Kcna3 (potassium voltage-gated channel subfamily A member 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Kcna3 (potassium voltage-gated channel subfamily A member 3) Rattus norvegicus
Analyze
Symbol: Kcna3
Name: potassium voltage-gated channel subfamily A member 3
RGD ID: 2951
Description: Enables delayed rectifier potassium channel activity and outward rectifier potassium channel activity. Involved in corpus callosum development; optic nerve development; and potassium ion transmembrane transport. Located in membrane raft and plasma membrane. Is active in calyx of Held; glutamatergic synapse; and synaptic membrane. Orthologous to human KCNA3 (potassium voltage-gated channel subfamily A member 3); INTERACTS WITH acetamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KV3; potassium channel, voltage gated shaker related subfamily A, member 3; Potassium voltage gated channel, shaker related subfamily, member 3; potassium voltage-gated channel, shaker-related subfamily, member 3; RCK3; RGK5; voltage-gated potassium channel subunit Kv1.3; voltage-gated potassium channel subunit Kv3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82197,320,324 - 197,322,277 (+)NCBIGRCr8
mRatBN7.22194,632,106 - 194,634,059 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2194,632,196 - 194,650,138 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2202,264,409 - 202,265,986 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,158,435 - 200,160,012 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02194,975,390 - 194,976,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02209,766,767 - 209,768,344 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2209,766,512 - 209,769,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02229,233,084 - 229,234,661 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42202,472,638 - 202,474,215 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12202,435,391 - 202,436,969 (+)NCBI
Celera2187,293,280 - 187,294,857 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization and functional expression of a rat genomic DNA clone encoding a lymphocyte potassium channel. Douglass J, etal., J Immunol 1990 Jun 15;144(12):4841-50.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
5. Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal. Ishikawa T, etal., J Neurosci. 2003 Nov 12;23(32):10445-53.
6. Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Kim E, etal., Nature. 1995 Nov 2;378(6552):85-8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Kv1.1 and Kv1.3 channels contribute to the delayed-rectifying K+ conductance in rat choroid plexus epithelial cells. Speake T, etal., Am J Physiol Cell Physiol 2004 Mar;286(3):C611-20. Epub 2003 Nov 5.
12. Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. Stuhmer W, etal., EMBO J 1989 Nov;8(11):3235-44.
13. Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain. Swanson R, etal., Neuron 1990 Jun;4(6):929-39.
14. Neurotrophin modulation of voltage-gated potassium channels in rat through TrkB receptors is time and sensory experience dependent. Tucker K and Fadool DA, J Physiol 2002 Jul 15;542(Pt 2):413-29.
15. Kv1.5 association modifies Kv1.3 traffic and membrane localization. Vicente R, etal., J Biol Chem. 2008 Mar 28;283(13):8756-64. doi: 10.1074/jbc.M708223200. Epub 2008 Jan 24.
16. [Voltage-dependent potassium channel and calcium-activated potassium channel current changes of peripheral blood T-lymphocytes from hypertensive patients in Xinjiang Kazakh]. Zhang QB, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Dec;41(12):1020-4.
Additional References at PubMed
PMID:12838421   PMID:12944270   PMID:16079396   PMID:17029597   PMID:17088564   PMID:18026984   PMID:18614767   PMID:19696788   PMID:19773357   PMID:20427469   PMID:20717640   PMID:21233214  
PMID:21430270   PMID:22547057   PMID:22613618   PMID:22761436   PMID:22952817   PMID:23300077   PMID:24144698   PMID:24244345   PMID:24533129   PMID:24644290   PMID:24924920   PMID:24939846  
PMID:27816768   PMID:28186199   PMID:28248292   PMID:28623364   PMID:29574670   PMID:30612588   PMID:32370164   PMID:36440534  


Genomics

Comparative Map Data
Kcna3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82197,320,324 - 197,322,277 (+)NCBIGRCr8
mRatBN7.22194,632,106 - 194,634,059 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2194,632,196 - 194,650,138 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2202,264,409 - 202,265,986 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,158,435 - 200,160,012 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02194,975,390 - 194,976,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02209,766,767 - 209,768,344 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2209,766,512 - 209,769,711 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02229,233,084 - 229,234,661 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42202,472,638 - 202,474,215 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12202,435,391 - 202,436,969 (+)NCBI
Celera2187,293,280 - 187,294,857 (+)NCBICelera
Cytogenetic Map2q34NCBI
KCNA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381110,653,560 - 110,674,940 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1110,653,560 - 110,674,940 (-)EnsemblGRCh38hg38GRCh38
GRCh371111,196,182 - 111,217,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,015,833 - 111,019,178 (-)NCBINCBI36Build 36hg18NCBI36
Build 341110,926,351 - 110,929,697NCBI
Celera1109,461,411 - 109,464,756 (-)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1109,085,699 - 109,089,044 (-)NCBIHuRef
CHM1_11111,329,439 - 111,332,784 (-)NCBICHM1_1
T2T-CHM13v2.01110,668,304 - 110,689,683 (-)NCBIT2T-CHM13v2.0
Kcna3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393106,943,486 - 106,947,223 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3106,943,485 - 106,945,386 (+)EnsemblGRCm39 Ensembl
GRCm383107,036,162 - 107,038,129 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,036,169 - 107,038,070 (+)EnsemblGRCm38mm10GRCm38
MGSCv373106,839,080 - 106,841,047 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363107,164,479 - 107,166,065 (+)NCBIMGSCv36mm8
Celera3109,365,430 - 109,367,397 (+)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.59NCBI
Kcna3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543514,147,454 - 14,148,926 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543514,132,877 - 14,148,911 (-)NCBIChiLan1.0ChiLan1.0
KCNA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,366,047 - 116,384,339 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11115,513,619 - 115,531,881 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01113,304,340 - 113,323,367 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,021,508 - 127,042,481 (+)NCBIpanpan1.1PanPan1.1panPan2
KCNA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1641,343,613 - 41,363,076 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha644,120,679 - 44,140,399 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0641,675,464 - 41,695,170 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl641,675,383 - 41,677,026 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1641,395,369 - 41,415,083 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0641,366,130 - 41,385,831 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0641,801,395 - 41,821,138 (+)NCBIUU_Cfam_GSD_1.0
Kcna3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,028,223 - 18,047,417 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367042,084,436 - 2,085,923 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367042,083,037 - 2,085,917 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4109,495,350 - 109,497,116 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14109,495,220 - 109,498,548 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24119,860,978 - 119,877,340 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12022,869,388 - 22,885,406 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2022,870,880 - 22,872,607 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603835,569,291 - 35,590,505 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcna3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247726,364,325 - 6,376,208 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247726,360,169 - 6,376,281 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcna3
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:106
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000024372
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system
High
Medium 25
Low 28 22 22 22 38 20 30
Below cutoff 4 6 6 6 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000092240   ⟹   ENSRNOP00000075761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2194,632,196 - 194,640,361 (+)Ensembl
Rnor_6.0 Ensembl2209,766,512 - 209,769,711 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108050   ⟹   ENSRNOP00000096474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2194,632,196 - 194,650,138 (+)Ensembl
RefSeq Acc Id: NM_019270   ⟹   NP_062143
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,320,324 - 197,322,277 (+)NCBI
mRatBN7.22194,632,106 - 194,634,059 (+)NCBI
Rnor_6.02209,766,767 - 209,768,344 (+)NCBI
Rnor_5.02229,233,084 - 229,234,661 (+)NCBI
RGSC_v3.42202,472,638 - 202,474,215 (+)RGD
Celera2187,293,280 - 187,294,857 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_062143   ⟸   NM_019270
- UniProtKB: P15384 (UniProtKB/Swiss-Prot),   A6HUR8 (UniProtKB/TrEMBL),   A6HUR9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075761   ⟸   ENSRNOT00000092240
RefSeq Acc Id: ENSRNOP00000096474   ⟸   ENSRNOT00000108050
Protein Domains
BTB   Ion transport   Potassium channel tetramerisation-type BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15384-F1-model_v2 AlphaFold P15384 1-525 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691656
Promoter ID:EPDNEW_R2181
Type:single initiation site
Name:Kcna3_1
Description:potassium voltage-gated channel subfamily A member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02209,766,517 - 209,766,577EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2951 AgrOrtholog
BioCyc Gene G2FUF-51689 BioCyc
Ensembl Genes ENSRNOG00000062002 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055020274 UniProtKB/Swiss-Prot
  ENSRNOG00060029881 UniProtKB/Swiss-Prot
  ENSRNOG00065022921 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000092240 ENTREZGENE
  ENSRNOT00000092240.2 UniProtKB/Swiss-Prot
  ENSRNOT00000108050.1 UniProtKB/Swiss-Prot
  ENSRNOT00055034614 UniProtKB/Swiss-Prot
  ENSRNOT00055034620 UniProtKB/Swiss-Prot
  ENSRNOT00060051882 UniProtKB/Swiss-Prot
  ENSRNOT00060051896 UniProtKB/Swiss-Prot
  ENSRNOT00065039148 UniProtKB/Swiss-Prot
  ENSRNOT00065039159 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv1.3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29731 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29731 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcna3 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KV13CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHAKERCHANEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000062002 RatGTEx
  ENSRNOG00055020274 RatGTEx
  ENSRNOG00060029881 RatGTEx
  ENSRNOG00065022921 RatGTEx
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HUR8 ENTREZGENE, UniProtKB/TrEMBL
  A6HUR9 ENTREZGENE, UniProtKB/TrEMBL
  KCNA3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9EPB0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcna3  potassium voltage-gated channel subfamily A member 3  Kcna3  potassium channel, voltage gated shaker related subfamily A, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcna3  potassium channel, voltage gated shaker related subfamily A, member 3  Kcna3  potassium voltage-gated channel, shaker-related subfamily, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kcna3  potassium voltage-gated channel, shaker-related subfamily, member 3    potassium voltage gated channel, shaker related subfamily, member 3   Name updated 1299863 APPROVED
2002-06-10 Kcna3  potassium voltage gated channel, shaker related subfamily, member 3       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the rat brain 633085
gene_function when injected into Xenopus oocytes it directs the potassium currents 633085
gene_product memberof the potassium channel family 633085
gene_protein encoded protein is 525 amino acid in size 633085