RGD Reference Report - Expression and the biological activities of insulin-like growth factor-binding protein related protein 1 in rat uterus during the periimplantation period. - Rat Genome Database

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Expression and the biological activities of insulin-like growth factor-binding protein related protein 1 in rat uterus during the periimplantation period.

Authors: Tamura, K  Hara, T  Kutsukake, M  Iwatsuki, K  Yanagida, M  Yoshie, M  Kogo, H 
Citation: Tamura K, etal., Endocrinology. 2004 Nov;145(11):5243-51. Epub 2004 Jul 29.
RGD ID: 1626544
Pubmed: PMID:15284205   (View Abstract at PubMed)
DOI: DOI:10.1210/en.2004-0415   (Journal Full-text)

IGF binding protein-related protein 1 (IGFBP-rP1) is highly expressed in the rat uterus around the time of implantation. In the present study, we determined the periimplantation localization of IGFBP-rP1 mRNA and assessed the effects of recombinant IGFBP-rP1 on the proliferative and prostacyclin (PGI(2))-producing abilities of cultured endometrial cells early in pregnancy. IGFBP-rP1 mRNA was detected at high levels in endometrial stromal cells close to the smooth muscle of interimplantation sites around the time of implantation but absent from decidual zones surrounding the embryo. Differential uterine IGFBP-rP1 expression was also recognized in the delayed implanting pregnant model, but the level of mRNA decreased as decidual tissues formed in the decidualization model. Recombinant IGFBP-rP1 inhibited the proliferation of endometrial stromal cells in vitro and arrested them in the G(1) phase of the cell cycle. Furthermore, IGFBP-rP1 significantly stimulated PGI(2) synthesis and cyclooxygenase II mRNA expression in myometrial cells, both of which are essential molecules for successful implantation. These data suggest that IGFBP-rP1 is an implantation-associated protein and that it modulates the proliferation of rat uterine cells and their production of PGI(2) during the periimplantation period.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
embryo implantation  IEP 1626544 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Igfbp7  (insulin-like growth factor binding protein 7)


Additional Information