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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306201
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igfbp7
Name: insulin-like growth factor binding protein 7
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igfbp7affects methylationISOIGFBP7 (Homo sapiens)6480464CTDDecitabine affects the methylation of IGFBP7 exonPMID:17334979
Igfbp7increases expressionISOIGFBP7 (Homo sapiens)6480464CTDDecitabine results in increased expression of IGFBP7 mRNA; Decitabine results in increased expression of IGFBP7 proteinPMID:16367923 PMID:18981723
Igfbp7multiple interactionsISOIGFBP7 (Homo sapiens)6480464CTDDecitabine inhibits the reaction [Smoke results in decreased expression of IGFBP7 mRNA]PMID:21095227
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