QTL 37		0.00095	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
737978	Pia23	Pristane induced arthritis QTL 23	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	65495851	159259805	Rat
6478737	Anxrr38	Anxiety related response QTL 38		0.00159	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	116184844	161184844	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
12798525	Anxrr57	Anxiety related response QTL 57	3.21	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	148834094	168870974	Rat

Markers in Region

UniSTS:224890

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	155,800,828 - 155,800,939 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	155,386,640 - 155,386,750	NCBI	Rnor6.0
Rnor_5.0	4	222,411,105 - 222,411,215	UniSTS	Rnor5.0
RGSC_v3.4	4	159,033,101 - 159,033,211	UniSTS	RGSC3.4
Celera	4	144,620,194 - 144,620,304	UniSTS
Cytogenetic Map	4	q42	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	63	160	91	90	59	86	59	6	346	182	11	139	81	92	31	12	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008763219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107109	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ006695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L07114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000020735 ⟹ ENSRNOP00000020735

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	157,472,881 - 157,487,601 (-)	Ensembl
mRatBN7.2 Ensembl	4	155,800,887 - 155,821,328 (-)	Ensembl
Rnor_6.0 Ensembl	4	155,386,711 - 155,401,480 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106242 ⟹ ENSRNOP00000078194

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	157,472,868 - 157,498,909 (-)	Ensembl
mRatBN7.2 Ensembl	4	155,800,887 - 155,816,217 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109144 ⟹ ENSRNOP00000077863

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	155,800,887 - 155,827,390 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118333 ⟹ ENSRNOP00000094681

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	155,800,887 - 155,827,390 (-)	Ensembl

RefSeq Acc Id:

NM_012907 ⟹ NP_037039

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	157,472,879 - 157,487,601 (-)	NCBI
mRatBN7.2	4	155,800,898 - 155,815,625 (-)	NCBI
Rnor_6.0	4	155,386,709 - 155,401,480 (-)	NCBI
Rnor_5.0	4	222,409,798 - 222,438,051 (-)	NCBI
RGSC_v3.4	4	159,033,170 - 159,048,108 (-)	RGD
Celera	4	144,620,263 - 144,634,783 (-)	RGD

Sequence:

show sequence

CCAAGGTCCTGCTTTTGCATCTTAAGCCGCCCCTCCTTTCTCCAACAGACACGAGGAGCAAAGG
GTAACTGAGAGGGAGTAGCAGGTAAAGCCCACAGTGTTCTCACCGGGTCACCCTGAGGACTTCT
TAGTTATAGGAGCTGCTTCATTCTCTCCGATCCGTGCTGGCTTCTCTCCCACTCTCACTTGAAG
GAAGGGGAAAGCTTTCTAAGTTTAGCCGTCACTCTGGAATTTAACATCATCGATGTTCTACTGT
GCAGCGTTGATGGTTCGATGGGCTCTCTCCAGGGAGGACGGAAATCCAGATGCCACTTCCTTCT
TCATTTACATAGCATTCATATCACGTCGCGACTGACGCTCAGGAATGAGTCATCCTGTGTCCCT
GCAGGTGGCCGTGGGCACACCTGAGGAAGCAAAGTCCGGCACGCAGCTGGCAGCAGCCATCGCC
GCAACATAAGCTCCCGAGGAAGGAGTCCAGAGACACAGAGAGCAAGATGAGTTCCGAGACAGGC
CCTGTAGCTGTTGATCCCACTCTGAGGAGAAGAATTGAGCCCCACGAGTTTGAAGTCTTCTTTG
ACCCCCGGGAACTTCGGAAAGAGACCTGTCTGCTGTATGAGATCAACTGGGGAGGAAGGCACAG
CATCTGGCGACACACGAGCCAAAACACCAACAAACACGTTGAAGTCAATTTCATAGAAAAATTT
ACTACAGAAAGATACTTTTGTCCAAACACCAGATGCTCCATTACCTGGTTCCTGTCCTGGAGTC
CCTGTGGGGAGTGCTCCAGGGCCATTACAGAATTTTTGAGCCGATACCCCCATGTAACTCTGTT
TATTTATATAGCACGGCTTTATCACCACGCAGATCCTCGAAATCGGCAAGGACTCAGGGACCTT
ATTAGCAGCGGTGTTACTATCCAGATCATGACGGAGCAAGAGTCTGGCTACTGCTGGAGGAATT
TTGTCAACTACTCCCCTTCGAATGAAGCTCATTGGCCAAGGTACCCCCATCTGTGGGTGAGGCT
GTACGTACTGGAACTCTACTGCATCATTTTAGGACTTCCACCCTGTTTAAATATTTTAAGAAGA
AAACAACCTCAACTCACGTTTTTCACGATTGCTCTTCAAAGCTGCCATTACCAAAGGCTACCAC
CCCACATCCTGTGGGCCACAGGGTTGAAATGACTTCTGGGAGTTGGGGATGGATGAAATGACTC
CTTGTATGTCTTGACAGCAAGCATTGATTACCCACTAAAGAGCGACTGCCACAAGGAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006237290 ⟹ XP_006237352

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	157,472,879 - 157,499,350 (-)	NCBI
mRatBN7.2	4	155,800,030 - 155,827,378 (-)	NCBI
Rnor_6.0	4	155,386,367 - 155,413,479 (-)	NCBI
Rnor_5.0	4	222,409,798 - 222,438,051 (-)	NCBI

Sequence:

show sequence

CTGTATTCTGATTTCTGGTTGGAGCCTGTCTGGGACCCAAGCAAGAAGAAAGTGGATGCGGCAC
TGCTCCTGGGGTTAGAGGTGGACAGGAGATGTCCTGCCTTTTCACTGGTTTCCACTGAGGGGAC
ATTTGGTTCTGGTTCTGGGCATGCGGGATTGCTCTTGTCGGTTTGTGTCTGTAGTTTGATTTAG
TTTGGTTGTTGCTCTGTGTTTCATATCCGGGAAAATGGACCAAAGTTCTTCTGCTGGCTGTTCA
CCTCTTGGCTTAGTATGTAACCATCTCAAGGATTTTCAGGGGGTAAAAAGCGGCTGAATCAGGA
CAACAACAATAACAACAAAAACAGATAAACTGGCTGACACTGAGTCCAGCGCTGCTGGTGAAGC
CCCGCCTCCTGCTCGCCTGACAGCAAACCCCAGCCACCTGATTTGTCCAAGTCCCTCTTAAAGC
CGAACCAGCAATTCCTCAGCTTTCTCTGGTCAGGAAGCCTGTGCCTACTCCCGCTACAGAACCA
CTGTGCCCATGAGAGTTGGATTTTGAAGGCAGAAAGGCGCTCCTCCCTTGAAATTAGATCAGGA
AGAAGTGGCCGTGGGCACACCTGAGGAAGCAAAGTCCGGCACGCAGCTGGCAGCAGCCATCGCC
GCAACATAAGCTCCCGAGGAAGGAGTCCAGAGACACAGAGAGCAAGATGAGTTCCGAGACAGGC
CCTGTAGCTGTTGATCCCACTCTGAGGAGAAGAATTGAGCCCCACGAGTTTGAAGTCTTCTTTG
ACCCCCGGGAACTTCGGAAAGAGACCTGTCTGCTGTATGAGATCAACTGGGGAGGAAGGCACAG
CATCTGGCGACACACGAGCCAAAACACCAACAAACACGTTGAAGTCAATTTCATAGAAAAATTT
ACTACAGAAAGATACTTTTGTCCAAACACCAGATGCTCCATTACCTGGTTCCTGTCCTGGAGTC
CCTGTGGGGAGTGCTCCAGGGCCATTACAGAATTTTTGAGCCGATACCCCCATGTAACTCTGTT
TATTTATATAGCACGGCTTTATCACCACGCAGATCCTCGAAATCGGCAAGGACTCAGGGACCTT
ATTAGCAGCGGTGTTACTATCCAGATCATGACGGAGCAAGAGTCTGGCTACTGCTGGAGGAATT
TTGTCAACTACTCCCCTTCGAATGAAGCTCATTGGCCAAGGTACCCCCATCTGTGGGTGAGGCT
GTACGTACTGGAACTCTACTGCATCATTTTAGGACTTCCACCCTGTTTAAATATTTTAAGAAGA
AAACAACCTCAACTCACGTTTTTCACGATTGCTCTTCAAAGCTGCCATTACCAAAGGCTACCAC
CCCACATCCTGTGGGCCACAGGGTTGAAATGACTTCTGGGAGTTGGGGATGGATGAAATGACTC
CTTGTATGTCTTGACAGCAAGCATTGATTACCCACTAAAGAGCGACTGCCACAAGGAATCTAGA
AGTCGATCCGGCCTGTCATTCCTGGGTAGCATGCTAGTTGCACACGAGGCCCTTGGTTTAACTC
CAAGAACATCCAGAAAAATGGAGGATCTAGAAATTGAGCCAGGAAGGGTTGTACATTCTTGTAA
CCTCAGCACTCGGGAGGCAGAGGCATTAGTTCTCTGTGAGCTCAAGGCCAGCCTGGTCTACATT
GCAAGACCCAGGCCAGCCTTGAACTACACAGTGAGACCTTGTCTAACACTCGCCTTCCTGCCCC
ATCACCCTCCATCAAGAATGTAGAAATTGAAGACCCGGGTAAGGTGGCGCAGTCCTGTAATCTC
AATGTTACAGGAAGCA

hide sequence

RefSeq Acc Id:

XM_006237293 ⟹ XP_006237355

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	157,472,879 - 157,500,496 (-)	NCBI
mRatBN7.2	4	155,800,030 - 155,828,266 (-)	NCBI
Rnor_6.0	4	155,386,367 - 155,413,797 (-)	NCBI
Rnor_5.0	4	222,409,798 - 222,438,051 (-)	NCBI

Sequence:

show sequence

ACCACAAAGGCGAGTTGCTAAGGAAGTCCTCTGTCCCTAAATCCTAATTAGTGGGATAACTTGG
CAGAGTTGTTTGTGGTTTTGGAGCTTACAAACTCTGTGGAATTCTTGGGAGGGGGGCAGGTCAG
TTTTTGCTGCCTAATTCAAATAAAGAAGTTGCGTCGCTGGACTCTTGTGATGGCTTAAATTTTT
TATTTTTTTATTTTTTTATTTTTACACCTAACGTTTGGGTACCAAACGCCAACCCACTTGATCC
CTAAAACTGAATTAGGAGCACCTCGGACTGTTTTTCAGTCATCTGGACTCTCGGAGGTGGCCGT
GGGCACACCTGAGGAAGCAAAGTCCGGCACGCAGCTGGCAGCAGCCATCGCCGCAACATAAGCT
CCCGAGGAAGGAGTCCAGAGACACAGAGAGCAAGATGAGTTCCGAGACAGGCCCTGTAGCTGTT
GATCCCACTCTGAGGAGAAGAATTGAGCCCCACGAGTTTGAAGTCTTCTTTGACCCCCGGGAAC
TTCGGAAAGAGACCTGTCTGCTGTATGAGATCAACTGGGGAGGAAGGCACAGCATCTGGCGACA
CACGAGCCAAAACACCAACAAACACGTTGAAGTCAATTTCATAGAAAAATTTACTACAGAAAGA
TACTTTTGTCCAAACACCAGATGCTCCATTACCTGGTTCCTGTCCTGGAGTCCCTGTGGGGAGT
GCTCCAGGGCCATTACAGAATTTTTGAGCCGATACCCCCATGTAACTCTGTTTATTTATATAGC
ACGGCTTTATCACCACGCAGATCCTCGAAATCGGCAAGGACTCAGGGACCTTATTAGCAGCGGT
GTTACTATCCAGATCATGACGGAGCAAGAGTCTGGCTACTGCTGGAGGAATTTTGTCAACTACT
CCCCTTCGAATGAAGCTCATTGGCCAAGGTACCCCCATCTGTGGGTGAGGCTGTACGTACTGGA
ACTCTACTGCATCATTTTAGGACTTCCACCCTGTTTAAATATTTTAAGAAGAAAACAACCTCAA
CTCACGTTTTTCACGATTGCTCTTCAAAGCTGCCATTACCAAAGGCTACCACCCCACATCCTGT
GGGCCACAGGGTTGAAATGACTTCTGGGAGTTGGGGATGGATGAAATGACTCCTTGTATGTCTT
GACAGCAAGCATTGATTACCCACTAAAGAGCGACTGCCACAAGGAATCTAGAAGTCGATCCGGC
CTGTCATTCCTGGGTAGCATGCTAGTTGCACACGAGGCCCTTGGTTTAACTCCAAGAACATCCA
GAAAAATGGAGGATCTAGAAATTGAGCCAGGAAGGGTTGTACATTCTTGTAACCTCAGCACTCG
GGAGGCAGAGGCATTAGTTCTCTGTGAGCTCAAGGCCAGCCTGGTCTACATTGCAAGACCCAGG
CCAGCCTTGAACTACACAGTGAGACCTTGTCTAACACTCGCCTTCCTGCCCCATCACCCTCCAT
CAAGAATGTAGAAATTGAAGACCCGGGTAAGGTGGCGCAGTCCTGTAATCTCAATGTTACAGGA
AGCA

hide sequence

RefSeq Acc Id:

XM_017592483 ⟹ XP_017447972

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	157,472,879 - 157,499,352 (-)	NCBI
mRatBN7.2	4	155,800,030 - 155,827,380 (-)	NCBI
Rnor_6.0	4	155,386,367 - 155,413,479 (-)	NCBI

Sequence:

show sequence

CTGTATTCTGATTTCTGGTTGGAGCCTGTCTGGGACCCAAGCAAGAAGAAAGTGGATGCGGCAC
TGCTCCTGGGGTTAGAGGTGGACAGGAGATGTCCTGCCTTTTCACTGGTTTCCACTGAGGGGAC
ATTTGGTTCTGGTTCTGGGCATGCGGGATTGCTCTTGTCGGTTTGTGTCTGTAGTTTGATTTAG
TTTGGTTGTTGCTCTGTGTTTCATATCCGGGAAAATGGACCAAAGTTCTTCTGCTGGCTGTTCA
CCTCTTGGCTTAGTATGTAACCATCTCAAGGATTTTCAGGGGGTAAAAAGCGGCTGAATCAGGA
CAACAACAATAACAACAAAAACAGATAAACTGGCTGACACTGAGTCCAGCGCTGCTGGTGAAGC
CCCGCCTCCTGCTCGCCTGACAGCAAACCCCAGCCACCTGATTTGTCCAAGTCCCTCTTAAAGC
CGAACCAGCAATTCCTCAGCTTTCTCTGGTCAGGAAGCCTGTGCCTACTCCCGCTACAGAACCA
CTGTGCCCATGAGAGTTGGATTTTGAAGGCAGAAAGGCGCTCCTCCCTTGAAATTAGATCAGGA
AGAAGAGGGCTAGAGACACAGGAGAGAAGCCACCTCCATCTGTACAGTCTCCGGCATCCTGACC
CACAAATCAGAGACTACCCAGAGACTACCGTCTGATTTGCCTTACTCCGAGAGTCTGAACTGGA
CCCTTAGCTAAGATACCTCACCCAGAGCATAAGATTATACCTGAAGGAATGGAAAGAAGGCTGA
TTTCAGGAAGCAGAGGTGAAGCATGCAAGGCTGCTTCACTGGAGAAGCATGAATCCAGGGAACC
TGTCTTTTCCAGGATGAGCCATGAGTGGCCGTGGGCACACCTGAGGAAGCAAAGTCCGGCACGC
AGCTGGCAGCAGCCATCGCCGCAACATAAGCTCCCGAGGAAGGAGTCCAGAGACACAGAGAGCA
AGATGAGTTCCGAGACAGGCCCTGTAGCTGTTGATCCCACTCTGAGGAGAAGAATTGAGCCCCA
CGAGTTTGAAGTCTTCTTTGACCCCCGGGAACTTCGGAAAGAGACCTGTCTGCTGTATGAGATC
AACTGGGGAGGAAGGCACAGCATCTGGCGACACACGAGCCAAAACACCAACAAACACGTTGAAG
TCAATTTCATAGAAAAATTTACTACAGAAAGATACTTTTGTCCAAACACCAGATGCTCCATTAC
CTGGTTCCTGTCCTGGAGTCCCTGTGGGGAGTGCTCCAGGGCCATTACAGAATTTTTGAGCCGA
TACCCCCATGTAACTCTGTTTATTTATATAGCACGGCTTTATCACCACGCAGATCCTCGAAATC
GGCAAGGACTCAGGGACCTTATTAGCAGCGGTGTTACTATCCAGATCATGACGGAGCAAGAGTC
TGGCTACTGCTGGAGGAATTTTGTCAACTACTCCCCTTCGAATGAAGCTCATTGGCCAAGGTAC
CCCCATCTGTGGGTGAGGCTGTACGTACTGGAACTCTACTGCATCATTTTAGGACTTCCACCCT
GTTTAAATATTTTAAGAAGAAAACAACCTCAACTCACGTTTTTCACGATTGCTCTTCAAAGCTG
CCATTACCAAAGGCTACCACCCCACATCCTGTGGGCCACAGGGTTGAAATGACTTCTGGGAGTT
GGGGATGGATGAAATGACTCCTTGTATGTCTTGACAGCAAGCATTGATTACCCACTAAAGAGCG
ACTGCCACAAGGAATCTAGAAGTCGATCCGGCCTGTCATTCCTGGGTAGCATGCTAGTTGCACA
CGAGGCCCTTGGTTTAACTCCAAGAACATCCAGAAAAATGGAGGATCTAGAAATTGAGCCAGGA
AGGGTTGTACATTCTTGTAACCTCAGCACTCGGGAGGCAGAGGCATTAGTTCTCTGTGAGCTCA
AGGCCAGCCTGGTCTACATTGCAAGACCCAGGCCAGCCTTGAACTACACAGTGAGACCTTGTCT
AACACTCGCCTTCCTGCCCCATCACCCTCCATCAAGAATGTAGAAATTGAAGACCCGGGTAAGG
TGGCGCAGTCCTGTAATCTCAATGTTACAGGAAGCA

hide sequence

RefSeq Acc Id:

XM_017592484 ⟹ XP_017447973

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	157,472,879 - 157,499,350 (-)	NCBI
mRatBN7.2	4	155,800,030 - 155,827,378 (-)	NCBI
Rnor_6.0	4	155,386,367 - 155,413,479 (-)	NCBI

Sequence:

show sequence

CTGTATTCTGATTTCTGGTTGGAGCCTGTCTGGGACCCAAGCAAGAAGAAAGTGGATGCGGCAC
TGCTCCTGGGGTTAGAGGTGGACAGGAGATGTCCTGCCTTTTCACTGGTTTCCACTGAGGGGAC
ATTTGGTTCTGGTTCTGGGCATGCGGGATTGCTCTTGTCGGTTTGTGTCTGTAGTTTGATTTAG
TTTGGTTGTTGCTCTGTGTTTCATATCCGGGAAAATGGACCAAAGTTCTTCTGCTGGCTGTTCA
CCTCTTGGCTTAGTATGTAACCATCTCAAGGATTTTCAGGGGGTAAAAAGCGGCTGAATCAGGA
CAACAACAATAACAACAAAAACAGATAAACTGGCTGACACTGAGTCCAGCGCTGCTGGTGAAGC
CCCGCCTCCTGCTCGCCTGACAGCAAACCCCAGCCACCTGATTTGTCCAAGTCCCTCTTAAAGC
CGAACCAGCAATTCCTCAGCTTTCTCTGGTCAGGAAGCCTGTGCCTACTCCCGCTACAGAACCA
CTGTGCCCATGAGAGTTGGATTTTGAAGGCAGAAAGGCGCTCCTCCCTTGAAATTAGATCAGGA
AGAAGAGGGCTAGAGACACAGGAGAGAAGCCACCTCCATCTGTACAGTCTCCGGCATCCTGACC
CACAAATCAGAGACTACCCAGAGACTACCGTCTGATTTGCCTTACTCCGAGAGTCTGAACTGGA
CCCTTAGCTAAGATACCTCACCCAGGTGGCCGTGGGCACACCTGAGGAAGCAAAGTCCGGCACG
CAGCTGGCAGCAGCCATCGCCGCAACATAAGCTCCCGAGGAAGGAGTCCAGAGACACAGAGAGC
AAGATGAGTTCCGAGACAGGCCCTGTAGCTGTTGATCCCACTCTGAGGAGAAGAATTGAGCCCC
ACGAGTTTGAAGTCTTCTTTGACCCCCGGGAACTTCGGAAAGAGACCTGTCTGCTGTATGAGAT
CAACTGGGGAGGAAGGCACAGCATCTGGCGACACACGAGCCAAAACACCAACAAACACGTTGAA
GTCAATTTCATAGAAAAATTTACTACAGAAAGATACTTTTGTCCAAACACCAGATGCTCCATTA
CCTGGTTCCTGTCCTGGAGTCCCTGTGGGGAGTGCTCCAGGGCCATTACAGAATTTTTGAGCCG
ATACCCCCATGTAACTCTGTTTATTTATATAGCACGGCTTTATCACCACGCAGATCCTCGAAAT
CGGCAAGGACTCAGGGACCTTATTAGCAGCGGTGTTACTATCCAGATCATGACGGAGCAAGAGT
CTGGCTACTGCTGGAGGAATTTTGTCAACTACTCCCCTTCGAATGAAGCTCATTGGCCAAGGTA
CCCCCATCTGTGGGTGAGGCTGTACGTACTGGAACTCTACTGCATCATTTTAGGACTTCCACCC
TGTTTAAATATTTTAAGAAGAAAACAACCTCAACTCACGTTTTTCACGATTGCTCTTCAAAGCT
GCCATTACCAAAGGCTACCACCCCACATCCTGTGGGCCACAGGGTTGAAATGACTTCTGGGAGT
TGGGGATGGATGAAATGACTCCTTGTATGTCTTGACAGCAAGCATTGATTACCCACTAAAGAGC
GACTGCCACAAGGAATCTAGAAGTCGATCCGGCCTGTCATTCCTGGGTAGCATGCTAGTTGCAC
ACGAGGCCCTTGGTTTAACTCCAAGAACATCCAGAAAAATGGAGGATCTAGAAATTGAGCCAGG
AAGGGTTGTACATTCTTGTAACCTCAGCACTCGGGAGGCAGAGGCATTAGTTCTCTGTGAGCTC
AAGGCCAGCCTGGTCTACATTGCAAGACCCAGGCCAGCCTTGAACTACACAGTGAGACCTTGTC
TAACACTCGCCTTCCTGCCCCATCACCCTCCATCAAGAATGTAGAAATTGAAGACCCGGGTAAG
GTGGCGCAGTCCTGTAATCTCAATGTTACAGGAAGCA

hide sequence

RefSeq Acc Id:

XM_039107109 ⟹ XP_038963037

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	157,472,879 - 157,494,764 (-)	NCBI
mRatBN7.2	4	155,800,030 - 155,822,674 (-)	NCBI

RefSeq Acc Id:

XM_039107110 ⟹ XP_038963038

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	157,472,879 - 157,500,382 (-)	NCBI
mRatBN7.2	4	155,800,030 - 155,828,405 (-)	NCBI

RefSeq Acc Id:

XM_039107113 ⟹ XP_038963041

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	157,472,879 - 157,500,496 (-)	NCBI
mRatBN7.2	4	155,800,030 - 155,828,515 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_037039	(Get FASTA)	NCBI Sequence Viewer
	XP_006237352	(Get FASTA)	NCBI Sequence Viewer
	XP_006237355	(Get FASTA)	NCBI Sequence Viewer
	XP_017447972	(Get FASTA)	NCBI Sequence Viewer
	XP_017447973	(Get FASTA)	NCBI Sequence Viewer
	XP_038963037	(Get FASTA)	NCBI Sequence Viewer
	XP_038963038	(Get FASTA)	NCBI Sequence Viewer
	XP_038963041	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA17394	(Get FASTA)	NCBI Sequence Viewer
	AAH85335	(Get FASTA)	NCBI Sequence Viewer
	CAB44439	(Get FASTA)	NCBI Sequence Viewer
	EDM01986	(Get FASTA)	NCBI Sequence Viewer
	EDM01987	(Get FASTA)	NCBI Sequence Viewer
	EDM01988	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020735
	ENSRNOP00000078194
GenBank Protein	P38483	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_037039 ⟸ NM_012907

- UniProtKB:

P38483 (UniProtKB/Swiss-Prot), A6ILF2 (UniProtKB/TrEMBL), A0A8L2QAE9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSSETGPVAVDPTLRRRIEPHEFEVFFDPRELRKETCLLYEINWGGRHSIWRHTSQNTNKHVEV
NFIEKFTTERYFCPNTRCSITWFLSWSPCGECSRAITEFLSRYPHVTLFIYIARLYHHADPRNR
QGLRDLISSGVTIQIMTEQESGYCWRNFVNYSPSNEAHWPRYPHLWVRLYVLELYCIILGLPPC
LNILRRKQPQLTFFTIALQSCHYQRLPPHILWATGLK

hide sequence

RefSeq Acc Id:	XP_006237355 ⟸ XM_006237293
- Peptide Label:	isoform X2
- UniProtKB:	P38483 (UniProtKB/Swiss-Prot), A6ILF2 (UniProtKB/TrEMBL), A0A8L2QAE9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSETGPVAVDPTLRRRIEPHEFEVFFDPRELRKETCLLYEINWGGRHSIWRHTSQNTNKHVEV NFIEKFTTERYFCPNTRCSITWFLSWSPCGECSRAITEFLSRYPHVTLFIYIARLYHHADPRNR QGLRDLISSGVTIQIMTEQESGYCWRNFVNYSPSNEAHWPRYPHLWVRLYVLELYCIILGLPPC LNILRRKQPQLTFFTIALQSCHYQRLPPHILWATGLK hide sequence

RefSeq Acc Id:	XP_006237352 ⟸ XM_006237290
- Peptide Label:	isoform X2
- UniProtKB:	P38483 (UniProtKB/Swiss-Prot), A6ILF2 (UniProtKB/TrEMBL), A0A8L2QAE9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSETGPVAVDPTLRRRIEPHEFEVFFDPRELRKETCLLYEINWGGRHSIWRHTSQNTNKHVEV NFIEKFTTERYFCPNTRCSITWFLSWSPCGECSRAITEFLSRYPHVTLFIYIARLYHHADPRNR QGLRDLISSGVTIQIMTEQESGYCWRNFVNYSPSNEAHWPRYPHLWVRLYVLELYCIILGLPPC LNILRRKQPQLTFFTIALQSCHYQRLPPHILWATGLK hide sequence

RefSeq Acc Id:	XP_017447973 ⟸ XM_017592484
- Peptide Label:	isoform X2
- UniProtKB:	P38483 (UniProtKB/Swiss-Prot), A6ILF2 (UniProtKB/TrEMBL), A0A8L2QAE9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSETGPVAVDPTLRRRIEPHEFEVFFDPRELRKETCLLYEINWGGRHSIWRHTSQNTNKHVEV NFIEKFTTERYFCPNTRCSITWFLSWSPCGECSRAITEFLSRYPHVTLFIYIARLYHHADPRNR QGLRDLISSGVTIQIMTEQESGYCWRNFVNYSPSNEAHWPRYPHLWVRLYVLELYCIILGLPPC LNILRRKQPQLTFFTIALQSCHYQRLPPHILWATGLK hide sequence

RefSeq Acc Id:	XP_017447972 ⟸ XM_017592483
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6B1D0 (UniProtKB/TrEMBL), A0A8I5Y2I8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MERRLISGSRGEACKAASLEKHESREPVFSRMSHEWPWAHLRKQSPARSWQQPSPQHKLPRKES RDTESKMSSETGPVAVDPTLRRRIEPHEFEVFFDPRELRKETCLLYEINWGGRHSIWRHTSQNT NKHVEVNFIEKFTTERYFCPNTRCSITWFLSWSPCGECSRAITEFLSRYPHVTLFIYIARLYHH ADPRNRQGLRDLISSGVTIQIMTEQESGYCWRNFVNYSPSNEAHWPRYPHLWVRLYVLELYCII LGLPPCLNILRRKQPQLTFFTIALQSCHYQRLPPHILWATGLK hide sequence

Ensembl Acc Id:

ENSRNOP00000020735 ⟸ ENSRNOT00000020735

RefSeq Acc Id:	XP_038963041 ⟸ XM_039107113
- Peptide Label:	isoform X2
- UniProtKB:	P38483 (UniProtKB/Swiss-Prot), A6ILF2 (UniProtKB/TrEMBL), A0A8L2QAE9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963038 ⟸ XM_039107110
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6B1D0 (UniProtKB/TrEMBL), A0A8I5Y2I8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963037 ⟸ XM_039107109
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6B1D0 (UniProtKB/TrEMBL), A0A8I5Y2I8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000078194 ⟸ ENSRNOT00000106242

Ensembl Acc Id:

ENSRNOP00000094681 ⟸ ENSRNOT00000118333

Ensembl Acc Id:

ENSRNOP00000077863 ⟸ ENSRNOT00000109144

Protein Domains

CMP/dCMP-type deaminase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P38483-F1-model_v2	AlphaFold	P38483	1-229	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2133	AgrOrtholog
BioCyc Gene	G2FUF-43150	BioCyc
Ensembl Genes	ENSRNOG00000015411	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000020735	ENTREZGENE
	ENSRNOT00000106242	ENTREZGENE
Gene3D-CATH	Cytidine Deaminase, domain 2	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7301703	IMAGE-MGC_LOAD
InterPro	APOBEC/CMP_deaminase_Zn-bd	UniProtKB/Swiss-Prot
	APOBEC1	UniProtKB/Swiss-Prot
	APOBEC_Cyt_Deaminase	UniProtKB/Swiss-Prot
	CMP_dCMP_dom	UniProtKB/Swiss-Prot
	Cytidine_deaminase-like	UniProtKB/Swiss-Prot
KEGG Report	rno:25383	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105503	IMAGE-MGC_LOAD
NCBI Gene	25383	ENTREZGENE
PANTHER	C-U-EDITING ENZYME APOBEC-1	UniProtKB/Swiss-Prot
	MRNA EDITING ENZYME	UniProtKB/Swiss-Prot
Pfam	APOBEC4_like	UniProtKB/Swiss-Prot
PhenoGen	Apobec1	PhenoGen
PROSITE	CYT_DCMP_DEAMINASES_1	UniProtKB/Swiss-Prot
	CYT_DCMP_DEAMINASES_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000015411	RatGTEx
Superfamily-SCOP	SSF53927	UniProtKB/Swiss-Prot
TIGR	TC222613
UniProt	A0A8I5Y2I8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6B1D0	ENTREZGENE
	A0A8L2QAE9	ENTREZGENE, UniProtKB/TrEMBL
	A6ILF2	ENTREZGENE, UniProtKB/TrEMBL
	A6ILF3_RAT	UniProtKB/TrEMBL
	ABEC1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-15	Apobec1	apolipoprotein B mRNA editing enzyme catalytic subunit 1	Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	Apobec1	apolipoprotein B editing complex 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Apobec1	Apolipoprotein B editing protein			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains several phosphorylation sites	634661
gene_domains	contains leucine zipper domains	634661
gene_expression	expressed in small intestine	634661
gene_process	required for post transcriptional mRNA editing of apolipoprotein B	634661
gene_process	contributes to post transcriptional cytidine deamination of apolipoprotein B mRNA	634661

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - CTD

RGD Manual Annotations