Nrp1 (neuropilin 1) - Rat Genome Database

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Gene: Nrp1 (neuropilin 1) Rattus norvegicus
Analyze
Symbol: Nrp1
Name: neuropilin 1
RGD ID: 621588
Description: Enables semaphorin receptor activity. Involved in several processes, including negative regulation of axon extension involved in axon guidance; positive regulation of platelet-derived growth factor receptor signaling pathway; and positive regulation of smooth muscle cell migration. Located in cell surface; growth cone; and neuronal cell body. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and tetralogy of Fallot. Orthologous to human NRP1 (neuropilin 1); PARTICIPATES IN vascular endothelial growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: neuropilin; neuropilin-1; Nrp; vascular endothelial cell growth factor 165 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81973,256,557 - 73,411,705 (+)NCBIGRCr8
mRatBN7.21956,359,455 - 56,514,628 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1956,359,455 - 56,513,633 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1963,149,364 - 63,302,459 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01964,009,290 - 64,162,389 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01966,091,958 - 66,245,057 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01961,332,351 - 61,486,166 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1961,332,351 - 61,485,858 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01971,984,687 - 72,138,092 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41958,332,004 - 58,487,686 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11958,337,063 - 58,492,741 (+)NCBI
Celera1955,693,756 - 55,846,090 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
depsipeptide  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
ferric oxide  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
graphite  (EXP)
hypochlorous acid  (ISO)
indoles  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
Morroniside  (EXP)
N-acetylsphingosine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
naproxen  (EXP)
nickel dichloride  (ISO)
nitrobenzenes  (EXP)
oxaliplatin  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
Ptaquiloside  (ISO)
quercetin  (ISO)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sphingosine 1-phosphate  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sumatriptan  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
angiogenesis involved in coronary vascular morphogenesis  (ISO)
artery morphogenesis  (ISO)
axon extension  (ISO)
axon extension involved in axon guidance  (ISO)
axon guidance  (IBA,IEA,ISO)
axonal fasciculation  (ISO)
axonogenesis involved in innervation  (ISO)
basal dendrite arborization  (ISO)
basal dendrite development  (ISO)
blood vessel endothelial cell migration  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
branchiomotor neuron axon guidance  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
cell migration involved in sprouting angiogenesis  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
commissural neuron axon guidance  (ISO)
coronary artery morphogenesis  (ISO)
dendrite development  (ISO)
dichotomous subdivision of terminal units involved in salivary gland branching  (ISO)
dorsal root ganglion morphogenesis  (ISO)
endothelial cell chemotaxis  (ISO)
endothelial cell migration  (ISO)
facial nerve structural organization  (ISO)
facioacoustic ganglion development  (ISO)
gonadotrophin-releasing hormone neuronal migration to the hypothalamus  (ISO)
heart development  (ISO)
hepatocyte growth factor receptor signaling pathway  (ISO)
integrin-mediated signaling pathway  (ISO)
motor neuron axon guidance  (ISO)
motor neuron migration  (ISO,ISS)
negative regulation of axon extension  (ISO)
negative regulation of axon extension involved in axon guidance  (IMP,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of neuron apoptotic process  (ISO)
nervous system development  (NAS)
neural crest cell migration  (IBA,IEA)
neural crest cell migration involved in autonomic nervous system development  (ISO)
neuron development  (ISO)
neuron migration  (ISO)
neuropilin signaling pathway  (ISO)
otic placode development  (ISO)
outflow tract septum morphogenesis  (ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive chemotaxis  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of axon extension involved in axon guidance  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of endothelial cell migration  (IBA,IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of filopodium assembly  (IBA,IEA,ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of platelet-derived growth factor receptor signaling pathway  (IMP)
positive regulation of smooth muscle cell chemotaxis  (IMP)
positive regulation of stress fiber assembly  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (IMP)
postsynapse organization  (ISO)
protein localization to early endosome  (ISO)
regulation of axon extension involved in axon guidance  (ISO)
regulation of Cdc42 protein signal transduction  (ISO)
regulation of plasma membrane bounded cell projection organization  (IEA)
regulation of vascular endothelial growth factor receptor signaling pathway  (IBA,IEA)
renal artery morphogenesis  (ISO)
response to wounding  (IBA,IEA)
retina vasculature development in camera-type eye  (ISO)
retina vasculature morphogenesis in camera-type eye  (ISO)
retinal ganglion cell axon guidance  (ISO)
semaphorin-plexin signaling pathway  (IEA,ISO)
sensory neuron axon guidance  (ISO)
sprouting angiogenesis  (IBA,IEA,ISO)
substrate-dependent cell migration, cell extension  (ISO)
sympathetic ganglion development  (ISO)
sympathetic nervous system development  (ISO)
sympathetic neuron projection extension  (ISO)
sympathetic neuron projection guidance  (ISO)
trigeminal ganglion development  (ISO)
trigeminal nerve morphogenesis  (ISO)
trigeminal nerve structural organization  (ISO)
vascular endothelial growth factor receptor signaling pathway  (IBA,IEA,ISO)
vascular endothelial growth factor signaling pathway  (IEA)
vasculogenesis  (IBA,IEA)
VEGF-activated neuropilin signaling pathway  (ISO)
ventral trunk neural crest cell migration  (ISO)
vestibulocochlear nerve structural organization  (ISO)
wound healing  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Cantuti-Castelvetri L, etal., Science. 2020 Nov 13;370(6518):856-860. doi: 10.1126/science.abd2985. Epub 2020 Oct 20.
2. Expression of VEGFR2 and NRP-1 in non-small cell lung cancer and their clinical significance. Ding M, etal., Chin J Cancer Res. 2014 Dec;26(6):669-77. doi: 10.3978/j.issn.1000-9604.2014.12.04.
3. Functional polymorphisms of the neuropilin 1 gene are associated with the risk of tetralogy of Fallot in a Chinese Han population. Fan SH, etal., Gene. 2018 May 5;653:72-79. doi: 10.1016/j.gene.2018.02.027. Epub 2018 Feb 10.
4. Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system. Fernando RN, etal., J Comp Neurol. 2005 Jul 11;487(4):372-90.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. He Z and Tessier-Lavigne M, Cell 1997 Aug 22;90(4):739-51.
8. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
9. Effects of experimental type 1 diabetes and exercise training on angiogenic gene expression and capillarization in skeletal muscle. Kivela R, etal., FASEB J. 2006 Jul;20(9):1570-2.
10. Neuropilin is a semaphorin III receptor. Kolodkin AL, etal., Cell 1997 Aug 22;90(4):753-62.
11. Long non-coding RNA THRIL inhibits miRNA-24-3p to upregulate neuropilin-1 to aggravate cerebral ischemia-reperfusion injury through regulating the nuclear factor κB p65 signaling. Kuai F, etal., Aging (Albany NY). 2021 Mar 6;13(6):9071-9084. doi: 10.18632/aging.202762. Epub 2021 Mar 6.
12. Identifying New COVID-19 Receptor Neuropilin-1 in Severe Alzheimer's Disease Patients Group Brain Using Genome-Wide Association Study Approach. Lim KH, etal., Front Genet. 2021 Oct 21;12:741175. doi: 10.3389/fgene.2021.741175. eCollection 2021.
13. Molecular regulation of the VEGF family -- inducers of angiogenesis and lymphangiogenesis. McColl BK, etal., APMIS 2004 Jul-Aug;112(7-8):463-80.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Perivascular Neuropilin-1 expression is an independent marker of improved survival in renal cell carcinoma. Morin E, etal., J Pathol. 2020 Apr;250(4):387-396. doi: 10.1002/path.5380. Epub 2020 Jan 29.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. VEGF receptor signalling - in control of vascular function. Olsson AK, etal., Nat Rev Mol Cell Biol. 2006 May;7(5):359-71.
18. Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3. Pandey J and Wendell DL, Mamm Genome. 2006 Jan;17(1):49-57. Epub 2006 Jan 13.
19. Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury. Pellet-Many C, etal., Cardiovasc Res. 2015 Nov 1;108(2):288-98. doi: 10.1093/cvr/cvv229. Epub 2015 Sep 25.
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes. Sola S, etal., Hepatology. 2005 Oct;42(4):925-34.
25. The Neuropilin-1 Inhibitor, ATWLPPR Peptide, Prevents Experimental Diabetes-Induced Retinal Injury by Preserving Vascular Integrity and Decreasing Oxidative Stress. Wang J, etal., PLoS One. 2015 Nov 10;10(11):e0142571. doi: 10.1371/journal.pone.0142571. eCollection 2015.
26. SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment. Wu CT, etal., Cell Metab. 2021 Aug 3;33(8):1565-1576.e5. doi: 10.1016/j.cmet.2021.05.013. Epub 2021 May 18.
27. Ganoderma lucidum polysaccharides ameliorate lipopolysaccharide-induced acute pneumonia via inhibiting NRP1-mediated inflammation. Zhang X, etal., Pharm Biol. 2022 Dec;60(1):2201-2209. doi: 10.1080/13880209.2022.2142615.
28. Peritumoral Neuropilin-1 and VEGF receptor-2 expression increases time to recurrence in hepatocellular carcinoma patients undergoing curative hepatectomy. Zhuang PY, etal., Oncotarget. 2014 Nov 30;5(22):11121-32. doi: 10.18632/oncotarget.2553.
Additional References at PubMed
PMID:9529250   PMID:9753685   PMID:10705382   PMID:12477932   PMID:12591607   PMID:12852851   PMID:15094469   PMID:15126502   PMID:15239958   PMID:15376331   PMID:15489334   PMID:15604101  
PMID:15677725   PMID:15695515   PMID:15737738   PMID:15814794   PMID:16502470   PMID:16540575   PMID:16906543   PMID:17428830   PMID:17626059   PMID:17983687   PMID:18356247   PMID:18436584  
PMID:18632792   PMID:18804103   PMID:19325129   PMID:19386662   PMID:20524965   PMID:20888378   PMID:20956519   PMID:21059704   PMID:21245381   PMID:21423176   PMID:21658587   PMID:21828096  
PMID:21852397   PMID:22206666   PMID:22683681   PMID:22790009   PMID:23049211   PMID:23315162   PMID:23621014   PMID:23639442   PMID:23716698   PMID:24401374   PMID:24863063   PMID:25244320  
PMID:25416424   PMID:26051942   PMID:26053665   PMID:26503042   PMID:26509169   PMID:29088765   PMID:29457037   PMID:31505169   PMID:32242249   PMID:33000221   PMID:33082294   PMID:37366599  


Genomics

Comparative Map Data
Nrp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81973,256,557 - 73,411,705 (+)NCBIGRCr8
mRatBN7.21956,359,455 - 56,514,628 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1956,359,455 - 56,513,633 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1963,149,364 - 63,302,459 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01964,009,290 - 64,162,389 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01966,091,958 - 66,245,057 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01961,332,351 - 61,486,166 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1961,332,351 - 61,485,858 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01971,984,687 - 72,138,092 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41958,332,004 - 58,487,686 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11958,337,063 - 58,492,741 (+)NCBI
Celera1955,693,756 - 55,846,090 (+)NCBICelera
Cytogenetic Map19q12NCBI
NRP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381033,177,493 - 33,334,667 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1033,177,492 - 33,336,262 (-)EnsemblGRCh38hg38GRCh38
GRCh371033,466,421 - 33,623,595 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361033,506,432 - 33,663,839 (-)NCBINCBI36Build 36hg18NCBI36
Build 341033,506,432 - 33,663,476NCBI
Celera1033,231,763 - 33,389,179 (-)NCBICelera
Cytogenetic Map10p11.22NCBI
HuRef1033,186,444 - 33,343,500 (-)NCBIHuRef
CHM1_11033,468,091 - 33,625,451 (-)NCBICHM1_1
T2T-CHM13v2.01033,206,293 - 33,375,463 (-)NCBIT2T-CHM13v2.0
Nrp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398129,085,553 - 129,231,957 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8129,085,085 - 129,229,844 (+)EnsemblGRCm39 Ensembl
GRCm388128,358,591 - 128,505,476 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8128,358,604 - 128,503,363 (+)EnsemblGRCm38mm10GRCm38
MGSCv378130,882,973 - 131,029,376 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368131,228,923 - 131,389,437 (+)NCBIMGSCv36mm8
Celera8132,685,332 - 132,831,714 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map875.78NCBI
Nrp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554624,101,999 - 4,241,012 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554624,101,997 - 4,241,012 (+)NCBIChiLan1.0ChiLan1.0
NRP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2845,819,786 - 45,977,758 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11045,825,106 - 45,982,734 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01033,298,918 - 33,456,466 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11033,883,162 - 34,039,645 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1033,883,173 - 34,039,648 (-)Ensemblpanpan1.1panPan2
NRP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.123,416,062 - 3,553,929 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl23,413,821 - 3,552,483 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha23,515,185 - 3,653,323 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.023,710,166 - 3,848,420 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl23,710,304 - 3,848,417 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.123,489,029 - 3,627,209 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.023,524,020 - 3,661,782 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.023,642,794 - 3,780,784 (+)NCBIUU_Cfam_GSD_1.0
Nrp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934412,194,941 - 12,335,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365741,694,336 - 1,834,720 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365741,694,433 - 1,834,720 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1056,280,665 - 56,430,777 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11056,280,673 - 56,430,832 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21061,651,758 - 61,802,358 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NRP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1932,474,787 - 32,632,746 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl932,474,309 - 32,633,101 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605641,535,637 - 41,695,579 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nrp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248058,438,498 - 8,574,508 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248058,438,485 - 8,574,845 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nrp1
90 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:130
Interacting mature miRNAs:149
Transcripts:ENSRNOT00000014492
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat

Markers in Region
D19Got121  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21956,483,791 - 56,484,006 (+)MAPPERmRatBN7.2
Rnor_6.01961,455,318 - 61,455,532NCBIRnor6.0
Rnor_5.01972,107,244 - 72,107,458UniSTSRnor5.0
RGSC_v3.41958,458,412 - 58,458,626UniSTSRGSC3.4
Celera1955,817,358 - 55,817,572UniSTS
Cytogenetic Map19q12UniSTS
D19Got141  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21956,468,387 - 56,468,544 (+)MAPPERmRatBN7.2
Rnor_6.01961,439,915 - 61,440,071NCBIRnor6.0
Rnor_5.01972,091,841 - 72,091,997UniSTSRnor5.0
RGSC_v3.41958,443,009 - 58,443,165UniSTSRGSC3.4
Celera1955,802,134 - 55,802,290UniSTS
Cytogenetic Map19q12UniSTS
RH127171  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21956,416,744 - 56,416,981 (+)MAPPERmRatBN7.2
Rnor_6.01961,389,662 - 61,389,898NCBIRnor6.0
Rnor_5.01972,041,877 - 72,042,113UniSTSRnor5.0
RGSC_v3.41958,390,825 - 58,391,061UniSTSRGSC3.4
Celera1955,750,447 - 55,750,683UniSTS
Cytogenetic Map19q12UniSTS
UniSTS:465488  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21956,512,021 - 56,512,410 (+)MAPPERmRatBN7.2
Rnor_6.01961,483,560 - 61,483,948NCBIRnor6.0
Rnor_5.01972,135,486 - 72,135,874UniSTSRnor5.0
RGSC_v3.41958,487,133 - 58,487,521UniSTSRGSC3.4
Celera1955,845,537 - 55,845,925UniSTS
Cytogenetic Map19q12UniSTS
Nrp1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21956,478,437 - 56,478,754 (+)MAPPERmRatBN7.2
Rnor_6.01961,449,964 - 61,450,280NCBIRnor6.0
Rnor_5.01972,101,890 - 72,102,206UniSTSRnor5.0
RGSC_v3.41958,453,058 - 58,453,374UniSTSRGSC3.4
Celera1955,812,004 - 55,812,320UniSTS
Cytogenetic Map19q12UniSTS
D17S1155  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21956,493,103 - 56,494,527 (+)MAPPERmRatBN7.2
Rnor_6.01961,464,630 - 61,466,053NCBIRnor6.0
Rnor_5.01972,116,556 - 72,117,979UniSTSRnor5.0
RGSC_v3.41958,467,726 - 58,469,149UniSTSRGSC3.4
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 36 22 17 22 8 9 70 35 34 11 8
Low 3 21 19 2 19 2 4 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014492   ⟹   ENSRNOP00000014492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1956,359,455 - 56,512,570 (+)Ensembl
Rnor_6.0 Ensembl1961,332,351 - 61,484,108 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080465   ⟹   ENSRNOP00000075034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1956,359,455 - 56,513,633 (+)Ensembl
Rnor_6.0 Ensembl1961,334,168 - 61,485,858 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108605   ⟹   ENSRNOP00000082340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1956,359,455 - 56,512,570 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114861   ⟹   ENSRNOP00000085705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1956,364,664 - 56,512,570 (+)Ensembl
RefSeq Acc Id: NM_145098   ⟹   NP_659566
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81973,256,557 - 73,409,652 (+)NCBI
mRatBN7.21956,359,455 - 56,512,575 (+)NCBI
Rnor_6.01961,332,351 - 61,484,113 (+)NCBI
Rnor_5.01971,984,687 - 72,138,092 (+)NCBI
RGSC_v3.41958,332,004 - 58,487,686 (+)RGD
Celera1955,693,756 - 55,846,090 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255825   ⟹   XP_006255887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81973,257,864 - 73,411,705 (+)NCBI
mRatBN7.21956,360,759 - 56,514,628 (+)NCBI
Rnor_6.01961,333,560 - 61,486,166 (+)NCBI
Rnor_5.01971,984,687 - 72,138,092 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255826   ⟹   XP_006255888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81973,258,302 - 73,411,705 (+)NCBI
mRatBN7.21956,361,202 - 56,514,628 (+)NCBI
Rnor_6.01961,334,102 - 61,486,166 (+)NCBI
Rnor_5.01971,984,687 - 72,138,092 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255827   ⟹   XP_006255889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81973,258,302 - 73,411,705 (+)NCBI
mRatBN7.21956,361,202 - 56,514,628 (+)NCBI
Rnor_6.01961,334,103 - 61,486,166 (+)NCBI
Rnor_5.01971,984,687 - 72,138,092 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063277784   ⟹   XP_063133854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81973,258,230 - 73,411,705 (+)NCBI
RefSeq Acc Id: XM_063277785   ⟹   XP_063133855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81973,258,302 - 73,411,705 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_659566   ⟸   NM_145098
- Peptide Label: precursor
- UniProtKB: Q9QWJ9 (UniProtKB/Swiss-Prot),   A6KJ62 (UniProtKB/TrEMBL),   Q9QX38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255887   ⟸   XM_006255825
- Peptide Label: isoform X1
- UniProtKB: Q9QWJ9 (UniProtKB/Swiss-Prot),   A6KJ62 (UniProtKB/TrEMBL),   Q9QX38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255888   ⟸   XM_006255826
- Peptide Label: isoform X2
- UniProtKB: Q9QX38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255889   ⟸   XM_006255827
- Peptide Label: isoform X3
- UniProtKB: A0A8L2R9S2 (UniProtKB/TrEMBL),   Q9QX38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075034   ⟸   ENSRNOT00000080465
RefSeq Acc Id: ENSRNOP00000014492   ⟸   ENSRNOT00000014492
RefSeq Acc Id: ENSRNOP00000085705   ⟸   ENSRNOT00000114861
RefSeq Acc Id: ENSRNOP00000082340   ⟸   ENSRNOT00000108605
RefSeq Acc Id: XP_063133854   ⟸   XM_063277784
- Peptide Label: isoform X1
- UniProtKB: Q9QWJ9 (UniProtKB/Swiss-Prot),   A6KJ62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133855   ⟸   XM_063277785
- Peptide Label: isoform X4
Protein Domains
CUB   F5/8 type C   MAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QWJ9-F1-model_v2 AlphaFold Q9QWJ9 1-922 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701262
Promoter ID:EPDNEW_R11781
Type:multiple initiation site
Name:Nrp1_2
Description:neuropilin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11782  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01961,334,143 - 61,334,203EPDNEW
RGD ID:13701259
Promoter ID:EPDNEW_R11782
Type:initiation region
Name:Nrp1_1
Description:neuropilin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11781  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01961,334,349 - 61,334,409EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621588 AgrOrtholog
BioCyc Gene G2FUF-5127 BioCyc
Ensembl Genes ENSRNOG00000010744 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055005353 UniProtKB/Swiss-Prot
  ENSRNOG00060005340 UniProtKB/Swiss-Prot
  ENSRNOG00065018438 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014492 ENTREZGENE
  ENSRNOT00000014492.6 UniProtKB/Swiss-Prot
  ENSRNOT00000080465.2 UniProtKB/TrEMBL
  ENSRNOT00000108605.1 UniProtKB/TrEMBL
  ENSRNOT00000114861.1 UniProtKB/TrEMBL
  ENSRNOT00055008628 UniProtKB/Swiss-Prot
  ENSRNOT00060008991 UniProtKB/Swiss-Prot
  ENSRNOT00065031030 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109697 IMAGE-MGC_LOAD
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CUB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuropilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuropilin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246331 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93089 IMAGE-MGC_LOAD
NCBI Gene 246331 ENTREZGENE
PANTHER F5/8 TYPE C DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46806:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3481 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F5_F8_type_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nrp1 PhenoGen
PIRSF Neuropilin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MAMDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010744 RatGTEx
  ENSRNOG00055005353 RatGTEx
  ENSRNOG00060005340 RatGTEx
  ENSRNOG00065018438 RatGTEx
SMART CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FA58C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZTD9_RAT UniProtKB/TrEMBL
  A0A8I6A3Y3_RAT UniProtKB/TrEMBL
  A0A8L2R9S2 ENTREZGENE, UniProtKB/TrEMBL
  A6KJ62 ENTREZGENE, UniProtKB/TrEMBL
  NRP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QX38 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Nrp1  neuropilin 1  Nrp  neuropilin  Symbol and Name updated 1299863 APPROVED
2002-08-07 Nrp  neuropilin      Symbol and Name status set to provisional 70820 PROVISIONAL