RGD Reference Report - Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress. - Rat Genome Database

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Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress.

Authors: Tanaka, T  Kondo, S  Iwasa, Y  Hiai, H  Toyokuni, S 
Citation: Tanaka T, etal., Am J Pathol. 2000 Jun;156(6):2149-57.
RGD ID: 1626565
Pubmed: PMID:10854235   (View Abstract at PubMed)
PMCID: PMC1850067   (View Article at PubMed Central)
DOI: DOI:10.1016/S0002-9440(10)65085-7   (Journal Full-text)

Ferric nitrilotriacetate induces oxidative damage in renal proximal tubules that ultimately leads to a high incidence of renal cell carcinoma (RCC) in rats. In search of genes specifically involved in oxystress-induced carcinogenesis, we have applied a modified fluorescent differential display technique to the tumors and an established cell line as well as their non-neoplastic counterparts. We screened approximately 84,000 products. Reverse Northern blotting confirmed differential expression of 20 transcripts, which showed either significant increase, decrease or lack of expression in the RCCs. Five cDNA clones encoded novel products of unknown function. Fifteen cDNA clones were identified by homology search, which included annexin II, Y-box binding protein, ribosomal proteins, heat shock proteins, DNA polymerase, nonmuscle caldesmon (increased); protein tyrosine phosphatase (decreased); selenoprotein P, stromal cell-derived factor 1, intestinal trefoil protein, nicotinamide adenine dinucleotide, reduced form (NADH) dehydrogenase, and insulin-like growth factor binding protein 7 (deleted). Most of the identified genes were associated with stress-response or cellular proliferation. These results suggest that multiple, interactive genetic pathways are involved in carcinogenesis induced by oxidative stress.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
renal cell carcinoma  ISOIgfbp7 (Rattus norvegicus)1626565; 1626565mRNA:decreased expression:kidneyRGD 
renal cell carcinoma  IEP 1626565mRNA:decreased expression:kidneyRGD 

Objects Annotated

Genes (Rattus norvegicus)
Igfbp7  (insulin-like growth factor binding protein 7)

Genes (Mus musculus)
Igfbp7  (insulin-like growth factor binding protein 7)

Genes (Homo sapiens)
IGFBP7  (insulin like growth factor binding protein 7)


Additional Information