Hsd3b1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) - Rat Genome Database

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Gene: Hsd3b1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) Rattus norvegicus
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Symbol: Hsd3b1
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
RGD ID: 1308676
Description: Enables several functions, including 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity; NAD binding activity; and steroid delta-isomerase activity. Involved in several processes, including cellular response to gonadotropin stimulus; gonad development; and response to glucocorticoid. Located in mitochondrial crista. Biomarker of several diseases, including hyperprolactinemia; hypertension; polycystic ovary syndrome; sciatic neuropathy; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH (+)-taxifolin; (-)-citrinin; (E)-thiamethoxam.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3 beta-hydroxysteroid dehydrogenase 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; 3betaHSD; delta-5-3-ketosteroid isomerase; dihydrotestosterone oxidoreductase; hydroxysteroid dehydrogenase-1, delta<5>-3-beta; LOC360348; MGC105549; steroid Delta-isomerase
RGD Orthologs
Human
Mouse
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,858,574 - 188,864,694 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.22186,169,864 - 186,175,984 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2186,169,863 - 186,175,999 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2193,825,866 - 193,831,935 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,621,665 - 191,627,731 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,458,432 - 186,464,495 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
RGSC_v3.42193,500,916 - 193,507,633 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2178,651,833 - 178,657,861 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(-)-citrinin  (EXP)
(E)-thiamethoxam  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trichlorophenol  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-methoxyethanol  (EXP)
2-tert-butylhydroquinone  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-Dimethylbisphenol A  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nitro-m-cresol  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-azacytidine  (ISO)
5-hydroxymethylfurfural  (ISO)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
androst-4-ene-3,17-dione  (ISO)
androst-5-ene-3beta,17beta-diol  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
atrazine  (EXP,ISO)
azithromycin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzophenone  (ISO)
Benzyl salicylate  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (EXP,ISO)
bisphenol F  (EXP)
Bisphenol Z  (ISO)
bosentan  (ISO)
bucladesine  (EXP)
Butyl salicylate  (ISO)
butylated hydroxyanisole  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
CARBENOXOLONE  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlormequat chloride  (EXP)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
Chorionic gonadotropin  (EXP)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
coumarin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
D-glucose  (ISO)
daidzein  (EXP)
daidzein 7-O-beta-D-glucoside  (EXP)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (EXP,ISO)
delta-hexachlorocyclohexane  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (EXP)
dibenzothiophene  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (EXP)
dichlorine  (EXP)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
difenoconazole  (ISO)
diisobutyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
dimethomorph  (EXP)
Dimethyl phthalate  (ISO)
dipentyl phthalate  (EXP)
elemental selenium  (EXP)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
entinostat  (ISO)
ethanol  (EXP)
Ethyl salicylate  (ISO)
fenarimol  (ISO)
fenvalerate  (EXP)
ferbam  (ISO)
Finrozole  (ISO)
fipronil  (ISO)
fisetin  (EXP)
flutamide  (EXP)
fluvastatin  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (EXP)
glucose  (ISO)
glutathione  (EXP)
glycidol  (ISO)
glycine  (ISO)
glycitein  (EXP)
glycitin  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (EXP,ISO)
Goe 6976  (ISO)
hesperidin  (EXP)
hexachlorobenzene  (ISO)
hexachlorophene  (ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP,ISO)
icariin  (ISO)
iodoacetic acid  (ISO)
Isoamyl salicylate  (ISO)
isoflavones  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
linuron  (EXP)
lycopene  (EXP)
menadione  (ISO)
mestranol  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP,ISO)
methyl salicylate  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (EXP,ISO)
monoethyl phthalate  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nobiletin  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
octabenzone  (ISO)
Octicizer  (ISO)
okadaic acid  (ISO)
Oxine-copper  (ISO)
ozone  (EXP)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorodecanoic acid  (EXP,ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
pregnenolone  (ISO)
progesterone  (EXP,ISO)
pyrethrins  (EXP)
quercetin  (EXP,ISO)
resveratrol  (EXP)
retinyl acetate  (EXP)
royal jelly  (EXP)
SB 431542  (ISO)
selenium atom  (EXP)
senecionine  (ISO)
sertraline  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sodium hypochlorite  (ISO)
sulfasalazine  (EXP)
sulindac sulfide  (ISO)
terbutylazine  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thiamethoxam  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
tributylstannane  (EXP)
trichlorfon  (EXP)
triclosan  (ISO)
triflumizole  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP)
uranium atom  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
wogonin  (EXP)
XAV939  (ISO)
zearalenone  (EXP,ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEP)
androgen biosynthetic process  (ISO)
C21-steroid hormone biosynthetic process  (IMP)
C21-steroid hormone metabolic process  (IBA,IEA)
cellular response to antibiotic  (IEP)
cellular response to cAMP  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to gonadotropin stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to luteinizing hormone stimulus  (IEP)
cellular response to mercury ion  (IEP)
cellular response to methylmercury  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP)
female gonad development  (IEP)
glucocorticoid biosynthetic process  (ISO)
granulocyte differentiation  (IEP)
hippocampus development  (IEP)
Leydig cell differentiation  (IEP)
lipid metabolic process  (IEA)
male gonad development  (IEP)
maternal process involved in female pregnancy  (IEP)
phosphatidylcholine metabolic process  (IEP)
progesterone biosynthetic process  (IDA,ISO)
response to activity  (IEP)
response to alkaloid  (IEP)
response to arsenic-containing substance  (IEP)
response to cadmium ion  (IEP)
response to calcium ion  (IEP)
response to corticosterone  (IEP)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to fatty acid  (IEP)
response to fungicide  (IEP)
response to herbicide  (IEP)
response to L-ascorbic acid  (IEP)
response to lead ion  (IEP)
response to metal ion  (IEP)
response to nutrient levels  (IEP)
response to vitamin E  (IEP)
response to xenobiotic stimulus  (IEP)
steroid biosynthetic process  (IBA,IEA)
steroid metabolic process  (IDA,IEA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis. Adamsson A, etal., Int J Androl. 2009 Oct;32(5):575-85. Epub 2008 Jul 9.
2. Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis. Brokken LJ, etal., Endocrinology. 2009 Jan;150(1):445-51. Epub 2008 Sep 4.
3. Effects of high levels of glucose on the steroidogenesis and the expression of adiponectin receptors in rat ovarian cells. Chabrolle C, etal., Reprod Biol Endocrinol. 2008 Mar 19;6:11.
4. Chromium induced testicular impairment in relation to adrenocortical activities in adult albino rats. Chandra AK, etal., Reprod Toxicol. 2007 Nov-Dec;24(3-4):388-96. Epub 2007 Aug 1.
5. Mutations in the type II 3 beta-hydroxysteroid dehydrogenase gene in a patient with classic salt-wasting 3 beta-hydroxysteroid dehydrogenase deficiency congenital adrenal hyperplasia. Chang YT, etal., Pediatr Res. 1993 Nov;34(5):698-700.
6. Lithium action on adrenomedullary and adrenocortical functions and serum ionic balance in different age-groups of albino rats. Chaudhuri-Sengupta S, etal., Arch Physiol Biochem. 2003 Jul;111(3):246-53.
7. Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells. Chen YJ, etal., Endocrinology. 2008 Sep;149(9):4658-68. Epub 2008 May 29.
8. Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome p450scc and 3beta-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells. Cherradi N, etal., J Biol Chem. 1997 Mar 21;272(12):7899-907.
9. Molecular study of the 3 beta-hydroxysteroid dehydrogenase gene type II in patients with hypospadias. Codner E, etal., J Clin Endocrinol Metab. 2004 Feb;89(2):957-64.
10. Identification and mechanism of action of phospholipids capable of modulating rat testicular microsomal 3 beta-hydroxysteroid dehydrogenase-isomerase activity in vitro. Cooke GM Biol Reprod. 1989 Sep;41(3):438-45.
11. Androgenic 17 beta-hydroxysteroid dehydrogenase activity of expressed rat type I 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase. de Launoit Y, etal., Endocrinology. 1992 Jan;130(1):553-5.
12. Expression of liver-specific member of the 3 beta-hydroxysteroid dehydrogenase family, an isoform possessing an almost exclusive 3-ketosteroid reductase activity. de Launoit Y, etal., J Biol Chem. 1992 Mar 5;267(7):4513-7.
13. Fibroblast growth factor-9, a local regulator of ovarian function. Drummond AE, etal., Endocrinology. 2007 Aug;148(8):3711-21. Epub 2007 May 10.
14. Ontogenesis of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in the rat adrenal as revealed by immunocytochemistry and in situ hybridization. Dupont E, etal., Endocrinology. 1991 Nov;129(5):2687-92.
15. Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats. Elumalai P, etal., Reprod Toxicol. 2009 Jan;27(1):41-5. Epub 2008 Nov 24.
16. Inhibition of rat granulosa cell differentiation by overexpression of Galphaq. Escamilla-Hernandez R, etal., Endocrine. 2008 Feb;33(1):21-31. Epub 2008 Apr 10.
17. Constitutively active protein kinase A qualitatively mimics the effects of follicle-stimulating hormone on granulosa cell differentiation. Escamilla-Hernandez R, etal., Mol Endocrinol. 2008 Aug;22(8):1842-52. Epub 2008 Jun 5.
18. Strontium fructose 1,6-diphosphate rescues adenine-induced male hypogonadism and upregulates the testicular endothelin-1 system. Feng Y, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1131-7.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. H2O2 at physiological concentrations modulates Leydig cell function inducing oxidative stress and apoptosis. Gautam DK, etal., Apoptosis. 2006 Jan;11(1):39-46.
21. In search of rat stem Leydig cells: identification, isolation, and lineage-specific development. Ge RS, etal., Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2719-24. Epub 2006 Feb 8.
22. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
23. Hypothyroidism prolongs corpus luteum function in the pregnant rat. Hapon MB, etal., Reproduction. 2007 Jan;133(1):197-205.
24. Increased expression of 3 beta-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons of adult rats following peripheral nerve injury. Hashimoto N, etal., Neurosci Lett 2003 Apr 3;340(1):45-8.
25. The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes. Hu GX, etal., J Steroid Biochem Mol Biol. 2009 May;115(1-2):14-9. Epub 2009 Feb 14.
26. Influence of commercial dietary oils on lipid composition and testosterone production in interstitial cells isolated from rat testis. Hurtado de Catalfo GE, etal., Lipids. 2009 Apr;44(4):345-57. Epub 2009 Jan 8.
27. Evaluation of single intratesticular injection of calcium chloride for nonsurgical sterilization in adult albino rats. Jana K and Samanta PK, Contraception. 2006 Mar;73(3):289-300. Epub 2005 Oct 20.
28. Protective effect of sodium selenite and zinc sulfate on intensive swimming-induced testicular gamatogenic and steroidogenic disorders in mature male rats. Jana K, etal., Appl Physiol Nutr Metab. 2008 Oct;33(5):903-14.
29. Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of action. Jana K, etal., Reprod Biol Endocrinol. 2006 Feb 16;4:9.
30. Ontogenesis of 3 beta-hydroxysteroid dehydrogenase delta 5-delta 4 isomerase in the rat ovary as studied by immunocytochemistry and in situ hybridization. Juneau C, etal., Biol Reprod. 1993 Feb;48(2):226-34.
31. Expression of testicular 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase: regulation by luteinizing hormone and forskolin in Leydig cells of adult rats. Keeney DS and Mason JI, Endocrinology. 1992 Apr;130(4):2007-15.
32. Semicomprehensive Analysis of the Postnatal Age-Related Changes in the mRNA Expression of Sex Steroidogenic Enzymes and Sex Steroid Receptors in the Male Rat Hippocampus. Kimoto T, etal., Endocrinology. 2010 Nov 3.
33. Spearmint induced hypothalamic oxidative stress and testicular anti-androgenicity in male rats - altered levels of gene expression, enzymes and hormones. Kumar V, etal., Food Chem Toxicol. 2008 Dec;46(12):3563-70. Epub 2008 Aug 31.
34. Effects of endocrine disrupting chemicals from leather industry effluents on male reproductive system. Kumar V, etal., J Steroid Biochem Mol Biol. 2008 Sep;111(3-5):208-16. Epub 2008 Jun 18.
35. Disruption of LH-induced testosterone biosynthesis in testicular Leydig cells by triclosan: probable mechanism of action. Kumar V, etal., Toxicology. 2008 Sep 4;250(2-3):124-31. Epub 2008 Jul 9.
36. Parabens Accelerate Ovarian Dysfunction in a 4-Vinylcyclohexene Diepoxide-Induced Ovarian Failure Model. Lee JH, etal., Int J Environ Res Public Health. 2017 Feb 8;14(2). pii: ijerph14020161. doi: 10.3390/ijerph14020161.
37. 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase expression in rat and characterization of the testis isoform. Lorence MC, etal., Mol Cell Endocrinol. 1991 Sep;80(1-3):21-31.
38. Dicyclohexyl phthalate blocks Leydig cell regeneration in adult rat testis. Lv Y, etal., Toxicology. 2019 Jan 1;411:60-70. doi: 10.1016/j.tox.2018.10.020. Epub 2018 Nov 1.
39. The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. MacKenzie SM, etal., J Endocrinol. 2008 Jan;196(1):123-30.
40. Effects of human chorionic gonadotropin (hCG) and prolactin (PRL) on 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) expression and activity in the rat ovary. Martel C, etal., Mol Cell Endocrinol. 1990 Aug 20;72(2):R7-13.
41. Effects of dietary fats and proteins on rat testicular steroidogenic enzymes and serum testosterone levels. McVey MJ, etal., Food Chem Toxicol. 2008 Jan;46(1):259-69. Epub 2007 Sep 11.
42. Evidence that Leydig precursors localize in immature band two cells isolated on Percoll gradients. Murono EP and Washburn AL, J Steroid Biochem Mol Biol. 1990 Dec 10;37(5):675-80.
43. Enhanced stimulation of 5 alpha-reductase activity in cultured Leydig cell precursors by human chorionic gonadotropin. Murono EP, etal., J Steroid Biochem Mol Biol. 1994 Mar;48(4):377-84.
44. Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells. Murugesan P, etal., Toxicology. 2007 Apr 11;232(3):170-82. Epub 2007 Jan 16.
45. A novel antagonistic effect of the bone morphogenetic protein system on prolactin actions in regulating steroidogenesis by granulosa cells. Nakamura E, etal., Endocrinology. 2010 Nov;151(11):5506-18. Epub 2010 Sep 1.
46. Biochemical effects of gestational coexposure to lead and cadmium on reproductive performance, placenta, and ovary. Nampoothiri LP and Gupta S, J Biochem Mol Toxicol. 2008 Sep;22(5):337-44.
47. Regulation of expression of male-specific rat liver microsomal 3 beta-hydroxysteroid dehydrogenase. Naville D, etal., Mol Endocrinol 1991 Aug;5(8):1090-100.
48. The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome. Nelson VL, etal., J Clin Endocrinol Metab. 2001 Dec;86(12):5925-33.
49. Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis. O'Shaughnessy PJ, etal., Reproduction. 2008 Jun;135(6):851-8.
50. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
51. Effects of corticosterone deficiency and its replacement on Leydig cell steroidogenesis. Parthasarathy C and Balasubramanian K, J Cell Biochem. 2008 Aug 1;104(5):1671-83.
52. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
53. Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system. Pinilla L, etal., Endocrinology. 2009 Jun;150(6):2889-97. Epub 2009 Feb 19.
54. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
55. Modulation of antioxidant defense system by the environmental fungicide carbendazim in Leydig cells of rats. Rajeswary S, etal., Reprod Toxicol. 2007 Nov-Dec;24(3-4):371-80. Epub 2007 Apr 5.
56. GOA pipeline RGD automated data pipeline
57. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure. Rosmond R, etal., Biochem Biophys Res Commun. 2002 Apr 26;293(1):629-32.
60. Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid. Shi Z, etal., Toxicol Sci. 2007 Jul;98(1):206-15. Epub 2007 Mar 30.
61. Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. Slominski AT, etal., PLoS One. 2009;4(2):e4309. Epub 2009 Feb 3.
62. Neurosteroids and female reproduction: estrogen increases 3beta-HSD mRNA and activity in rat hypothalamus. Soma KK, etal., Endocrinology. 2005 Oct;146(10):4386-90. Epub 2005 Jul 14.
63. Effect of exogenous selenium on the testicular toxicity induced by ethanol in rats. Swathy SS, etal., Indian J Physiol Pharmacol. 2006 Jul-Sep;50(3):215-24.
64. Immunolocalization of androgen receptor and steroidogenic enzymes in cumuli oophori of pre- and post-ovulatory rats. Szoltys M, etal., Acta Histochem. 2010 Nov;112(6):576-82. Epub 2009 Sep 22.
65. Expression of androgen receptor and 3beta-hydroxysteroid dehydrogenase in corpora lutea during pregnancy in the rat. Szoltys M, etal., Reprod Fertil Dev. 2007;19(2):356-65.
66. Effects of maternal toluene exposure on testosterone levels in fetal rats. Tsukahara S, etal., Toxicol Lett. 2009 Mar 10;185(2):79-84. Epub 2008 Dec 6.
67. Distribution of mercury and evaluation of testicular steroidogenesis in mercuric chloride and methylmercury administered rats. Vachhrajani KD and Chowdhury AR, Indian J Exp Biol. 1990 Aug;28(8):746-51.
68. Transient inhibitory effect of methoxychlor on testicular steroidogenesis in rat: an in vivo study. Vaithinathan S, etal., Arch Toxicol. 2008 Nov;82(11):833-9. Epub 2008 Apr 10.
69. Changes in testicular morphology and steroidogenesis in adult rats exposed to Atrazine. Victor-Costa AB, etal., Reprod Toxicol. 2010 Jun;29(3):323-31. Epub 2010 Jan 4.
70. Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms. Viollet B, etal., J Biol Chem 1996 Jan 19;271(3):1405-15.
71. Zhonghua nan ke xue = National journal of andrology Wu XY, etal., Zhonghua Nan Ke Xue. 2008 Apr;14(4):371-6.
72. Glucocorticoid suppresses steroidogenesis in rat progenitor leydig cells. Xiao YC, etal., J Androl. 2010 Jul-Aug;31(4):365-71. Epub 2010 Jan 14.
73. Characterization of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase cDNAs and differential tissue-specific expression of the corresponding mRNAs in steroidogenic and peripheral tissues. Zhao HF, etal., J Biol Chem 1991 Jan 5;266(1):583-93.
74. Gonadotropin stimulation of ovarian fractalkine expression and fractalkine augmentation of progesterone biosynthesis by luteinizing granulosa cells. Zhao P, etal., Endocrinology. 2008 Jun;149(6):2782-9. Epub 2008 Feb 21.
75. Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat. Zurvarra FM, etal., Reprod Fertil Dev. 2009;21(7):827-39.
Additional References at PubMed
PMID:2243100   PMID:8274411   PMID:12477932   PMID:15489334   PMID:18614015   PMID:21166213   PMID:21427060   PMID:22217836   PMID:23332974   PMID:34215832  


Genomics

Comparative Map Data
Hsd3b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,858,574 - 188,864,694 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.22186,169,864 - 186,175,984 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2186,169,863 - 186,175,999 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2193,825,866 - 193,831,935 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,621,665 - 191,627,731 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,458,432 - 186,464,495 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
RGSC_v3.42193,500,916 - 193,507,633 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2178,651,833 - 178,657,861 (-)NCBICelera
Cytogenetic Map2q34NCBI
HSD3B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,507,203 - 119,515,058 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,507,198 - 119,515,054 (+)Ensemblhg38GRCh38
GRCh371120,049,826 - 120,057,681 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361119,851,349 - 119,859,204 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341119,761,892 - 119,769,716NCBI
Celera1118,280,577 - 118,288,432 (+)NCBICelera
Cytogenetic Map1p12NCBI
HuRef1117,908,314 - 117,916,173 (+)NCBIHuRef
CHM1_11120,165,347 - 120,173,201 (+)NCBICHM1_1
T2T-CHM13v2.01119,520,389 - 119,528,244 (+)NCBIT2T-CHM13v2.0
Hsd3b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39398,749,672 - 98,767,110 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl398,759,510 - 98,767,110 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38398,842,356 - 98,859,794 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,852,194 - 98,859,794 (-)Ensemblmm10GRCm38
MGSCv37398,656,120 - 98,663,717 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36398,981,255 - 98,987,280 (-)NCBIMGSCv36mm8
Celera3100,188,018 - 100,195,618 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.89NCBI
HSD3B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.14101,565,229 - 101,574,110 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24111,555,576 - 111,564,185 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4q16-q21NCBI

Variants

.
Variants in Hsd3b1
140 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:6
Count of miRNA genes:4
Interacting mature miRNAs:4
Transcripts:ENSRNOT00000026306, ENSRNOT00000056172, ENSRNOT00000068511
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2187663373195783351Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
renal system
reproductive system
6 3 1 37 4 3 27 5

Sequence


Ensembl Acc Id: ENSRNOT00000086835   ⟹   ENSRNOP00000075324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2186,169,863 - 186,175,999 (-)Ensembl
RefSeq Acc Id: NM_001007719   ⟹   NP_001007720
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,858,574 - 188,864,694 (-)NCBI
mRatBN7.22186,169,864 - 186,175,984 (-)NCBI
RGSC_v3.42193,500,916 - 193,507,633 (-)RGD
Celera2178,651,833 - 178,657,861 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001007720 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA63474 (Get FASTA)   NCBI Sequence Viewer  
  AAH86578 (Get FASTA)   NCBI Sequence Viewer  
  ABF70960 (Get FASTA)   NCBI Sequence Viewer  
  EDL85558 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075324.2
GenBank Protein P22071 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007720   ⟸   NM_001007719
- UniProtKB: Q19P43 (UniProtKB/Swiss-Prot),   P22071 (UniProtKB/Swiss-Prot),   A6K3E2 (UniProtKB/TrEMBL),   F1LNS3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075324   ⟸   ENSRNOT00000086835
Protein Domains
3-beta hydroxysteroid dehydrogenase/isomerase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22071-F1-model_v2 AlphaFold P22071 1-373 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308676 AgrOrtholog
BioCyc Gene G2FUF-51907 BioCyc
Ensembl Genes ENSRNOG00000070622 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000086835.2 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7306702 IMAGE-MGC_LOAD
InterPro 3Beta_OHSteriod_DH/Estase UniProtKB/Swiss-Prot
  Lipid_A_modif_metabolic_enz UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:360348 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105549 IMAGE-MGC_LOAD
NCBI Gene 360348 ENTREZGENE
PANTHER BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA UniProtKB/Swiss-Prot
  EPIMERASE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam 3Beta_HSD UniProtKB/Swiss-Prot
PhenoGen Hsd3b1 PhenoGen
RatGTEx ENSRNOG00000070622 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt 3BHS1_RAT UniProtKB/Swiss-Prot
  A6K3E2 ENTREZGENE, UniProtKB/TrEMBL
  F1LNS3 ENTREZGENE, UniProtKB/TrEMBL
  P22071 ENTREZGENE
  Q19P43 ENTREZGENE
UniProt Secondary Q19P43 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-18 Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Hsd3b2  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2  Name and Symbol changed 629549 APPROVED
2010-11-02 Hsd3b2  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2  Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-12-18 Hsd3b1  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  Hsd3b1_predicted  hydroxysteroid dehydrogenase-1, delta<5>-3-beta (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-12 Hsd3b1_predicted  hydroxysteroid dehydrogenase-1, delta<5>-3-beta (predicted)      Symbol and Name status set to approved 70820 APPROVED