Aplp1 (amyloid beta precursor like protein 1) - Rat Genome Database

Send us a Message



Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Grant Resources Citing RGD About Us Contact Us
Search by Genomic Position Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quantitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Aplp1 (amyloid beta precursor like protein 1) Rattus norvegicus
Analyze
Symbol: Aplp1
Name: amyloid beta precursor like protein 1 (Ensembl:amyloid beta like protein 1)
RGD ID: 69257
Description: Predicted to enable adrenergic receptor binding activity and identical protein binding activity. Predicted to be involved in cellular response to norepinephrine stimulus; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and nervous system development. Predicted to act upstream of or within several processes, including cytosolic mRNA polyadenylation; extracellular matrix organization; and regulation of translation. Predicted to be located in membrane and perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus and plasma membrane. Orthologous to human APLP1 (amyloid beta precursor like protein 1); INTERACTS WITH (+)-pilocarpine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: amyloid beta (A4) precursor-like protein 1; amyloid beta (A4) precursor-like protein 1 (mapped); amyloid-like protein 1; Aplp1_mapped; Aplp1_retired; LOC502317; RGD1561211; similar to Amyloid beta (A4) precursor-like protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,824,330 - 94,834,705 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl194,824,072 - 94,834,610 (-)EnsemblGRCr8
mRatBN7.2185,696,880 - 85,707,215 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,696,882 - 85,707,155 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx191,113,388 - 91,123,714 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,579,915 - 99,590,199 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,871,656 - 92,881,982 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd193,440,309 - 93,450,589 (-)NCBI
Lyon_Normotensive198,582,857 - 98,592,962 (-)NCBI
Lyon_Hypertensive195,116,154 - 95,126,259 (-)NCBI
F344_StmMcwi193,566,951 - 93,577,292 (-)NCBI
Rnor_6.0188,897,525 - 88,908,750 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,897,532 - 88,908,750 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0190,053,390 - 90,063,110 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4185,390,217 - 85,401,952 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera180,069,348 - 80,079,276 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dibenzofurans  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethylenediaminetetraacetic acid  (ISO)
etoposide  (ISO)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Heptachlor epoxide  (ISO)
hydrazine  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rotenone  (ISO)
sarin  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
Golgi apparatus  (IBA,IEA,ISO)
membrane  (IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein. Duilio A, etal., Biochem J 1998 Feb 15;330 ( Pt 1):513-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment. Lee NH, etal., Proc Natl Acad Sci U S A 1995 Aug 29;92(18):8303-7.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1279693   PMID:12477932   PMID:15385965   PMID:16193067   PMID:16314516   PMID:16531006   PMID:21930949   PMID:25683482  


Genomics

Comparative Map Data
Aplp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,824,330 - 94,834,705 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl194,824,072 - 94,834,610 (-)EnsemblGRCr8
mRatBN7.2185,696,880 - 85,707,215 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,696,882 - 85,707,155 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx191,113,388 - 91,123,714 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,579,915 - 99,590,199 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,871,656 - 92,881,982 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd193,440,309 - 93,450,589 (-)NCBI
Lyon_Normotensive198,582,857 - 98,592,962 (-)NCBI
Lyon_Hypertensive195,116,154 - 95,126,259 (-)NCBI
F344_StmMcwi193,566,951 - 93,577,292 (-)NCBI
Rnor_6.0188,897,525 - 88,908,750 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,897,532 - 88,908,750 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0190,053,390 - 90,063,110 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4185,390,217 - 85,401,952 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera180,069,348 - 80,079,276 (-)NCBICelera
Cytogenetic Map1q21NCBI
APLP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,868,574 - 35,879,792 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,867,899 - 35,879,803 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371936,359,476 - 36,370,694 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,051,241 - 41,062,539 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341941,051,309 - 41,062,530NCBI
Celera1933,073,585 - 33,084,883 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,864,721 - 32,875,938 (+)NCBIHuRef
CHM1_11936,360,683 - 36,371,980 (+)NCBICHM1_1
T2T-CHM13v2.01938,414,328 - 38,425,546 (+)NCBIT2T-CHM13v2.0
Aplp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,134,405 - 30,144,960 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,134,404 - 30,145,102 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38730,434,980 - 30,445,582 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,434,982 - 30,445,535 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37731,220,001 - 31,230,580 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36730,143,742 - 30,154,321 (-)NCBIMGSCv36mm8
Celera725,026,598 - 25,037,193 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map718.32NCBI
Aplp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554682,694,591 - 2,703,656 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554682,694,286 - 2,703,658 (-)NCBIChiLan1.0ChiLan1.0
APLP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,867,959 - 41,879,251 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,852,723 - 43,864,012 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,786,362 - 32,797,728 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,534,776 - 41,545,908 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,534,569 - 41,545,906 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
APLP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,774,392 - 116,783,101 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,728,529 - 116,783,046 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1116,179,958 - 116,188,648 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01117,377,571 - 117,386,261 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,377,575 - 117,386,219 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,941,125 - 116,949,814 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,564,643 - 116,573,333 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,620,429 - 117,629,122 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aplp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11517,143,517 - 17,152,366 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_02440934911,161,610 - 11,170,431 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570474,902 - 484,188 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936570475,446 - 484,379 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APLP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,285,718 - 45,295,350 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1645,285,698 - 45,295,355 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,669,837 - 40,672,028 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APLP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1623,014,551 - 23,025,999 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_0236660738,572,301 - 8,583,860 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1630,780,112 - 30,791,582 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,780,085 - 30,791,636 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Aplp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479410,148,575 - 10,158,101 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462479410,148,522 - 10,167,543 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl2824,833,541 - 24,843,556 (-)Ensembl
Aplp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12165,556,084 - 165,566,706 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Aplp1
84 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:238
Count of miRNA genes:142
Interacting mature miRNAs:149
Transcripts:ENSRNOT00000028297
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat

Markers in Region
D1Bda13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2185,697,170 - 85,697,453 (+)MAPPERmRatBN7.2
Rnor_6.0188,897,814 - 88,898,096NCBIRnor6.0
Rnor_5.0190,053,673 - 90,053,955UniSTSRnor5.0
RGSC_v3.4185,390,508 - 85,390,790UniSTSRGSC3.4
Celera180,069,631 - 80,069,913UniSTS
Cytogenetic Map1q21UniSTS
RH135017  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2185,697,011 - 85,697,196 (+)MAPPERmRatBN7.2
Rnor_6.0188,897,655 - 88,897,839NCBIRnor6.0
Rnor_5.0190,053,514 - 90,053,698UniSTSRnor5.0
RGSC_v3.4185,390,349 - 85,390,533UniSTSRGSC3.4
Celera180,069,472 - 80,069,656UniSTS
RH 3.4 Map1848.9UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
275 156 728 1589 4063 1007 1722 133 870 422 852 156 5311 2519 443 3966 38 1388 740 907 160 158

Sequence


Ensembl Acc Id: ENSRNOT00000028297   ⟹   ENSRNOP00000028297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl194,824,072 - 94,834,610 (-)Ensembl
mRatBN7.2 Ensembl185,696,882 - 85,707,155 (-)Ensembl
Rnor_6.0 Ensembl188,897,532 - 88,908,750 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106909   ⟹   ENSRNOP00000092071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl194,824,330 - 94,834,610 (-)Ensembl
mRatBN7.2 Ensembl185,696,882 - 85,707,155 (-)Ensembl
RefSeq Acc Id: NM_001100802   ⟹   NP_001094272
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,824,330 - 94,834,610 (-)NCBI
mRatBN7.2185,696,880 - 85,707,160 (-)NCBI
Dahl_SR_JrHsd193,440,309 - 93,450,589 (-)NCBI
Lyon_Normotensive198,582,857 - 98,592,962 (-)NCBI
Lyon_Hypertensive195,116,154 - 95,126,259 (-)NCBI
F344_StmMcwi193,566,951 - 93,577,292 (-)NCBI
Rnor_6.0188,897,531 - 88,908,750 (-)NCBI
Celera180,069,348 - 80,079,276 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001399814   ⟹   NP_001386743
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,824,330 - 94,834,610 (-)NCBI
mRatBN7.2185,696,880 - 85,707,160 (-)NCBI
Dahl_SR_JrHsd193,440,309 - 93,450,589 (-)NCBI
Lyon_Normotensive198,582,857 - 98,592,962 (-)NCBI
Lyon_Hypertensive195,116,154 - 95,126,259 (-)NCBI
F344_StmMcwi193,566,951 - 93,577,292 (-)NCBI
RefSeq Acc Id: XM_039088308   ⟹   XP_038944236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,824,332 - 94,834,705 (-)NCBI
mRatBN7.2185,696,880 - 85,707,215 (-)NCBI
RefSeq Acc Id: NP_001094272   ⟸   NM_001100802
- Peptide Label: isoform 2 precursor
- UniProtKB: B1WBV6 (UniProtKB/TrEMBL),   F1LRS5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028297   ⟸   ENSRNOT00000028297
RefSeq Acc Id: XP_038944236   ⟸   XM_039088308
- Peptide Label: isoform X1
- UniProtKB: F1LRS5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092071   ⟸   ENSRNOT00000106909
RefSeq Acc Id: NP_001386743   ⟸   NM_001399814
- Peptide Label: isoform 1 precursor
- UniProtKB: F1LRS5 (UniProtKB/TrEMBL)
Protein Domains
Beta-amyloid precursor protein C-terminal   E1   E2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LRS5-F1-model_v2 AlphaFold F1LRS5 1-639 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689917
Promoter ID:EPDNEW_R440
Type:single initiation site
Name:Aplp1_1
Description:amyloid beta precursor like protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0188,908,776 - 88,908,836EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69257 AgrOrtholog
BioCyc Gene G2FUF-60110 BioCyc
Ensembl Genes ENSRNOG00000020851 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028297 ENTREZGENE
  ENSRNOT00000028297.7 UniProtKB/TrEMBL
  ENSRNOT00000106909 ENTREZGENE
  ENSRNOT00000106909.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.770 UniProtKB/TrEMBL
  3.30.1490.140 UniProtKB/TrEMBL
  3.90.570.10 UniProtKB/TrEMBL
InterPro Amyloid_Cu-bd_sf UniProtKB/TrEMBL
  Amyloid_glyco UniProtKB/TrEMBL
  Amyloid_glyco_Cu-bd UniProtKB/TrEMBL
  Amyloid_glyco_E2_domain UniProtKB/TrEMBL
  Amyloid_glyco_extra UniProtKB/TrEMBL
  Amyloid_glyco_extracell_CS UniProtKB/TrEMBL
  Amyloid_glyco_heparin-bd UniProtKB/TrEMBL
  Amyloid_glyco_heparin-bd_sf UniProtKB/TrEMBL
  Amyloid_glyco_intracell_CS UniProtKB/TrEMBL
  APP_amyloid UniProtKB/TrEMBL
  E2_sf UniProtKB/TrEMBL
KEGG Report rno:502317 UniProtKB/TrEMBL
NCBI Gene Aplp1 ENTREZGENE
PANTHER AMYLOID-LIKE PROTEIN 1 UniProtKB/TrEMBL
  PTHR23103 UniProtKB/TrEMBL
Pfam APP_amyloid UniProtKB/TrEMBL
  APP_Cu_bd UniProtKB/TrEMBL
  APP_E2 UniProtKB/TrEMBL
  APP_N UniProtKB/TrEMBL
PhenoGen Aplp1 PhenoGen
PRINTS AMYLOIDA4 UniProtKB/TrEMBL
PROSITE A4_EXTRA UniProtKB/TrEMBL
  A4_INTRA UniProtKB/TrEMBL
  APP_E1 UniProtKB/TrEMBL
  APP_E2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020851 RatGTEx
SMART A4_EXTRA UniProtKB/TrEMBL
Superfamily-SCOP A4_extra UniProtKB/TrEMBL
  Amyloid_glyco_Cu-bd UniProtKB/TrEMBL
  SSF109843 UniProtKB/TrEMBL
UniProt A0A8I6AD03_RAT UniProtKB/TrEMBL
  B1WBV6 ENTREZGENE, UniProtKB/TrEMBL
  F1LRS5 ENTREZGENE, UniProtKB/TrEMBL
  Q1P9T9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Aplp1  amyloid beta precursor like protein 1  Aplp1  amyloid beta (A4) precursor-like protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-04 Aplp1  amyloid beta (A4) precursor-like protein 1  RGD1561211  similar to Amyloid beta (A4) precursor-like protein 1   Data merged from RGD:1561211 737654 APPROVED
2008-04-30 RGD1561211  similar to Amyloid beta (A4) precursor-like protein 1   RGD1561211_predicted  similar to Amyloid beta (A4) precursor-like protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2007-04-13   amyloid beta (A4) precursor-like protein 1  Aplp1  amyloid beta (A4) precursor-like protein 1 (mapped)  Name updated 737654 APPROVED
2007-04-10 Aplp1    Aplp1_mapped  amyloid beta (A4) precursor-like protein 1 (mapped)  Symbol updated 737654 APPROVED
2006-11-19 Aplp1_mapped  amyloid beta (A4) precursor-like protein 1(mapped)  Aplp1  amyloid beta (A4) precursor-like protein 1  Symbol set to symbol_mapped, name set to name (mapped) 1582166 APPROVED
2006-11-19 Aplp1  amyloid beta (A4) precursor-like protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1561211_predicted  similar to Amyloid beta (A4) precursor-like protein 1 (predicted)  LOC502317  similar to Amyloid beta (A4) precursor-like protein 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC502317  similar to Amyloid beta (A4) precursor-like protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Aplp1  amyloid beta (A4) precursor-like protein 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference