Sirt5 (sirtuin 5) - Rat Genome Database

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Gene: Sirt5 (sirtuin 5) Mus musculus
Analyze
Symbol: Sirt5
Name: sirtuin 5
RGD ID: 1332358
MGI Page MGI
Description: Enables protein-glutaryllysine deglutarylase activity; protein-malonyllysine demalonylase activity; and protein-succinyllysine desuccinylase activity. Involved in regulation of ketone biosynthetic process. Acts upstream of or within response to ischemia. Located in cytosol and mitochondrial inner membrane. Is expressed in several structures, including 1st branchial arch maxillary component; heart; oocyte; palatal shelf; and sensory organ. Orthologous to human SIRT5 (sirtuin 5).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 0610012J09Rik; 1500032M05Rik; AV001953; NAD-dependent deacetylase sirtuin-5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial; regulatory protein SIR2 homolog 5; SIR2-like protein 5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391343,518,849 - 43,549,073 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1343,518,972 - 43,548,679 (+)EnsemblGRCm39 Ensembl
GRCm381343,365,389 - 43,395,203 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1343,365,496 - 43,395,203 (+)EnsemblGRCm38mm10GRCm38
MGSCv371343,460,904 - 43,490,572 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361343,376,507 - 43,406,175 (+)NCBIMGSCv36mm8
Celera1344,444,248 - 44,473,768 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1321.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. NAD(+) in aging, metabolism, and neurodegeneration. Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
10. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17923681   PMID:18054327  
PMID:18614015   PMID:18680753   PMID:18799693   PMID:18824292   PMID:19410549   PMID:20059953   PMID:20097174   PMID:20157539   PMID:20506229   PMID:20644252   PMID:21873635   PMID:21908771  
PMID:22076378   PMID:23085393   PMID:23673559   PMID:23806337   PMID:24076663   PMID:24315375   PMID:24687991   PMID:24703692   PMID:24703693   PMID:25541039   PMID:25811481   PMID:26073543  
PMID:26208827   PMID:26388266   PMID:26472659   PMID:26767982   PMID:27051063   PMID:27052737   PMID:27113762   PMID:27166947   PMID:27435822   PMID:27445698   PMID:27681422   PMID:28340937  
PMID:28458255   PMID:28614718   PMID:28972174   PMID:29440987   PMID:29491006   PMID:29769314   PMID:30017194   PMID:30098330   PMID:30279144   PMID:30471144   PMID:30515162   PMID:30726738  
PMID:30759120   PMID:30846716   PMID:30849386   PMID:31000437   PMID:31010955   PMID:31575700   PMID:31632409   PMID:32026628   PMID:32301534   PMID:32325033   PMID:32415480   PMID:32931562  
PMID:33110171   PMID:33479498   PMID:33567897   PMID:33945506   PMID:34158847   PMID:34245764   PMID:34507876   PMID:34642466   PMID:34644302   PMID:34788008   PMID:34966740   PMID:35157847  
PMID:35292350   PMID:35613279   PMID:35770730   PMID:35851833   PMID:35995176   PMID:36096355   PMID:36479818   PMID:36517900   PMID:36653443   PMID:36736426   PMID:36879797   PMID:36921688  
PMID:37343537   PMID:37515421   PMID:38169591   PMID:38355793   PMID:38635631  


Genomics

Comparative Map Data
Sirt5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391343,518,849 - 43,549,073 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1343,518,972 - 43,548,679 (+)EnsemblGRCm39 Ensembl
GRCm381343,365,389 - 43,395,203 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1343,365,496 - 43,395,203 (+)EnsemblGRCm38mm10GRCm38
MGSCv371343,460,904 - 43,490,572 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361343,376,507 - 43,406,175 (+)NCBIMGSCv36mm8
Celera1344,444,248 - 44,473,768 (+)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1321.6NCBI
SIRT5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38613,574,274 - 13,615,158 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl613,574,227 - 13,615,158 (+)EnsemblGRCh38hg38GRCh38
GRCh37613,574,506 - 13,615,390 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36613,682,812 - 13,720,500 (+)NCBINCBI36Build 36hg18NCBI36
Build 34613,682,811 - 13,713,947NCBI
Celera614,814,287 - 14,854,285 (+)NCBICelera
Cytogenetic Map6p23NCBI
HuRef613,519,134 - 13,559,766 (+)NCBIHuRef
CHM1_1613,577,139 - 13,617,757 (+)NCBICHM1_1
T2T-CHM13v2.0613,447,831 - 13,488,715 (+)NCBIT2T-CHM13v2.0
Sirt5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81721,515,982 - 21,543,529 (-)NCBIGRCr8
mRatBN7.21721,310,028 - 21,337,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1721,310,028 - 21,337,101 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1721,198,845 - 21,226,111 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01722,802,514 - 22,829,782 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01721,125,948 - 21,153,215 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01723,986,710 - 24,013,854 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1723,986,758 - 24,013,881 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01725,936,391 - 25,963,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41727,135,610 - 27,162,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11727,138,453 - 27,165,556 (-)NCBI
Celera1721,007,452 - 21,034,513 (-)NCBICelera
Cytogenetic Map17p14NCBI
Sirt5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554651,129,217 - 1,167,604 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554651,129,217 - 1,167,604 (-)NCBIChiLan1.0ChiLan1.0
SIRT5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2528,228,262 - 28,266,098 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1624,218,286 - 24,256,255 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0613,419,242 - 13,457,200 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1613,790,576 - 13,828,464 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl613,791,112 - 13,828,464 (+)Ensemblpanpan1.1panPan2
SIRT5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13513,017,397 - 13,055,655 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3513,017,397 - 13,063,022 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3512,966,806 - 13,004,993 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03513,115,780 - 13,154,165 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3513,115,780 - 13,179,805 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13512,941,308 - 12,979,591 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03512,994,546 - 13,031,107 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03514,317,852 - 14,356,107 (+)NCBIUU_Cfam_GSD_1.0
Sirt5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494611,516,904 - 11,539,107 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936552192,226 - 214,030 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936552192,182 - 214,037 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl79,951,030 - 9,968,448 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.179,951,024 - 9,968,004 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2710,327,724 - 10,330,511 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11758,535,645 - 58,573,769 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1758,532,650 - 58,563,818 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604413,624,450 - 13,664,862 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475612,678,877 - 12,706,604 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475612,678,866 - 12,705,862 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sirt5
1088 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:89
Interacting mature miRNAs:102
Transcripts:ENSMUST00000066804
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse

Markers in Region
AV001953  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381343,394,817 - 43,394,897UniSTSGRCm38
MGSCv371343,490,186 - 43,490,266UniSTSGRCm37
Celera1344,473,382 - 44,473,462UniSTS
Cytogenetic Map13A4UniSTS
Whitehead/MRC_RH13442.29UniSTS
Sirt5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A4UniSTS
cM Map1321.6UniSTS
Sirt5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A4UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_178848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030247387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030247388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030247389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030247390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK005346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000066804   ⟹   ENSMUSP00000071048
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1343,524,186 - 43,548,678 (+)Ensembl
GRCm38.p6 Ensembl1343,370,710 - 43,395,202 (+)Ensembl
RefSeq Acc Id: ENSMUST00000220458   ⟹   ENSMUSP00000152668
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1343,519,104 - 43,530,208 (+)Ensembl
GRCm38.p6 Ensembl1343,365,628 - 43,376,732 (+)Ensembl
RefSeq Acc Id: ENSMUST00000220576   ⟹   ENSMUSP00000152740
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1343,519,140 - 43,541,135 (+)Ensembl
GRCm38.p6 Ensembl1343,365,664 - 43,387,659 (+)Ensembl
RefSeq Acc Id: ENSMUST00000220645   ⟹   ENSMUSP00000152760
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1343,519,114 - 43,534,029 (+)Ensembl
GRCm38.p6 Ensembl1343,365,638 - 43,380,553 (+)Ensembl
RefSeq Acc Id: ENSMUST00000220874
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1343,518,989 - 43,534,183 (+)Ensembl
GRCm38.p6 Ensembl1343,365,513 - 43,380,707 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221481   ⟹   ENSMUSP00000152640
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1343,518,972 - 43,541,132 (+)Ensembl
GRCm38.p6 Ensembl1343,365,496 - 43,387,656 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221515   ⟹   ENSMUSP00000152526
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1343,519,162 - 43,539,815 (+)Ensembl
GRCm38.p6 Ensembl1343,365,686 - 43,386,339 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221955
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1343,519,006 - 43,534,165 (+)Ensembl
GRCm38.p6 Ensembl1343,365,530 - 43,380,689 (+)Ensembl
RefSeq Acc Id: ENSMUST00000222106   ⟹   ENSMUSP00000152763
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1343,533,149 - 43,541,132 (+)Ensembl
GRCm38.p6 Ensembl1343,379,673 - 43,387,656 (+)Ensembl
RefSeq Acc Id: ENSMUST00000222489
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1343,518,972 - 43,531,780 (+)Ensembl
GRCm38.p6 Ensembl1343,365,496 - 43,378,304 (+)Ensembl
RefSeq Acc Id: ENSMUST00000223194   ⟹   ENSMUSP00000152796
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1343,518,982 - 43,548,679 (+)Ensembl
GRCm38.p6 Ensembl1343,365,506 - 43,395,203 (+)Ensembl
RefSeq Acc Id: NM_178848   ⟹   NP_849179
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,519,011 - 43,548,679 (+)NCBI
GRCm381343,365,535 - 43,395,203 (+)NCBI
MGSCv371343,460,904 - 43,490,572 (+)RGD
Celera1344,444,248 - 44,473,768 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516951   ⟹   XP_006517014
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,518,849 - 43,540,152 (+)NCBI
GRCm381343,365,389 - 43,386,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006516952   ⟹   XP_006517015
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,519,066 - 43,540,152 (+)NCBI
GRCm381343,365,591 - 43,386,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006516953   ⟹   XP_006517016
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,519,066 - 43,540,152 (+)NCBI
GRCm381343,365,591 - 43,386,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006516954   ⟹   XP_006517017
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,518,928 - 43,540,152 (+)NCBI
GRCm381343,371,882 - 43,386,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011244412   ⟹   XP_011242714
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,521,883 - 43,540,152 (+)NCBI
GRCm381343,368,399 - 43,386,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011244413   ⟹   XP_011242715
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,521,541 - 43,540,152 (+)NCBI
GRCm381343,368,064 - 43,386,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030247387   ⟹   XP_030103247
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,519,060 - 43,549,073 (+)NCBI
GRCm381343,365,592 - 43,395,203 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030247388   ⟹   XP_030103248
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,519,068 - 43,549,073 (+)NCBI
GRCm381343,365,592 - 43,395,203 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030247389   ⟹   XP_030103249
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,521,876 - 43,549,073 (+)NCBI
GRCm381343,368,400 - 43,395,203 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030247390   ⟹   XP_030103250
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,519,067 - 43,540,152 (+)NCBI
GRCm381343,365,592 - 43,386,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036158142   ⟹   XP_036014035
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,519,064 - 43,540,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036158143   ⟹   XP_036014036
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,518,939 - 43,540,152 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_849179   ⟸   NM_178848
- UniProtKB: Q8K2C6 (UniProtKB/Swiss-Prot),   A0A1Y7VJY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006517014   ⟸   XM_006516951
- Peptide Label: isoform X1
- UniProtKB: A0A1Y7VM56 (UniProtKB/TrEMBL),   A0A1Y7VJY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006517015   ⟸   XM_006516952
- Peptide Label: isoform X1
- UniProtKB: A0A1Y7VM56 (UniProtKB/TrEMBL),   A0A1Y7VJY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006517016   ⟸   XM_006516953
- Peptide Label: isoform X1
- UniProtKB: A0A1Y7VM56 (UniProtKB/TrEMBL),   A0A1Y7VJY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006517017   ⟸   XM_006516954
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011242715   ⟸   XM_011244413
- Peptide Label: isoform X1
- UniProtKB: A0A1Y7VM56 (UniProtKB/TrEMBL),   A0A1Y7VJY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011242714   ⟸   XM_011244412
- Peptide Label: isoform X1
- UniProtKB: A0A1Y7VM56 (UniProtKB/TrEMBL),   A0A1Y7VJY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030103248   ⟸   XM_030247388
- Peptide Label: isoform X2
- UniProtKB: Q8K2C6 (UniProtKB/Swiss-Prot),   A0A1Y7VJY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030103247   ⟸   XM_030247387
- Peptide Label: isoform X2
- UniProtKB: Q8K2C6 (UniProtKB/Swiss-Prot),   A0A1Y7VJY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030103250   ⟸   XM_030247390
- Peptide Label: isoform X4
RefSeq Acc Id: XP_030103249   ⟸   XM_030247389
- Peptide Label: isoform X2
- UniProtKB: Q8K2C6 (UniProtKB/Swiss-Prot),   A0A1Y7VJY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000071048   ⟸   ENSMUST00000066804
RefSeq Acc Id: ENSMUSP00000152796   ⟸   ENSMUST00000223194
RefSeq Acc Id: ENSMUSP00000152763   ⟸   ENSMUST00000222106
RefSeq Acc Id: ENSMUSP00000152526   ⟸   ENSMUST00000221515
RefSeq Acc Id: ENSMUSP00000152640   ⟸   ENSMUST00000221481
RefSeq Acc Id: ENSMUSP00000152668   ⟸   ENSMUST00000220458
RefSeq Acc Id: ENSMUSP00000152760   ⟸   ENSMUST00000220645
RefSeq Acc Id: ENSMUSP00000152740   ⟸   ENSMUST00000220576
RefSeq Acc Id: XP_036014036   ⟸   XM_036158143
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036014035   ⟸   XM_036158142
- Peptide Label: isoform X3
Protein Domains
Deacetylase sirtuin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K2C6-F1-model_v2 AlphaFold Q8K2C6 1-310 view protein structure

Promoters
RGD ID:8680200
Promoter ID:EPDNEW_M18130
Type:multiple initiation site
Name:Sirt5_1
Description:Mus musculus sirtuin 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381343,365,506 - 43,365,566EPDNEW
RGD ID:6824381
Promoter ID:MM_KWN:13932
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4
Transcripts:UC007QFZ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361343,460,744 - 43,461,244 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915596 AgrOrtholog
Ensembl Genes ENSMUSG00000054021 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000066804.5 UniProtKB/Swiss-Prot
  ENSMUST00000220458.2 UniProtKB/TrEMBL
  ENSMUST00000220576 ENTREZGENE
  ENSMUST00000220576.2 UniProtKB/TrEMBL
  ENSMUST00000220645.2 UniProtKB/TrEMBL
  ENSMUST00000221481.2 UniProtKB/TrEMBL
  ENSMUST00000221515 ENTREZGENE
  ENSMUST00000221515.2 UniProtKB/TrEMBL
  ENSMUST00000222106.2 UniProtKB/TrEMBL
  ENSMUST00000223194 ENTREZGENE
  ENSMUST00000223194.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1600.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin_cat_small_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin_class_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:68346 UniProtKB/Swiss-Prot
MGD MGI:1915596 ENTREZGENE
NCBI Gene 68346 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sirt5 PhenoGen
PROSITE SIRTUIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1Y7VJY8 ENTREZGENE, UniProtKB/TrEMBL
  A0A1Y7VK33_MOUSE UniProtKB/TrEMBL
  A0A1Y7VM56 ENTREZGENE, UniProtKB/TrEMBL
  A0A1Y7VMJ7_MOUSE UniProtKB/TrEMBL
  A0A1Y7VNW0_MOUSE UniProtKB/TrEMBL
  Q5M8R0_MOUSE UniProtKB/TrEMBL
  Q8K2C6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-06 Sirt5  sirtuin 5    sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED