Hsp90b1 (heat shock protein 90 beta family member 1) - Rat Genome Database

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Gene: Hsp90b1 (heat shock protein 90 beta family member 1) Rattus norvegicus
Analyze
Symbol: Hsp90b1
Name: heat shock protein 90 beta family member 1
RGD ID: 1310482
Description: Predicted to enable several functions, including low-density lipoprotein particle receptor binding activity; protein phosphatase binding activity; and unfolded protein binding activity. Involved in cellular response to manganese ion. Located in smooth endoplasmic reticulum. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 94 kDa glucose-regulated protein; endoplasmin; GRP-94; GRP94; heat shock protein 90 kDa beta member 1; heat shock protein 90, beta, member 1; heat shock protein 90kDa beta (Grp94), member 1; LOC362862; Tra1; tumor rejection antigen gp96
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,997,962 - 23,012,293 (-)NCBIGRCr8
mRatBN7.2721,110,431 - 21,124,762 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl721,110,457 - 21,124,788 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx723,085,224 - 23,099,540 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0725,247,933 - 25,262,249 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0725,025,008 - 25,039,326 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0727,226,570 - 27,240,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl727,226,569 - 27,240,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0727,345,730 - 27,359,757 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4723,332,986 - 23,347,525 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1723,353,261 - 23,367,796 (-)NCBI
Celera718,290,242 - 18,304,551 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1,4-dithiothreitol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-deoxy-D-glucose  (ISO)
2-methoxyethanol  (EXP)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-aminophenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-(N,N-hexamethylene)amiloride  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP,ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apigenin  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
azoxystrobin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
brefeldin A  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroacetic acid  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
Dienochlor  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (EXP,ISO)
dopamine  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (EXP)
fenofibrate  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
glafenine  (EXP)
glucose  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
Ibutilide  (EXP)
imidacloprid  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
isoliquiritigenin  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-1,4-dithiothreitol  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
manganese(II) chloride  (EXP)
meglumine amidotrizoate  (EXP)
menadione  (ISO)
mercury dichloride  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methomyl  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
morphine  (EXP)
N,N-dimethylformamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosomorpholine  (EXP)
oxidopamine  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
poly(propylene imine) macromolecule  (ISO)
potassium dichromate  (ISO)
procymidone  (EXP)
progesterone  (ISO)
Propiverine  (EXP)
prostaglandin A1  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (EXP)
surfactin  (ISO)
surfactin C  (ISO)
T-2 toxin  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (EXP,ISO)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
triadimefon  (EXP)
trichostatin A  (ISO)
tungsten  (ISO)
tunicamycin  (EXP,ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. An interaction map of endoplasmic reticulum chaperones and foldases. Jansen G, etal., Mol Cell Proteomics. 2012 Sep;11(9):710-23. doi: 10.1074/mcp.M111.016550. Epub 2012 Jun 4.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis. Wang S, etal., Aging (Albany NY). 2022 Aug 30;14(16):6809-6828. doi: 10.18632/aging.204256. Epub 2022 Aug 30.
12. Suppression subtractive hybridization identified differentially expressed genes in lung adenocarcinoma: ERGIC3 as a novel lung cancer-related gene. Wu M, etal., BMC Cancer. 2013 Feb 1;13:44. doi: 10.1186/1471-2407-13-44.
13. alpha-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Xu B, etal., Mol Neurobiol. 2014 Feb;49(1):399-412. doi: 10.1007/s12035-013-8527-2. Epub 2013 Aug 10.
Additional References at PubMed
PMID:8314313   PMID:9006956   PMID:9596688   PMID:10444069   PMID:10497210   PMID:11958450   PMID:12135983   PMID:12475965   PMID:12477932   PMID:15082773   PMID:15166316   PMID:15192333  
PMID:15252132   PMID:15620698   PMID:16854843   PMID:17278885   PMID:17344063   PMID:18264092   PMID:19000834   PMID:19199708   PMID:19946888   PMID:20458337   PMID:21120645   PMID:21423176  
PMID:21630459   PMID:21807380   PMID:23233060   PMID:23349634   PMID:23658023   PMID:23979707   PMID:24093939   PMID:24489578   PMID:24625528   PMID:25660456   PMID:26316108   PMID:29414031  
PMID:29476059   PMID:30188326   PMID:30486828   PMID:30670477   PMID:35352799   PMID:38081093  


Genomics

Comparative Map Data
Hsp90b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,997,962 - 23,012,293 (-)NCBIGRCr8
mRatBN7.2721,110,431 - 21,124,762 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl721,110,457 - 21,124,788 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx723,085,224 - 23,099,540 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0725,247,933 - 25,262,249 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0725,025,008 - 25,039,326 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0727,226,570 - 27,240,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl727,226,569 - 27,240,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0727,345,730 - 27,359,757 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4723,332,986 - 23,347,525 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1723,353,261 - 23,367,796 (-)NCBI
Celera718,290,242 - 18,304,551 (-)NCBICelera
Cytogenetic Map7q13NCBI
HSP90B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812103,930,410 - 103,947,926 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12103,930,107 - 103,953,931 (+)EnsemblGRCh38hg38GRCh38
GRCh3712104,324,188 - 104,341,704 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612102,848,319 - 102,865,833 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412102,826,655 - 102,844,170NCBI
Celera12103,987,945 - 104,005,473 (+)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12101,383,834 - 101,401,444 (+)NCBIHuRef
CHM1_112104,290,083 - 104,307,660 (+)NCBICHM1_1
T2T-CHM13v2.012103,892,110 - 103,909,638 (+)NCBIT2T-CHM13v2.0
Hsp90b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391086,526,705 - 86,541,308 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1086,526,073 - 86,541,373 (-)EnsemblGRCm39 Ensembl
GRCm381086,690,841 - 86,705,444 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1086,690,209 - 86,705,509 (-)EnsemblGRCm38mm10GRCm38
MGSCv371086,153,586 - 86,168,189 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361086,120,640 - 86,135,243 (-)NCBIMGSCv36mm8
Celera1088,669,594 - 88,684,200 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1043.05NCBI
Hsp90b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540538,629,691 - 38,645,202 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540538,629,691 - 38,645,202 (+)NCBIChiLan1.0ChiLan1.0
HSP90B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210111,992,374 - 112,010,769 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112111,988,771 - 112,007,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012101,506,845 - 101,524,407 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112104,901,997 - 104,919,592 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12104,901,997 - 104,919,329 (+)Ensemblpanpan1.1panPan2
HSP90B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11542,456,793 - 42,474,122 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1542,456,764 - 42,579,311 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1542,826,278 - 42,843,622 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01543,114,295 - 43,131,887 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1543,114,231 - 43,235,108 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11542,380,743 - 42,398,025 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01542,479,226 - 42,496,568 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01542,750,406 - 42,767,726 (+)NCBIUU_Cfam_GSD_1.0
Hsp90b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494517,503,494 - 17,517,769 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649210,513,908 - 10,528,285 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649210,513,908 - 10,528,281 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSP90B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl580,511,506 - 80,530,991 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1580,511,513 - 80,531,016 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2584,016,174 - 84,083,931 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSP90B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11199,119,268 - 99,139,988 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1199,119,224 - 99,139,722 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037145,859,568 - 145,877,331 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsp90b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247504,737,894 - 4,752,221 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247504,738,563 - 4,752,227 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsp90b1
84 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:196
Count of miRNA genes:151
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000029435
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)71816950526029351Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)72055570529891047Rat

Markers in Region
RH129351  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2721,110,544 - 21,110,724 (+)MAPPERmRatBN7.2
Rnor_6.0727,226,684 - 27,226,863NCBIRnor6.0
Rnor_5.0727,345,844 - 27,346,023UniSTSRnor5.0
RGSC_v3.4723,333,100 - 23,333,279UniSTSRGSC3.4
Celera718,290,356 - 18,290,535UniSTS
Cytogenetic Map7q13UniSTS
RH135295  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2721,114,563 - 21,114,783 (+)MAPPERmRatBN7.2
Rnor_6.0727,230,703 - 27,230,922NCBIRnor6.0
Rnor_5.0727,349,906 - 27,350,125UniSTSRnor5.0
RGSC_v3.4723,337,162 - 23,337,381UniSTSRGSC3.4
Celera718,294,371 - 18,294,590UniSTS
RH 3.4 Map7118.6UniSTS
Cytogenetic Map7q13UniSTS
RH140630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2721,111,284 - 21,111,914 (+)MAPPERmRatBN7.2
Rnor_6.0727,227,424 - 27,228,053NCBIRnor6.0
Rnor_5.0727,346,627 - 27,347,256UniSTSRnor5.0
RGSC_v3.4723,333,883 - 23,334,512UniSTSRGSC3.4
Celera718,291,092 - 18,291,721UniSTS
RH 3.4 Map7114.65UniSTS
Cytogenetic Map7q13UniSTS
MARC_26038-26039:1032450563:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2721,122,164 - 21,122,753 (+)MAPPERmRatBN7.2
Rnor_6.0727,238,304 - 27,238,892NCBIRnor6.0
Rnor_5.0727,357,528 - 27,358,116UniSTSRnor5.0
RGSC_v3.4723,344,782 - 23,345,370UniSTSRGSC3.4
Celera718,301,954 - 18,302,542UniSTS
Cytogenetic Map7q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 6 6 6
Medium 3 43 51 35 19 35 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000029435   ⟹   ENSRNOP00000034846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl721,110,592 - 21,124,788 (-)Ensembl
Rnor_6.0 Ensembl727,226,569 - 27,240,528 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079731   ⟹   ENSRNOP00000073056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl721,110,457 - 21,124,762 (-)Ensembl
Rnor_6.0 Ensembl727,226,596 - 27,240,533 (-)Ensembl
RefSeq Acc Id: NM_001012197   ⟹   NP_001012197
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,997,962 - 23,012,293 (-)NCBI
mRatBN7.2721,110,431 - 21,124,762 (-)NCBI
Rnor_6.0727,226,570 - 27,240,533 (-)NCBI
Rnor_5.0727,345,730 - 27,359,757 (-)NCBI
RGSC_v3.4723,332,986 - 23,347,525 (-)RGD
Celera718,290,242 - 18,304,551 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012197 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB29919 (Get FASTA)   NCBI Sequence Viewer  
  AAH81917 (Get FASTA)   NCBI Sequence Viewer  
  AAZ41383 (Get FASTA)   NCBI Sequence Viewer  
  EDM17052 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034846.5
  ENSRNOP00000073056
  ENSRNOP00000073056.2
GenBank Protein Q66HD0 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001012197   ⟸   NM_001012197
- Peptide Label: precursor
- UniProtKB: A6IFJ6 (UniProtKB/Swiss-Prot),   Q66HD0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073056   ⟸   ENSRNOT00000079731
RefSeq Acc Id: ENSRNOP00000034846   ⟸   ENSRNOT00000029435
Protein Domains
Histidine kinase/HSP90-like ATPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HD0-F1-model_v2 AlphaFold Q66HD0 1-804 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695115
Promoter ID:EPDNEW_R5640
Type:multiple initiation site
Name:Hsp90b1_1
Description:heat shock protein 90 beta family member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0727,240,517 - 27,240,577EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310482 AgrOrtholog
BioCyc Gene G2FUF-34545 BioCyc
Ensembl Genes ENSRNOG00000026963 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029435.6 UniProtKB/TrEMBL
  ENSRNOT00000079731 UniProtKB/TrEMBL
  ENSRNOT00000079731.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.230.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.11260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7112411 IMAGE-MGC_LOAD
InterPro HATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_protein_90_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP90_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp90_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp90_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:362862 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93881 IMAGE-MGC_LOAD
NCBI Gene 362862 ENTREZGENE
PANTHER ENDOPLASMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11528 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HATPase_c_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsp90b1 PhenoGen
PIRSF Hsp90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HEATSHOCK90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ER_TARGET UniProtKB/Swiss-Prot
  HSP90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026963 RatGTEx
SMART HATPase_c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF110942 UniProtKB/Swiss-Prot
  SSF54211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MY09_RAT UniProtKB/TrEMBL
  A0A0G2K4I4_RAT UniProtKB/TrEMBL
  A6IFJ6 ENTREZGENE
  ENPL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A6IFJ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Hsp90b1  heat shock protein 90 beta family member 1  Hsp90b1  heat shock protein 90, beta, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-27 Hsp90b1  heat shock protein 90, beta, member 1  Hsp90b1  heat shock protein 90kDa beta (Grp94), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 Hsp90b1  heat shock protein 90kDa beta (Grp94), member 1  Tra1  tumor rejection antigen gp96  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-19 Tra1  tumor rejection antigen gp96  Tra1_predicted  tumor rejection antigen gp96 (predicted)  Symbol and Name updated 1299863 APPROVED
2008-05-19 Tra1_predicted  tumor rejection antigen gp96 (predicted)  Tra1  tumor rejection antigen gp96  Data merged from RGD:727969 737654 APPROVED
2005-07-08 Tra1  tumor rejection antigen gp96  Grp94    Symbol updated 1299863 APPROVED
2005-01-12 Tra1_predicted  tumor rejection antigen gp96 (predicted)      Symbol and Name status set to approved 70820 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs activity is inhibited by geldanamycin 1298851