Akr1c1 (aldo-keto reductase family 1, member C1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Akr1c1 (aldo-keto reductase family 1, member C1) Rattus norvegicus
Analyze
Symbol: Akr1c1
Name: aldo-keto reductase family 1, member C1
RGD ID: 1306847
Description: Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NADP+) activity. Involved in response to estrogen and response to xenobiotic stimulus. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; alcohol dependence; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); Akr1c6; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1, 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); aldo-keto reductase family 1, member C6; Hsd17b5; LOC307092; MGC125057; type 5 17beta-hydroxysteroid dehydrogenase
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81770,720,397 - 70,747,285 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1770,720,398 - 70,747,247 (-)EnsemblGRCr8
mRatBN7.21765,810,474 - 65,837,385 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1765,810,475 - 65,837,326 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1769,306,245 - 69,325,133 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,135,098 - 73,153,981 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,178,080 - 67,196,962 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,441,253 - 69,460,334 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,441,223 - 69,460,321 (-)Ensemblrn6Rnor6.0
Rnor_5.01771,155,010 - 71,174,079 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41777,084,306 - 77,112,994 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1765,342,356 - 65,364,506 (-)NCBICelera
RGSC_v3.11777,095,138 - 77,123,818 (-)NCBI
Cytogenetic Map17q12.2NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(E)-cinnamyl alcohol  (ISO)
(S)-naringenin  (ISO)
1,10-phenanthroline  (ISO)
1,2-dichloroethane  (ISO)
1,7-phenanthroline  (ISO)
1,8-Dinitropyrene  (ISO)
1-Aminopyrene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxybenzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-alpha-THDOC  (ISO)
5-fluorouracil  (ISO)
5alpha-pregnane-3,20-dione  (ISO)
7-hydroxyflavone  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinal  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
allopurinol  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
amiodarone  (ISO)
anthranilic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astilbin  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
Bandrowski's base  (ISO)
benzbromarone  (ISO)
Benzo[a]fluorene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[b]fluorene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoic acid  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorohydrocarbon  (EXP)
chrysene  (ISO)
ciglitazone  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
Clofop  (ISO)
cloxazolam  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
crotonaldehyde  (ISO)
cyclopentanol  (ISO)
cyclopentanone  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
Dibenz[a,c]anthracene  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dicoumarol  (EXP)
dienogest  (ISO)
dimethylarsinous acid  (ISO)
diquat  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
drometrizole  (ISO)
dutasteride  (ISO)
dydrogesterone  (ISO)
entinostat  (ISO)
estazolam  (ISO)
etacrynic acid  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
farnesol  (ISO)
fenamic acid  (ISO)
flufenamic acid  (ISO)
flunitrazepam  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP)
fructose  (ISO)
furan  (EXP)
gamma-linolenic acid  (ISO)
gedunin  (ISO)
genistein  (EXP)
geraniol  (ISO)
glafenine  (EXP)
glimepiride  (ISO)
glipizide  (ISO)
glucose  (ISO)
glyburide  (ISO)
glycidyl methacrylate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
hexane  (ISO)
hexestrol  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
isoeugenol  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
leflunomide  (EXP,ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
malathion  (ISO)
meclofenamic acid  (ISO)
Medazepam  (ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methyl salicylate  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
monosodium L-glutamate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naproxen  (ISO)
nefazodone  (EXP)
neoastilbin  (ISO)
nickel sulfate  (ISO)
nitrazepam  (ISO)
norethisterone  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
octyl gallate  (ISO)
oxaliplatin  (ISO)
oxcarbazepine  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
Paraoxon-methyl  (ISO)
parathion-methyl  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenanthrene  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenolphthalein  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propan-2-ol  (ISO)
prostaglandin G2  (ISO)
pyrimidine  (ISO)
quercetin  (EXP)
quinolin-8-ol  (ISO)
quinomethionate  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salicylic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
tartrazine  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
tolcapone  (EXP)
trans-isoeugenol  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
Tungsten carbide  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin D  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
cytosol  (IBA,ISO)
endoplasmic reticulum  (ISO)
nucleus  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system. Azzarello J, etal., J Histochem Cytochem. 2008 Sep;56(9):853-61. doi: 10.1369/jhc.2008.951384. Epub 2008 Jun 23.
2. Expression and activity of steroid aldoketoreductases 1C in omental adipose tissue are positive correlates of adiposity in women. Blouin K, etal., Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E398-404. Epub 2004 Oct 19.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Molecular cloning of a novel type of rat cytoplasmic 17beta-hydroxysteroid dehydrogenase distinct from the type 5 isozyme. Ishikura S, etal., J Biochem (Tokyo). 2006 Jun;139(6):1053-63.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:7737980   PMID:12477932   PMID:15632090   PMID:19487289   PMID:20837989   PMID:21851338   PMID:23533145   PMID:23636947  


Genomics

Comparative Map Data
Akr1c1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81770,720,397 - 70,747,285 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1770,720,398 - 70,747,247 (-)EnsemblGRCr8
mRatBN7.21765,810,474 - 65,837,385 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1765,810,475 - 65,837,326 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1769,306,245 - 69,325,133 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,135,098 - 73,153,981 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,178,080 - 67,196,962 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,441,253 - 69,460,334 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,441,223 - 69,460,321 (-)Ensemblrn6Rnor6.0
Rnor_5.01771,155,010 - 71,174,079 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41777,084,306 - 77,112,994 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1765,342,356 - 65,364,506 (-)NCBICelera
RGSC_v3.11777,095,138 - 77,123,818 (-)NCBI
Cytogenetic Map17q12.2NCBI
AKR1C1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38104,963,415 - 4,983,283 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl104,963,253 - 4,983,283 (+)Ensemblhg38GRCh38
GRCh37105,005,607 - 5,025,475 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36104,995,454 - 5,010,158 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34104,995,453 - 5,010,157NCBI
Cytogenetic Map10p15.1NCBI
HuRef104,965,234 - 4,979,935 (-)NCBIHuRef
CHM1_1105,005,791 - 5,020,495 (+)NCBICHM1_1
T2T-CHM13v2.0104,963,746 - 4,983,614 (+)NCBIT2T-CHM13v2.0
Akr1c6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,484,354 - 4,507,529 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,484,305 - 4,507,876 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38134,434,311 - 4,457,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,434,306 - 4,457,877 (+)Ensemblmm10GRCm38
MGSCv37134,433,589 - 4,456,776 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36134,433,637 - 4,456,642 (+)NCBIMGSCv36mm8
Celera134,408,738 - 4,431,843 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.48NCBI

Variants

.
Variants in Akr1c1
170 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:114
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000058367
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)177061350286062352Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176369714782818564Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176456982086954580Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 6 8 29 67 68 46 15 46 6 158 35 15 69 23 22

Sequence


Ensembl Acc Id: ENSRNOT00000058367   ⟹   ENSRNOP00000055169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1770,720,398 - 70,747,247 (-)Ensembl
mRatBN7.2 Ensembl1765,810,475 - 65,837,326 (-)Ensembl
Rnor_6.0 Ensembl1769,441,223 - 69,460,321 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109784   ⟹   ENSRNOP00000097530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1770,737,354 - 70,747,247 (-)Ensembl
mRatBN7.2 Ensembl1765,826,144 - 65,837,326 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000127796   ⟹   ENSRNOP00000102681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1770,737,354 - 70,747,238 (-)Ensembl
RefSeq Acc Id: NM_001033697   ⟹   NP_001028869
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,720,397 - 70,747,247 (-)NCBI
mRatBN7.21765,810,474 - 65,837,326 (-)NCBI
Rnor_6.01769,441,253 - 69,460,287 (-)NCBI
Rnor_5.01771,155,010 - 71,174,079 (-)NCBI
RGSC_v3.41777,084,306 - 77,112,994 (-)RGD
Celera1765,342,356 - 65,364,506 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254188   ⟹   XP_006254250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,720,397 - 70,747,285 (-)NCBI
mRatBN7.21765,810,474 - 65,837,385 (-)NCBI
Rnor_6.01769,441,253 - 69,460,334 (-)NCBI
Rnor_5.01771,155,010 - 71,174,079 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001028869   ⟸   NM_001033697
- UniProtKB: Q3MHS3 (UniProtKB/TrEMBL),   Q5I0L1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254250   ⟸   XM_006254188
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AV33 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000055169   ⟸   ENSRNOT00000058367
Ensembl Acc Id: ENSRNOP00000097530   ⟸   ENSRNOT00000109784
Ensembl Acc Id: ENSRNOP00000102681   ⟸   ENSRNOT00000127796
Protein Domains
NADP-dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3MHS3-F1-model_v2 AlphaFold Q3MHS3 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700542
Promoter ID:EPDNEW_R11065
Type:multiple initiation site
Name:Akr1c1_1
Description:aldo-keto reductase family 1, member C1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01769,460,309 - 69,460,369EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306847 AgrOrtholog
BioCyc Gene G2FUF-8840 BioCyc
Ensembl Genes ENSRNOG00000038331 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058367 ENTREZGENE
  ENSRNOT00000058367.5 UniProtKB/TrEMBL
  ENSRNOT00000109784.2 UniProtKB/TrEMBL
  ENSRNOT00000127796.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7322699 IMAGE-MGC_LOAD
  IMAGE:7373256 IMAGE-MGC_LOAD
InterPro AKR1C UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/TrEMBL
  Aldo/keto_reductase_sg UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
KEGG Report rno:307092 UniProtKB/TrEMBL
MGC_CLONE MGC:108985 IMAGE-MGC_LOAD
  MGC:125057 IMAGE-MGC_LOAD
NCBI Gene 307092 ENTREZGENE
PANTHER ALDO/KETO REDUCTASE UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
PhenoGen Akr1c1 PhenoGen
PIRSF AKR UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038331 RatGTEx
Superfamily-SCOP Aldo/ket_red UniProtKB/TrEMBL
UniProt A0A8I6AV33 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L237_RAT UniProtKB/TrEMBL
  Q3MHS3 ENTREZGENE, UniProtKB/TrEMBL
  Q5I0L1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Akr1c1  aldo-keto reductase family 1, member C1  Akr1c1  aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Akr1c1  aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)  Akr1c6  aldo-keto reductase family 1, member C6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Akr1c6  aldo-keto reductase family 1, member C6  Akr1c6_predicted  aldo-keto reductase family 1, member C6 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Akr1c6_predicted  aldo-keto reductase family 1, member C6 (predicted)      Symbol and Name status set to approved 70820 APPROVED