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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306847
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1c1
Name: aldo-keto reductase family 1, member C1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c1affects response to substanceISOAKR1C1 (Homo sapiens)6480464CTDAKR1C1 protein affects the susceptibility to Benzo(a)pyrenePMID:19800895
Akr1c1decreases expressionISOAKR1C1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of AKR1C1 mRNAPMID:16545412
Akr1c1decreases expressionISOAkr1c6 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of AKR1C6 mRNAPMID:19770486
Akr1c1increases expressionISOAKR1C1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of AKR1C1 mRNAPMID:15735009 PMID:17253728 PMID:19800895 PMID:20064835 PMID:20106945 PMID:21632981 PMID:22316170 PMID:26238291
Akr1c1multiple interactionsISOAKR1C1 (Homo sapiens)6480464CTD[Butyric Acid co-treated with Benzo(a)pyrene] results in increased expression of AKR1C1 mRNA; [Particulate Matter co-treated with Benzo(a)pyrene] results in increased expression of AKR1C1 mRNA; [Vehicle Emissions co-treated with Benzo(a)pyrene] results in increased expression of AKR1C1 mRNA; AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion]; AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with methylparaoxon]; Benzo(a)pyrene promotes the reaction [Methyl Parathion results in increased activity of AKR1C1 protein]; Methyl Parathion promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1C1 mRNA]PMID:17612574 PMID:19800895 PMID:30439556
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