Sirt5 (sirtuin 5) - Rat Genome Database

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Gene: Sirt5 (sirtuin 5) Rattus norvegicus
Analyze
Symbol: Sirt5
Name: sirtuin 5
RGD ID: 1303285
Description: Predicted to enable several functions, including NAD+ binding activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; and zinc ion binding activity. Involved in negative regulation of cardiac muscle cell apoptotic process and response to nutrient levels. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be active in cytosol; mitochondrial matrix; and nucleus. Orthologous to human SIRT5 (sirtuin 5); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93823; NAD-dependent deacetylase sirtuin-5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial; regulatory protein SIR2 homolog 5; SIR2-like protein 5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae); sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81721,515,982 - 21,543,529 (-)NCBIGRCr8
mRatBN7.21721,310,028 - 21,337,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1721,310,028 - 21,337,101 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1721,198,845 - 21,226,111 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01722,802,514 - 22,829,782 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01721,125,948 - 21,153,215 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01723,986,710 - 24,013,854 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1723,986,758 - 24,013,881 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01725,936,391 - 25,963,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41727,135,610 - 27,162,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11727,138,453 - 27,165,556 (-)NCBI
Celera1721,007,452 - 21,034,513 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction. Geng YQ, etal., J Cell Biochem. 2011 Dec;112(12):3755-61. doi: 10.1002/jcb.23315.
3. SIRT5: a safeguard against oxidative stress-induced apoptosis in cardiomyocytes. Liu B, etal., Cell Physiol Biochem. 2013;32(4):1050-9. doi: 10.1159/000354505. Epub 2013 Oct 31.
4. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. NAD(+) in aging, metabolism, and neurodegeneration. Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
Additional References at PubMed
PMID:15489334   PMID:16079181   PMID:17923681   PMID:18054327   PMID:18555008   PMID:18614015   PMID:18680753   PMID:21908771   PMID:22076378   PMID:23806337   PMID:24140062   PMID:24315375  
PMID:24703693   PMID:26388266   PMID:26767982   PMID:29180469   PMID:30098330   PMID:32099074   PMID:33191606   PMID:36653443   PMID:38170384  


Genomics

Comparative Map Data
Sirt5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81721,515,982 - 21,543,529 (-)NCBIGRCr8
mRatBN7.21721,310,028 - 21,337,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1721,310,028 - 21,337,101 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1721,198,845 - 21,226,111 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01722,802,514 - 22,829,782 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01721,125,948 - 21,153,215 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01723,986,710 - 24,013,854 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1723,986,758 - 24,013,881 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01725,936,391 - 25,963,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41727,135,610 - 27,162,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11727,138,453 - 27,165,556 (-)NCBI
Celera1721,007,452 - 21,034,513 (-)NCBICelera
Cytogenetic Map17p14NCBI
SIRT5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38613,574,274 - 13,615,158 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl613,574,227 - 13,615,158 (+)EnsemblGRCh38hg38GRCh38
GRCh37613,574,506 - 13,615,390 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36613,682,812 - 13,720,500 (+)NCBINCBI36Build 36hg18NCBI36
Build 34613,682,811 - 13,713,947NCBI
Celera614,814,287 - 14,854,285 (+)NCBICelera
Cytogenetic Map6p23NCBI
HuRef613,519,134 - 13,559,766 (+)NCBIHuRef
CHM1_1613,577,139 - 13,617,757 (+)NCBICHM1_1
T2T-CHM13v2.0613,447,831 - 13,488,715 (+)NCBIT2T-CHM13v2.0
Sirt5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391343,518,849 - 43,549,073 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1343,518,972 - 43,548,679 (+)EnsemblGRCm39 Ensembl
GRCm381343,365,389 - 43,395,203 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1343,365,496 - 43,395,203 (+)EnsemblGRCm38mm10GRCm38
MGSCv371343,460,904 - 43,490,572 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361343,376,507 - 43,406,175 (+)NCBIMGSCv36mm8
Celera1344,444,248 - 44,473,768 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1321.6NCBI
Sirt5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554651,129,217 - 1,167,604 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554651,129,217 - 1,167,604 (-)NCBIChiLan1.0ChiLan1.0
SIRT5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2528,228,262 - 28,266,098 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1624,218,286 - 24,256,255 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0613,419,242 - 13,457,200 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1613,790,576 - 13,828,464 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl613,791,112 - 13,828,464 (+)Ensemblpanpan1.1panPan2
SIRT5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13513,017,397 - 13,055,655 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3513,017,397 - 13,063,022 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3512,966,806 - 13,004,993 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03513,115,780 - 13,154,165 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3513,115,780 - 13,179,805 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13512,941,308 - 12,979,591 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03512,994,546 - 13,031,107 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03514,317,852 - 14,356,107 (+)NCBIUU_Cfam_GSD_1.0
Sirt5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494611,516,904 - 11,539,107 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936552192,226 - 214,030 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936552192,182 - 214,037 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl79,951,030 - 9,968,448 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.179,951,024 - 9,968,004 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2710,327,724 - 10,330,511 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11758,535,645 - 58,573,769 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1758,532,650 - 58,563,818 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604413,624,450 - 13,664,862 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475612,678,877 - 12,706,604 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475612,678,866 - 12,705,862 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sirt5
240 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:197
Interacting mature miRNAs:225
Transcripts:ENSRNOT00000024066
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)171398677321975515Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171533061323017269Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat

Markers in Region
RH142048  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81721,516,006 - 21,516,205 (+)Marker Load Pipeline
mRatBN7.21721,310,052 - 21,310,251 (-)MAPPERmRatBN7.2
Rnor_6.01724,013,631 - 24,013,829NCBIRnor6.0
Rnor_5.01725,963,211 - 25,963,409UniSTSRnor5.0
RGSC_v3.41727,135,635 - 27,135,833UniSTSRGSC3.4
Celera1721,007,477 - 21,007,675UniSTS
RH 3.4 Map17267.9UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024066   ⟹   ENSRNOP00000024067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1721,310,028 - 21,337,101 (-)Ensembl
Rnor_6.0 Ensembl1723,986,758 - 24,013,881 (+)Ensembl
RefSeq Acc Id: NM_001004256   ⟹   NP_001004256
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,515,982 - 21,543,056 (-)NCBI
mRatBN7.21721,310,028 - 21,337,103 (-)NCBI
Rnor_6.01723,986,796 - 24,013,854 (+)NCBI
Rnor_5.01725,936,391 - 25,963,434 (+)NCBI
RGSC_v3.41727,135,610 - 27,162,715 (-)RGD
Celera1721,007,452 - 21,034,513 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253801   ⟹   XP_006253863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,515,982 - 21,543,529 (-)NCBI
mRatBN7.21721,310,028 - 21,337,101 (-)NCBI
Rnor_6.01723,986,808 - 24,013,854 (+)NCBI
Rnor_5.01725,936,391 - 25,963,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253802   ⟹   XP_006253864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,515,982 - 21,543,090 (-)NCBI
mRatBN7.21721,310,028 - 21,337,137 (-)NCBI
Rnor_6.01723,986,710 - 24,013,854 (+)NCBI
Rnor_5.01725,936,391 - 25,963,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253803   ⟹   XP_006253865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,515,982 - 21,542,870 (-)NCBI
mRatBN7.21721,310,028 - 21,336,871 (-)NCBI
Rnor_6.01723,986,994 - 24,013,854 (+)NCBI
Rnor_5.01725,936,391 - 25,963,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253804   ⟹   XP_006253866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,515,982 - 21,542,858 (-)NCBI
mRatBN7.21721,310,028 - 21,336,695 (-)NCBI
Rnor_6.01723,987,199 - 24,013,854 (+)NCBI
Rnor_5.01725,936,391 - 25,963,434 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095673   ⟹   XP_038951601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,515,982 - 21,543,023 (-)NCBI
mRatBN7.21721,310,028 - 21,336,996 (-)NCBI
RefSeq Acc Id: XM_063276376   ⟹   XP_063132446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,522,862 - 21,543,529 (-)NCBI
RefSeq Acc Id: XM_063276377   ⟹   XP_063132447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,522,862 - 21,543,176 (-)NCBI
RefSeq Acc Id: XM_063276378   ⟹   XP_063132448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,522,862 - 21,543,090 (-)NCBI
RefSeq Acc Id: XM_063276379   ⟹   XP_063132449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81721,522,862 - 21,542,931 (-)NCBI
RefSeq Acc Id: NP_001004256   ⟸   NM_001004256
- UniProtKB: Q68FX9 (UniProtKB/Swiss-Prot),   A6J749 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253863   ⟸   XM_006253801
- Peptide Label: isoform X1
- UniProtKB: Q68FX9 (UniProtKB/Swiss-Prot),   A6J749 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253864   ⟸   XM_006253802
- Peptide Label: isoform X1
- UniProtKB: Q68FX9 (UniProtKB/Swiss-Prot),   A6J749 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253865   ⟸   XM_006253803
- Peptide Label: isoform X1
- UniProtKB: Q68FX9 (UniProtKB/Swiss-Prot),   A6J749 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253866   ⟸   XM_006253804
- Peptide Label: isoform X1
- UniProtKB: Q68FX9 (UniProtKB/Swiss-Prot),   A6J749 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024067   ⟸   ENSRNOT00000024066
RefSeq Acc Id: XP_038951601   ⟸   XM_039095673
- Peptide Label: isoform X1
- UniProtKB: Q68FX9 (UniProtKB/Swiss-Prot),   A6J749 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132446   ⟸   XM_063276376
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063132447   ⟸   XM_063276377
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063132448   ⟸   XM_063276378
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063132449   ⟸   XM_063276379
- Peptide Label: isoform X2
Protein Domains
Deacetylase sirtuin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68FX9-F1-model_v2 AlphaFold Q68FX9 1-310 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700385
Promoter ID:EPDNEW_R10909
Type:initiation region
Name:Sirt5_1
Description:sirtuin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01723,986,769 - 23,986,829EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303285 AgrOrtholog
BioCyc Gene G2FUF-9799 BioCyc
Ensembl Genes ENSRNOG00000017866 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024066.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1600.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110841 IMAGE-MGC_LOAD
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD-dep_sirtuin_deacylases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin_cat_small_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin_class_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:306840 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93823 IMAGE-MGC_LOAD
NCBI Gene 306840 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sirt5 PhenoGen
PROSITE SIRTUIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017866 RatGTEx
Superfamily-SCOP DHS-like NAD/FAD-binding domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6J749 ENTREZGENE, UniProtKB/TrEMBL
  Q68FX9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Sirt5  sirtuin 5  Sirt5  sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Sirt5  sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)  Sirt5  sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Sirt5  sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)    sirtuin 5  Name updated 1299863 APPROVED
2005-09-30 Sirt5        Symbol and Name status set to provisional 70820 PROVISIONAL