RGD Reference Report - Effects of corticosterone deficiency and its replacement on Leydig cell steroidogenesis. - Rat Genome Database

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Effects of corticosterone deficiency and its replacement on Leydig cell steroidogenesis.

Authors: Parthasarathy, C  Balasubramanian, K 
Citation: Parthasarathy C and Balasubramanian K, J Cell Biochem. 2008 Aug 1;104(5):1671-83.
RGD ID: 4831835
Pubmed: PMID:18335507   (View Abstract at PubMed)
DOI: DOI:10.1002/jcb.21733   (Journal Full-text)

Clinical and experimental studies have shown the adverse effects of glucocorticoid deficiency/metyrapone treatment on testicular Leydig cell testosterone production. However, molecular mechanisms that underlie the effects of glucocorticoid deficiency on Leydig cell steroidogenesis are not yet determined. Therefore, the present study was designed to assess the mechanism of this phenomenon. Following metyrapone-induced corticosterone deficiency, serum testosterone, and Leydig cell 14C-glucose oxidation were decreased. StAR mRNA and protein levels were significantly increased in Leydig cells of corticosterone-deficient animals. mRNA levels and the specific activities of P(450)scc and 17beta-HSD were decreased by corticosterone deficiency, whereas the activity and mRNA of 3beta-HSD were increased. Simultaneous administration of corticosterone prevented its deficiency-induced changes in Leydig cells. Our results show that metyrapone-induced corticosterone deficiency impairs Leydig cell testosterone production by decreasing the activities of steroidogenic enzymes and their mRNA expression and glucose oxidation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to corticosterone  IEP 4831835; 4831835; 4831835; 4831835 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cyp11a1  (cytochrome P450, family 11, subfamily a, polypeptide 1)
Hsd17b3  (hydroxysteroid (17-beta) dehydrogenase 3)
Hsd3b1  (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1)
Star  (steroidogenic acute regulatory protein)


Additional Information