IGFBP7 (insulin like growth factor binding protein 7) - Rat Genome Database

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Gene: IGFBP7 (insulin like growth factor binding protein 7) Canis lupus familiaris
Analyze
Symbol: IGFBP7
Name: insulin like growth factor binding protein 7
RGD ID: 12377502
Description: ENCODES a protein that exhibits insulin-like growth factor binding (inferred); INVOLVED IN cellular response to hormone stimulus (ortholog); embryo implantation (ortholog); inner ear development (ortholog); ASSOCIATED WITH breast cancer (ortholog); Breast Neoplasms (ortholog); Burns (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH masitinib
Type: protein-coding
RefSeq Status: MODEL
Previously known as: insulin-like growth factor-binding protein 7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11349,138,406 - 49,207,235 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1349,138,402 - 49,207,394 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1349,028,576 - 49,097,306 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01349,752,889 - 49,821,655 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,721,911 - 49,821,863 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11349,425,405 - 49,494,729 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,954,676 - 49,023,903 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,900,155 - 49,969,383 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
masitinib  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IGFBP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11349,138,406 - 49,207,235 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1349,138,402 - 49,207,394 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1349,028,576 - 49,097,306 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01349,752,889 - 49,821,655 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,721,911 - 49,821,863 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11349,425,405 - 49,494,729 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,954,676 - 49,023,903 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,900,155 - 49,969,383 (-)NCBIUU_Cfam_GSD_1.0
IGFBP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38457,030,773 - 57,110,385 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl457,030,773 - 57,110,385 (-)EnsemblGRCh38hg38GRCh38
GRCh37457,896,939 - 57,976,551 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36457,592,001 - 57,671,296 (-)NCBINCBI36Build 36hg18NCBI36
Build 34457,738,173 - 57,817,467NCBI
Celera455,402,268 - 55,481,287 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,850,811 - 53,930,091 (-)NCBIHuRef
CHM1_1457,933,093 - 58,012,367 (-)NCBICHM1_1
T2T-CHM13v2.0460,522,210 - 60,601,772 (-)NCBIT2T-CHM13v2.0
Igfbp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,497,092 - 77,555,892 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,497,087 - 77,555,888 (-)EnsemblGRCm39 Ensembl
GRCm38577,349,240 - 77,408,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl577,349,240 - 77,408,041 (-)EnsemblGRCm38mm10GRCm38
MGSCv37577,778,265 - 77,837,070 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36578,424,020 - 78,482,816 (-)NCBIMGSCv36mm8
Celera574,616,957 - 74,675,885 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.71NCBI
Igfbp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,091,681 - 31,151,623 (+)NCBIGRCr8
mRatBN7.21430,737,414 - 30,797,317 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1430,737,164 - 30,797,314 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1431,117,785 - 31,178,240 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,426,112 - 32,486,565 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01430,910,759 - 30,971,221 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,010,300 - 33,070,193 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,010,300 - 33,070,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01432,803,851 - 32,863,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41433,010,198 - 33,070,055 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11433,010,197 - 33,070,052 (+)NCBI
Celera1430,057,050 - 30,116,691 (+)NCBICelera
Cytogenetic Map14p11NCBI
Igfbp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544714,047,732 - 14,108,414 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544714,048,834 - 14,110,264 (+)NCBIChiLan1.0ChiLan1.0
IGFBP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2372,662,038 - 72,744,322 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1472,870,306 - 72,949,674 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0466,808,845 - 66,888,301 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1473,382,745 - 73,462,087 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl473,382,745 - 73,462,087 (+)Ensemblpanpan1.1panPan2
Igfbp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,102,600 - 27,178,901 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648219,118,321 - 19,186,685 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648219,119,339 - 19,186,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl856,279,895 - 56,357,822 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1856,283,089 - 56,357,822 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2859,064,683 - 59,139,438 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IGFBP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1711,617,096 - 11,694,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606612,195,308 - 12,273,610 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfbp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476112,318,006 - 12,387,582 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476112,318,571 - 12,387,489 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IGFBP7
859 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 9 6 8
Medium 5 5 13 6 6 6 6 12 8 2 6
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000003651   ⟹   ENSCAFP00000003380
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1349,138,402 - 49,207,394 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000077726   ⟹   ENSCAFP00000053815
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1349,146,632 - 49,207,394 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845025363   ⟹   ENSCAFP00845019961
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1349,721,911 - 49,821,863 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845025373   ⟹   ENSCAFP00845019970
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1349,754,490 - 49,821,863 (-)Ensembl
RefSeq Acc Id: XM_038493883   ⟹   XP_038349811
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11349,425,405 - 49,494,729 (-)NCBI
RefSeq Acc Id: XM_038556189   ⟹   XP_038412117
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01349,900,155 - 49,969,383 (-)NCBI
RefSeq Acc Id: XM_038620121   ⟹   XP_038476049
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01348,954,676 - 49,023,903 (-)NCBI
RefSeq Acc Id: XM_038685739   ⟹   XP_038541667
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01349,752,889 - 49,821,655 (-)NCBI
RefSeq Acc Id: XM_845177   ⟹   XP_850270
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11349,138,406 - 49,207,235 (-)NCBI
Dog10K_Boxer_Tasha1349,028,576 - 49,097,306 (-)NCBI
Sequence:
RefSeq Acc Id: XP_850270   ⟸   XM_845177
- UniProtKB: A0A8C0LS99 (UniProtKB/TrEMBL),   A0A8C0PID2 (UniProtKB/TrEMBL),   A0A8P0N5E5 (UniProtKB/TrEMBL),   A0A8I3NTJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000053815   ⟸   ENSCAFT00000077726
RefSeq Acc Id: ENSCAFP00000003380   ⟸   ENSCAFT00000003651
RefSeq Acc Id: XP_038349811   ⟸   XM_038493883
RefSeq Acc Id: XP_038476049   ⟸   XM_038620121
RefSeq Acc Id: XP_038541667   ⟸   XM_038685739
- UniProtKB: A0A8C0LS99 (UniProtKB/TrEMBL),   A0A8C0PID2 (UniProtKB/TrEMBL),   A0A8P0N5E5 (UniProtKB/TrEMBL),   A0A8I3NTJ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038412117   ⟸   XM_038556189
- UniProtKB: A0A8C0LS99 (UniProtKB/TrEMBL),   A0A8C0PID2 (UniProtKB/TrEMBL),   A0A8I3NTJ7 (UniProtKB/TrEMBL),   A0A8P0N5E5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845019961   ⟸   ENSCAFT00845025363
RefSeq Acc Id: ENSCAFP00845019970   ⟸   ENSCAFT00845025373
Protein Domains
Ig-like   IGFBP N-terminal   Kazal-like

Promoters
RGD ID:13685666
Promoter ID:EPDNEW_C3734
Type:multiple initiation site
Name:IGFBP7_1
Description:insulin like growth factor binding protein 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11349,207,237 - 49,207,297EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002330 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022114 UniProtKB/TrEMBL
  ENSCAFG00040019016 UniProtKB/TrEMBL
  ENSCAFG00845014179 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003651.5 UniProtKB/TrEMBL
  ENSCAFT00030040656.1 UniProtKB/TrEMBL
  ENSCAFT00040035207.1 UniProtKB/TrEMBL
  ENSCAFT00845025363 ENTREZGENE
  ENSCAFT00845025363.1 UniProtKB/TrEMBL
  ENSCAFT00845025373.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.30.60.30 UniProtKB/TrEMBL
  4.10.40.20 UniProtKB/TrEMBL
InterPro Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  IGFBP-like UniProtKB/TrEMBL
  IGFBP_rP_mac25 UniProtKB/TrEMBL
  Kazal_dom UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:608559 UniProtKB/TrEMBL
NCBI Gene IGFBP7 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7 UniProtKB/TrEMBL
  PTHR14186 UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  IGFBP UniProtKB/TrEMBL
  Kazal_2 UniProtKB/TrEMBL
PIRSF IGFBP_rP_mac25 UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/TrEMBL
SMART KAZAL UniProtKB/TrEMBL
  SM00121 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A8C0LS99 ENTREZGENE
  A0A8C0PID2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NTJ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P1V2_CANLF UniProtKB/TrEMBL
  A0A8P0N5E5 ENTREZGENE
UniProt Secondary A0A8P0N5E5 UniProtKB/TrEMBL
VGNC ID VGNC:41908 ENTREZGENE