Apbb1 (amyloid beta precursor protein binding family B member 1) - Rat Genome Database

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Gene: Apbb1 (amyloid beta precursor protein binding family B member 1) Rattus norvegicus
Analyze
Symbol: Apbb1
Name: amyloid beta precursor protein binding family B member 1
RGD ID: 2122
Description: Enables DNA-binding transcription factor binding activity; amyloid-beta binding activity; and tau protein binding activity. Involved in several processes, including DNA repair-dependent chromatin remodeling; negative regulation of cell cycle G1/S phase transition; and regulation of transcription by RNA polymerase II. Located in several cellular components, including axon; dendritic spine; and synaptic membrane. Part of protein-containing complex. Is active in Schaffer collateral - CA1 synapse; postsynaptic density; and presynapse. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human APBB1 (amyloid beta precursor protein binding family B member 1); PARTICIPATES IN Alzheimer's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amyloid beta (A4) precursor protein-binding, family B, member 1; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); amyloid beta A4 precursor protein-binding family B member 1; amyloid-beta A4 precursor protein-binding family B member 1; FE65
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHRSP.WKY-(Apbb1-D1Arb21)/Izm  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,308,719 - 169,332,372 (-)NCBIGRCr8
mRatBN7.21159,896,889 - 159,920,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1159,896,880 - 159,920,627 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1167,919,373 - 167,935,733 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01175,105,367 - 175,121,733 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,007,191 - 168,023,554 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,387,625 - 170,411,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,387,609 - 170,404,056 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,393,531 - 177,417,140 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,282,918 - 163,299,333 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,378,394 - 163,394,810 (-)NCBI
Celera1157,829,568 - 157,845,995 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interaction of Tau with Fe65 links tau to APP. Barbato C, etal., Neurobiol Dis. 2005 Mar;18(2):399-408.
2. Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression. Bruni P, etal., J Biol Chem. 2002 Sep 20;277(38):35481-8. doi: 10.1074/jbc.M205227200. Epub 2002 Jun 27.
3. A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Cao X and Sudhof TC, Science. 2001 Jul 6;293(5527):115-20.
4. Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis. Carlson ES, etal., Brain Res. 2008 Aug 7.
5. Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers. Chen GB, etal., Hum Genet. 2008 Nov;124(4):393-8. doi: 10.1007/s00439-008-0558-9. Epub 2008 Sep 7.
6. FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth. Cheung HN, etal., FASEB J. 2014 Jan;28(1):337-49. doi: 10.1096/fj.13-232694. Epub 2013 Sep 20.
7. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Cook PJ, etal., Nature. 2009 Apr 2;458(7238):591-6. doi: 10.1038/nature07849. Epub 2009 Feb 22.
8. A risk for early-onset Alzheimer's disease associated with the APBB1 gene (FE65) intron 13 polymorphism. Cousin E, etal., Neurosci Lett. 2003 May 15;342(1-2):5-8.
9. Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein. Duilio A, etal., Biochem J 1998 Feb 15;330 ( Pt 1):513-9.
10. FE65 as a link between VLDLR and APP to regulate their trafficking and processing. Dumanis SB, etal., Mol Neurodegener. 2012 Mar 19;7:9. doi: 10.1186/1750-1326-7-9.
11. The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. Ermekova KS, etal., J Biol Chem. 1997 Dec 26;272(52):32869-77.
12. The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein. Fiore F, etal., J Biol Chem 1995 Dec 29;270(52):30853-6.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients. Guenette SY, etal., Neurosci Lett. 2000 Dec 15;296(1):17-20.
15. The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type. Hu Q, etal., Hum Genet. 1998 Sep;103(3):295-303.
16. Broadly altered expression of the mRNA isoforms of FE65, a facilitator of beta amyloidogenesis, in Alzheimer cerebellum and other brain regions. Hu Q, etal., J Neurosci Res. 2000 Apr 1;60(1):73-86.
17. Real-time PCR quantitation of FE65 a beta-amyloid precursor protein-binding protein after traumatic brain injury in rats. Iino M, etal., Int J Legal Med. 2003 Jun;117(3):153-9. Epub 2003 Apr 18.
18. FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4. Kajiwara Y, etal., PLoS One. 2009;4(4):e5071. doi: 10.1371/journal.pone.0005071. Epub 2009 Apr 3.
19. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
20. Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription. Lau KF, etal., J Biol Chem. 2008 Dec 12;283(50):34728-37. doi: 10.1074/jbc.M801874200. Epub 2008 Oct 15.
21. Regulation Fe65 localization to the nucleus by SGK1 phosphorylation of its Ser566 residue. Lee EJ, etal., BMB Rep. 2008 Jan 31;41(1):41-7.
22. Fe65 interacts with P2X2 subunits at excitatory synapses and modulates receptor function. Masin M, etal., J Biol Chem. 2006 Feb 17;281(7):4100-8. Epub 2005 Dec 5.
23. Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157. Matz A, etal., Cell Death Differ. 2015 Apr;22(4):626-42. doi: 10.1038/cdd.2014.163. Epub 2014 Oct 24.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation. Minopoli G, etal., J Biol Chem. 2001 Mar 2;276(9):6545-50. Epub 2000 Nov 20.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein. Sabo SL, etal., J Biol Chem. 1999 Mar 19;274(12):7952-7.
31. The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo. Sabo SL, etal., J Neurosci. 2003 Jul 2;23(13):5407-15.
32. Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks. Stante M, etal., Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5093-8. doi: 10.1073/pnas.0810869106. Epub 2009 Mar 12.
33. The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1. Zambrano N, etal., J Biol Chem. 1998 Aug 7;273(32):20128-33.
34. The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene. Zambrano N, etal., J Biol Chem. 2001 Jun 8;276(23):19787-92. Epub 2001 Feb 21.
Additional References at PubMed
PMID:1923810   PMID:7800475   PMID:8887653   PMID:9045663   PMID:10358088   PMID:14689444   PMID:15944124   PMID:16377899   PMID:16407979   PMID:17121854   PMID:17686488   PMID:18278038  
PMID:18468999   PMID:19340611   PMID:19381069   PMID:21803450   PMID:21824145   PMID:23531501   PMID:27734846   PMID:29615491  


Genomics

Comparative Map Data
Apbb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,308,719 - 169,332,372 (-)NCBIGRCr8
mRatBN7.21159,896,889 - 159,920,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1159,896,880 - 159,920,627 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1167,919,373 - 167,935,733 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01175,105,367 - 175,121,733 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,007,191 - 168,023,554 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,387,625 - 170,411,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,387,609 - 170,404,056 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,393,531 - 177,417,140 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,282,918 - 163,299,333 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,378,394 - 163,394,810 (-)NCBI
Celera1157,829,568 - 157,845,995 (-)NCBICelera
Cytogenetic Map1q32NCBI
APBB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,395,124 - 6,419,453 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,395,125 - 6,419,414 (-)EnsemblGRCh38hg38GRCh38
GRCh37116,416,354 - 6,440,683 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,372,931 - 6,397,220 (-)NCBINCBI36Build 36hg18NCBI36
Build 34116,372,930 - 6,397,220NCBI
Celera116,535,423 - 6,559,715 (-)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef116,075,464 - 6,099,756 (-)NCBIHuRef
CHM1_1116,415,490 - 6,439,780 (-)NCBICHM1_1
T2T-CHM13v2.0116,453,583 - 6,477,913 (-)NCBIT2T-CHM13v2.0
Apbb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397105,207,691 - 105,231,151 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7105,207,690 - 105,230,860 (-)EnsemblGRCm39 Ensembl
GRCm387105,558,465 - 105,581,924 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7105,558,483 - 105,581,653 (-)EnsemblGRCm38mm10GRCm38
MGSCv377112,706,998 - 112,730,049 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367105,432,305 - 105,455,356 (-)NCBIMGSCv36mm8
Celera7105,829,626 - 105,852,681 (-)NCBICelera
Cytogenetic Map7E3NCBI
cM Map755.9NCBI
Apbb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541422,117,470 - 22,137,849 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541422,121,867 - 22,137,849 (-)NCBIChiLan1.0ChiLan1.0
APBB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v298,831,613 - 8,855,768 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1118,795,471 - 8,819,634 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0116,526,477 - 6,550,509 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,210,077 - 6,233,992 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,209,812 - 6,225,972 (-)Ensemblpanpan1.1panPan2
APBB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12129,719,386 - 29,741,658 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2129,719,589 - 29,759,046 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2129,421,423 - 29,443,492 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02130,545,680 - 30,567,749 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2130,545,331 - 30,585,167 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12129,866,583 - 29,888,629 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02130,032,363 - 30,054,462 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02130,227,710 - 30,249,777 (-)NCBIUU_Cfam_GSD_1.0
Apbb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494756,198,968 - 56,222,805 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936842452,681 - 476,513 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936842452,682 - 476,533 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APBB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl93,303,112 - 3,324,037 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.193,303,032 - 3,323,828 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.293,964,689 - 3,977,972 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APBB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1158,407,323 - 58,431,551 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl158,421,847 - 58,431,144 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038156,233,110 - 156,257,185 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apbb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248177,909,468 - 7,936,487 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248177,913,541 - 7,937,945 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apbb1
137 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:310
Count of miRNA genes:186
Interacting mature miRNAs:218
Transcripts:ENSRNOT00000024402
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat

Markers in Region
AF206720  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21159,897,088 - 159,897,230 (+)MAPPERmRatBN7.2
Rnor_6.01170,387,825 - 170,387,966NCBIRnor6.0
Rnor_5.01177,393,731 - 177,393,872UniSTSRnor5.0
RGSC_v3.41163,283,113 - 163,283,254UniSTSRGSC3.4
Celera1157,829,763 - 157,829,904UniSTS
Cytogenetic Map1q33UniSTS
RH130448  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21159,896,553 - 159,896,734 (+)MAPPERmRatBN7.2
Rnor_6.01170,387,290 - 170,387,470NCBIRnor6.0
Rnor_5.01177,393,196 - 177,393,376UniSTSRnor5.0
RGSC_v3.41163,282,578 - 163,282,758UniSTSRGSC3.4
Celera1157,829,228 - 157,829,408UniSTS
RH 3.4 Map11295.8UniSTS
Cytogenetic Map1q33UniSTS
RH134756  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21159,897,030 - 159,897,222 (+)MAPPERmRatBN7.2
Rnor_6.01170,387,767 - 170,387,958NCBIRnor6.0
Rnor_5.01177,393,673 - 177,393,864UniSTSRnor5.0
RGSC_v3.41163,283,055 - 163,283,246UniSTSRGSC3.4
Celera1157,829,705 - 157,829,896UniSTS
RH 3.4 Map11297.5UniSTS
Cytogenetic Map1q33UniSTS
Apbb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21159,906,160 - 159,906,363 (+)MAPPERmRatBN7.2
Rnor_6.01170,396,897 - 170,397,099NCBIRnor6.0
Rnor_5.01177,402,803 - 177,403,005UniSTSRnor5.0
RGSC_v3.41163,292,185 - 163,292,387UniSTSRGSC3.4
Celera1157,838,828 - 157,839,030UniSTS
Cytogenetic Map1q33UniSTS


Related Rat Strains
The following Strains have been annotated to Apbb1
SHRSP.WKY-(Apbb1-D1Arb21)/Izm    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 14 6 6 1 2 74 27 38 11 1
Low 3 43 35 19 35 7 9 8 3 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024402   ⟹   ENSRNOP00000024402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1159,896,880 - 159,920,627 (-)Ensembl
Rnor_6.0 Ensembl1170,387,609 - 170,404,056 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090181   ⟹   ENSRNOP00000072751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1159,896,880 - 159,907,827 (-)Ensembl
Rnor_6.0 Ensembl1170,387,630 - 170,397,191 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101195   ⟹   ENSRNOP00000081663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1159,896,880 - 159,920,627 (-)Ensembl
RefSeq Acc Id: NM_080478   ⟹   NP_536726
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,308,720 - 169,325,135 (-)NCBI
mRatBN7.21159,896,894 - 159,913,309 (-)NCBI
Rnor_6.01170,387,630 - 170,404,045 (-)NCBI
Rnor_5.01177,393,531 - 177,417,140 (-)NCBI
RGSC_v3.41163,282,918 - 163,299,333 (-)RGD
Celera1157,829,568 - 157,845,995 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229935   ⟹   XP_006229997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,308,719 - 169,332,172 (-)NCBI
mRatBN7.21159,896,889 - 159,920,346 (-)NCBI
Rnor_6.01170,387,625 - 170,411,082 (-)NCBI
Rnor_5.01177,393,531 - 177,417,140 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759717   ⟹   XP_008757939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,308,719 - 169,319,397 (-)NCBI
mRatBN7.21159,896,889 - 159,907,505 (-)NCBI
Rnor_6.01170,387,625 - 170,398,220 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063287918   ⟹   XP_063143988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,308,719 - 169,326,867 (-)NCBI
RefSeq Acc Id: XM_063287919   ⟹   XP_063143989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,308,719 - 169,332,372 (-)NCBI
RefSeq Acc Id: XM_063287922   ⟹   XP_063143992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,308,719 - 169,319,554 (-)NCBI
RefSeq Acc Id: XM_063287931   ⟹   XP_063144001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,308,719 - 169,319,867 (-)NCBI
RefSeq Acc Id: XM_063287933   ⟹   XP_063144003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,308,719 - 169,319,887 (-)NCBI
RefSeq Acc Id: XM_063287936   ⟹   XP_063144006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,308,719 - 169,319,884 (-)NCBI
RefSeq Acc Id: XM_063287939   ⟹   XP_063144009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,308,719 - 169,320,671 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_536726   ⟸   NM_080478
- UniProtKB: Q99MK3 (UniProtKB/Swiss-Prot),   P46933 (UniProtKB/Swiss-Prot),   A0A8I5ZS47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229997   ⟸   XM_006229935
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QDX1 (UniProtKB/TrEMBL),   A0A8I5ZS47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757939   ⟸   XM_008759717
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000072751   ⟸   ENSRNOT00000090181
RefSeq Acc Id: ENSRNOP00000024402   ⟸   ENSRNOT00000024402
RefSeq Acc Id: ENSRNOP00000081663   ⟸   ENSRNOT00000101195
RefSeq Acc Id: XP_063143989   ⟸   XM_063287919
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063143988   ⟸   XM_063287918
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063144009   ⟸   XM_063287939
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063144003   ⟸   XM_063287933
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063144006   ⟸   XM_063287936
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063144001   ⟸   XM_063287931
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063143992   ⟸   XM_063287922
- Peptide Label: isoform X3
Protein Domains
PID   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46933-F1-model_v2 AlphaFold P46933 1-711 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2122 AgrOrtholog
BioCyc Gene G2FUF-58016 BioCyc
Ensembl Genes ENSRNOG00000018020 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024402.5 UniProtKB/TrEMBL
  ENSRNOT00000090181.2 UniProtKB/TrEMBL
  ENSRNOT00000101195.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fe65 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29722 UniProtKB/Swiss-Prot
NCBI Gene 29722 ENTREZGENE
PANTHER AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14058 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00397 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Apbb1 PhenoGen
PROSITE PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018020 RatGTEx
SMART PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00456 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51045 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K3S1_RAT UniProtKB/TrEMBL
  A0A8I5ZS47 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QDX1 ENTREZGENE, UniProtKB/TrEMBL
  A6I7I7_RAT UniProtKB/TrEMBL
  A6I7I8_RAT UniProtKB/TrEMBL
  A6I7I9_RAT UniProtKB/TrEMBL
  APBB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q99MK3 ENTREZGENE
UniProt Secondary Q99MK3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Apbb1  amyloid beta precursor protein binding family B member 1  Apbb1  amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Apbb1  amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)  Apbb1  amyloid beta (A4) precursor protein-binding, family B, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Apbb1  amyloid beta (A4) precursor protein-binding, family B, member 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease binds the Alzheimers disease associated human beta amyloid precursor protein in vitro 69752
gene_domains contains two phosphotyrosine binding domains 69752
gene_expression expressed in brain 69752
gene_function binds the NPTY intracellular domain of human beta amyloid precursor protein in vitro 69752