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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:altered phosphatidylinositol 3-kinase-Akt signaling pathway
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Accession:PW:0000622 term browser browse the term
Definition:A phosphatidylinositol 3-kinase-Akt signaling pathway that deviates from what its normal course should be. Altered phosphatidylinositol 3-kinase-Akt signaling pathway has been implicated in several forms of cancer. The components of the pathway are attractive targets for the development of therapeutics.


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altered phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:18955974 PMID:21277552 RGD:2313763, RGD:5133243 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO RGD PMID:18955974 PMID:19506583 PMID:15166380 RGD:2313763, RGD:5490965, RGD:2313408 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 ISO RGD PMID:18955974 RGD:2313763 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO RGD PMID:18955974 PMID:19078924 PMID:20951313 PMID:21277552 RGD:2313763, RGD:4143515, RGD:5133242, RGD:5133243 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:18955974 PMID:18008377 PMID:19078924 PMID:20951313 PMID:19506583 RGD:2313763, RGD:2326139, RGD:4143515, RGD:5133242, RGD:5490965 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      altered signaling pathway 115
        altered kinase mediated signaling pathway 13
          altered serine/threonine-specific kinase mediated signaling pathway 11
            altered phosphatidylinositol 3-kinase-Akt signaling pathway 5
Path 2
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      signaling pathway involving second messengers 359
        phosphatidylinositol 3-kinase signaling pathway 153
          phosphatidylinositol 3-kinase class I signaling pathway 91
            phosphatidylinositol 3-kinase-Akt signaling pathway 58
              altered phosphatidylinositol 3-kinase-Akt signaling pathway 5
paths to the root