Sirt5 (sirtuin 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Sirt5 (sirtuin 5) Heterocephalus glaber
Analyze
Symbol: Sirt5
Name: sirtuin 5
RGD ID: 18919916
Description: ENCODES a protein that exhibits metal ion binding (inferred); NAD+ binding (inferred); NAD-dependent histone deacetylase activity (inferred); INVOLVED IN negative regulation of cardiac muscle cell apoptotic process (ortholog); regulation of ketone biosynthetic process (ortholog); response to ischemia (ortholog); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; FOUND IN mitochondrial inner membrane (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mitochondrial NAD-dependent protein deacylase sirtuin-5; NAD-dependent deacetylase sirtuin-5; NAD-dependent protein deacylase sirtuin-5, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475612,678,877 - 12,706,604 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475612,678,866 - 12,705,862 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:26763976  


Genomics

Comparative Map Data
Sirt5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475612,678,877 - 12,706,604 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475612,678,866 - 12,705,862 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SIRT5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38613,574,274 - 13,615,158 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl613,574,227 - 13,615,158 (+)EnsemblGRCh38hg38GRCh38
GRCh37613,574,506 - 13,615,390 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36613,682,812 - 13,720,500 (+)NCBINCBI36Build 36hg18NCBI36
Build 34613,682,811 - 13,713,947NCBI
Celera614,814,287 - 14,854,285 (+)NCBICelera
Cytogenetic Map6p23NCBI
HuRef613,519,134 - 13,559,766 (+)NCBIHuRef
CHM1_1613,577,139 - 13,617,757 (+)NCBICHM1_1
T2T-CHM13v2.0613,447,831 - 13,488,715 (+)NCBIT2T-CHM13v2.0
Sirt5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391343,518,849 - 43,549,073 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1343,518,972 - 43,548,679 (+)EnsemblGRCm39 Ensembl
GRCm381343,365,389 - 43,395,203 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1343,365,496 - 43,395,203 (+)EnsemblGRCm38mm10GRCm38
MGSCv371343,460,904 - 43,490,572 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361343,376,507 - 43,406,175 (+)NCBIMGSCv36mm8
Celera1344,444,248 - 44,473,768 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1321.6NCBI
Sirt5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81721,515,982 - 21,543,529 (-)NCBIGRCr8
mRatBN7.21721,310,028 - 21,337,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1721,310,028 - 21,337,101 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1721,198,845 - 21,226,111 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01722,802,514 - 22,829,782 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01721,125,948 - 21,153,215 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01723,986,710 - 24,013,854 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1723,986,758 - 24,013,881 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01725,936,391 - 25,963,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41727,135,610 - 27,162,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11727,138,453 - 27,165,556 (-)NCBI
Celera1721,007,452 - 21,034,513 (-)NCBICelera
Cytogenetic Map17p14NCBI
Sirt5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554651,129,217 - 1,167,604 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554651,129,217 - 1,167,604 (-)NCBIChiLan1.0ChiLan1.0
SIRT5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2528,228,262 - 28,266,098 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1624,218,286 - 24,256,255 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0613,419,242 - 13,457,200 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1613,790,576 - 13,828,464 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl613,791,112 - 13,828,464 (+)Ensemblpanpan1.1panPan2
SIRT5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13513,017,397 - 13,055,655 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3513,017,397 - 13,063,022 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3512,966,806 - 13,004,993 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03513,115,780 - 13,154,165 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3513,115,780 - 13,179,805 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13512,941,308 - 12,979,591 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03512,994,546 - 13,031,107 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03514,317,852 - 14,356,107 (+)NCBIUU_Cfam_GSD_1.0
Sirt5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494611,516,904 - 11,539,107 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936552192,226 - 214,030 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936552192,182 - 214,037 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl79,951,030 - 9,968,448 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.179,951,024 - 9,968,004 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2710,327,724 - 10,330,511 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11758,535,645 - 58,573,769 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1758,532,650 - 58,563,818 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604413,624,450 - 13,664,862 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000005979   ⟹   ENSHGLP00000005905
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475612,678,877 - 12,706,604 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000005980   ⟹   ENSHGLP00000005906
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475612,679,275 - 12,700,555 (-)Ensembl
RefSeq Acc Id: NM_001310253   ⟹   NP_001297182
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475612,678,866 - 12,705,531 (-)NCBI
RefSeq Acc Id: XM_004847665   ⟹   XP_004847722
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475612,678,877 - 12,705,862 (-)NCBI
RefSeq Acc Id: XM_004847668   ⟹   XP_004847725
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475612,678,877 - 12,702,594 (-)NCBI
RefSeq Acc Id: XM_013073262   ⟹   XP_012928716
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475612,678,877 - 12,705,691 (-)NCBI
RefSeq Acc Id: XM_021260470   ⟹   XP_021116129
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475612,678,877 - 12,705,496 (-)NCBI
RefSeq Acc Id: XM_021260471   ⟹   XP_021116130
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475612,678,877 - 12,702,987 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001297182   ⟸   NM_001310253
- UniProtKB: G5BN47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004847722   ⟸   XM_004847665
- Peptide Label: isoform X1
- UniProtKB: G5BN47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012928716   ⟸   XM_013073262
- Peptide Label: isoform X1
- UniProtKB: G5BN47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116129   ⟸   XM_021260470
- Peptide Label: isoform X1
- UniProtKB: G5BN47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021116130   ⟸   XM_021260471
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004847725   ⟸   XM_004847668
- Peptide Label: isoform X1
- UniProtKB: G5BN47 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000005906   ⟸   ENSHGLT00000005980
RefSeq Acc Id: ENSHGLP00000005905   ⟸   ENSHGLT00000005979


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004314 Ensembl, ENTREZGENE
  ENSHGLG00100003189 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000005979 ENTREZGENE
  ENSHGLT00000005980 ENTREZGENE
  ENSHGLT00100004263 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1600.10 UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  Sirtuin UniProtKB/TrEMBL
  Sirtuin_cat_small_dom_sf UniProtKB/TrEMBL
  Sirtuin_class_III UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/TrEMBL
KEGG Report hgl:101718891 UniProtKB/TrEMBL
NCBI Gene Sirt5 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/TrEMBL
PROSITE SIRTUIN UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/TrEMBL
UniProt G5BN47 ENTREZGENE, UniProtKB/TrEMBL