Dvl3 (dishevelled segment polarity protein 3) - Rat Genome Database

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Gene: Dvl3 (dishevelled segment polarity protein 3) Rattus norvegicus
Analyze
Symbol: Dvl3
Name: dishevelled segment polarity protein 3
RGD ID: 1308834
Description: Enables signaling receptor binding activity. Involved in positive regulation of neuron projection arborization and response to xenobiotic stimulus. Predicted to be located in chromatin and cytoplasm. Predicted to be part of Wnt signalosome. Predicted to be active in cytosol and glutamatergic synapse. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3 and lung cancer. Orthologous to human DVL3 (dishevelled segment polarity protein 3); PARTICIPATES IN Wnt signaling pathway; Wnt signaling, canonical pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; clozapine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dishevelled 3, dsh homolog; dishevelled 3, dsh homolog (Drosophila); dishevelled, dsh homolog 3; dishevelled, dsh homolog 3 (Drosophila); LOC303811; segment polarity protein dishevelled homolog DVL-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,869,834 - 93,887,013 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1193,869,834 - 93,886,903 (-)EnsemblGRCr8
mRatBN7.21180,365,446 - 80,382,641 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,366,117 - 80,382,462 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1189,090,200 - 89,104,688 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,743,619 - 81,758,109 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,804,686 - 80,819,179 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,051,177 - 84,068,479 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,051,078 - 84,068,302 (-)Ensemblrn6Rnor6.0
Rnor_5.01187,123,483 - 87,139,802 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41182,597,654 - 82,622,175 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1179,207,145 - 79,222,292 (-)NCBICelera
RGSC_v3.11182,654,389 - 82,679,764 (-)NCBI
Cytogenetic Map11q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP)
buta-1,3-diene  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chrysene  (ISO)
clobetasol  (ISO)
clozapine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
haloperidol  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
N-ethyl-N-nitrosourea  (ISO)
niclosamide  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
proanthocyanidin  (ISO)
risperidone  (EXP)
Salinomycin  (ISO)
sodium arsenite  (ISO)
tert-butyl hydroperoxide  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO,TAS)
glutamatergic synapse  (ISO)
synapse  (ISO)
Wnt signalosome  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Bian WJ, etal., Dev Neurobiol. 2015 Aug;75(8):805-22. doi: 10.1002/dneu.22250. Epub 2014 Dec 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Kishida S, etal., Mol Cell Biol. 1999 Jun;19(6):4414-22.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
13. Activation of the canonical Wnt pathway by the antipsychotics haloperidol and clozapine involves dishevelled-3. Sutton LP, etal., J Neurochem. 2007 Jul;102(1):153-69. Epub 2007 May 1.
14. Integrating expression-related SNPs into genome-wide gene- and pathway-based analyses identified novel lung cancer susceptibility genes. Wang Y, etal., Int J Cancer. 2018 Apr 15;142(8):1602-1610. doi: 10.1002/ijc.31182. Epub 2017 Dec 12.
Additional References at PubMed
PMID:10644691   PMID:11274398   PMID:12805222   PMID:16501258   PMID:17005174   PMID:17030191   PMID:17593335   PMID:18093802   PMID:19008950   PMID:19137009   PMID:19388021   PMID:19625296  
PMID:20137080   PMID:20227366   PMID:21718540   PMID:21880741   PMID:22899650   PMID:23109420   PMID:26359454   PMID:30808893  


Genomics

Comparative Map Data
Dvl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,869,834 - 93,887,013 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1193,869,834 - 93,886,903 (-)EnsemblGRCr8
mRatBN7.21180,365,446 - 80,382,641 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,366,117 - 80,382,462 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1189,090,200 - 89,104,688 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,743,619 - 81,758,109 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,804,686 - 80,819,179 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,051,177 - 84,068,479 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,051,078 - 84,068,302 (-)Ensemblrn6Rnor6.0
Rnor_5.01187,123,483 - 87,139,802 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41182,597,654 - 82,622,175 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1179,207,145 - 79,222,292 (-)NCBICelera
RGSC_v3.11182,654,389 - 82,679,764 (-)NCBI
Cytogenetic Map11q23NCBI
DVL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383184,155,377 - 184,173,614 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3184,155,159 - 184,173,614 (+)Ensemblhg38GRCh38
GRCh373183,873,165 - 183,891,402 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,355,978 - 185,374,008 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343185,355,985 - 185,374,016NCBI
Celera3182,315,580 - 182,333,025 (+)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3181,280,976 - 181,298,206 (+)NCBIHuRef
CHM1_13183,837,689 - 183,855,719 (+)NCBICHM1_1
T2T-CHM13v2.03186,964,902 - 186,982,556 (+)NCBIT2T-CHM13v2.0
Dvl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,335,694 - 20,352,763 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,335,732 - 20,352,760 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381620,516,949 - 20,534,013 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,516,982 - 20,534,010 (+)Ensemblmm10GRCm38
MGSCv371620,517,137 - 20,532,260 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361620,430,525 - 20,445,193 (+)NCBIMGSCv36mm8
Celera1621,081,348 - 21,096,276 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.46NCBI
Dvl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,293,222 - 23,301,694 (-)Ensembl
ChiLan1.0NW_00495542023,291,650 - 23,301,695 (-)NCBIChiLan1.0ChiLan1.0
DVL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22182,027,024 - 182,044,975 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13182,031,934 - 182,049,695 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03181,190,961 - 181,207,831 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,674,405 - 189,691,749 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,674,399 - 189,693,130 (+)EnsemblpanPan2panpan1.1
DVL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,053,534 - 17,069,965 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,053,343 - 17,068,389 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3421,140,844 - 21,154,943 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03416,961,718 - 16,975,817 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3416,961,342 - 16,976,564 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13416,999,057 - 17,013,143 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03416,995,018 - 17,011,464 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03417,225,218 - 17,241,675 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dvl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,602,013 - 119,618,283 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365785,693,342 - 5,710,143 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365785,693,433 - 5,710,137 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DVL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,076,003 - 122,092,971 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113122,075,851 - 122,092,975 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,521,353 - 131,532,563 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DVL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,254,764 - 5,270,661 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,254,661 - 5,270,403 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606314,033,307 - 14,049,218 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dvl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473072,396,343 - 72,413,175 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473072,396,437 - 72,412,260 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dvl3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v145,355,659 - 5,372,916 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:40
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000002323
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)119046178196556255Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
RH127970  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,365,547 - 80,365,733 (+)MAPPERmRatBN7.2
mRatBN7.27110,707,666 - 110,707,852 (+)MAPPERmRatBN7.2
Rnor_6.07120,375,647 - 120,375,832NCBIRnor6.0
Rnor_6.01184,051,273 - 84,051,458NCBIRnor6.0
Rnor_5.01187,123,585 - 87,123,770UniSTSRnor5.0
Rnor_5.07120,369,726 - 120,369,911UniSTSRnor5.0
RGSC_v3.47117,117,919 - 117,118,104UniSTSRGSC3.4
RGSC_v3.41182,595,563 - 82,595,748UniSTSRGSC3.4
Celera1179,204,941 - 79,205,126UniSTS
Celera7107,042,159 - 107,042,344UniSTS
RH 3.4 Map11654.01UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map7q34UniSTS
UniSTS:532277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,367,808 - 80,368,299 (+)MAPPERmRatBN7.2
Rnor_6.01184,053,534 - 84,054,024NCBIRnor6.0
Rnor_5.01187,125,846 - 87,126,336UniSTSRnor5.0
Celera1179,207,202 - 79,207,692UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002323   ⟹   ENSRNOP00000002323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1193,871,376 - 93,886,903 (-)Ensembl
mRatBN7.2 Ensembl1180,366,117 - 80,382,462 (-)Ensembl
Rnor_6.0 Ensembl1184,051,078 - 84,068,302 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101876   ⟹   ENSRNOP00000094862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1193,869,834 - 93,886,772 (-)Ensembl
mRatBN7.2 Ensembl1180,367,624 - 80,382,391 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125059   ⟹   ENSRNOP00000110749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1193,869,834 - 93,886,903 (-)Ensembl
RefSeq Acc Id: NM_001107081   ⟹   NP_001100551
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,869,834 - 93,886,903 (-)NCBI
mRatBN7.21180,365,452 - 80,382,522 (-)NCBI
Rnor_6.01184,053,477 - 84,068,087 (-)NCBI
Rnor_5.01187,123,483 - 87,139,802 (-)NCBI
RGSC_v3.41182,597,654 - 82,622,175 (-)RGD
Celera1179,207,145 - 79,222,292 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063270474   ⟹   XP_063126544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,869,834 - 93,887,013 (-)NCBI
RefSeq Acc Id: XM_063270475   ⟹   XP_063126545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,869,834 - 93,887,013 (-)NCBI
RefSeq Acc Id: XM_063270476   ⟹   XP_063126546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,869,834 - 93,887,012 (-)NCBI
RefSeq Acc Id: NP_001100551   ⟸   NM_001107081
- UniProtKB: A6JSB1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002323   ⟸   ENSRNOT00000002323
Ensembl Acc Id: ENSRNOP00000094862   ⟸   ENSRNOT00000101876
RefSeq Acc Id: XP_063126545   ⟸   XM_063270475
- Peptide Label: isoform X2
- UniProtKB: A6JSB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126544   ⟸   XM_063270474
- Peptide Label: isoform X1
- UniProtKB: A6JSB1 (UniProtKB/TrEMBL),   D4ADV8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126546   ⟸   XM_063270476
- Peptide Label: isoform X3
- UniProtKB: A6JSB1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110749   ⟸   ENSRNOT00000125059
Protein Domains
DEP   DIX   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADV8-F1-model_v2 AlphaFold D4ADV8 1-716 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698280
Promoter ID:EPDNEW_R8804
Type:initiation region
Name:Dvl3_1
Description:dishevelled segment polarity protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01184,068,362 - 84,068,422EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308834 AgrOrtholog
BioCyc Gene G2FUF-20730 BioCyc
Ensembl Genes ENSRNOG00000001708 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002323 ENTREZGENE
  ENSRNOT00000002323.8 UniProtKB/TrEMBL
  ENSRNOT00000101876.2 UniProtKB/TrEMBL
  ENSRNOT00000125059 ENTREZGENE
  ENSRNOT00000125059.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  2.40.240.130 UniProtKB/TrEMBL
InterPro DEP_dom UniProtKB/TrEMBL
  Dishevell UniProtKB/TrEMBL
  Dishevelled_3 UniProtKB/TrEMBL
  Dishevelled_C-dom UniProtKB/TrEMBL
  Dishevelled_protein UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  DIX_dom_sf UniProtKB/TrEMBL
  Dsh UniProtKB/TrEMBL
  PDZ/DHR/GLGF UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:303811 UniProtKB/TrEMBL
NCBI Gene 303811 ENTREZGENE
PANTHER Dsh UniProtKB/TrEMBL
  PTHR10878:SF6 UniProtKB/TrEMBL
Pfam DEP UniProtKB/TrEMBL
  Dishevelled UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  Dsh_C UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
PhenoGen Dvl3 PhenoGen
PRINTS DISHEVELLED UniProtKB/TrEMBL
  DISHEVELLED3 UniProtKB/TrEMBL
PROSITE DEP UniProtKB/TrEMBL
  DIX UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001708 RatGTEx
SMART DAX UniProtKB/TrEMBL
  DEP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
Superfamily-SCOP PDZ UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8I6GKX7_RAT UniProtKB/TrEMBL
  A0ABK0LWI7_RAT UniProtKB/TrEMBL
  A6JSB1 ENTREZGENE, UniProtKB/TrEMBL
  D4ADV8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-05 Dvl3  dishevelled segment polarity protein 3  Dvl3  dishevelled, dsh homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Dvl3  dishevelled, dsh homolog 3 (Drosophila)  Dvl3  dishevelled 3, dsh homolog (Drosophila)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dvl3  dishevelled 3, dsh homolog (Drosophila)   Dvl3_predicted  dishevelled 3, dsh homolog (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dvl3_predicted  dishevelled 3, dsh homolog (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED