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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcna3
Name: potassium voltage-gated channel subfamily A member 3
Acc ID: CHEBI:31264
Term: benzethonium chloride
Definition: A (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. An antiseptic and disinfectant, it is active against a broad spectrum of bacteria, fungi, moulds and viruses.
Chemical ID: MESH:D001558
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcna3decreases activityISOKCNA3 (Homo sapiens)6480464CTDBenzethonium results in decreased activity of KCNA3 proteinPMID:21362439
Kcna3multiple interactionsISOKCNA3 (Homo sapiens)6480464CTD[Benzethonium results in decreased activity of KCNA3 protein] which results in decreased import of ThalliumPMID:21362439
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