RGD Reference Report - Chromium induced testicular impairment in relation to adrenocortical activities in adult albino rats. - Rat Genome Database

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Chromium induced testicular impairment in relation to adrenocortical activities in adult albino rats.

Authors: Chandra, AK  Chatterjee, A  Ghosh, R  Sarkar, M  Chaube, SK 
Citation: Chandra AK, etal., Reprod Toxicol. 2007 Nov-Dec;24(3-4):388-96. Epub 2007 Aug 1.
RGD ID: 4890970
Pubmed: PMID:17822870   (View Abstract at PubMed)
DOI: DOI:10.1016/j.reprotox.2007.07.009   (Journal Full-text)

The present study investigates the testicular and adrenocortical activities under different doses and durations of chromium (Cr) exposure and their interactions. Mature male Sprague Dawley rats were injected daily with three different doses (0.2, 0.4, and 0.6 mg/kg bw) of Cr salt (K(2)Cr(2)O(7)) intraperitonealy for 13 and 26 days, respectively. The medium (0.4 mg/kg bw/day) and higher dose (0.6 mg/kg bw/day) of Cr significantly (p<0.05) decrease accessory sex organs weight, testicular Delta(5)3beta-hydroxysteroid dehydrogenase (HSD) and 17beta-HSD activities, epididymal sperm count, effective spermatid degeneration, serum testosterone, LH level, testicular catalase and superoxide dismutase (SOD) activities while testicular lipid peroxidation, serum FSH, corticosterone level, adrenal weight and adrenal Delta(5)3beta-HSD activity increased significantly than that of control and lower dose (0.2 mg/kg bw/day) Cr exposed animals. Testicular histoarchitechture shows deterioration after critical dose (0.4 mg/kg bw/day) and duration (26 days) of Cr exposure. Cr induced alterations on testicular and adrenocortical activities are dose and duration dependent. Adrecortical hyperactivity accompanied by testicular oxidative stress might have a crucial role for Cr induced male reproductive impairment.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to metal ion  IEP 4890970; 4890970hexavalent chromiumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Hsd17b3  (hydroxysteroid (17-beta) dehydrogenase 3)
Hsd3b1  (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1)


Additional Information