RGD Reference Report - Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons. - Rat Genome Database

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Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons.

Authors: Waldmann, R  Bassilana, F  De Weille, J  Champigny, G  Heurteaux, C  Lazdunski, M 
Citation: Waldmann R, etal., J Biol Chem 1997 Aug 22;272(34):20975-8.
RGD ID: 1299543
Pubmed: PMID:9261094   (View Abstract at PubMed)

We have cloned and expressed a novel proton-gated Na+ channel subunit that is specific for sensory neurons. In COS cells, it forms a Na+ channel that responds to a drop of the extracellular pH with both a rapidly inactivating and a sustained Na+ current. This biphasic kinetic closely resembles that of the H+-gated current described in sensory neurons of dorsal root ganglia (1). Both the abundance of this novel H+-gated Na+ channel subunit in sensory neurons and the kinetics of the channel suggest that it is part of the channel complex responsible for the sustained H+-activated cation current in sensory neurons that is thought to be important for the prolonged perception of pain that accompanies tissue acidosis (1, 2).

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to acidic pH acts_upstream_of_or_withinIDA 1299543PMID:9261094MGI 
sodium ion transport acts_upstream_of_or_withinIDA 1299543PMID:9261094MGI 
sodium ion transport  IMP 1299543 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
plasma membrane located_inIDA 1299543PMID:9261094MGI 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
ligand-gated sodium channel activity enablesIDA 1299543PMID:9261094MGI 
ligand-gated sodium channel activity  IMP 1299543 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Asic3  (acid sensing ion channel subunit 3)


Additional Information