Asic3 (acid sensing ion channel subunit 3)

Gene: Asic3 (acid sensing ion channel subunit 3) Rattus norvegicus

Analyze

Symbol:

Asic3

Name:

acid sensing ion channel subunit 3

RGD ID:

708578

Description:

Enables ligand-gated sodium channel activity. Involved in monoatomic ion transmembrane transport. Acts upstream of or within response to acidic pH and sodium ion transport. Located in perinuclear region of cytoplasm and plasma membrane. Orthologous to human ASIC3 (acid sensing ion channel subunit 3); INTERACTS WITH acetylsalicylic acid; ammonium chloride; ATP.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Accn3; acid sensing ion channel 3; acid-sensing (proton-gated) ion channel 3; acid-sensing ion channel 3; amiloride-sensitive cation channel 3; dorsal root ASIC; DRASIC; proton gated cation channel DRASIC

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ASIC3 (acid sensing ion channel subunit 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Asic3 (acid-sensing ion channel 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Asic3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ASIC3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ASIC3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Asic3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ASIC3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ASIC3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Asic3 (acid sensing ion channel subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Asic3 (acid-sensing ion channel 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ASIC3 (acid sensing ion channel subunit 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	asic1b (acid-sensing (proton-gated) ion channel 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Caenorhabditis elegans (roundworm):	acd-1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	acd-2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	acd-4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	acd-5	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	delm-2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	flr-1	Alliance	DIOPT (OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	ppk	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk11	Alliance	DIOPT (Ensembl Compara\|InParanoid\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	ppk12	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk28	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	delm-1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	ppk8	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk16	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ppk5	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Nach	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER)

Allele / Splice:

Asic3^em6Mcwi

Genetic Models:

WKY-Asic3^em6Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	11,652,946 - 11,657,415 (-)	NCBI		GRCr8
mRatBN7.2	4	10,760,509 - 10,764,987 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	10,760,597 - 10,764,643 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	15,906,873 - 15,910,919 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	11,727,066 - 11,731,112 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	10,078,850 - 10,082,896 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	7,287,868 - 7,293,295 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	7,288,855 - 7,292,901 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	7,300,219 - 7,304,265 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	6,125,614 - 6,129,660 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	6,125,613 - 6,129,660 (-)	NCBI
Celera	4	6,375,165 - 6,379,211 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Inflammation (ISO)

lethal congenital glycogen storage disease of heart (ISO)

long QT syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

acetylsalicylic acid (EXP)

acrylamide (ISO)

amiloride (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

ATP (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (EXP)

diclofenac (EXP)

ethanol (ISO)

folic acid (ISO)

furan (EXP)

genistein (ISO)

ibuprofen (EXP)

methamphetamine (EXP)

methoxychlor (EXP)

Muraglitazar (EXP)

paracetamol (ISO)

paraquat (EXP)

procymidone (EXP)

salicylic acid (EXP)

silicon dioxide (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

tetramethylpyrazine (ISO)

trichloroethene (EXP)

troglitazone (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

detection of chemical stimulus involved in sensory perception (ISO)

detection of chemical stimulus involved in sensory perception of pain (ISO)

detection of mechanical stimulus involved in sensory perception (ISO)

detection of mechanical stimulus involved in sensory perception of pain (ISO)

detection of temperature stimulus involved in sensory perception (ISO)

detection of temperature stimulus involved in sensory perception of pain (ISO)

enterobactin transport (IEA)

establishment of localization in cell (ISO)

monoatomic cation transport (ISO)

monoatomic ion transmembrane transport (IDA,ISO)

response to acidic pH (IDA,ISO)

response to heat (ISO)

response to mechanical stimulus (ISO)

sensory perception of sour taste (ISO)

sodium ion transmembrane transport (IBA,IEA)

sodium ion transport (IDA,IMP)

Cellular Component

membrane (IEA)

perinuclear region of cytoplasm (IDA)

plasma membrane (IBA,IDA,ISO)

Molecular Function

enterobactin transmembrane transporter activity (ISO)

ligand-gated sodium channel activity (IBA,IDA,IMP)

monoatomic cation channel activity (ISO)

pH-gated monoatomic ion channel activity (IBA)

protein binding (IPI)

sodium channel activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons.	Anzai N, etal., J Biol Chem. 2002 May 10;277(19):16655-61. Epub 2002 Feb 28.
2.	A stomatin dimer modulates the activity of acid-sensing ion channels.	Brand J, etal., EMBO J. 2012 Aug 29;31(17):3635-46. doi: 10.1038/emboj.2012.203. Epub 2012 Jul 31.
3.	Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1.	Deval E, etal., J Biol Chem. 2006 Jan 20;281(3):1796-807. Epub 2005 Oct 17.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton.	Takeda T, etal., J Clin Invest 2001 Jul;108(2):289-301.
9.	Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons.	Waldmann R, etal., J Biol Chem 1997 Aug 22;272(34):20975-8.
10.	A stomatin-domain protein essential for touch sensation in the mouse.	Wetzel C, etal., Nature. 2007 Jan 11;445(7124):206-9. Epub 2006 Dec 13.

Additional References at PubMed

PMID:9368048	PMID:9707631	PMID:10187795	PMID:10842183	PMID:11120882	PMID:11528414	PMID:11587714	PMID:11588175	PMID:11754838	PMID:11842212	PMID:11854527	PMID:12060708
PMID:12486159	PMID:12526774	PMID:12668052	PMID:14522957	PMID:14976185	PMID:15044953	PMID:15317815	PMID:15452199	PMID:16085050	PMID:16305749	PMID:16319075	PMID:16510130
PMID:17389250	PMID:17696763	PMID:17872465	PMID:17936312	PMID:18466073	PMID:18579798	PMID:18923424	PMID:19339181	PMID:19356693	PMID:19590043	PMID:19812697	PMID:20019330
PMID:20206612	PMID:20501405	PMID:20860671	PMID:20924599	PMID:21078372	PMID:21143836	PMID:21508231	PMID:21998313	PMID:22842475	PMID:23135698	PMID:23808707	PMID:24942880
PMID:25006846	PMID:25377529	PMID:26823770	PMID:28765874	PMID:29636447	PMID:29736613	PMID:29802295	PMID:30209688	PMID:31314951	PMID:31347922	PMID:31565832	PMID:32012213
PMID:32302492	PMID:32592826	PMID:32887365	PMID:33280501	PMID:34088898	PMID:34918385	PMID:37604935

Genomics

Comparative Map Data

Asic3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	11,652,946 - 11,657,415 (-)	NCBI		GRCr8
mRatBN7.2	4	10,760,509 - 10,764,987 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	10,760,597 - 10,764,643 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	15,906,873 - 15,910,919 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	11,727,066 - 11,731,112 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	10,078,850 - 10,082,896 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	7,287,868 - 7,293,295 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	7,288,855 - 7,292,901 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	7,300,219 - 7,304,265 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	6,125,614 - 6,129,660 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	6,125,613 - 6,129,660 (-)	NCBI
Celera	4	6,375,165 - 6,379,211 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

ASIC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	151,048,292 - 151,052,756 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	151,048,292 - 151,052,756 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	150,745,379 - 150,749,843 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	150,376,885 - 150,380,774 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	150,183,609 - 150,187,488	NCBI
Celera	7	145,302,914 - 145,307,152 (+)	NCBI		Celera
Cytogenetic Map	7	q36.1	NCBI
HuRef	7	144,557,715 - 144,562,179 (+)	NCBI		HuRef
CHM1_1	7	150,753,727 - 150,758,191 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	152,221,380 - 152,225,844 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	150,074,918 - 150,079,382 (+)	NCBI

Asic3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	24,618,449 - 24,622,836 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	24,618,390 - 24,622,833 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	24,413,451 - 24,417,840 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	24,413,392 - 24,417,835 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	23,919,269 - 23,923,652 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	23,923,516 - 23,927,899 (+)	NCBI		MGSCv36	mm8
Celera	5	21,363,200 - 21,367,641 (+)	NCBI		Celera
Cytogenetic Map	5	A3	NCBI
cM Map	5	11.72	NCBI

Asic3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955491	5,488,249 - 5,491,447 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955491	5,487,788 - 5,491,562 (+)	NCBI	ChiLan1.0	ChiLan1.0

ASIC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	187,467,618 - 187,474,669 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	39,478,716 - 39,485,845 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	142,633,357 - 142,639,571 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	154,786,835 - 154,792,289 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	154,786,835 - 154,792,289 (+)	Ensembl	panpan1.1		panPan2

ASIC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	15,099,023 - 15,104,088 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	15,099,883 - 15,104,080 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	15,706,096 - 15,712,334 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	16,820,077 - 16,826,314 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	16,822,357 - 16,826,307 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	15,192,516 - 15,198,753 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	15,775,203 - 15,780,207 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	15,824,677 - 15,830,914 (+)	NCBI		UU_Cfam_GSD_1.0

Asic3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	6,424,673 - 6,428,461 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	6,474,995 - 6,478,711 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936527	6,473,305 - 6,478,756 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ASIC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	6,172,471 - 6,180,440 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	6,172,410 - 6,180,440 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	6,542,445 - 6,547,297 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ASIC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	119,226,940 - 119,234,626 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	119,230,796 - 119,234,696 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	15,198,711 - 15,205,127 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Asic3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624800	5,567,541 - 5,570,851 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624800	5,567,516 - 5,571,292 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Asic3
2 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	41
Count of miRNA genes:	40
Interacting mature miRNAs:	41
Transcripts:	ENSRNOT00000011300
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61351	Bp33	Blood pressure QTL 33		0.0018	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	1	27716890	Rat
61408	Scl23	Serum cholesterol level QTL 23		0.0005	blood HDL phospholipid amount (VT:0010504)	serum high density lipoprotein phospholipid level (CMO:0001567)	4	1	27716890	Rat
724557	Plsm1	Polydactyly-luxate syndrome (PLS) morphotypes QTL 1		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	4	1	27716890	Rat
1641905	Colcr1	Colorectal carcinoma resistance QTL 1	4.3	0.0003	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	4	1	29494328	Rat
61333	Gluco16	Glucose level QTL 16	4.3	0.00001	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	1	30372989	Rat
9589097	Slep11	Serum leptin concentration QTL 11	5.09	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	4	1	31934116	Rat
8552903	Pigfal2	Plasma insulin-like growth factor 1 level QTL 2	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	1	31934116	Rat
9589046	Scfw2	Subcutaneous fat weight QTL 2	5.54	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	4	1	31934116	Rat
9590100	Sffal4	Serum free fatty acids level QTL 4	7.36	0.05	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	4	1	31934116	Rat
738021	Hcar13	Hepatocarcinoma resistance QTL 13	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	4	1	32584199	Rat
1357341	Gluco5	Glucose level QTL 5	6.4		adipocyte free fatty acid secretion trait (VT:0010465)	absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)	4	1	33250345	Rat
1357343	Gluco4	Glucose level QTL 4		0.00002	adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	4	1	33250345	Rat
61415	Eae11	Experimental allergic encephalomyelitis QTL 11	2.9		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	1	39505420	Rat
634323	Hc2	Hypercalciuria QTL 2	2.15		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	4	210796	45210796	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	57114705	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	65958103	Rat
1358201	Gluco12	Glucose level QTL12	1.6		adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake (CMO:0000870)	4	5218392	29593287	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5219178	56647776	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	9940885	44463908	Rat
1300141	Bp178	Blood pressure QTL 178			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	10024901	39524530	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	10084089	55084089	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	10084089	55084089	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	10084089	55084089	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	10084089	55084089	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	10084089	55084089	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	10084089	55084089	Rat

Markers in Region

RH133078

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	10,766,311 - 10,766,495 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	7,294,570 - 7,294,753	NCBI	Rnor6.0
Rnor_5.0	4	7,305,934 - 7,306,117	UniSTS	Rnor5.0
RGSC_v3.4	4	6,131,329 - 6,131,512	UniSTS	RGSC3.4
Celera	4	6,380,880 - 6,381,063	UniSTS
Cytogenetic Map	4	q11	UniSTS

Genetic Models

This gene Asic3 is modified in the following models/strains:

WKY-Asic3^em6Mcwi

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low			7		8		1	1	37	2	8	1	1
Below cutoff	2	21	13	4	11	4	5	5	37	27	32	10	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_173135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762632	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285654	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285656	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC097312	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF013598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF527175	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CQ815093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000011300 ⟹ ENSRNOP00000011300

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	10,760,597 - 10,764,643 (-)	Ensembl
Rnor_6.0 Ensembl	4	7,288,855 - 7,292,901 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000110269 ⟹ ENSRNOP00000080943

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	10,760,597 - 10,764,643 (-)	Ensembl

RefSeq Acc Id:

NM_173135 ⟹ NP_775158

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,652,946 - 11,657,367 (-)	NCBI
mRatBN7.2	4	10,760,509 - 10,764,930 (-)	NCBI
Rnor_6.0	4	7,288,855 - 7,292,901 (-)	NCBI
Rnor_5.0	4	7,300,219 - 7,304,265 (-)	NCBI
RGSC_v3.4	4	6,125,614 - 6,129,660 (-)	RGD
Celera	4	6,375,165 - 6,379,211 (-)	RGD

Sequence:

show sequence

ATGAAACCTCGCTCCGGACTGGAGGAGGCCCAGCGGCGACAGGCCTCAGACATCCGGGTGTTTG
CCAGCAGCTGCACAATGCATGGTCTGGGCCACATCTTTGGCCCTGGAGGCCTGACCCTGCGCCG
AGGGCTGTGGGCCACAGCTGTGCTCCTGTCGCTGGCGGCCTTCCTCTACCAGGTGGCTGAGCGG
GTTCGCTACTATGGGGAGTTCCACCATAAGACCACCCTGGATGAGCGTGAGAGCCACCAGCTCA
CCTTCCCAGCTGTGACTCTGTGTAATATCAACCCACTGCGCCGCTCACGCCTCACACCCAATGA
CTTGCACTGGGCTGGAACAGCGCTGCTGGGCCTGGACCCTGCTGAACATGCTGCCTACCTTCGT
GCACTGGGCCAGCCCCCCGCACCACCTGGCTTCATGCCCAGTCCGACCTTTGACATGGCACAAC
TCTACGCCAGAGCCGGCCACTCCCTTGAGGACATGTTGTTGGATTGCCGATACCGTGGCCAGCC
CTGTGGGCCTGAGAACTTCACAGTGATCTTTACTCGAATGGGGCAATGCTACACCTTCAACTCT
GGTGCCCACGGTGCAGAGCTGCTCACCACTCCAAAGGGTGGTGCTGGCAACGGACTGGAGATTA
TGCTAGATGTACAGCAAGAGGAGTATCTGCCCATCTGGAAGGACATGGAAGAGACCCCGTTTGA
GGTGGGGATCCGAGTGCAGATTCACAGCCAGGATGAGCCCCCTGCCATTGACCAGCTGGGCTTC
GGGGCAGCCCCAGGCCATCAGACTTTTGTGTCCTGTCAGCAGCAGCAACTGAGTTTCCTGCCAC
CACCCTGGGGTGACTGCAATACCGCATCTTTGGATCCCGACGACTTTGATCCAGAGCCCTCTGA
TCCCTTGGGTTCCCCCAGACCCAGACCCAGCCCTCCTTATAGTTTAATAGGTTGTCGCCTGGCC
TGTGAGTCTCGCTATGTGGCTCGGAAGTGTGGCTGTCGAATGATGCATATGCCTGGAAACTCCC
CAGTGTGCAGCCCCCAGCAGTACAAGGACTGCGCCAGCCCAGCTCTGGACGCTATGCTGCGAAA
GGACACGTGTGTCTGCCCCAACCCGTGCGCTACTACACGCTATGCCAAGGAGCTCTCCATGGTG
CGGATTCCCAGCCGCGCGTCAGCTCGCTACCTGGCCCGGAAATACAACCGCAGCGAGTCCTACA
TTACGGAGAATGTACTGGTTCTGGATATCTTCTTTGAGGCCCTCAACTATGAAGCGGTGGAACA
AAAGGCGGCCTATGAAGTGTCGGAGCTGCTGGGAGACATTGGGGGACAGATGGGACTGTTTATT
GGAGCAAGCCTGCTTACCATCCTTGAGATCCTCGACTATCTCTGTGAGGTTTTCCAAGACAGAG
TCCTGGGGTATTTCTGGAACAGAAGGAGCGCTCAAAAGCGCTCTGGCAACACTCTGCTCCAGGA
AGAGTTGAATGGCCATCGAACACATGTTCCCCACCTCAGCCTAGGGCCCAGGCCTCCTACCACT
CCCTGTGCTGTCACCAAGACACTCTCTGCCTCCCACCGTACCTGTTACCTCGTCACAAGGCTCT
AG

hide sequence

RefSeq Acc Id:

XM_008762632 ⟹ XP_008760854

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,652,946 - 11,657,414 (-)	NCBI
mRatBN7.2	4	10,760,509 - 10,764,987 (-)	NCBI
Rnor_6.0	4	7,287,868 - 7,293,292 (-)	NCBI

Sequence:

show sequence

GACCTTCCCTACCCCCCCAGACTGCTCTGCTGCCCCCCAGCCCCCCTCGTGCTGAAACCTAATC
CTCTGCCGCAGCTCTAGCTCAGTGCTGCTCCGCAGCCCCTGCCTGCTGCTACATCCCGTGCCCT
ACTCGGTCTTCACTGCAGAGACCCAGCCCCACGGAGCCAACGCCTGTTCTGGGGAAGGCAGAAC
TGGACCGAAGTTCAACTCATCCAGTCCTAGCAGGCCAGTACTTTCACCTCTGTCTTGGCTCCTC
CCTTCTCTCCCTTCTTCTCCTTTTCTTTCCTCCCTAGTCCTTGCTACTTGAGTCCCATCTCCAT
CCCCACCACTACCCTGCTAGCCCTACAAAACAGCTTCCCCAGTCAGCAACTCCCCGGTCCCTGG
TCCAGCCATGAAACCTCGCTCCGGACTGGAGGAGGCCCAGCGGCGACAGGCCTCAGACATCCGG
GTGTTTGCCAGCAGCTGCACAATGCATGGTCTGGGCCACATCTTTGGCCCTGGAGGCCTGACCC
TGCGCCGAGGGCTGTGGGCCACAGCTGTGCTCCTGTCGCTGGCGGCCTTCCTCTACCAGGTGGC
TGAGCGGGTTCGCTACTATGGGGAGTTCCACCATAAGACCACCCTGGATGAGCGTGAGAGCCAC
CAGCTCACCTTCCCAGCTGTGACTCTGTGTAATATCAACCCACTGCGCCGCTCACGCCTCACAC
CCAATGACTTGCACTGGGCTGGAACAGCGCTGCTGGGCCTGGACCCTGCTGAACATGCTGCCTA
CCTTCGTGCACTGGGCCAGCCCCCCGCACCACCTGGCTTCATGCCCAGTCCGACCTTTGACATG
GCACAACTCTACGCCAGAGCCGGCCACTCCCTTGAGGACATGTTGTTGGATTGCCGATACCGTG
GCCAGCCCTGTGGGCCTGAGAACTTCACAGTGATCTTTACTCGAATGGGGCAATGCTACACCTT
CAACTCTGGTGCCCACGGTGCAGAGCTGCTCACCACTCCAAAGGGTGGTGCTGGCAACGGACTG
GAGATTATGCTAGATGTACAGCAAGAGGAGTATCTGCCCATCTGGAAGGACATGGAAGAGACCC
CGTTTGAGGTGGGGATCCGAGTGCAGATTCACAGCCAGGATGAGCCCCCTGCCATTGACCAGCT
GGGCTTCGGGGCAGCCCCAGGCCATCAGACTTTTGTGTCCTGTCAGCAGCAGCAACTGAGTTTC
CTGCCACCACCCTGGGGTGACTGCAATACCGCATCTTTGGATCCCGACGACTTTGATCCAGAGC
CCTCTGATCCCTTGGGTTCCCCCAGACCCAGACCCAGCCCTCCTTATAGTTTAATAGGTTGTCG
CCTGGCCTGTGAGTCTCGCTATGTGGCTCGGAAGTGTGGCTGTCGAATGATGCATATGCCTGGA
AACTCCCCAGTGTGCAGCCCCCAGCAGTACAAGGACTGCGCCAGCCCAGCTCTGGACGCTATGC
TGCGAAAGGACACGTGTGTCTGCCCCAACCCGTGCGCTACTACACGCTATGCCAAGGAGCTCTC
CATGGTGCGGATTCCCAGCCGCGCGTCAGCTCGCTACCTGGCCCGGAAATACAACCGCAGCGAG
TCCTACATTACGGAGAATGTACTGGTTCTGGATATCTTCTTTGAGGCCCTCAACTATGAAGCGG
TGGAACAAAAGGCGGCCTATGAAGTGTCGGAGCTGCTGGGAGACATTGGGGGACAGATGGGACT
GTTTATTGGAGCAAGCCTGCTTACCATCCTTGAGATCCTCGACTATCTCTGTGAGGTTTTCCAA
GACAGAGTCCTGGGGTATTTCTGGAACAGAAGGAGCGCTCAAAAGCGCTCTGGCAACACTCTGG
CCTCCTACCACTCCCTGTGCTGTCACCAAGACACTCTCTGCCTCCCACCGTACCTGTTACCTCG
TCACAAGGCTCTAGACCAGCTTGGCTGCACTGTGACATCTTGGACATGTCCAGCCTGTATATCT
TTGCTGTCTCCACCCTAATAAAGCTCTCGTACATGTGCCTCAGATGTCTACCTTACAGATCAGA
CACTACCACAGTCGATGAGAGCCCCCAGCCTCATCCATTCTCCCGCTGGGACCTGGATCCCAGT
TAGACTTAACAACTCATTTGAGGTGTGGGTGGGGCTAATTTTAAGACGAGATCAGTCAGGTGCA
CCCTAGTGTTAGTGAGCTTCTCAAAGATTTTCATTTAATTTTGTGTTTCTTGAGTAATGGGGAC
AGAACCTCGAGTCTGGAGGATGCCCACTGTTTGAATGTTTTCCCATGGAAGGGTATCCCCTTCA
CTCTGGTTCTTCTGAGGCAGGACCTCCAGCTGGGCTTGTACTATGCAGCCAAGGATGATCTTGA
ACTCCTAACCTCCCAAACATTGACATCATAGGCATATAGCACCATGGTTGGCTTCCCTTTTTAT
ATCTTGTTTATTTAGAAACAGTCTCACTAAGTTGTCCAGATTACCTTGAACTCACTCTGAAGCC
CACACTAGCCTTGCAGCACATCTGCCTCAGGCTTCTTGGTAGTTTGGAATACCGGCCAGTACCA
CTAGGCCCACCTCCAACAATGTCTAAGAAGGTAGTCTCTCCATGCCCAGAGCTTAGGTGATGGC
CCACAGGGGGCATGGTCAGGAGGTATTCACTGCACCAACAGTGGAGAGCTGGAACAAAGTTCTA
AGTAGCTCAGTGAGATGGTGGAAGTGGCAGGGTTACCCAAGAAACTAGTCCACGTGTAAGAACA
CCAATCAGCGTCCCGCCTTCAAAGGTTCTTGCCTTCCTGACCTCTCCACAGGAGCTGAGAGTGG
GCGGGAAAGAGCTTTCCCTTCCCCTTCCTGTCAAGAGGGCACCCCTGGAGATCTGCCTCAGCTC
CCCTTCCCTACGCTCACTGTACCCTAAGCCCTGGAAAAGTG

hide sequence

RefSeq Acc Id:

XM_017592496 ⟹ XP_017447985

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,652,946 - 11,657,413 (-)	NCBI
mRatBN7.2	4	10,760,509 - 10,764,987 (-)	NCBI
Rnor_6.0	4	7,287,868 - 7,293,295 (-)	NCBI

Sequence:

show sequence

AGGGACCTTCCCTACCCCCCCAGACTGCTCTGCTGCCCCCCAGCCCCCCTCGTGCTGAAACCTA
ATCCTCTGCCGCAGCTCTAGCTCAGTGCTGCTCCGCAGCCCCTGCCTGCTGCTACATCCCGTGC
CCTACTCGGTCTTCACTGCAGAGACCCAGCCCCACGGAGCCAACGCCTGTTCTGGGGAAGGCAG
AACTGGACCGAAGTTCAACTCATCCAGTCCTAGCAGGCCAGTACTTTCACCTCTGTCTTGGCTC
CTCCCTTCTCTCCCTTCTTCTCCTTTTCTTTCCTCCCTAGTCCTTGCTACTTGAGTCCCATCTC
CATCCCCACCACTACCCTGCTAGCCCTACAAAACAGCTTCCCCAGTCAGCAACTCCCCGGTCCC
TGGTCCAGCCATGAAACCTCGCTCCGGACTGGAGGAGGCCCAGCGGCGACAGGCCTCAGACATC
CGGGTGTTTGCCAGCAGCTGCACAATGCATGGTCTGGGCCACATCTTTGGCCCTGGAGGCCTGA
CCCTGCGCCGAGGGCTGTGGGCCACAGCTGTGCTCCTGTCGCTGGCGGCCTTCCTCTACCAGGT
GGCTGAGCGGGTTCGCTACTATGGGGAGTTCCACCATAAGACCACCCTGGATGAGCGTGAGAGC
CACCAGCTCACCTTCCCAGCTGTGACTCTGTGTAATATCAACCCACTGCGCCGCTCACGCCTCA
CACCCAATGACTTGCACTGGGCTGGAACAGCGCTGCTGGGCCTGGACCCTGCTGAACATGCTGC
CTACCTTCGTGCACTGGGCCAGCCCCCCGCACCACCTGGCTTCATGCCCAGTCCGACCTTTGAC
ATGGCACAACTCTACGCCAGAGCCGGCCACTCCCTTGAGGACATGTTGTTGGATTGCCGATACC
GTGGCCAGCCCTGTGGGCCTGAGAACTTCACAGTGATCTTTACTCGAATGGGGCAATGCTACAC
CTTCAACTCTGGTGCCCACGGTGCAGAGCTGCTCACCACTCCAAAGGGTGGTGCTGGCAACGGA
CTGGAGATTATGCTAGATGTACAGCAAGAGGAGTATCTGCCCATCTGGAAGGACATGGAAGAGA
CCCCGTTTGAGGTGGGGATCCGAGTGCAGATTCACAGCCAGGATGAGCCCCCTGCCATTGACCA
GCTGGGCTTCGGGGCAGCCCCAGGCCATCAGACTTTTGTGTCCTGTCAGCAGCAGCAACTGAGT
TTCCTGCCACCACCCTGGGGTGACTGCAATACCGCATCTTTGGATCCCGACGACTTTGATCCAG
AGCCCTCTGATCCCTTGGGTTCCCCCAGACCCAGACCCAGCCCTCCTTATAGTTTAATAGGTTG
TCGCCTGGCCTGTGAGTCTCGCTATGTGGCTCGGAAGTGTGGCTGTCGAATGATGCATATGCCT
GGAAACTCCCCAGTGTGCAGCCCCCAGCAGTACAAGGACTGCGCCAGCCCAGCTCTGGACGCTA
TGCTGCGAAAGGACACGTGTGTCTGCCCCAACCCGTGCGCTACTACACGCTATGCCAAGGAGCT
CTCCATGGTGCGGATTCCCAGCCGCGCGTCAGCTCGCTACCTGGCCCGGAAATACAACCGCAGC
GAGTCCTACATTACGGAGAATGTACTGGTTCTGGATATCTTCTTTGAGGCCCTCAACTATGAAG
CGGTGGAACAAAAGGCGGCCTATGAAGTGTCGGAGCTGCTGGGTGTGTACAGAGTGCCGGGGTC
TGCGAGGTGCAGACACGGTTTTCCAAGACAGAGTCCTGGGGTATTTCTGGAACAGAAGGAGCGC
TCAAAAGCGCTCTGGCAACACTCTGCTCCAGGAAGAGTTGAATGGCCATCGAACACATGTTCCC
CACCTCAGCCTAGGGCCCAGGCCTCCTACCACTCCCTGTGCTGTCACCAAGACACTCTCTGCCT
CCCACCGTACCTGTTACCTCGTCACAAGGCTCTAGACCAGCTTGGCTGCACTGTGACATCTTGG
ACATGTCCAGCCTGTATATCTTTGCTGTCTCCACCCTAATAAAGCTCTCGTACATGTGCCTCAG
ATGTCTACCTTACAGATCAGACACTACCACAGTCGATGAGAGCCCCCAGCCTCATCCATTCTCC
CGCTGGGACCTGGATCCCAGTTAGACTTAACAACTCATTTGAGGTGTGGGTGGGGCTAATTTTA
AGACGAGATCAGTCAGGTGCACCCTAGTGTTAGTGAGCTTCTCAAAGATTTTCATTTAATTTTG
TGTTTCTTGAGTAATGGGGACAGAACCTCGAGTCTGGAGGATGCCCACTGTTTGAATGTTTTCC
CATGGAAGGGTATCCCCTTCACTCTGGTTCTTCTGAGGCAGGACCTCCAGCTGGGCTTGTACTA
TGCAGCCAAGGATGATCTTGAACTCCTAACCTCCCAAACATTGACATCATAGGCATATAGCACC
ATGGTTGGCTTCCCTTTTTATATCTTGTTTATTTAGAAACAGTCTCACTAAGTTGTCCAGATTA
CCTTGAACTCACTCTGAAGCCCACACTAGCCTTGCAGCACATCTGCCTCAGGCTTCTTGGTAGT
TTGGAATACCGGCCAGTACCACTAGGCCCACCTCCAACAATGTCTAAGAAGGTAGTCTCTCCAT
GCCCAGAGCTTAGGTGATGGCCCACAGGGGGCATGGTCAGGAGGTATTCACTGCACCAACAGTG
GAGAGCTGGAACAAAGTTCTAAGTAGCTCAGTGAGATGGTGGAAGTGGCAGGGTTACCCAAGAA
ACTAGTCCACGTGTAAGAACACCAATCAGCGTCCCGCCTTCAAAGGTTCTTGCCTTCCTGACCT
CTCCACAGGAGCTGAGAGTGGGCGGGAAAGAGCTTTCCCTTCCCCTTCCTGTCAAGAGGGCACC
CCTGGAGATCTGCCTCAGCTCCCCTTCCCTACGCTCACTGTACCCTAAGCCCTGGAAAAGTG

hide sequence

RefSeq Acc Id:

XM_039107164 ⟹ XP_038963092

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,652,946 - 11,657,414 (-)	NCBI
mRatBN7.2	4	10,760,509 - 10,764,987 (-)	NCBI

RefSeq Acc Id:

XM_063285654 ⟹ XP_063141724

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,652,946 - 11,657,414 (-)	NCBI

RefSeq Acc Id:

XM_063285655 ⟹ XP_063141725

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,652,946 - 11,657,414 (-)	NCBI

RefSeq Acc Id:

XM_063285656 ⟹ XP_063141726

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,653,273 - 11,657,415 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_775158	(Get FASTA)	NCBI Sequence Viewer
	XP_008760854	(Get FASTA)	NCBI Sequence Viewer
	XP_017447985	(Get FASTA)	NCBI Sequence Viewer
	XP_038963092	(Get FASTA)	NCBI Sequence Viewer
	XP_063141724	(Get FASTA)	NCBI Sequence Viewer
	XP_063141725	(Get FASTA)	NCBI Sequence Viewer
	XP_063141726	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB69328	(Get FASTA)	NCBI Sequence Viewer
	AAN77135	(Get FASTA)	NCBI Sequence Viewer
	CAG30027	(Get FASTA)	NCBI Sequence Viewer
	EDL99368	(Get FASTA)	NCBI Sequence Viewer
	EDL99369	(Get FASTA)	NCBI Sequence Viewer
	EDL99370	(Get FASTA)	NCBI Sequence Viewer
	EDL99371	(Get FASTA)	NCBI Sequence Viewer
	EDL99372	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011300
	ENSRNOP00000011300.1
	ENSRNOP00000080943.1
	ENSRNOP00055031698
	ENSRNOP00060032063
	ENSRNOP00065023149
GenBank Protein	O35240	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_775158 ⟸ NM_173135

- UniProtKB:

O35240 (UniProtKB/Swiss-Prot), A6K560 (UniProtKB/TrEMBL), A6K562 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKPRSGLEEAQRRQASDIRVFASSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAER
VRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLR
ALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQPCGPENFTVIFTRMGQCYTFNS
GAHGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHSQDEPPAIDQLGF
GAAPGHQTFVSCQQQQLSFLPPPWGDCNTASLDPDDFDPEPSDPLGSPRPRPSPPYSLIGCRLA
CESRYVARKCGCRMMHMPGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMV
RIPSRASARYLARKYNRSESYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFI
GASLLTILEILDYLCEVFQDRVLGYFWNRRSAQKRSGNTLLQEELNGHRTHVPHLSLGPRPPTT
PCAVTKTLSASHRTCYLVTRL

hide sequence

RefSeq Acc Id:	XP_008760854 ⟸ XM_008762632
- Peptide Label:	isoform X4
- UniProtKB:	A6K562 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPRSGLEEAQRRQASDIRVFASSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAER VRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLR ALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQPCGPENFTVIFTRMGQCYTFNS GAHGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHSQDEPPAIDQLGF GAAPGHQTFVSCQQQQLSFLPPPWGDCNTASLDPDDFDPEPSDPLGSPRPRPSPPYSLIGCRLA CESRYVARKCGCRMMHMPGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMV RIPSRASARYLARKYNRSESYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFI GASLLTILEILDYLCEVFQDRVLGYFWNRRSAQKRSGNTLASYHSLCCHQDTLCLPPYLLPRHK ALDQLGCTVTSWTCPACISLLSPP hide sequence

RefSeq Acc Id:	XP_017447985 ⟸ XM_017592496
- Peptide Label:	isoform X3
- UniProtKB:	A6K559 (UniProtKB/TrEMBL), A6K562 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPRSGLEEAQRRQASDIRVFASSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAER VRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLR ALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQPCGPENFTVIFTRMGQCYTFNS GAHGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHSQDEPPAIDQLGF GAAPGHQTFVSCQQQQLSFLPPPWGDCNTASLDPDDFDPEPSDPLGSPRPRPSPPYSLIGCRLA CESRYVARKCGCRMMHMPGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMV RIPSRASARYLARKYNRSESYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGVYRVPGSARC RHGFPRQSPGVFLEQKERSKALWQHSAPGRVEWPSNTCSPPQPRAQASYHSLCCHQDTLCLPPY LLPRHKALDQLGCTVTSWTCPACISLLSPP hide sequence

RefSeq Acc Id:

ENSRNOP00000011300 ⟸ ENSRNOT00000011300

RefSeq Acc Id:	XP_038963092 ⟸ XM_039107164
- Peptide Label:	isoform X1
- UniProtKB:	A6K562 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000080943 ⟸ ENSRNOT00000110269

RefSeq Acc Id:	XP_063141725 ⟸ XM_063285655
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063141724 ⟸ XM_063285654
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063141726 ⟸ XM_063285656
- Peptide Label:	isoform X5

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35240-F1-model_v2	AlphaFold	O35240	1-533	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692791

Promoter ID:

EPDNEW_R3316

Type:

single initiation site

Name:

Asic3_1

Description:

acid sensing ion channel subunit 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	7,292,964 - 7,293,024	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708578	AgrOrtholog
BioCyc Gene	G2FUF-46041	BioCyc
Ensembl Genes	ENSRNOG00000008380	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055022738	UniProtKB/Swiss-Prot
	ENSRNOG00060022384	UniProtKB/Swiss-Prot
	ENSRNOG00065017478	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000011300	ENTREZGENE
	ENSRNOT00000011300.3	UniProtKB/Swiss-Prot
	ENSRNOT00000110269.1	UniProtKB/TrEMBL
	ENSRNOT00055039031	UniProtKB/Swiss-Prot
	ENSRNOT00060038811	UniProtKB/Swiss-Prot
	ENSRNOT00065029200	UniProtKB/Swiss-Prot
Gene3D-CATH	acid-sensing ion channel 1 domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Acid-sensing ion channel domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Acid-sensing ion channels like domains	UniProtKB/TrEMBL
	YojJ-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	ENaC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENaC_chordates	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENaC_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:286920	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	286920	ENTREZGENE
PANTHER	ACID-SENSING ION CHANNEL 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11690	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ASC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Asic3	PhenoGen
PRINTS	AMINACHANNEL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ASC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008380	RatGTEx
	ENSRNOG00055022738	RatGTEx
	ENSRNOG00060022384	RatGTEx
	ENSRNOG00065017478	RatGTEx
UniProt	A0A8I5ZRU8_RAT	UniProtKB/TrEMBL
	A6K559	ENTREZGENE, UniProtKB/TrEMBL
	A6K560	ENTREZGENE, UniProtKB/TrEMBL
	A6K562	ENTREZGENE, UniProtKB/TrEMBL
	ASIC3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-23	Asic3	acid sensing ion channel subunit 3	Asic3	acid sensing ion channel 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-12-09	Asic3	acid sensing ion channel 3	Asic3	acid-sensing (proton-gated) ion channel 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-13	Asic3	acid-sensing (proton-gated) ion channel 3	Accn3	amiloride-sensitive cation channel 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Accn3	amiloride-sensitive cation channel 3	Asic3	proton gated cation channel DRASIC	Symbol and Name updated	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed specifically in sensory neurons	1299543

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

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