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Gene: Tab1 (TGF-beta activated kinase 1/MAP3K7 binding protein 1) Rattus norvegicus

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Symbol:

Tab1

Name:

TGF-beta activated kinase 1/MAP3K7 binding protein 1

RGD ID:

1306216

Description:

Enables mitogen-activated protein kinase p38 binding activity. Predicted to be involved in non-canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including circulatory system development; positive regulation of innate immune response; and transforming growth factor beta receptor signaling pathway. Part of protein-containing complex. Orthologous to human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; interleukin-1 signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC315139; Map3k7ip1; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; Tak1-binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	113,556,157 - 113,587,351 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	113,555,819 - 113,587,351 (+)	Ensembl				GRCr8
mRatBN7.2	7	111,675,829 - 111,707,058 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	111,686,371 - 111,707,058 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	113,430,333 - 113,461,541 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	115,653,881 - 115,685,092 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	115,623,239 - 115,654,452 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	121,350,953 - 121,382,100 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	121,350,965 - 121,382,088 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	121,340,948 - 121,371,923 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	118,368,997 - 118,402,928 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	108,004,014 - 108,035,121 (+)	NCBI		Celera
RGSC_v3.1	7	118,403,087 - 118,435,710 (+)	NCBI
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

polycystic ovary syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

aripiprazole (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (EXP)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

cylindrospermopsin (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

diquat (ISO)

doxorubicin (EXP,ISO)

endosulfan (EXP)

folic acid (EXP)

glycine betaine (EXP)

ivermectin (ISO)

L-methionine (EXP)

manganese atom (ISO)

manganese(0) (ISO)

mangiferin (ISO)

methoxychlor (EXP)

nicotine (EXP)

o-anisidine (ISO)

obeticholic acid (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

pregnenolone 16alpha-carbonitrile (EXP)

rotenone (ISO)

simvastatin (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

urethane (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aorta development (ISO)

canonical NF-kappaB signal transduction (IEA,ISO)

cardiac septum development (ISO)

coronary vasculature development (ISO)

heart morphogenesis (ISO)

in utero embryonic development (ISO)

lung development (ISO)

non-canonical NF-kappaB signal transduction (IEA,ISO)

positive regulation of cGAS/STING signaling pathway (IEA,ISO)

positive regulation of intracellular signal transduction (IEA)

positive regulation of MAP kinase activity (IMP)

positive regulation of MAPK cascade (ISO)

regulation of MAPK cascade (IEA,ISO)

signal transduction (IBA,IEA)

transforming growth factor beta receptor signaling pathway (ISO)

Cellular Component

cytoplasm (IEA,ISO)

cytosol (IEA)

endoplasmic reticulum (IEA,ISO)

endoplasmic reticulum membrane (IEA,ISO)

protein-containing complex (IDA)

serine/threonine protein kinase complex (IEA,ISO)

Molecular Function

identical protein binding (IEA,ISO)

kinase activator activity (IEA,ISO)

MAP kinase kinase kinase activity (IPI)

mitogen-activated protein kinase p38 binding (IPI)

molecular adaptor activity (IEA,ISO)

phosphoprotein phosphatase activity (IEA)

protein binding (IPI,ISO)

protein serine/threonine kinase activator activity (IEA,ISO)

protein serine/threonine phosphatase activity (IBA,IEA)

protein-containing complex binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

Bone morphogenetic proteins signaling pathway (ISO)

interleukin-1 signaling pathway (ISO)

nuclear factor kappa B signaling pathway (ISO)

p38 MAPK signaling pathway (ISO)

Toll-like receptor signaling pathway (ISO)

transforming growth factor-beta Smad dependent signaling pathway (ISO)

tumor necrosis factor mediated signaling pathway (ISO)

Wnt signaling, non-canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.	Brown J, etal., J Dent Res. 2011 Apr;90(4):417-27. Epub 2010 Oct 12.
2.	Magnesium Lithospermate B Protects Cardiomyocytes from Ischemic Injury Via Inhibition of TAB1-p38 Apoptosis Signaling.	Du CS, etal., Front Pharmacol. 2010;1:111. Epub 2010 Aug 24.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Expanding role of ubiquitination in NF-kappaB signaling.	Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme.	Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
10.	Interleukin-1 (IL-1) pathway.	Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
11.	Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion.	Xia W, etal., J Biol Chem. 2006 Jun 16;281(24):16799-813. Epub 2006 Apr 13.
12.	RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1.	Yuan L, etal., Cardiovasc Res. 2022 Mar 30:cvac039. doi: 10.1093/cvr/cvac039.

Additional References at PubMed

PMID:12464436	PMID:16407200	PMID:20730577	PMID:25807483

Genomics

Comparative Map Data

Tab1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	113,556,157 - 113,587,351 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	113,555,819 - 113,587,351 (+)	Ensembl				GRCr8
mRatBN7.2	7	111,675,829 - 111,707,058 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	111,686,371 - 111,707,058 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	113,430,333 - 113,461,541 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	115,653,881 - 115,685,092 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	115,623,239 - 115,654,452 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	121,350,953 - 121,382,100 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	121,350,965 - 121,382,088 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	121,340,948 - 121,371,923 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	118,368,997 - 118,402,928 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	108,004,014 - 108,035,121 (+)	NCBI		Celera
RGSC_v3.1	7	118,403,087 - 118,435,710 (+)	NCBI
Cytogenetic Map	7	q34	NCBI

TAB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	39,399,780 - 39,437,132 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	39,399,778 - 39,437,060 (+)	Ensembl			hg38	GRCh38
GRCh37	22	39,795,785 - 39,833,137 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	38,125,705 - 38,163,078 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	22	38,120,258 - 38,157,632	NCBI
Celera	22	23,597,809 - 23,635,185 (+)	NCBI		Celera
Cytogenetic Map	22	q13.1	NCBI
HuRef	22	22,760,425 - 22,797,733 (+)	NCBI		HuRef
CHM1_1	22	39,754,498 - 39,791,875 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	39,870,398 - 39,907,761 (+)	NCBI		T2T-CHM13v2.0

Tab1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	80,017,333 - 80,045,908 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	80,017,328 - 80,045,908 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	80,133,127 - 80,161,707 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	80,133,127 - 80,161,707 (+)	Ensembl			mm10	GRCm38
MGSCv37	15	79,963,584 - 79,992,132 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	79,960,409 - 79,988,957 (+)	NCBI		MGSCv36	mm8
Celera	15	82,249,914 - 82,278,414 (+)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	37.85	NCBI

Tab1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	25,290,828 - 25,313,969 (+)	Ensembl
ChiLan1.0	NW_004955413	25,290,733 - 25,315,267 (+)	NCBI	ChiLan1.0	ChiLan1.0

TAB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	49,244,509 - 49,279,097 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	51,935,877 - 51,970,474 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	20,303,547 - 20,343,314 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	38,122,835 - 38,158,015 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	38,122,835 - 38,162,705 (+)	Ensembl			panPan2	panpan1.1

TAB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	25,623,381 - 25,657,630 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	25,623,940 - 25,657,543 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	25,559,053 - 25,593,235 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	26,375,000 - 26,409,197 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	26,375,011 - 26,409,213 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	26,089,607 - 26,123,813 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	26,409,038 - 26,443,015 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	26,584,751 - 26,618,730 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tab1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	9,196,563 - 9,224,198 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	2,210,197 - 2,234,489 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	2,207,147 - 2,234,573 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TAB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	8,826,840 - 8,852,776 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	8,827,363 - 8,852,814 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	6,122,718 - 6,146,897 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TAB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	21,971,362 - 22,004,289 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666045	103,706,687 - 103,740,657 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tab1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	8,913,900 - 8,937,329 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624752	8,912,467 - 8,937,313 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tab1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	249,898,434 - 249,927,523 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tab1
164 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	335
Count of miRNA genes:	212
Interacting mature miRNAs:	243
Transcripts:	ENSRNOT00000067904
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	92388565	119280177	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	82111245	123048330	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	104186212	135371468	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	73618702	118618702	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	93302009	131686183	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	71621154	114982716	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	95485047	137014596	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	46307490	127866166	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	85043242	130043242	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	85497398	130497398	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	92362341	137014596	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	83626689	128626689	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	82111382	132099989	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	98549867	137014596	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
631201	Panci1	Pancreas inflammation QTL 1	0	0.001	pancreas integrity trait (VT:0010560)	percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)	7	73557047	118557047	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	82111245	123048330	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	96700404	118618702	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	40540077	123682549	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	110725024	135371468	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	49682832	115766396	Rat
10450862	Kidm55	Kidney mass QTL 55	4.9		kidney mass (VT:0002707)	kidney weight (CMO:0000081)	7	72725037	117725037	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	100548246	137014596	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	82111245	134948181	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
10450856	Livw4	Liver weight QTL 4	3.8		liver mass (VT:0003402)	liver weight (CMO:0000092)	7	72725037	117725037	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	49682832	115766396	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	78682549	123682549	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	49682832	115766396	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	71621154	119349044	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	71827901	136544683	Rat

Markers in Region

RH141717

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	111,706,779 - 111,706,975 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	121,381,822 - 121,382,017	NCBI	Rnor6.0
Rnor_5.0	7	121,371,645 - 121,371,840	UniSTS	Rnor5.0
RGSC_v3.4	7	118,402,650 - 118,402,845	UniSTS	RGSC3.4
Celera	7	108,034,843 - 108,035,038	UniSTS
RH 3.4 Map	7	857.5	UniSTS
Cytogenetic Map	7	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	357	192	11	145	82	92	31	19	19

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC127784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BP466072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BP483385	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB605878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB706441	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB779067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB802111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO385750	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO567997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DN948807	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DY311072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EV771639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000067904 ⟹ ENSRNOP00000059322

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	113,566,667 - 113,587,329 (+)	Ensembl
mRatBN7.2 Ensembl	7	111,686,371 - 111,707,036 (+)	Ensembl
Rnor_6.0 Ensembl	7	121,361,415 - 121,382,088 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092614 ⟹ ENSRNOP00000075816

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	113,555,819 - 113,587,351 (+)	Ensembl
mRatBN7.2 Ensembl	7	111,692,309 - 111,707,058 (+)	Ensembl
Rnor_6.0 Ensembl	7	121,350,965 - 121,380,878 (+)	Ensembl

RefSeq Acc Id:

NM_001109976 ⟹ NP_001103446

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	113,556,157 - 113,587,351 (+)	NCBI
mRatBN7.2	7	111,675,858 - 111,707,058 (+)	NCBI
Rnor_6.0	7	121,350,953 - 121,382,100 (+)	NCBI
Rnor_5.0	7	121,340,948 - 121,371,923 (+)	NCBI
RGSC_v3.4	7	118,368,997 - 118,402,928 (+)	RGD
Celera	7	108,004,014 - 108,035,121 (+)	RGD

Sequence:

show sequence

CGGGGTCCTCCAAGATGGCGGCGCAGAGGAGGAGCCTGCTCCAGAGTGAGCAGCAGCCAAGCTG
GACAGATGACCTGCCACTCTGTCACTTCTCCGGCGTTGGTTCAGCTTCCAACCGTAGCTACTCT
GCTGATGGCAAGGGCACTGAGAGTCACCCTCCGGAGGACAACTGGCTCAAGTTCAGAAGTGAAA
ACAACTGCTTCCTGTATGGGGTCTTCAATGGCTATGATGGCAACCGCGTGACCAACTTTGTGGC
GCAGAGACTCTCTGCAGAGCTCCTGCTGGGCCAGCTCAACACCGAACACACAGATGCTGATGTG
CGACGGGTCCTGCTGCAGGCCTTCGATGTGGTGGAGAGGAGCTTCCTGGAGTCTATCGATGATG
CCTTGGCTGAGAAAGCAAGCCTCCAGTCCCAGCTGCCGGAGGGTGTGCCCCAACACCAGCTGCT
ACCTCAGTATCAGAAGATCCTGGAGAGACTCAAGGCACTGGAGAAGGAGATCTCGGGAGGGGCC
ATGGCTGTTGTGGCGGTCCTTCTCAACAACAAGCTCTACGTTGCCAATGTTGGTACGAACAGGG
CCCTTCTGTGCAGATCCACCGTGGACGGGCTACAGGTCACACAGCTGAACGTGGACCACACCGC
CGAGAATGAGGACGAGCTCTTCCGTCTCTCACAACTGGGTTTAGACGCAGGGAAGATCAAGCAG
GTGGGCGTCATCTGTGGACAGGAGAGCACCAGGCGAATTGGGGATTACAAGGTCAAATATGGCT
ACACTGACATTGACCTGCTCAGCACTGCCAAATCCAAACCCATCATCGCAGAGCCCGAAATCCA
CGGCGCACAGCCTCTGGATGGCGTGACGGGCTTCCTGGTACTGATGTCGGAGGGGCTGTACAAG
GCCCTGGAGGCAGCCCATGGGCCTGGGCAGGCCAACCAGGAGGTTGCCGCAATGATTGACACCG
AATTTGCCAAGCAGACCTCCCTCGATGCAGTTGCCCAGGCTGTGGTAGACCGTGTAAAGCGTAT
CCACAGTGACACCTTTGCCAGCGGTGGGGAGCGGGCCAAGTTCTGCCCACGGCATGAAGACATG
ACCCTGCTGGTGAGGAACTTTGGCTATCCATTAGGTGAAATGAGCCAGCCGACACCCACCCCGG
CCCCAGGGGGCCGTGTGTACCCTGTTTCTGTGCCCTACTCAAGTGCCCAGAGCACCAGCAAGAC
CAGTGTGACTCTGTCCCTCGTCATGCCTTCTCAGGGCCAGATGGTCAACGGCTCTCACAGTGCC
TCCACCTTGGATGAAGCCACTCCTACTCTCACTAACCAGAGCCCCACTCTGACCCTGCAGTCTA
CCAACACCCACACCCAGAGCAGCAGCTCCAGCTCGGACGGGGGCCTCTTCCGCTCCAGACCGGC
TCACTCACTTCCACCTGGAGAGGATGGCAGGGTCGAGCCCTATGTGGACTTTGCTGAGTTTTAC
CGACTCTGGAGCGTGGACCATGGCGAGCAGAGTGTGATGACGGCACCTTAGTCTAGCCTCAGAG
GGCGAGTGACAAGACAAGACAAGACAAGACAAGACAAGCTTCTTAACCTTTGCAGGTGCCGTGG
AACCAGTGGGCAGTGTGTCACTGATGTACTGCAGCCTGAGTACTGACTGCACTGCTGCTCCACA
CAGGAAGCTAGAGTCCAGACTACAGGCAACCTTAGGCAGGGCCAACGGGAAAGCCGCAGGTGGC
TTACAAACCATCAAGAGTGCCTCTTGACAAGTTCAAAGAAGGAAGCCATCCTGTGGACCCCATC
TACTACAGGCCAGACAGACACTGCTCCCTCGAGGCTGCTCTACCTGCCTCAAGTTCCCCTGGAA
TAGCCTGTGGCCTCTGCTTTAGCTGAGTTCCTCTGGAATAGCTAGTGCCCTTTGCTTCTGGGTG
GTTATCCCTTTCCCATCTTTCAGCCTAAACTCCTAGATCCAGAGTACAGAGTAATGGGAGTAGG
TGCCTGTCATTGGATGTCACTGGAAAAGTCTAGGGAAGCAGAGGGGCCTGCAACAGTCACAGGG
GAGCAGGACAAGGAAGGACTGGACCAGAGAGAGCTGGCCAAGGAATGTCAGTCCTGGGCTGCAG
GTCAGCCAGCTGGCAGCTGAGCTAACCCAGAGAGCTGGCTTCCCAGTGGGGTACAGATGGCAGG
ACAGGCCCAAGTGCTGTAGTGTCTGCTTCTGTTAGATCCTGCCCTGGGGTGGGGCAGGCCAAGT
CAGAAGCCAGTGCCTTTCTCCCAGCTGGTACTGGGAAGCCGGTGATAGGGGTGCTGAGTCAACA
GCTTTCACTCTGATGAGGAAGCTGATTGGCTCTGGGTTCTGCTGAAAGAGGAGTAGAAGATGGC
TGTGAGACGGAAGAGATTGAGTCGCCCACCCAGAAAGACCAAGGGCATCAGATGTGATGGTGTG
GACATGCTGGGGAAAGATTGTGCCTGTCAGGCTCTGACTTGGACCTGTTGACATGTTTCCTACC
ATCAGACAGGAGGTCACTACAGCTGCCTGCAGTGTGGCTGCCCCTATGCTCAGAGGAGGAAGCA
GGCTGGGTGCTCCCCCTTACCTGAGCCCTCCCATCAGGATTGGAGTCCAAGCTCAAATCTGTAG
CCTTGTAACTGGTATTCTGCAACCCTTTCTACGGTGCAGCTAGTGGGCGGGTGAGTCCAGTGTC
TCCTGTTGGCAAAGGCCAGTTTAGAGCATGTCTCACTCAGACTCCATTTCCGTAAGGAGGCTGT
TTGCTCAGTGCTGAGGAGAAACCGTGGGATGGTGGGGAGAAGAGGAAGAAGCCTTCTTGCTCCC
CACTAGGAAGTCACCTTGCCCTTCAGGTGAGCAGCTTTCAGCCGATGCACAAAGACCTGGGACA
ATGGAGAGCCTCCCCTGGGGATGTGGTGCTGTTTGGTCTCTAGAAATAGAACCATGTTCTTAAT
GCAGTACAGTAAAGATGTCATGTGTCA

hide sequence

RefSeq Acc Id:

XM_063263616 ⟹ XP_063119686

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	113,566,672 - 113,587,351 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001103446	(Get FASTA)	NCBI Sequence Viewer
	XP_063119686	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM15764	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000059322
	ENSRNOP00000059322.2
	ENSRNOP00000075816
	ENSRNOP00000075816.3

RefSeq Acc Id:

NP_001103446 ⟸ NM_001109976

- UniProtKB:

A6HSV8 (UniProtKB/TrEMBL), A0A0U1RRU5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAQRRSLLQSEQQPSWTDDLPLCHFSGVGSASNRSYSADGKGTESHPPEDNWLKFRSENNCFL
YGVFNGYDGNRVTNFVAQRLSAELLLGQLNTEHTDADVRRVLLQAFDVVERSFLESIDDALAEK
ASLQSQLPEGVPQHQLLPQYQKILERLKALEKEISGGAMAVVAVLLNNKLYVANVGTNRALLCR
STVDGLQVTQLNVDHTAENEDELFRLSQLGLDAGKIKQVGVICGQESTRRIGDYKVKYGYTDID
LLSTAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEVAAMIDTEFAKQ
TSLDAVAQAVVDRVKRIHSDTFASGGERAKFCPRHEDMTLLVRNFGYPLGEMSQPTPTPAPGGR
VYPVSVPYSSAQSTSKTSVTLSLVMPSQGQMVNGSHSASTLDEATPTLTNQSPTLTLQSTNTHT
QSSSSSSDGGLFRSRPAHSLPPGEDGRVEPYVDFAEFYRLWSVDHGEQSVMTAP

hide sequence

Ensembl Acc Id:

ENSRNOP00000075816 ⟸ ENSRNOT00000092614

Ensembl Acc Id:

ENSRNOP00000059322 ⟸ ENSRNOT00000067904

RefSeq Acc Id:	XP_063119686 ⟸ XM_063263616
- Peptide Label:	isoform X1
- UniProtKB:	D4A6C6 (UniProtKB/TrEMBL), A0A0U1RRU5 (UniProtKB/TrEMBL)

Protein Domains

PPM-type phosphatase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0U1RRU5-F1-model_v2	AlphaFold	A0A0U1RRU5	1-502	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695495

Promoter ID:

EPDNEW_R6019

Type:

multiple initiation site

Name:

Tab1_1

Description:

TGF-beta activated kinase 1/MAP3K7 binding protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	121,350,960 - 121,351,020	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306216	AgrOrtholog
BioCyc Gene	G2FUF-32713	BioCyc
Ensembl Genes	ENSRNOG00000017285	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000067904	ENTREZGENE
	ENSRNOT00000067904.5	UniProtKB/TrEMBL
	ENSRNOT00000092614	ENTREZGENE
	ENSRNOT00000092614.3	UniProtKB/TrEMBL
Gene3D-CATH	3.60.40.10	UniProtKB/TrEMBL
InterPro	PP2C-like	UniProtKB/TrEMBL
	PPM-type_dom_sf	UniProtKB/TrEMBL
	Protein_Pase_2C	UniProtKB/TrEMBL
KEGG Report	rno:315139	UniProtKB/TrEMBL
NCBI Gene	315139	ENTREZGENE
PANTHER	PP2C	UniProtKB/TrEMBL
	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1	UniProtKB/TrEMBL
Pfam	PP2C	UniProtKB/TrEMBL
PhenoGen	Tab1	PhenoGen
PROSITE	PPM_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017285	RatGTEx
SMART	PP2Cc	UniProtKB/TrEMBL
Superfamily-SCOP	PP2C-related	UniProtKB/TrEMBL
UniProt	A0A0U1RRU5	ENTREZGENE, UniProtKB/TrEMBL
	A6HSV8	ENTREZGENE, UniProtKB/TrEMBL
	D4A6C6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-09-08	Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	Map3k7ip1	mitogen-activated protein kinase kinase kinase 7 interacting protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Map3k7ip1	mitogen-activated protein kinase kinase kinase 7 interacting protein 1	Map3k7ip1_predicted	mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Map3k7ip1_predicted	mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)