Igfbp7 (insulin-like growth factor binding protein 7) - Rat Genome Database

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Gene: Igfbp7 (insulin-like growth factor binding protein 7) Rattus norvegicus
Analyze
Symbol: Igfbp7
Name: insulin-like growth factor binding protein 7
RGD ID: 1306201
Description: Predicted to enable receptor ligand activity. Involved in several processes, including cellular response to prostaglandin E stimulus; embryo implantation; and response to cortisol. Located in extracellular space. Biomarker of metabolic dysfunction-associated steatotic liver disease and renal cell carcinoma. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IGFBP-RP-1; IGFBP-rP1; IGFBPRP1; insulin-like growth factor-binding protein 7; LOC289560; mac25
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,091,681 - 31,151,623 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1431,091,347 - 31,151,620 (+)EnsemblGRCr8
mRatBN7.21430,737,414 - 30,797,317 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1430,737,164 - 30,797,314 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1431,117,785 - 31,178,240 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,426,112 - 32,486,565 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01430,910,759 - 30,971,221 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,010,300 - 33,070,193 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,010,300 - 33,070,190 (+)Ensemblrn6Rnor6.0
Rnor_5.01432,803,851 - 32,863,716 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41433,010,198 - 33,070,055 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1430,057,050 - 30,116,691 (+)NCBICelera
RGSC_v3.11433,010,197 - 33,070,052 (+)NCBI
Cytogenetic Map14p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arachidonic acid  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carnosic acid  (ISO)
CHIR 99021  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibromoacetic acid  (EXP)
dibutyl phthalate  (EXP)
dichromium trioxide  (ISO)
dipentyl phthalate  (EXP)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
folic acid  (ISO)
furan  (EXP)
graphene oxide  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
rotenone  (EXP)
Salinomycin  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP,ISO)
triacsin C  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XAV939  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis. Cheriyan VT, etal., PLoS One. 2014 Apr 1;9(4):e93711. doi: 10.1371/journal.pone.0093711. eCollection 2014.
2. Comprehensive analysis of endoplasmic reticulum-related and secretome gene expression profiles in the progression of non-alcoholic fatty liver disease. Gao R, etal., Front Endocrinol (Lausanne). 2022 Aug 12;13:967016. doi: 10.3389/fendo.2022.967016. eCollection 2022.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Prognostic impact of tumor-specific insulin-like growth factor binding protein 7 (IGFBP7) levels in breast cancer: a prospective cohort study. Godina C, etal., Carcinogenesis. 2021 Nov 12;42(11):1314-1325. doi: 10.1093/carcin/bgab090.
6. The change of circulating insulin like growth factor binding protein 7 levels may correlate with postoperative cognitive dysfunction. Jiang J, etal., Neurosci Lett. 2015 Feb 19;588:125-30. doi: 10.1016/j.neulet.2014.12.046. Epub 2014 Dec 24.
7. Burn-induced changes in IGF-I and IGF-binding proteins are partially glucocorticoid dependent. Lang CH, etal., Am J Physiol Regul Integr Comp Physiol. 2002 Jan;282(1):R207-15.
8. Target genes associated with lipid and glucose metabolism in non-alcoholic fatty liver disease. Li T, etal., Lipids Health Dis. 2019 Dec 5;18(1):211. doi: 10.1186/s12944-019-1154-9.
9. Insulin resistance is associated with increased serum concentration of IGF-binding protein-related protein 1 (IGFBP-rP1/MAC25). Lopez-Bermejo A, etal., Diabetes. 2006 Aug;55(8):2333-9.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Parathyroid hormone increases mac25/insulin-like growth factor-binding protein-related protein-1 expression in cultured osteoblasts. Pereira RC and Canalis E, Endocrinology. 1999 May;140(5):1998-2003.
13. Cortisol enhances the expression of mac25/insulin-like growth factor-binding protein-related protein-1 in cultured osteoblasts. Pereira RC, etal., Endocrinology. 1999 Jan;140(1):228-32.
14. Protection of rats from thioacetamide-induced hepatic fibrosis by the extracts of a traditional Uighur medicine Cichorium glandulosum. Qin D, etal., Iran J Basic Med Sci. 2014 Nov;17(11):879-85.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Effect of Insulin-Like Growth Factor-Binding Protein 7 on Steroidogenesis in Granulosa Cells Derived from Equine Chorionic Gonadotropin-Primed Immature Rat Ovaries. Tamura K, etal., Biol Reprod. 2007 May 23;.
21. Expression and the biological activities of insulin-like growth factor-binding protein related protein 1 in rat uterus during the periimplantation period. Tamura K, etal., Endocrinology. 2004 Nov;145(11):5243-51. Epub 2004 Jul 29.
22. Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress. Tanaka T, etal., Am J Pathol. 2000 Jun;156(6):2149-57.
23. Insulin-like growth factor binding protein 7 accelerates hepatic steatosis and insulin resistance in non-alcoholic fatty liver disease. Yan H, etal., Clin Exp Pharmacol Physiol. 2019 Dec;46(12):1101-1110. doi: 10.1111/1440-1681.13159. Epub 2019 Aug 29.
24. Transcriptomic profiling of a multiethnic pediatric NAFLD cohort reveals genes and pathways associated with disease. Yao K, etal., Hepatol Commun. 2022 Jul;6(7):1598-1610. doi: 10.1002/hep4.1940. Epub 2022 Mar 21.
Additional References at PubMed
PMID:8117260   PMID:20551380   PMID:20644209   PMID:21795542   PMID:23376485   PMID:23533145   PMID:24006456   PMID:27068509   PMID:27559042   PMID:28823370   PMID:29280192   PMID:30834595  


Genomics

Comparative Map Data
Igfbp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,091,681 - 31,151,623 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1431,091,347 - 31,151,620 (+)EnsemblGRCr8
mRatBN7.21430,737,414 - 30,797,317 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1430,737,164 - 30,797,314 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1431,117,785 - 31,178,240 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,426,112 - 32,486,565 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01430,910,759 - 30,971,221 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,010,300 - 33,070,193 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,010,300 - 33,070,190 (+)Ensemblrn6Rnor6.0
Rnor_5.01432,803,851 - 32,863,716 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41433,010,198 - 33,070,055 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1430,057,050 - 30,116,691 (+)NCBICelera
RGSC_v3.11433,010,197 - 33,070,052 (+)NCBI
Cytogenetic Map14p11NCBI
IGFBP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38457,030,773 - 57,110,385 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl457,030,766 - 57,110,690 (-)Ensemblhg38GRCh38
GRCh37457,896,939 - 57,976,551 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36457,592,001 - 57,671,296 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34457,738,173 - 57,817,467NCBI
Celera455,402,268 - 55,481,287 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,850,811 - 53,930,091 (-)NCBIHuRef
CHM1_1457,933,093 - 58,012,367 (-)NCBICHM1_1
T2T-CHM13v2.0460,522,210 - 60,601,772 (-)NCBIT2T-CHM13v2.0
Igfbp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,497,092 - 77,555,892 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,497,087 - 77,555,888 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38577,349,240 - 77,408,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl577,349,240 - 77,408,041 (-)Ensemblmm10GRCm38
MGSCv37577,778,265 - 77,837,070 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36578,424,020 - 78,482,816 (-)NCBIMGSCv36mm8
Celera574,616,957 - 74,675,885 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.71NCBI
Igfbp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544714,047,732 - 14,108,414 (+)Ensembl
ChiLan1.0NW_00495544714,048,834 - 14,110,264 (+)NCBIChiLan1.0ChiLan1.0
IGFBP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2372,662,038 - 72,744,322 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1472,870,306 - 72,949,674 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0466,808,845 - 66,888,301 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1473,382,745 - 73,462,087 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl473,382,745 - 73,462,087 (+)EnsemblpanPan2panpan1.1
IGFBP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11349,138,406 - 49,207,235 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1349,138,402 - 49,207,394 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1349,028,576 - 49,097,306 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01349,752,889 - 49,821,655 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,721,911 - 49,821,863 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11349,425,405 - 49,494,729 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,954,676 - 49,023,903 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,900,155 - 49,969,383 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Igfbp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,102,600 - 27,178,901 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648219,118,321 - 19,186,685 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648219,119,339 - 19,186,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl856,279,895 - 56,357,822 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1856,283,089 - 56,357,822 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2859,064,683 - 59,139,438 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IGFBP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1711,617,096 - 11,694,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606612,195,308 - 12,273,610 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfbp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476112,318,006 - 12,387,582 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476112,318,571 - 12,387,489 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Igfbp7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11134,106,142 - 34,167,630 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Igfbp7
397 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:86
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000002809
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143112133339507682Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142252151767521517Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat

Markers in Region
D14Rat36  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81431,121,333 - 31,121,464 (+)Marker Load Pipeline
mRatBN7.21430,767,025 - 30,767,156 (+)MAPPERmRatBN7.2
Rnor_6.01433,039,912 - 33,040,042NCBIRnor6.0
Rnor_5.01432,833,464 - 32,833,594UniSTSRnor5.0
RGSC_v3.41433,039,698 - 33,040,140RGDRGSC3.4
RGSC_v3.41433,039,810 - 33,039,940UniSTSRGSC3.4
Celera1430,086,651 - 30,086,781UniSTS
RGSC_v3.11433,039,810 - 33,039,940RGD
RH 3.4 Map14391.5RGD
RH 3.4 Map14391.5UniSTS
RH 2.0 Map14364.6RGD
SHRSP x BN Map1419.2999RGD
FHH x ACI Map1426.22RGD
Cytogenetic Map14p11UniSTS
RH135403  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21430,793,712 - 30,793,897 (+)MAPPERmRatBN7.2
Rnor_6.01433,066,589 - 33,066,773NCBIRnor6.0
Rnor_5.01432,860,110 - 32,860,294UniSTSRnor5.0
RGSC_v3.41433,066,451 - 33,066,635UniSTSRGSC3.4
Celera1430,113,087 - 30,113,271UniSTS
RH 3.4 Map14391.4UniSTS
Cytogenetic Map14p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 13 82 178 91 90 59 53 59 6 368 176 20 158 109 118 31 22 22

Sequence


Ensembl Acc Id: ENSRNOT00000002809   ⟹   ENSRNOP00000002809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1431,091,347 - 31,151,620 (+)Ensembl
mRatBN7.2 Ensembl1430,737,164 - 30,797,314 (+)Ensembl
Rnor_6.0 Ensembl1433,010,300 - 33,070,190 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000168109   ⟹   ENSRNOP00000108243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1431,091,403 - 31,151,620 (+)Ensembl
RefSeq Acc Id: NM_001013048   ⟹   NP_001013066
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,091,736 - 31,151,623 (+)NCBI
mRatBN7.21430,737,414 - 30,797,317 (+)NCBI
Rnor_6.01433,010,300 - 33,070,193 (+)NCBI
Rnor_5.01432,803,851 - 32,863,716 (+)NCBI
RGSC_v3.41433,010,198 - 33,070,055 (+)RGD
Celera1430,057,050 - 30,116,691 (+)RGD
Sequence:
RefSeq Acc Id: XM_063272904   ⟹   XP_063128974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,091,681 - 31,151,623 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001013066 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128974 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86582 (Get FASTA)   NCBI Sequence Viewer  
  EDL89869 (Get FASTA)   NCBI Sequence Viewer  
  EDL89870 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002809.7
  ENSRNOP00000108243.1
RefSeq Acc Id: NP_001013066   ⟸   NM_001013048
- Peptide Label: precursor
- UniProtKB: Q5RJM3 (UniProtKB/TrEMBL),   A6JCU7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002809   ⟸   ENSRNOT00000002809
RefSeq Acc Id: XP_063128974   ⟸   XM_063272904
- Peptide Label: isoform X1
- UniProtKB: A6JCU7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108243   ⟸   ENSRNOT00000168109
Protein Domains
Ig-like   IGFBP N-terminal   Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M9B2-F1-model_v2 AlphaFold F1M9B2 1-281 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699263
Promoter ID:EPDNEW_R9788
Type:multiple initiation site
Name:Igfbp7_1
Description:insulin-like growth factor binding protein 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01433,010,289 - 33,010,349EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306201 AgrOrtholog
BioCyc Gene G2FUF-16000 BioCyc
Ensembl Genes ENSRNOG00000002050 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002809.6 UniProtKB/TrEMBL
  ENSRNOT00000168109.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.30.60.30 UniProtKB/TrEMBL
  4.10.40.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7307584 IMAGE-MGC_LOAD
InterPro Growth_fac_rcpt_N_dom UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  IGFBP-like UniProtKB/TrEMBL
  IGFBP_rP_mac25 UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
  Prot_inh_Kazal UniProtKB/TrEMBL
KEGG Report rno:289560 UniProtKB/TrEMBL
MGC_CLONE MGC:105555 IMAGE-MGC_LOAD
NCBI Gene 289560 ENTREZGENE
PANTHER IGFBP_rP_mac25 UniProtKB/TrEMBL
  INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7 UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  IGFBP UniProtKB/TrEMBL
  Kazal_2 UniProtKB/TrEMBL
PhenoGen Igfbp7 PhenoGen
PIRSF IGFBP_rP_mac25 UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002050 RatGTEx
SMART KAZAL UniProtKB/TrEMBL
  SM00121 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0ABK0LQF2_RAT UniProtKB/TrEMBL
  A6JCU7 ENTREZGENE, UniProtKB/TrEMBL
  A6JCU8_RAT UniProtKB/TrEMBL
  F1M9B2_RAT UniProtKB/TrEMBL
  Q5RJM3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Igfbp7  insulin-like growth factor binding protein 7  Igfbp7_predicted  insulin-like growth factor binding protein 7 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Igfbp7_predicted  insulin-like growth factor binding protein 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED